Published in Mol Biol Cell on May 01, 2001
Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev (2007) 3.30
The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell (2003) 2.57
The yeast actin cytoskeleton: from cellular function to biochemical mechanism. Microbiol Mol Biol Rev (2006) 2.55
Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p. J Cell Biol (2002) 1.94
Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud. J Cell Biol (2001) 1.94
Remodeling of organelle-bound actin is required for yeast vacuole fusion. J Cell Biol (2002) 1.92
The rate of cell growth is governed by cell cycle stage. Genes Dev (2009) 1.82
Dual modes of cdc42 recycling fine-tune polarized morphogenesis. Dev Cell (2009) 1.73
Role of a Cdc42p effector pathway in recruitment of the yeast septins to the presumptive bud site. Mol Biol Cell (2005) 1.51
Septin function in yeast model systems and pathogenic fungi. Eukaryot Cell (2005) 1.41
Singularity in budding: a role for the evolutionarily conserved small GTPase Cdc42p. Proc Natl Acad Sci U S A (2002) 1.33
Morphogenesis and the cell cycle. Genetics (2012) 1.29
Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle. Mol Biol Cell (2007) 1.18
Genetic interactions among regulators of septin organization. Eukaryot Cell (2004) 1.16
Shs1 plays separable roles in septin organization and cytokinesis in Saccharomyces cerevisiae. Genetics (2007) 1.08
Identification of novel membrane-binding domains in multiple yeast Cdc42 effectors. Mol Biol Cell (2007) 1.07
Modeling the function of bacterial virulence factors in Saccharomyces cerevisiae. Eukaryot Cell (2004) 1.05
Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42. J Biol Chem (2008) 1.02
Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth. Eukaryot Cell (2005) 1.02
Budding yeast PAK kinases regulate mitotic exit by two different mechanisms. J Cell Biol (2003) 0.95
Cdc42p GDP/GTP cycling is necessary for efficient cell fusion during yeast mating. Mol Biol Cell (2006) 0.93
Role of Cdc42-Cla4 interaction in the pheromone response of Saccharomyces cerevisiae. Eukaryot Cell (2006) 0.82
Septins and Generation of Asymmetries in Fungal Cells. Annu Rev Microbiol (2015) 0.81
A switch I mutant of Cdc42 exhibits less conformational freedom. Biochemistry (2011) 0.81
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
Rho GTPases and the actin cytoskeleton. Science (1998) 28.19
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell (1995) 24.99
Multifunctional yeast high-copy-number shuttle vectors. Gene (1992) 19.47
Relationship of actin and tubulin distribution to bud growth in wild-type and morphogenetic-mutant Saccharomyces cerevisiae. J Cell Biol (1984) 13.62
Rho GTPases and signaling networks. Genes Dev (1997) 11.70
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell (1995) 9.82
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell (1995) 9.30
A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature (1994) 9.18
High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol (1997) 8.18
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell (1999) 8.07
An essential G1 function for cyclin-like proteins in yeast. Cell (1989) 7.43
CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol (1990) 7.29
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J (1990) 6.51
Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. Mol Cell Biol (1991) 6.30
Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. J Cell Biol (1993) 6.28
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell (1996) 5.34
Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis. Science (1997) 5.27
Multiple Ras functions can contribute to mammalian cell transformation. Cell (1995) 5.24
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol (1997) 4.91
The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response. Genes Dev (1995) 4.85
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem (1995) 4.62
Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae. J Cell Biol (1991) 4.54
The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes. Curr Biol (1998) 4.14
Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. J Cell Biol (1998) 4.07
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components. EMBO J (1992) 3.91
Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev (1995) 3.79
Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol Biol Cell (1993) 3.70
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev (1999) 3.61
Staining of bud scars and other cell wall chitin with calcofluor. Methods Enzymol (1991) 3.40
Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev (1999) 3.36
RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science (1996) 3.30
Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity. Mol Cell Biol (1991) 3.20
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science (1996) 3.18
Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells. Nat Cell Biol (1999) 3.12
Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol (2000) 2.99
Establishment of cell polarity in yeast. Cold Spring Harb Symp Quant Biol (1995) 2.87
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol (1996) 2.69
Developmental control of endocytosis in dendritic cells by Cdc42. Cell (2000) 2.64
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature (1993) 2.60
Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast. J Cell Biol (1995) 2.59
Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J (1996) 2.58
Components required for cytokinesis are important for bud site selection in yeast. J Cell Biol (1993) 2.50
Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway. Nature (1995) 2.48
Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol (1999) 2.44
Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9. J Cell Biol (1999) 2.33
Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24. Mol Cell Biol (1995) 2.31
RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. EMBO J (1998) 2.22
Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J (1997) 2.20
The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol (1999) 2.19
Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol Biol Cell (1996) 2.16
Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Genes Dev (1997) 2.12
A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J Biol Chem (1996) 2.06
Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. J Biol Chem (2000) 2.04
The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae. Genes Dev (1997) 1.79
A role for the actin cytoskeleton of Saccharomyces cerevisiae in bipolar bud-site selection. J Cell Biol (1997) 1.65
Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast. Mol Biol Cell (2000) 1.64
PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae. J Cell Biol (1999) 1.58
The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. J Cell Biol (1999) 1.57
Mechanism of Cdc42-induced actin polymerization in neutrophil extracts. J Cell Biol (1998) 1.51
The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex. EMBO J (1998) 1.50
Functions and functional domains of the GTPase Cdc42p. Mol Biol Cell (2000) 1.45
Ras effectors and their role in mitogenesis and oncogenesis. J Mol Med (Berl) (1997) 1.40
The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast. J Biol Chem (1999) 1.39
Actin polymerization: Where the WASP stings. Curr Biol (1999) 1.35
How Ras-related proteins talk to their effectors. Trends Biochem Sci (1996) 1.33
Rac GTPase interacts with GAPs and target proteins through multiple effector sites. EMBO J (1995) 1.25
Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae. Mol Cell Biol (2000) 1.24
Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK-like protein kinase. Mol Microbiol (1997) 1.16
Induction of exocytosis from permeabilized mast cells by the guanosine triphosphatases Rac and Cdc42. Mol Biol Cell (1998) 1.07
Saccharomyces cerevisiae cdc42p GTPase is involved in preventing the recurrence of bud emergence during the cell cycle. Mol Cell Biol (2000) 1.03
Residues in Cdc42 that specify binding to individual CRIB effector proteins. Biochemistry (2000) 1.01
SPECs, small binding proteins for Cdc42. J Biol Chem (2000) 0.88
A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell (1991) 4.90
Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. J Cell Biol (1998) 4.07
Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. Genes Dev (1992) 3.83
Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. EMBO J (1991) 3.28
The septin cortex at the yeast mother-bud neck. Curr Opin Microbiol (2001) 3.23
A protein interaction map for cell polarity development. J Cell Biol (2001) 3.23
Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol (2000) 2.99
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75
Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. Genes Dev (1998) 2.75
AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol Cell Biol (1997) 2.56
Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein. EMBO J (1989) 2.39
The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol (1999) 2.19
Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol Biol Cell (1996) 2.16
A morphogenesis checkpoint monitors the actin cytoskeleton in yeast. J Cell Biol (1998) 2.13
Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. J Biol Chem (2000) 2.04
Flow cytometric analysis of DNA content in budding yeast. Methods Enzymol (1997) 2.03
Control of Swe1p degradation by the morphogenesis checkpoint. EMBO J (1998) 1.99
Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud. J Cell Biol (2001) 1.94
The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J (1994) 1.87
Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.80
Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene. Mol Cell Biol (1991) 1.75
Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants. Mol Biol Cell (2000) 1.65
A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint. Nat Cell Biol (2001) 1.62
A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res (1996) 1.57
The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. J Cell Biol (1999) 1.57
Phosphorylation-independent inhibition of Cdc28p by the tyrosine kinase Swe1p in the morphogenesis checkpoint. Mol Cell Biol (1999) 1.37
A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse. Proc Natl Acad Sci U S A (1992) 1.36
The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene (1995) 1.35
Identification of a conserved family of Meis1-related homeobox genes. Genome Res (1997) 1.26
Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae. Mol Cell Biol (2000) 1.24
Induction of cyclin mRNA and cyclin-associated histone H1 kinase during liver regeneration. J Biol Chem (1992) 1.07
Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. J Biol Chem (1998) 0.93
Mouse chromosome 11. Mamm Genome (1991) 0.88
G1 control in yeast and animal cells. Cold Spring Harb Symp Quant Biol (1991) 0.84
Dehydration and delayed proton equilibria of red blood cells suspended in isosmotic phosphate buffers. Implications for studies of sickled cells. J Lab Clin Med (1984) 0.82
G1 control in yeast and animal cells. Ciba Found Symp (1992) 0.82
Epidermal surface antigen (MS17S1) is highly conserved between mouse and human. Genomics (1995) 0.76
Seroprevalence of HTLV-I in Cheju Island, a Korean island adjacent to the endemic area of Japan. J Acquir Immune Defic Syndr (1999) 0.76