Published in Biochemistry on June 19, 2001
RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Blood (2007) 1.33
Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion. Nat Commun (2013) 1.13
The diverse functions of Src family kinases in macrophages. Front Biosci (2008) 1.01
Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis. Am J Pathol (2010) 0.98
A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets. Br J Pharmacol (2012) 0.97
Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biol (2012) 0.96
Down-regulation of c-Cbl by morphine accounts for persistent ERK1/2 signaling in delta-opioid receptor-expressing HEK293 cells. J Biol Chem (2009) 0.84
An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma. Biochem Biophys Res Commun (2012) 0.82
The Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation. PLoS One (2015) 0.78
Src regulates sequence-dependent beta-2 adrenergic receptor recycling via cortactin phosphorylation. Traffic (2014) 0.76
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther (2001) 4.37
The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett (2000) 2.22
Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process. Biochemistry (1995) 2.13
Citrobacter infections in humans: experience at the Seattle Veterans Administration Medical Center and a review of the literature. Rev Infect Dis (1983) 2.08
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. Cancer Res (2001) 2.06
Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia. J Med Chem (1990) 2.04
SH2- and SH3-mediated interactions between focal adhesion kinase and Src. J Biol Chem (1998) 1.77
Regulation of methionine synthesis in Escherichia coli: Effect of metJ gene product and S-adenosylmethionine on the expression of the metF gene. Proc Natl Acad Sci U S A (1985) 1.45
Supplemental oxygen: ensuring its safe delivery during facial surgery. Plast Reconstr Surg (1995) 1.43
Accuracy of ultrasonography performed by examiners with varied training and experience in predicting specific pathology of adnexal masses. Ultrasound Obstet Gynecol (2015) 1.39
Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition. Antimicrob Agents Chemother (1993) 1.36
Isolation and characterization of the product of the methionine-regulatory gene metJ of Escherichia coli K-12. Proc Natl Acad Sci U S A (1985) 1.34
Regulation of the methionine regulon in Escherichia coli. Bioessays (1985) 1.33
Changes in pulmonary circulation in severe bronchopulmonary dysplasia. Arch Dis Child (1990) 1.31
A modification of the formol-ether concentration technique for increased sensitivity in detecting Schistosoma mansoni eggs. Am J Trop Med Hyg (1976) 1.25
Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity. Antimicrob Agents Chemother (1991) 1.24
Evaluation of "electronic" spirometers. N Engl J Med (1973) 1.23
Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol. Proc Natl Acad Sci U S A (1991) 1.19
Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). J Med Chem (1993) 1.13
Does prostacyclin enhance the selective pulmonary vasodilator effect of oxygen in children with congenital heart disease? Circulation (1986) 1.13
Familial dysautonomia. N Engl J Med (1966) 1.12
Regulation of methionine synthesis in Escherichia coli: effect of metJ gene product and S-adenosylmethionine on the in vitro expression of the metB, metL and metJ genes. Biochem Biophys Res Commun (1985) 1.11
Family involvement in the nursing home: family-oriented practices and staff-family relationships. Res Nurs Health (1997) 1.11
Correlation of the phosphorylation states of pp60c-src with tyrosine kinase activity: the intramolecular pY530-SH2 complex retains significant activity if Y419 is phosphorylated. Biochemistry (1996) 1.05
Multicentre external validation of IOTA prediction models and RMI by operators with varied training. Br J Cancer (2013) 1.05
Oxygen supplementation before or after submaximal exercise in patients with chronic obstructive pulmonary disease. Thorax (2003) 1.04
Factors in the pathogenesis of acute schistosomiasis mansoni. J Infect Dis (1979) 1.03
Trends in ixodid tick abundance and distribution in Great Britain. Med Vet Entomol (2008) 1.02
