Long-term safety and efficacy of etanercept in patients with rheumatoid arthritis.

Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: clinical experience using a structured follow up programme in southern Sweden. Ann Rheum Dis (2002) 3.10

Risk of serious infections during rituximab, abatacept and anakinra treatments for rheumatoid arthritis: meta-analyses of randomised placebo-controlled trials. Ann Rheum Dis (2008) 2.33

Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4 year extended study. Ann Rheum Dis (2005) 1.84

Safety of extended treatment with anakinra in patients with rheumatoid arthritis. Ann Rheum Dis (2006) 1.74

Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety. BMC Musculoskelet Disord (2008) 1.63

The risk of infection and malignancy with tumor necrosis factor antagonists in adults with psoriatic disease: a systematic review and meta-analysis of randomized controlled trials. J Am Acad Dermatol (2011) 1.59

Integrated safety in tocilizumab clinical trials. Arthritis Res Ther (2011) 1.55

A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate. Ann Rheum Dis (2004) 1.53

Survival during treatment with tumour necrosis factor blocking agents in rheumatoid arthritis. Ann Rheum Dis (2003) 1.44

Efficacy and safety of combination etanercept and methotrexate versus etanercept alone in patients with rheumatoid arthritis with an inadequate response to methotrexate: the ADORE study. Ann Rheum Dis (2006) 1.42

A long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs. Ann Rheum Dis (2006) 1.24

Therapy of ankylosing spondylitis and other spondyloarthritides: established medical treatment, anti-TNF-alpha therapy and other novel approaches. Arthritis Res (2002) 1.21

Long term safety of etanercept in elderly subjects with rheumatic diseases. Ann Rheum Dis (2005) 1.19

Results from a nationwide postmarketing cohort study of patients in Sweden treated with etanercept. Ann Rheum Dis (2004) 1.14

Interleukin 10 promoter microsatellite polymorphisms are associated with response to long term treatment with etanercept in patients with rheumatoid arthritis. Ann Rheum Dis (2004) 1.06

Potential therapeutic uses of interleukin 1 receptor antagonists in human diseases. Ann Rheum Dis (2002) 0.99

Evidence of effectiveness: how much can we extrapolate from existing studies? AAPS J (2005) 0.93

Etanercept 25 mg/week is effective enough to maintain remission for ankylosing spondylitis among Korean patients. Clin Rheumatol (2007) 0.92

Does safety make a difference in selecting the right TNF antagonist? Arthritis Res Ther (2004) 0.89

-174G/C interleukin-6 gene promoter polymorphism predicts therapeutic response to etanercept in rheumatoid arthritis. Rheumatol Int (2012) 0.88

Should anti-TNF therapy be discontinued in rheumatoid arthritis patients undergoing elective orthopaedic surgery? A systematic review of the evidence. Rheumatol Int (2011) 0.86

A comparison study of a recombinant tumor necrosis factor receptor:Fc fusion protein (rhTNFR:Fc) and methotrexate in treatment of patients with active rheumatoid arthritis in China. Rheumatol Int (2008) 0.84

Efficacy and Safety of Subcutaneous Golimumab in Methotrexate-Naive Patients With Rheumatoid Arthritis: Five-Year Results of a Randomized Clinical Trial. Arthritis Care Res (Hoboken) (2016) 0.80

Tumor Necrosis Factor, but Not Neutrophils, Alters the Metabolic Profile in Acute Experimental Arthritis. PLoS One (2016) 0.79

Psoriatic arthritis: pathogenesis and novel immunomodulatory approaches to treatment. J Immune Based Ther Vaccines (2005) 0.78

Rheumatology and musculoskeletal medicine. Br J Gen Pract (2004) 0.77

Autologous haematopoietic stem cell transplantation in juvenile idiopathic arthritis. Arch Dis Child (2003) 0.77

Adenoviral pneumonia during etanercept treatment in a patient with rheumatoid arthritis. Korean J Intern Med (2007) 0.76

Biologic agents-a panacea for inflammatory arthritis or not? Int J Rheumatol (2009) 0.76

[Four-year observation of etanercept therapy for rheumatoid arthritis in a single German center]. Z Rheumatol (2005) 0.75

Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland. Nat Genet (1992) 15.62

