c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.

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Published in J Clin Invest on July 01, 2001

Authors

Z Han1, D L Boyle, L Chang, B Bennett, M Karin, L Yang, A M Manning, G S Firestein

Author Affiliations

1: Division of Rheumatology, Allergy and Immunology, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA.

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A method for isolation of intact, translationally active ribonucleic acid. DNA (1983) 13.67

Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science (1966) 13.12

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Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene. Nature (1982) 7.05

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Inhibition of JNK activation through NF-kappaB target genes. Nature (2001) 5.03

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature (1998) 4.89

Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells. J Biol Chem (1981) 4.86

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature (1994) 4.77

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Reactions in vivo and in vitro produced by a soluble substance associated with delayed-type hypersensitivity. Proc Natl Acad Sci U S A (1968) 4.57

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol (1996) 4.56

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science (1984) 4.52

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Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 3.98

Membrane pores induced by magainin. Biochemistry (1996) 3.97

Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature (1987) 3.94

A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene (2006) 3.89

T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years. Science (1995) 3.87

The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE (1999) 3.79

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A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol (2001) 3.74

Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol (1991) 3.70

Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene. EMBO J (1987) 3.65

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. Genes Dev (1993) 3.64

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell (1988) 3.64

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Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. J Neurosci (2001) 3.46

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell (1994) 3.44

The children's depression inventory: a systematic evaluation of psychometric properties. J Consult Clin Psychol (1984) 3.41

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev (1999) 3.41

Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature (1996) 3.37

Cloning and characterization of adeno-associated virus type 5. J Virol (1999) 3.36

CYP3A variation and the evolution of salt-sensitivity variants. Am J Hum Genet (2004) 3.32

Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc Natl Acad Sci U S A (1984) 3.28

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science (1998) 3.26

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science (1993) 3.25

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21

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HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells. J Immunol (1991) 3.18

Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature (1998) 3.16

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10. J Immunol (1993) 3.14

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