Published in Nucleic Acids Res on June 11, 1985
Linkage map of Escherichia coli K-12, edition 8. Microbiol Rev (1990) 18.60
Functions of the gene products of Escherichia coli. Microbiol Rev (1993) 15.51
Codon usage in regulatory genes in Escherichia coli does not reflect selection for 'rare' codons. Nucleic Acids Res (1986) 5.68
Codon preferences in free-living microorganisms. Microbiol Rev (1990) 4.66
Linkage map of Escherichia coli K-12, edition 10: the traditional map. Microbiol Mol Biol Rev (1998) 4.18
Nucleotide sequence of the uhp region of Escherichia coli. J Bacteriol (1987) 2.79
Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation. Proc Natl Acad Sci U S A (2007) 2.43
Regulation of the Bacillus subtilis alsS, alsD, and alsR genes involved in post-exponential-phase production of acetoin. J Bacteriol (1993) 2.35
Branched-chain amino acid biosynthesis genes in Lactococcus lactis subsp. lactis. J Bacteriol (1992) 2.26
Isolation and characterization of plant genes coding for acetolactate synthase, the target enzyme for two classes of herbicides. Plant Physiol (1987) 2.09
Single amino acid substitutions in the enzyme acetolactate synthase confer resistance to the herbicide sulfometuron methyl. Proc Natl Acad Sci U S A (1986) 1.81
Identification of uhp polypeptides and evidence for their role in exogenous induction of the sugar phosphate transport system of Escherichia coli K-12. J Bacteriol (1987) 1.74
Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes. J Bacteriol (1993) 1.52
Sensitivity of a Salmonella typhimurium aspC mutant to sulfometuron methyl, a potent inhibitor of acetolactate synthase II. J Bacteriol (1986) 1.42
Properties of subcloned subunits of bacterial acetohydroxy acid synthases. J Bacteriol (1992) 1.38
Cosmid-derived map of E. coli strain BHB2600 in comparison to the map of strain W3110. Nucleic Acids Res (1989) 1.28
Common ancestry of Escherichia coli pyruvate oxidase and the acetohydroxy acid synthases of the branched-chain amino acid biosynthetic pathway. J Bacteriol (1988) 1.25
Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine. Appl Environ Microbiol (2003) 1.21
Acetohydroxy acid synthase I, a required enzyme for isoleucine and valine biosynthesis in Escherichia coli K-12 during growth on acetate as the sole carbon source. J Bacteriol (1986) 1.17
Isolation, characterization and sequence analysis of a full-length cDNA clone encoding acetohydroxy acid reductoisomerase from spinach chloroplasts. Biochem J (1991) 1.16
Role of small subunit (IlvN polypeptide) of acetohydroxyacid synthase I from Escherichia coli K-12 in sensitivity of the enzyme to valine inhibition. J Bacteriol (1986) 1.12
Functional expression of plant acetolactate synthase genes in Escherichia coli. Proc Natl Acad Sci U S A (1989) 1.11
Multiple copies of a bile acid-inducible gene in Eubacterium sp. strain VPI 12708. J Bacteriol (1990) 1.02
Effects of deletion and insertion mutations in the ilvM gene of Escherichia coli. J Bacteriol (1987) 1.01
Purification and characterization of the oxygen-sensitive acetohydroxy acid synthase from the archaebacterium Methanococcus aeolicus. J Bacteriol (1994) 1.00
Nucleotide sequence and deduced amino acid sequence of Escherichia coli pyruvate oxidase, a lipid-activated flavoprotein. Nucleic Acids Res (1986) 0.98
Analysis and comparison of the internal promoter, pE, of the ilvGMEDA operons from Escherichia coli K-12 and Salmonella typhimurium. Nucleic Acids Res (1986) 0.93
Acetohydroxy acid synthase I is required for isoleucine and valine biosynthesis by Salmonella typhimurium LT2 during growth on acetate or long-chain fatty acids. J Bacteriol (1987) 0.92
Effect of the deletion of upstream DNA sequences on expression from the ilvGp2 promoter of the ilvGMEDA operon of Escherichia coli K-12. Nucleic Acids Res (1987) 0.87
Regulation of Caulobacter crescentus ilvBN gene expression. J Bacteriol (1994) 0.83
Locations of the lip, poxB, and ilvBN genes on the physical map of Escherichia coli. J Bacteriol (1991) 0.82
Enhanced acetohydroxy acid synthase III activity in an ilvH mutant of Escherichia coli K-12. J Bacteriol (1988) 0.78
Alkylation of acetohydroxyacid synthase I from Escherichia coli K-12 by 3-bromopyruvate: evidence for a single active site catalyzing acetolactate and acetohydroxybutyrate synthesis. J Bacteriol (1987) 0.76
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
Regulatory sequences involved in the promotion and termination of RNA transcription. Annu Rev Genet (1979) 54.83