A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med (1999) 11.62

A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med (2000) 10.21

Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med (1997) 8.65

Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann Intern Med (1999) 6.84

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest (1998) 6.51

Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet (2000) 6.49

The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell (1994) 5.21

Viability and isolation of marine bacteria by dilution culture: theory, procedures, and initial results. Appl Environ Microbiol (1993) 5.09

The Medical Expenditure Panel Survey: a national health information resource. Inquiry (1997) 4.92

A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology (Oxford) (2003) 4.86

One or more bound planets per Milky Way star from microlensing observations. Nature (2012) 4.68

Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain. N Engl J Med (1995) 4.38

A genetic linkage map of the mouse: current applications and future prospects. Science (1993) 4.24

Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis. J Rheumatol (1995) 4.11

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med (2000) 3.98

Discovery of a cool planet of 5.5 Earth masses through gravitational microlensing. Nature (2006) 3.53

Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide. Ann Rheum Dis (2002) 3.53

Trends in antimicrobial resistance of clinical isolates of Streptococcus pneumoniae in Bellvitge Hospital, Barcelona, Spain (1979-1990). Clin Infect Dis (1992) 3.37

Public-health impact of accelerated measles control in the WHO African Region 2000-03. Lancet (2005) 3.36

Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med (1999) 3.10

A self-administered questionnaire for assessment of symptoms and function of the shoulder. J Bone Joint Surg Am (1997) 2.98

Nurses taking on junior doctors' work: a confusion of accountability. BMJ (1996) 2.88

Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1. Kidney Int (2007) 2.87

Instrumentation of the airway in the absence of intravenous access. Paediatr Anaesth (2003) 2.73

Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis (2008) 2.55

Calcium-dependent protein kinases play an essential role in a plant defence response. EMBO J (2001) 2.53

Can prosody aid the automatic classification of dialog acts in conversational speech? Lang Speech (2000) 2.51

Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease. Ann Neurol (1998) 2.48

Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet (1996) 2.48

Treatment of early rheumatoid arthritis with minocycline or placebo: results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum (1997) 2.41

A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum (2001) 2.37

Gastric adenocarcinoma and Helicobacter pylori infection. J Natl Cancer Inst (1991) 2.35

Treating sexually abused children with posttraumatic stress symptoms: a randomized clinical trial. J Am Acad Child Adolesc Psychiatry (2000) 2.33

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature (1996) 2.30

The organization of the araBAD operon of Escherichia coli. Gene (1986) 2.16

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol (2006) 2.13

Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease. Nat Med (1999) 2.11

COX-2 specific inhibitors in the management of osteoarthritis of the knee: a placebo-controlled, randomized, double-blind study. J Clin Rheumatol (2001) 2.09

Evidence-based recommendations for the use of Negative Pressure Wound Therapy in traumatic wounds and reconstructive surgery: steps towards an international consensus. Injury (2011) 2.07

Cause of death and correlation with autopsy findings in burns patients. Burns (2012) 2.07

CARE-LASS (calcein-release-assay), an improved fluorescence-based test system to measure cytotoxic T lymphocyte activity. J Immunol Methods (1994) 2.01

The learning curve of total laparoscopic hysterectomy: comparative analysis of 1647 cases. J Am Assoc Gynecol Laparosc (2002) 1.99

Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet (2001) 1.95

The Use of a Helium-Oxygen Mixture during Maximum Expiratory Flow to Demonstrate Obstruction in Small Airways in Smokers. J Clin Invest (1975) 1.93

Laparoscopically assisted vaginal hysterectomy superfluous? S Afr Med J (1998) 1.92

Incidence and prevalence of epilepsy among older U.S. Medicare beneficiaries. Neurology (2012) 1.92

The relationships between interphase Schwann cells and axons before myelination: a quantitative electron microscopic study. Dev Biol (1973) 1.91

Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis. Nature (1993) 1.89

Axillary plexus block using a peripheral nerve stimulator: single or multiple injections. Can J Anaesth (1992) 1.87

Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature (1995) 1.85

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J Clin Invest (1994) 1.81

Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J Exp Med (1997) 1.81

Patient-oriented outcome assessment after temporal lobectomy for refractory epilepsy. Neurology (1999) 1.80

Bradycardia during sleep apnea. Characteristics and mechanism. J Clin Invest (1982) 1.74