Exo-site affinity labeling of human thrombins. Similar labeling on the A chain and B chain/fragments of clotting alpha- and nonclotting gamma/beta-thrombins. J Biol Chem (1977) 1.01
Androgen transport and receptor mechanisms in testis and epididymis. Nature (1974) 0.99
Cloning of the methionine regulatory gene, metJ, of Escherichia coli K12 and identification of its product. J Biol Chem (1984) 0.99
Immunodiagnosis of infection with Schistosoma mansoni: comparison of ELISA, radioimmunoassay, and precipitation tests performed with antigens from eggs. Am J Trop Med Hyg (1979) 0.99
Correlations of lung morphology, pulmonary vascular resistance, and outcome in children with congenital heart disease. Br Heart J (1988) 0.97
(1-Pyrenylmethyl)amino alcohols, a new class of antitumor DNA intercalators. Discovery and initial amine side chain structure-activity studies. J Med Chem (1990) 0.96
Pathologica, physiological, and radiological correlations in the pneumoconioses. Ann N Y Acad Sci (1972) 0.95
The influence of infection intensity of Schistosoma mansoni on resistance against existing and subsequent infections in Macaca mulatta. Am J Trop Med Hyg (1966) 0.95
Preoperative measurement of pulmonary vascular resistance in complete transposition of the great arteries. Br Heart J (1990) 0.94
Sickness absence patterns in hospital staff. Occup Health (Lond) (1977) 0.94
[The monaural pseudo-stereophonic hearing aid (BAHA) in unilateral total deafness: a study of 29 patients]. Rev Laryngol Otol Rhinol (Bord) (2001) 0.94
Low exposure to asbestos. Gas exchange in ship pipe coverers and controls. Arch Environ Health (1972) 0.93
The effect of acyl CoA: cholesterol acyltransferase inhibition on the uptake, esterification and secretion of cholesterol by the hamster small intestine. J Pharmacol Exp Ther (1995) 0.92
Schistosoma mansoni in Macaca mulatta. Long-term studies on the course of primary and challenge infections. Am J Trop Med Hyg (1967) 0.91
Chemical burns. J Trauma (1988) 0.91
Molecular diversity in chemical databases: comparison of medicinal chemistry knowledge bases and databases of commercially available compounds. J Chem Inf Comput Sci (1996) 0.91
Escherichia coli leader peptidase: production of an active form lacking a requirement for detergent and development of peptide substrates. Arch Biochem Biophys (1993) 0.89
Infection of modified Blalock shunts. Br Heart J (1987) 0.88
Limitations of the intradermal test for schistosomiasis mansoni: experience from epidemiologic studies in a Puerto Rican community. Am J Trop Med Hyg (1978) 0.87
Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions. Biochemistry (1995) 0.87
Attachment for automated single breath diffusing capacity measurement. Chest (1973) 0.87
Absence of alpha 2(1) procollagen synthesis in a clone of SV40-transformed WI-38 human fibroblasts. J Biol Chem (1989) 0.87
Modification of pulmonary hypertension secondary to congenital heart disease by prostacyclin therapy. Am Rev Respir Dis (1987) 0.87
2-[(arylmethyl) amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding. J Med Chem (1991) 0.86
Comparison of the proteoglycanolytic activities of human leukocyte elastase and human cathepsin G in vitro and in vivo. Connect Tissue Res (1993) 0.86
Catecholamine release in familial dysautonomia. N Engl J Med (1967) 0.86
Clinicopathologic findings in congenital aneurysms of the great vessels. Am J Med Genet (1996) 0.86
Morbidity from Schistosoma mansoni in a Puerto Rican community: a population-based study. Am J Trop Med Hyg (1977) 0.85
Mucin immunohistochemistry in the diagnosis and mapping of extramammary Paget's disease. J Cell Mol Med (2007) 0.85
Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. Arch Biochem Biophys (1996) 0.85
Characterization of leucocin B-Ta11a: a bacteriocin from Leuconostoc carnosum Ta11a isolated from meat. Curr Microbiol (1994) 0.84
Nerves in the skin of a patient with familial dysautonomia (Riley-Day Syndrome). Pediatrics (1966) 0.84
Interaction of a macrocyclic bisacridine with DNA. Biochemistry (1990) 0.83
Potency of antileukoprotease and alpha 1-antitrypsin to inhibit degradation of fibrinogen by adherent polymorphonuclear leukocytes from normal subjects and patients with chronic granulomatous disease. Am J Respir Cell Mol Biol (1992) 0.83