Enhanced graphic matrix analysis of nucleic acid and protein sequences. Proc Natl Acad Sci U S A (1981) 46.11
Evidence for use of rare codons in the dnaG gene and other regulatory genes of Escherichia coli. Proc Natl Acad Sci U S A (1983) 5.79
Synthesis of ribonucleic acid and protein in plasmid-containing minicells of Escherichia coli K-12. J Bacteriol (1971) 5.35
The inverted repeats of Tn5 are functionally different. Cell (1980) 5.05
Molecular basis of valine resistance in Escherichia coli K-12. Proc Natl Acad Sci U S A (1981) 3.55
Multivalent translational control of transcription termination at attenuator of ilvGEDA operon of Escherichia coli K-12. Proc Natl Acad Sci U S A (1980) 3.30
leu operon of Salmonella typhimurium is controlled by an attenuation mechanism. Proc Natl Acad Sci U S A (1979) 2.91
Nucleotide sequence of ilvGEDA operon attenuator region of Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.61
Nucleotide sequence of the ilvB promoter-regulatory region: a biosynthetic operon controlled by attenuation and cyclic AMP. Proc Natl Acad Sci U S A (1982) 2.50
Molecular structure of ilvIH and its evolutionary relationship to ilvG in Escherichia coli K12. Nucleic Acids Res (1983) 2.39
Growth inhibition as a consequence of antagonism between related amino acids: effect of valine in Escherichia coli K-12. Microbiol Rev (1979) 2.25
Structural genes for a newly recognized acetolactate synthase in Escherichia coli K-12. J Bacteriol (1974) 1.94
Acetohydroxy acid synthase I of Escherichia coli: purification and properties. J Bacteriol (1979) 1.90
Purification and subunit composition of acetohydroxyacid synthase I from Escherichia coli K-12. J Bacteriol (1984) 1.77
The acetolactate synthase isoenzymes of Escherichia coli K-12. Mol Gen Genet (1977) 1.77
The acetohydroxy acid synthase III isoenzyme of Escherichia coli K-12: regulation of synthesis by leucine. Biochem Biophys Res Commun (1977) 1.73
Regulation of cyclic AMP of the ilvB-encoded biosynthetic acetohydroxy acid synthase in Escherichia coli K-12. Mol Gen Genet (1980) 1.63
Reduced expression of the isoleucine and valine enzymes in integration host factor mutants of Escherichia coli. J Mol Biol (1984) 1.45
Cloning and expression of the ilvB gene of Escherichia coli K-12. Mol Gen Genet (1982) 1.42
Nucleotide sequence of the ilvB multivalent attenuator region of Escherichia coli K12. Nucleic Acids Res (1983) 1.40
The ilvIH operon of Escherichia coli K-12. Identification of the gene products and recognition of the translational start by polypeptide microsequencing. Biochim Biophys Acta (1985) 1.25
Interaction of cyclic AMP receptor protein with the ilvB biosynthetic operon in E. coli. Nucleic Acids Res (1984) 1.10
Attenuation of the ilvB operon by amino acids reflecting substrates or products of the ilvB gene product. Proc Natl Acad Sci U S A (1984) 1.08
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell (1992) 6.89
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol (1998) 5.66
Improved statistical inference from DNA microarray data using analysis of variance and a Bayesian statistical framework. Analysis of global gene expression in Escherichia coli K12. J Biol Chem (2001) 4.35
Molecular basis of valine resistance in Escherichia coli K-12. Proc Natl Acad Sci U S A (1981) 3.55
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol (1995) 3.36
Global gene expression profiling in Escherichia coli K12. The effects of integration host factor. J Biol Chem (2000) 3.32
Multivalent translational control of transcription termination at attenuator of ilvGEDA operon of Escherichia coli K-12. Proc Natl Acad Sci U S A (1980) 3.30
Separation of transfer ribonucleic acid by sepharose chromatography using reverse salt gradients. Proc Natl Acad Sci U S A (1975) 3.23
Nonrandom utilization of codon pairs in Escherichia coli. Proc Natl Acad Sci U S A (1989) 2.81
Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol Cell Biol (1996) 2.79
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics (2000) 2.73
Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol Cell Biol (1992) 2.51
Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in Escherichia coli K12. Transcription from divergent overlapping promoters. J Biol Chem (1986) 2.44
Transcriptional activation at adjacent operators in the divergent-overlapping ilvY and ilvC promoters of Escherichia coli. J Mol Biol (1988) 2.41
Effects of promoter strengths and growth conditions on copy number of transcription-fusion vectors. J Biol Chem (1984) 2.31