Safety of extended treatment with anakinra in patients with rheumatoid arthritis. Ann Rheum Dis (2006) 1.74

A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paper. Mult Scler (2012) 1.74

CD4+CD28- costimulation-independent T cells in multiple sclerosis. J Clin Invest (2001) 1.74

[Nucleotide sequence determination of yeast mitochondrial phenylalanine-tRNA]. C R Acad Sci Hebd Seances Acad Sci D (1978) 1.73

Data collection frequency effect in the National Medical Care Expenditure Survey. J Econ Soc Meas (1985) 1.72

Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007. Ann Rheum Dis (2007) 1.70

A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis. Brain (2009) 1.69

Declining financial capacity in mild cognitive impairment: A 1-year longitudinal study. Neurology (2009) 1.69

Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. Arthritis Rheum (2001) 1.68

London bombings July 2005: the immediate pre-hospital medical response. Resuscitation (2005) 1.67

Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Arthritis Rheum (2008) 1.66

Rotavirus epidemiology in Vellore, south India: group, subgroup, serotype, and electrophoretype. J Clin Microbiol (1988) 1.60

Metachronous colon cancer in persons who have had a large adenomatous polyp. Am J Gastroenterol (1996) 1.56

Improved complete response rate and survival in advanced head and neck cancer after three-course induction therapy with 120-hour 5-FU infusion and cisplatin. Cancer (1985) 1.56

Clinical characteristics of fibrositis. I. A "blinded," controlled study of symptoms and tender points. Arthritis Rheum (1983) 1.54

[Age dependence of laboratory parameters in a health study--attempt at calculating a laboratory index for assessing biological aging]. Z Gerontol Geriatr (2002) 1.53

A systematic approach to spinal reconstruction after anterior decompression for neoplastic disease of the thoracic and lumbar spine. Neurosurgery (1993) 1.52

Retroviral marking identifies grafted autologous keratinocytes in porcine wounds receiving cultured epithelium. J Invest Dermatol (1997) 1.52

Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled clinical study. Br J Dermatol (2008) 1.51

Estrogen receptor: a prognostic factor in breast cancer. Cancer (1981) 1.51

Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. Ann Neurol (1992) 1.50

The use of fibrin glue in skin grafts and tissue-engineered skin replacements: a review. Plast Reconstr Surg (2001) 1.50

Adalimumab effectiveness for the treatment of ankylosing spondylitis is maintained for up to 2 years: long-term results from the ATLAS trial. Ann Rheum Dis (2008) 1.49

Carbon substrate utilization studies of some cultures of Alcaligenes denitrificans, Alcaligenes faecalis, and Alcaligenes odorans isolated from clinical specimens. J Clin Microbiol (1978) 1.48

Atracurium and vecuronium interaction with gentamicin and tobramycin. Can J Anaesth (1989) 1.47

Primary pulmonary hypertension favorable effect of isoproterenol. N Engl J Med (1976) 1.46

Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant (2011) 1.46

Complex visual disturbances in Alzheimer's disease. Neurology (1990) 1.45

Increased serum levels of soluble CD95 (APO-1/Fas) in relapsing-remitting multiple sclerosis. Ann Neurol (1998) 1.45

Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. J Immunol (1998) 1.44

Use of overpressure to assess the role of bubbles in focused ultrasound lesion shape in vitro. Ultrasound Med Biol (2001) 1.44

Mapping and complementation studies of the gene for release factor 1. J Bacteriol (1986) 1.43

Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects. Lab Invest (2001) 1.43

Long-term safety and effectiveness of etanercept in children with selected categories of juvenile idiopathic arthritis. Arthritis Rheum (2009) 1.42

A dose-response meta-analysis for quantifying relative efficacy of biologics in rheumatoid arthritis. Clin Pharmacol Ther (2011) 1.42

Interactions within the yeast Sm core complex: from proteins to amino acids. Mol Cell Biol (1998) 1.42

Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II. Immunity (2001) 1.42

Demonstration of epidermal transfer from a polymer membrane using genetically marked porcine keratinocytes. Burns (2001) 1.40

[Videolaryngoscopy, for everybody?]. Ann Fr Anesth Reanim (2012) 1.40

How common is attention-deficit/hyperactivity disorder? Towards resolution of the controversy: results from a population-based study. Acta Paediatr Suppl (2004) 1.40