Published in Eukaryot Cell on August 01, 2004
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking. Proc Natl Acad Sci U S A (2005) 2.05
LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathway. Infect Immun (2005) 1.49
Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways. Cell Microbiol (2008) 1.47
Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation. PLoS Pathog (2007) 1.37
The Yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins. Cell Host Microbe (2008) 1.33
Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formation. J Bacteriol (2013) 1.00
Cholera- and anthrax-like toxins are among several new ADP-ribosyltransferases. PLoS Comput Biol (2010) 0.96
Functional characterization of a phospholipase A(2) homolog from Rickettsia typhi. J Bacteriol (2010) 0.95
Rickettsia typhi possesses phospholipase A2 enzymes that are involved in infection of host cells. PLoS Pathog (2013) 0.89
A simple yeast-based strategy to identify host cellular processes targeted by bacterial effector proteins. PLoS One (2011) 0.88
Genome-wide analysis of cellular response to bacterial genotoxin CdtB in yeast. Infect Immun (2007) 0.86
RipAY, a Plant Pathogen Effector Protein, Exhibits Robust γ-Glutamyl Cyclotransferase Activity When Stimulated by Eukaryotic Thioredoxins. J Biol Chem (2016) 0.79
Identification of Critical Amino Acids Conferring Lethality in VopK, a Type III Effector Protein of Vibrio cholerae: Lessons from Yeast Model System. PLoS One (2015) 0.78
The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae. Mol Biol Cell (2012) 0.78
The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection. Infect Immun (2016) 0.77
Studying Coxiella burnetii Type IV Substrates in the Yeast Saccharomyces cerevisiae: Focus on Subcellular Localization and Protein Aggregation. PLoS One (2016) 0.76
A multifunctional region of the Shigella type 3 effector IpgB1 is important for secretion from bacteria and membrane targeting in eukaryotic cells. PLoS One (2014) 0.76
Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. Mol Biol Cell (2010) 0.76
VopE, a Vibrio cholerae Type III Effector, Attenuates the Activation of CWI-MAPK Pathway in Yeast Model System. Front Cell Infect Microbiol (2017) 0.75
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
Global analysis of protein expression in yeast. Nature (2003) 34.15
Global analysis of protein localization in budding yeast. Nature (2003) 33.22
Rho and Rac take center stage. Cell (2004) 10.64
Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev (1997) 10.52
A network of protein-protein interactions in yeast. Nat Biotechnol (2000) 10.31
Autophagy as a cell death and tumor suppressor mechanism. Oncogene (2004) 6.92
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev (1998) 6.20
Interfaces between the detection, signaling, and repair of DNA damage. Science (2002) 5.33
A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science (2000) 5.31
Systematic screen for human disease genes in yeast. Nat Genet (2002) 4.97
Bacterial invasion: the paradigms of enteroinvasive pathogens. Science (2004) 4.95
Actin assembly and endocytosis: from yeast to mammals. Annu Rev Cell Dev Biol (2003) 4.38
Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science (2000) 4.22
Pseudomonas-Candida interactions: an ecological role for virulence factors. Science (2002) 3.35
The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J (2003) 3.10
Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Science (1999) 2.78
The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane. Mol Microbiol (1996) 2.65
GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure. Mol Microbiol (2000) 2.56
The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence. Mol Microbiol (2000) 2.56
Sorting in the endosomal system in yeast and animal cells. Curr Opin Cell Biol (2000) 2.50
DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae. Mutat Res (2001) 2.50
Pseudomonas type III effector AvrPtoB induces plant disease susceptibility by inhibition of host programmed cell death. EMBO J (2003) 2.48
Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol (2003) 2.46
A quantitative model of intracellular growth of Legionella pneumophila in Acanthamoeba castellanii. Infect Immun (1992) 2.44
Salmonella entry into host cells: the work in concert of type III secreted effector proteins. Microbes Infect (2001) 2.39
Microbial pathogenesis and cytoskeletal function. Nature (2003) 2.38
The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae. Mol Microbiol (1999) 2.31
Controlling the maturation of pathogen-containing vacuoles: a matter of life and death. Nat Cell Biol (1999) 2.17
A Salmonella protein causes macrophage cell death by inducing autophagy. J Cell Biol (2003) 2.15
The cytolethal distending toxin family. Trends Microbiol (1999) 2.15
Multiple sorting pathways between the late Golgi and the vacuole in yeast. Biochim Biophys Acta (1998) 1.96
Pathogenic trickery: deception of host cell processes. Nat Rev Mol Cell Biol (2001) 1.95
Chlamydia trachomatis uses host cell dynein to traffic to the microtubule-organizing center in a p50 dynamitin-independent process. J Cell Sci (2003) 1.94
Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia. J Infect Dis (2003) 1.90
Striking a balance: modulation of the actin cytoskeleton by Salmonella. Proc Natl Acad Sci U S A (2000) 1.89
