Safety of extended treatment with anakinra in patients with rheumatoid arthritis.

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Published in Ann Rheum Dis on January 05, 2006

Authors

R M Fleischmann1, J Tesser, M H Schiff, J Schechtman, G-R Burmester, R Bennett, D Modafferi, L Zhou, D Bell, B Appleton

Author Affiliations

1: University of Texas Southwestern Medical Center at Dallas, Radiant Research, 5939 Harry Hines Boulevard, Dallas, TX 75235, USA. royfleischmann@radiantresearch.com

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Lumbosacral joint angles in children. J Pediatr Orthop (1992) 1.52

Adherence to antiviral drug regimens in HIV-infected adolescent patients engaged in care in a comprehensive adolescent and young adult clinic. J Natl Med Assoc (2000) 1.52

Chloroquine as a malarial suppressive: absence of visual effects. Mil Med (1973) 1.51

A fluorescence energy transfer method for analyzing protein oligomeric structure: application to phospholamban. Biophys J (1999) 1.50

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