Major contribution of a carboxymethyl group to transition-state stabilization by cytidine deaminase: mutation and rescue. Biochemistry (1995) 0.83
Ions and the transport of gamma-aminobutyric acid by synaptosomes. J Neurochem (1972) 0.83
Intensity of infection with Schistosoma mansoni: its relationship to the sensitivity and specificity of serologic tests. Am J Trop Med Hyg (1979) 0.83
Schistosoma mansoni infections in Cercopithecus sabaeus monkeys. J Parasitol (1967) 0.83
Cardiovascular effects of tolazoline and ranitidine. Arch Dis Child (1987) 0.83
Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands. J Med Chem (1989) 0.83
Regional differentiation in the stomach of the green anole. Anat Rec (1988) 0.82
Demonstration of a direct effect on hepatic acyl CoA: cholesterol acyl transferase (ACAT) activity by an orally administered enzyme inhibitor in the hamster. Biochem Pharmacol (1994) 0.82
Investigation of the catalytic mechanism of yeast inorganic pyrophosphatase. Biochemistry (1981) 0.82
Insertion mutagenesis of the metJBLF gene cluster of Escherichia coli K-12: evidence for an metBL operon. J Bacteriol (1984) 0.82
The abolition of collagen gene expression in SV40-transformed fibroblasts is associated with trans-acting factor switching. Nucleic Acids Res (1992) 0.82
Rising burden of immature sheep ticks (Ixodes ricinus) on red grouse (Lagopus lagopus scoticus) chicks in the Scottish uplands. Med Vet Entomol (2004) 0.82
The Boqueron Project after 5 years: a prospective community-based study of infection with Schistosoma mansoni in Puerto Rico. Am J Trop Med Hyg (1980) 0.80
Investigations of the metal ion-binding sites of yeast inorganic pyrophosphatase. J Biol Chem (1984) 0.80
Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate. J Biol Chem (1997) 0.80
Lenticular opacities induced in mice by chlorpromazine. Arch Ophthalmol (1966) 0.80
Heterotopic bone formation in burned patients. J Trauma (1988) 0.80
Distribution and inducibility of P-glycoprotein in the catfish: immunohistochemical detection using the mammalian C-219 monoclonal. Mar Environ Res (2001) 0.79
Muscle flap reconstruction aids in urethral regeneration. Ann Plast Surg (1996) 0.79
Irreversible enzyme inhibitors. CLXIV. Proteolytic enzymes. XIV. Inhibition of guinea pig complement by meta-substituted benzamidines. J Med Chem (1969) 0.79
Experimentally induced phenylketonuria. II. Potential inhibitors of phenylalanine hydroxylase. J Med Chem (1968) 0.79
Androgen receptors in rat testis. Steroids (1974) 0.79
Experimentally induced phenylketonuria. I. Inhibitors of phenylalanine hydroxylase. J Med Chem (1967) 0.79
Inhibition of C1s-induced vascular leakage in guinea pigs by substituted benzamidine and pyridinium compounds. J Immunol (1977) 0.79
Irreversible enzyme inhibitors. 186. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine by bridging to a terminal sulfonyl fluoride. J Med Chem (1971) 0.79
The split calvarial graft donor site in the elderly: a study in cadavers. Plast Reconstr Surg (1989) 0.79
Compete or complement? An interdisciplinary approach to training health professionals. Nurs Health Care Perspect (2000) 0.79
Irreversible enzyme inhibitors. CLXV. Proteolytic enzymes. XV. Inhibition of guinea pig complement by derivatives of m-phenoxypropoxybenzamidine. J Med Chem (1969) 0.79
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide. J Med Chem (1971) 0.79
Amiloride intercalates into DNA and inhibits DNA topoisomerase II. J Biol Chem (1987) 0.78
Interactions between alveolar hypercapnia and epoprostenol on the pulmonary circulation: clinical and pharmacological implications. Pulm Pharmacol (1990) 0.78
Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides. J Med Chem (1990) 0.78
Comparison of the haemodynamic effects of epoprostenol (prostacyclin) and tolazoline. Br Heart J (1988) 0.78
Localization of androgen target cells in the rat testis: autoradiographic studies. Curr Top Mol Endocrinol (1975) 0.78
Metastatic osteogenic sarcoma to the heart presenting as bacterial endocarditis. Pathology (1993) 0.78
Orally active beta-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution. J Med Chem (1993) 0.78
Androgen transport and receptor mechnisms in testis and epididymis. Curr Top Mol Endocrinol (1974) 0.78