Specific binding of leucyl transfer RNA to an immature form of L-threonine deaminase: its implications in repression. Proc Natl Acad Sci U S A (1970) 2.18
The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae. Genetics (1990) 2.15
Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae. Mol Cell Biol (1991) 2.09
The nucleotide sequence preceding and including the beginning of the ilvE gene of the ilvGEDA operon of Escherichia coli K12. Nucleic Acids Res (1979) 2.07
The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12. Nucleic Acids Res (1987) 2.04
Codon pair utilization biases influence translational elongation step times. J Biol Chem (1995) 2.00
Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase. Mol Cell Biol (2000) 1.80
Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. Cell (1985) 1.73
Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2. J Biol Chem (1996) 1.73
Molecular analysis of the human class I alcohol dehydrogenase gene family and nucleotide sequence of the gene encoding the beta subunit. J Biol Chem (1986) 1.72
Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Mol Cell Biol (1997) 1.69
Ribosome targeting of PKR is mediated by two double-stranded RNA-binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2. J Biol Chem (1997) 1.53
Threonine deaminase from Escherichia coli. I. Purification and properties. J Biol Chem (1973) 1.51
Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase. Genetics (1998) 1.51
Phosphate-induced protein chromatography. Science (1973) 1.50
Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. Oncogene (1994) 1.48
Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. Proc Natl Acad Sci U S A (1989) 1.40
Nucleotide sequence of the ilvB multivalent attenuator region of Escherichia coli K12. Nucleic Acids Res (1983) 1.40
Oncogenic Neu/ErbB-2 increases ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting ets activation blocks Neu-mediated cellular transformation. J Biol Chem (1996) 1.39
Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA. Mol Cell Biol (1994) 1.36
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem (1999) 1.35
Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2). Eur J Biochem (2001) 1.34
A site of action for tRNA mediated regulation of the ilvOEDA operon of Escherichia coli K12. Mol Gen Genet (1978) 1.33
Activation of gene expression by a novel DNA structural transmission mechanism that requires supercoiling-induced DNA duplex destabilization in an upstream activating sequence. J Biol Chem (1998) 1.33
Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. J Biol Chem (2000) 1.31
Transcriptional activation by protein-induced DNA bending: evidence for a DNA structural transmission model. Proc Natl Acad Sci U S A (1996) 1.30
Autoregulation: a role for a biosynthetic enzyme in the control of gene expression. Proc Natl Acad Sci U S A (1973) 1.29
DNA sequence fine-structure analysis of ilvG (IlvG+) mutations of Escherichia coli K-12. J Bacteriol (1982) 1.27
A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J Biol Chem (1999) 1.26
Asparaginyl-tRNA aminoacylation levels and asparagine synthetase expression in cultured Chinese hamster ovary cells. J Biol Chem (1979) 1.25
The ilvEDA operon of Escherichia coli K12 encodes only one valine-alpha-ketoglutarate transaminase activity. Biochem Biophys Res Commun (1979) 1.23
Examination of the internal promoter, PE, in the ilvGMEDA operon of E. coli K-12. Nucleic Acids Res (1986) 1.22
Valyl-tRNA synthetase gene of Escherichia coli K12. Primary structure and homology within a family of aminoacyl-TRNA synthetases. J Biol Chem (1988) 1.21
The primary structure of a halorhodopsin from Natronobacterium pharaonis. Structural, functional and evolutionary implications for bacterial rhodopsins and halorhodopsins. J Biol Chem (1990) 1.21
Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control. J Biol Chem (1998) 1.19
Threonine deaminase from Salmonella typhimurium. 3. The intermediate substructure. J Biol Chem (1970) 1.18
Threonine deaminase from Bacillus subtilis. I. Purification of the enzyme. J Biol Chem (1970) 1.16
DNA sequence and structure: direct and indirect recognition in protein-DNA binding. Bioinformatics (2002) 1.13
Molecular cloning and characterization of a cDNA for the beta subunit of human alcohol dehydrogenase. Proc Natl Acad Sci U S A (1984) 1.13
DNA topology-mediated regulation of transcription initiation from the tandem promoters of the ilvGMEDA operon of Escherichia coli. J Mol Biol (1992) 1.12
