Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

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Published in Diabetes on May 01, 2000

Authors

D A Stoffers1, T J Kieffer, M A Hussain, D J Drucker, S Bonner-Weir, J F Habener, J M Egan

Author Affiliations

1: Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, USA.

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Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet (1997) 5.47

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Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques (1990) 5.02

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Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20

The glucagon-like peptides. Endocr Rev (1999) 3.51

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes (1995) 3.47

Retracted Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. EMBO J (1990) 3.29

Pre-proparathyroid hormone: a direct translation product of parathyroid messenger RNA. Proc Natl Acad Sci U S A (1974) 3.24

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Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia (2005) 3.10

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New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes (1982) 2.87

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Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab (2001) 2.49

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Pre-proparathyroid hormone: analysis of radioactive tryptic peptides and amino acid sequence. Biochemistry (1976) 2.25

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem (1986) 2.22

Chemical characterization of leptin-activated neurons in the rat brain. J Comp Neurol (2000) 2.21

Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects. Diabetes Care (1992) 2.21

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Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation (1987) 2.14

Predicting cardiac complications in patients undergoing non-cardiac surgery. J Gen Intern Med (1986) 2.13

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci U S A (1993) 2.09

Pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor region. Proc Natl Acad Sci U S A (1978) 2.07

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology (1996) 2.06

Parathyroid hormone: secretion and metabolism in vivo. Proc Natl Acad Sci U S A (1971) 2.04

Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia (2010) 2.04

Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes (1996) 2.04

Proparathyroid hormone: identification of a biosynthetic precursor to parathyroid hormone. Proc Natl Acad Sci U S A (1972) 1.97

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes (1997) 1.96

Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A (1984) 1.93

Structural determinants for transcriptional activation by cAMP-responsive DNA elements. J Biol Chem (1988) 1.93

A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element. EMBO J (1990) 1.92

Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci U S A (2000) 1.91

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest (1999) 1.89

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest (1998) 1.86

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An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene. Mol Cell Biol (1990) 1.81

Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes (2001) 1.81

Subcutaneous infusion and intramuscular injection of desferrioxamine in patients with transfusional iron overload. Lancet (1976) 1.81

Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology (2000) 1.81

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci U S A (1996) 1.80

Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans. Gastroenterology (1999) 1.79

Parathyroid Hormone in Human Plasma: IMMUNOCHEMICAL CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS. J Clin Invest (1972) 1.77

Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care (1992) 1.76

Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice. J Clin Invest (1993) 1.75

Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression. J Biol Chem (1987) 1.75

Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest (1986) 1.73

Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. Proc Natl Acad Sci U S A (1990) 1.71

Improvement in iron status and liver function in patients with transfusional iron overload with long-term subcutaneous desferrioxamine. Lancet (1979) 1.70

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Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia. Diabetes (1981) 1.68

Pre-proparathyroid hormone. Evidence for an early biosynthetic precursor of proparathyroid hormone. J Biol Chem (1976) 1.67

Leptin receptors expressed on pancreatic beta-cells. Biochem Biophys Res Commun (1996) 1.67

Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. Am J Physiol Endocrinol Metab (2001) 1.67

Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling. Endocrinology (2000) 1.63

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Regulatory factor linked to late-onset diabetes? Nature (1998) 1.55

Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest (1993) 1.55

Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor. Diabetes (1990) 1.55

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res (2001) 1.54

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem. Proc Natl Acad Sci U S A (1982) 1.54

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Glucose-dependent insulin release from genetically engineered K cells. Science (2000) 1.52

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest (1998) 1.51

Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo. J Invest Dermatol (1998) 1.51

Structural analysis of human proparathyroid hormone by a new microsequencing approach. Nature (1974) 1.50

Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem Sci (1992) 1.50

Novel cyclic adenosine 3',5'-monophosphate (cAMP) response element modulator theta isoforms expressed by two newly identified cAMP-responsive promoters active in the testis. Endocrinology (2000) 1.50

Events surrounding the early development of Euglena chloroplasts: cellular origins of chloroplast enzymes in euglena. J Gen Microbiol (1974) 1.48

Glucagonlike peptide I (7-37) actions on endocrine pancreas. Diabetes (1989) 1.48

cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37). J Biol Chem (1999) 1.47

Proparathyroid hormone: biosynthesis by human parathyroid adenomas. Science (1972) 1.47

Cyclic AMP signaling and gene regulation. Annu Rev Nutr (1998) 1.46

The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul Pept (1994) 1.46

Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge. Biochemistry (1998) 1.45