Published in Eur J Biochem on July 01, 2001
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics (2010) 2.80
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1. J Virol (2006) 1.50
Mechanism of PKR Activation by dsRNA. J Mol Biol (2008) 1.42
Activation of PKR: an open and shut case? Trends Biochem Sci (2006) 1.41
Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control. Biochem J (2004) 1.31
Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Mol Cell Biol (2002) 1.28
Analysis of PKR structure by small-angle scattering. J Mol Biol (2009) 1.14
Unactivated PKR exists in an open conformation capable of binding nucleotides. Biochemistry (2006) 1.06
Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol (2006) 1.04
Viral dsRNA inhibitors prevent self-association and autophosphorylation of PKR. J Mol Biol (2007) 0.98
Domain stabilities in protein kinase R (PKR): evidence for weak interdomain interactions. Biochemistry (2008) 0.97
The integrated stress response. EMBO Rep (2016) 0.96
Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes. Toxicol Sci (2010) 0.94
The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1. J Virol (2013) 0.91
Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop. J Biol Chem (2013) 0.82
Analysis of PKR activation using analytical ultracentrifugation. Macromol Biosci (2010) 0.79
The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs. J Biol Chem (2015) 0.77
Regulation of Stress Responses and Translational Control by Coronavirus. Viruses (2016) 0.75
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell (1992) 6.89
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol (1998) 5.66
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol (1995) 3.36
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics (2000) 2.73
Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol Cell Biol (1992) 2.51
Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in Escherichia coli K12. Transcription from divergent overlapping promoters. J Biol Chem (1986) 2.44
The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae. Genetics (1990) 2.15
The nucleotide sequence of the ilvBN operon of Escherichia coli: sequence homologies of the acetohydroxy acid synthase isozymes. Nucleic Acids Res (1985) 2.12
Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae. Mol Cell Biol (1991) 2.09
The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12. Nucleic Acids Res (1987) 2.04
Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase. Mol Cell Biol (2000) 1.80
Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2. J Biol Chem (1996) 1.73
Ribosome targeting of PKR is mediated by two double-stranded RNA-binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2. J Biol Chem (1997) 1.53
Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase. Genetics (1998) 1.51
Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA. Mol Cell Biol (1994) 1.36
Examination of the internal promoter, PE, in the ilvGMEDA operon of E. coli K-12. Nucleic Acids Res (1986) 1.22
Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control. J Biol Chem (1998) 1.19
A single sequence change destabilizes the influenza virus neuraminidase tetramer. Virology (1997) 1.10
The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection. Prog Drug Res (1998) 1.05
The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation. Biochem Biophys Res Commun (2001) 0.96
Overlapping transcription and termination of the convergent ilvA and ilvY genes of Escherichia coli. J Biol Chem (1989) 0.93
Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). Eur J Biochem (2001) 0.92
Partial nucleotide sequence similarity within species of Mycoplasma and Acholeplasma. J Gen Microbiol (1980) 0.87
Approaches and strategies for the treatment of influenza virus infections. Antivir Chem Chemother (1999) 0.85
Mitochondrial respiratory mutants in yeast inhibit glycogen accumulation by blocking activation of glycogen synthase. J Biol Chem (1998) 0.85
Expression of vaccinia virus K3L protein in yeast inhibits eukaryotic initiation factor-2 kinase GCN2 and the general amino acid control pathway. J Biol Chem (1996) 0.83
Synthesis and antiviral activity of prodrugs of the nucleoside 1-[2',3'-dideoxy-3'-C-(hydroxymethyl)-beta-D-erythropentofuranosyl] cytosine. Bioorg Med Chem (1998) 0.77