Differential utilization of leucyl-tRNAs by Escherichia coli. Proc Natl Acad Sci U S A (1977) 1.12
A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. Cancer Res (1999) 1.10
A role for asparaginyl-tRNA in the regulation of asparagine synthetase in a mammalian cell line. Proc Natl Acad Sci U S A (1977) 1.09
Transcriptional coupling between the divergent promoters of a prototypic LysR-type regulatory system, the ilvYC operon of Escherichia coli. Proc Natl Acad Sci U S A (1999) 1.09
Threonine deaminase from Bacillus subtilis. II. The steady state kinetic properties. J Biol Chem (1970) 1.09
Attenuation of the ilvB operon by amino acids reflecting substrates or products of the ilvB gene product. Proc Natl Acad Sci U S A (1984) 1.08
Analysis of in vivo RNA transcription products of the ilvGEDA attenuator region of Escherichia coli K12. J Biol Chem (1985) 1.07
Rho-dependent transcriptional polarity in the ilvGMEDA operon of wild-type Escherichia coli K12. J Biol Chem (1987) 1.07
Specificity of codon recognition by Escherichia coli tRNALeu isoaccepting species determined by protein synthesis in vitro directed by phage RNA. J Mol Biol (1979) 1.07
Specific ion mediated chromatography of glycoproteins and neutral polysaccharides on substituted agarose gels. Anal Biochem (1975) 1.07
Intron-dependent evolution of the nucleotide-binding domains within alcohol dehydrogenase and related enzymes. Nucleic Acids Res (1986) 1.06
Oncogene activation of human keratin 18 transcription via the Ras signal transduction pathway. Proc Natl Acad Sci U S A (1994) 1.06
Valyl-tRNA synthetase gene of Escherichia coli K12. Molecular genetic characterization. J Biol Chem (1988) 1.05
Altered Ets transcription factor activity in prostate tumor cells inhibits anchorage-independent growth, survival, and invasiveness. Oncogene (2000) 1.04
Leucine-responsive regulatory protein-DNA interactions in the leader region of the ilvGMEDA operon of Escherichia coli. J Biol Chem (1996) 1.04
Pausing and termination of human RNA polymerase II transcription at a procaryotic terminator. Mol Cell Biol (1983) 1.04
Chinese hamster ovary cells resistant to beta-aspartylhydroxamate contain increased levels of asparagine synthetase. J Biol Chem (1980) 1.04
Branched-chain amino acid transport regulation in mutants blocked in tRNA maturation and transcriptional termination. J Bacteriol (1978) 1.03
Elevated expression of Ets2 or distinct portions of Ets2 can reverse Ras-mediated cellular transformation. J Biol Chem (1998) 1.02
Pausing of RNA polymerase during in vitro transcription through the ilvB and ilvGEDA attenuator regions of Escherichia coli K12. J Biol Chem (1985) 1.02
Inhibition of DNA supercoiling-dependent transcriptional activation by a distant B-DNA to Z-DNA transition. J Biol Chem (1999) 1.00
Threonine deaminase from Bacillus subtilis. 3. Pre-steady state kinetic properties. J Biol Chem (1970) 0.99
Activation of gene expression by a ligand-induced conformational change of a protein-DNA complex. J Biol Chem (1998) 0.97
The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation. Biochem Biophys Res Commun (2001) 0.96
Integration host factor-mediated expression of the ilvGMEDA operon of Escherichia coli. J Biol Chem (1991) 0.96
Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro. Mol Cell Biol (1993) 0.95
Ligand-induced maturation of threonine deaminase. Science (1970) 0.95
DNA supercoiling-dependent transcriptional coupling between the divergently transcribed promoters of the ilvYC operon of Escherichia coli is proportional to promoter strengths and transcript lengths. Mol Microbiol (2001) 0.94
Overlapping transcription and termination of the convergent ilvA and ilvY genes of Escherichia coli. J Biol Chem (1989) 0.93
Use of purified isoacceptor tRNAs for the study of codon-anticodon recognition in vitro with sequenced natural messenger RNA. Methods Enzymol (1979) 0.93
Activation and repression of transcription initiation by a distant DNA structural transition. Mol Microbiol (2001) 0.92
Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). Eur J Biochem (2001) 0.92
Evidence for misreading during tRNA-dependent protein synthesis in vitro. J Biol Chem (1978) 0.91
Biochemical characterization of a mutant asparaginyl-tRNA synthetase from Chinese hamster ovary cells. J Biol Chem (1978) 0.91
Effects of altered rho gene product on the expression of the Escherichia coli histidine operon. J Bacteriol (1978) 0.90