Published in Anesthesiology on May 01, 2001
General anesthetics have additive actions on three ligand gated ion channels. Anesth Analg (2008) 1.03
Volatile anesthetics affect nutrient availability in yeast. Genetics (2002) 0.92
Paired assessment of volatile anesthetic concentrations with synaptic actions recorded in vitro. PLoS One (2008) 0.85
G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels. J Biol Chem (2010) 0.80
The effect of desflurane on neuronal communication at a central synapse. PLoS One (2015) 0.77
Interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor. Biochemistry (2008) 0.77
What are "relevant" concentrations? Anesthesiology (2001) 0.76
A Mechanistic Neural Field Theory of How Anesthesia Suppresses Consciousness: Synaptic Drive Dynamics, Bifurcations, Attractors, and Partial State Equipartitioning. J Math Neurosci (2015) 0.75
The steep dose-response curves of anesthesia. Anesthesiology (2002) 0.75
Seeking an integrated model of anesthetic action. Anesthesiology (2001) 0.75
On the relevance of "clinically relevant concentrations" of inhaled anesthetics in in vitro experiments. Anesthesiology (1999) 3.20
Tree allometry and improved estimation of carbon stocks and balance in tropical forests. Oecologia (2005) 10.52
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature (1997) 7.49
Molecular and cellular mechanisms of general anaesthesia. Nature (1994) 6.94
Spatial patterns in the distribution of tropical tree species. Science (2000) 5.46
Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials. Lancet (1996) 5.03
The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci (2002) 3.52
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure (1996) 3.51
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J (1998) 3.36
Structural analysis of hydrated egg lecithin and cholesterol bilayers. II. Neutrol diffraction. J Mol Biol (1976) 3.30
Do general anaesthetics act by competitive binding to specific receptors? Nature (1984) 3.09
Whole cell currents and mechanical responses of isolated outer hair cells. Hear Res (1988) 2.98
The effects of bilayer thickness and tension on gramicidin single-channel lifetime. Biochim Biophys Acta (1983) 2.97
RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages. Scand J Immunol (2005) 2.96
Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy: a randomized double-blind study. Anesthesiology (2000) 2.95
Molecular mechanisms of general anaesthesia. Nature (1982) 2.76
The structure of lipid bilayers and the effects of general anaesthetics. An x-ray and neutron diffraction study. J Mol Biol (1979) 2.67
The "educated hand". Can anesthesiologists assess changes in neonatal pulmonary compliance manually? Anesthesiology (1991) 2.61
Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals. Anesthesiology (1998) 2.50
Structural analysis of hydrated egg lecithin and cholesterol bilayers. I. X-ray diffraction. J Mol Biol (1976) 2.44
Transport of protons across membranes by weak acids. Physiol Rev (1980) 2.38
The role of coronary angiography and coronary revascularization before noncardiac vascular surgery. JAMA (1995) 2.38
Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J Biol Chem (2000) 2.37
Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects. Nature (1985) 2.27
Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci U S A (2000) 2.24
Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA (1998) 2.16
Intramuscular rocuronium in infants and children. Dose-ranging and tracheal intubating conditions. Anesthesiology (1996) 2.14
Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J (1998) 2.11
A confidential study of deaths after emergency medical admission: issues relating to quality of care. Clin Med (2003) 2.10
A molecular model of human branched-chain amino acid metabolism. Am J Clin Nutr (1998) 2.09
Surrogate end points. Are they meaningful? Anesthesiology (1994) 2.05
Conformational basis of energy transformations in membrane systems. 3. Configurational changes in the mitochondrial inner membrane induced by changes in functional states. Arch Biochem Biophys (1968) 2.04
A pharmacodynamic explanation for the rapid onset/offset of rapacuronium bromide. Anesthesiology (1999) 2.03
Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol (2001) 2.01
Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg (1997) 1.98
Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes. Diabetes (1999) 1.95
Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res (2000) 1.93
Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon. Anesthesiology (2000) 1.93
G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat Neurosci (1999) 1.92