Control of actin turnover by a salmonella invasion protein. Mol Cell (2004) 1.89
Identification of Pseudomonas syringae type III effectors that can suppress programmed cell death in plants and yeast. Plant J (2004) 1.86
Cloning, expression, purification and characterization of patatin, a novel phospholipase A. Eur J Biochem (2001) 1.80
Transposon-based strategies for microbial functional genomics and proteomics. Annu Rev Genet (2003) 1.77
Evolutionary conservation of microtubule-capture mechanisms. Nat Rev Mol Cell Biol (2002) 1.76
Maximizing the potential of functional genomics. Nat Rev Genet (2004) 1.72
Characterization of mediators of microbial virulence and innate immunity using the Caenorhabditis elegans host-pathogen model. Cell Microbiol (2003) 1.70
Rho GTPases as targets of bacterial protein toxins. Biol Chem (2000) 1.68
Human targets of Pseudomonas aeruginosa pyocyanin. Proc Natl Acad Sci U S A (2003) 1.65
Targeting of the Yersinia pestis YopM protein into HeLa cells and intracellular trafficking to the nucleus. Mol Microbiol (1998) 1.62
Cell-cycle checkpoints that ensure coordination between nuclear and cytoplasmic events in Saccharomyces cerevisiae. Curr Opin Genet Dev (2000) 1.52
Expression of microbial virulence proteins in Saccharomyces cerevisiae models mammalian infection. EMBO J (2001) 1.51
Bacterial interactions with the autophagic pathway. Cell Microbiol (2002) 1.46
COPs regulating membrane traffic. Annu Rev Cell Dev Biol (1995) 1.38
COPI in ER/Golgi and intra-Golgi transport: do yeast COPI mutants point the way? Biochim Biophys Acta (1998) 1.36
Pseudomonas aeruginosa ExoU, a toxin transported by the type III secretion system, kills Saccharomyces cerevisiae. Infect Immun (2003) 1.26
The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Infect Immun (2004) 1.25
Pseudomonas aeruginosa exoenzyme S, a bifunctional type-III secreted cytotoxin. Int J Med Microbiol (2000) 1.25
Cytolethal distending toxin demonstrates genotoxic activity in a yeast model. Infect Immun (2001) 1.23
YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. Cell Microbiol (2001) 1.21
Insights from yeast endosomes. Curr Opin Cell Biol (2002) 1.21
Super models. Physiol Genomics (2003) 1.20
Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation? FEMS Microbiol Lett (2001) 1.18
Determinants of pathogenicity and avirulence in plant pathogenic bacteria. Curr Opin Plant Biol (1998) 1.17
Involvement of SipA in modulating actin dynamics during Salmonella invasion into cultured epithelial cells. Cell Microbiol (2002) 1.16
Various bacterial pathogens and symbionts infect the amoeba Dictyostelium discoideum. Int J Med Microbiol (2002) 1.15
The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell (2001) 1.14
Modular complexes that regulate actin assembly in budding yeast. Curr Opin Microbiol (2001) 1.13
Isolation and characterization of effector-loop mutants of CDC42 in yeast. Mol Biol Cell (2001) 1.13
Different domains of the essential GTPase Cdc42p required for growth and development of Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.12
Yeast as a touchstone in post-genomic research: strategies for integrative analysis in functional genomics. J Biochem Mol Biol (2004) 1.12
ACTIN: general principles from studies in yeast. Annu Rev Cell Dev Biol (1996) 1.11
Identification of a nuclear targeting signal in YopM from Yersinia spp. Microb Pathog (2004) 1.10
Exploiting host microtubule dynamics: a new aspect of bacterial invasion. Trends Microbiol (2003) 1.05
RHO GTPases in the control of cell morphology, cell polarity, and actin localization in fission yeast. Microsc Res Tech (1999) 1.05
Cell biology. Microtubule asymmetry. Science (2003) 1.04
Apoptosis-like yeast cell death in response to DNA damage and replication defects. Mutat Res (2003) 1.02
Application of a Saccharomyces cerevisiae model to study requirements for trafficking of Yersinia pestis YopM in eucaryotic cells. Infect Immun (2003) 1.00
Replication of bovine papillomavirus type 1 (BPV-1) DNA in Saccharomyces cerevisiae following infection with BPV-1 virions. J Virol (2002) 0.97
Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism. J Biol Chem (2002) 0.95
Large-scale mutagenesis and functional genomics in yeast. Funct Integr Genomics (2002) 0.94
Defining the molecular and cellular basis of toxicity using comparative models. Toxicol Appl Pharmacol (2002) 0.94
Yeast as a tool to study Bax/mitochondrial interactions in cell death. FEMS Yeast Res (2003) 0.92
Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1. J Virol (2002) 0.91
Exploitation of the endoplasmic reticulum by bacterial pathogens. Trends Microbiol (2002) 0.89
A novel connection between the yeast Cdc42 GTPase and the Slt2-mediated cell integrity pathway identified through the effect of secreted Salmonella GTPase modulators. J Biol Chem (2002) 0.86
Surrogate hosts: protozoa and invertebrates as models for studying pathogen-host interactions. Int J Med Microbiol (2003) 0.83
Screening the fruitfly immune system. Genome Biol (2002) 0.83
Cellular microbiology: cycling into the millennium. Trends Cell Biol (1998) 0.81
High-throughput cell-based assays in yeast. Drug Discov Today (2002) 0.79
Yeast functional genomics and cell biology: no longer in the dark. Genome Biol (2003) 0.76