The conformational basis of energy conservation in membrane systems. II. Correlation between conformational change and functional states. Proc Natl Acad Sci U S A (1968) 1.91
Xenon: no stranger to anaesthesia. Br J Anaesth (2003) 1.86
Twenty-four-hour pharmacokinetics of rectal acetaminophen in children: an old drug with new recommendations. Anesthesiology (1997) 1.84
Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics. Anesthesiology (1997) 1.84
Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophys J (1998) 1.83
Implications for prediction and hazard assessment from the 2004 Parkfield earthquake. Nature (2005) 1.81
Where do general anaesthetics act? Nature (1978) 1.81
Neurobiology of alcohol abuse. Trends Pharmacol Sci (1992) 1.81
Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesth Analg (1997) 1.80
Opening rate of acetylcholine receptor channels. Biophys J (1991) 1.80
Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. J Biol Chem (1998) 1.77
Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc Natl Acad Sci U S A (1998) 1.76
Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate. Arch Biochem Biophys (1975) 1.73
Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. Br J Pharmacol (1996) 1.72
The placement of the epidural catheter at the predicted site by electrical stimulation test. Anesth Analg (2001) 1.71
Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation. J Biol Chem (1982) 1.71
Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology (2000) 1.70
Biological membranes behave as non-porous polymeric sheets with respect to the diffusion of non-electrolytes. Nature (1969) 1.69
Identification by mutagenesis of a Mg(2+)-block site of the NMDA receptor channel. Nature (1992) 1.68
Genetic factors influencing alcohol dependence. Br J Pharmacol (2008) 1.64
Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels. Science (1991) 1.63
Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia. Proc Natl Acad Sci U S A (1986) 1.61
Regulation of branched-chain alpha-ketoacid dehydrogenase kinase. Arch Biochem Biophys (1984) 1.57
Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. J Biol Chem (1998) 1.57
Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues. Arch Biochem Biophys (2000) 1.57
A method for the rapid exchange of solutions bathing excised membrane patches. Biophys J (1986) 1.56
The dielectric constant of phospholipid bilayers and the permeability of membranes to ions. Science (1979) 1.55
Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev (1989) 1.52
Highly efficient generation of recombinant baculoviruses by enzymatically medicated site-specific in vitro recombination. Nucleic Acids Res (1992) 1.52
Cation movements in the high sodium erythrocyte of the cat. J Gen Physiol (1967) 1.52
A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors. Mol Pharmacol (1996) 1.51
Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha. Biochem Biophys Res Commun (2001) 1.50
Propofol and barbiturate depression of spinal nociceptive neurotransmission. Anesthesiology (1992) 1.50
Activity state of the branched chain alpha-ketoacid dehydrogenase complex in heart, liver, and kidney of normal, fasted, diabetic, and protein-starved rats. Biochem Biophys Res Commun (1983) 1.50
How does xenon produce anaesthesia? Nature (1998) 1.49
Volatile general anaesthetics activate a novel neuronal K+ current. Nature (1988) 1.49
The conformational basis of energy transformations in membrane systems. I. Conformational changes in mitochondria. Proc Natl Acad Sci U S A (1968) 1.46
Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav Immun (2011) 1.46
Improving the design of muscle relaxant studies. Stabilization period and tetanic recruitment. Anesthesiology (1997) 1.45
Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases. J Biol Chem (1993) 1.45
Testing and characterizing the simple carrier. Biochim Biophys Acta (1974) 1.44
Effects of naloxone and morphine on acute hypoxic survival in mice. Crit Care Med (1999) 1.44
Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases. J Biol Chem (1992) 1.42
Haematological effects of reinfused mediastinal blood after cardiac surgery. Med J Aust (1991) 1.42
Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther (1999) 1.42
Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. J Pharmacol Exp Ther (2001) 1.42
Fatty acid binding to human serum albumin: new insights from crystallographic studies. Biochim Biophys Acta (1999) 1.42
Does nitrous oxide cause vomiting? Anesth Analg (1996) 1.41
Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. J Biol Chem (1996) 1.41
Sedating pediatric patients: is propofol a panacea? Radiology (1993) 1.39