NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments.

PubWeight™: 1.68‹?› | Rank: Top 3%

🔗 View Article (PMC 2903737)

Published in J Immunol on May 01, 2005

Authors

Judit I Pulai1, Hong Chen, Hee-Jeong Im, Sanjay Kumar, Charles Hanning, Priti S Hegde, Richard F Loeser

Author Affiliations

1: Department of Internal Medicine, Section of Rheumatology, Rush Medical College, Chicago, IL 60612, USA.

Articles citing this

Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum (2012) 4.28

Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther (2009) 2.44

Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build. Cell Mol Life Sci (2013) 2.14

NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets (2010) 1.89

Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem (2007) 1.80

Biomechanical signals inhibit IKK activity to attenuate NF-kappaB transcription activity in inflamed chondrocytes. Arthritis Rheum (2007) 1.76

Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta. Osteoarthritis Cartilage (2008) 1.49

Role of NF-κB in the skeleton. Cell Res (2010) 1.45

Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep (2013) 1.31

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis (2012) 1.23

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther (2008) 1.22

Functions of nuclear factor kappaB in bone. Ann N Y Acad Sci (2010) 1.21

Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation. Breast Cancer Res (2010) 1.17

Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. Arthritis Res Ther (2011) 1.15

Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Int J Exp Pathol (2009) 1.13

CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1β. J Biol Chem (2010) 1.09

Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis. Ther Adv Musculoskelet Dis (2012) 1.09

Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes. J Immunol (2008) 1.08

Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization. Arthritis Rheum (2010) 1.04

Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. Free Radic Biol Med (2007) 1.04

Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis Res Ther (2007) 1.03

Role of fibronectin-binding proteins A and B in in vitro cellular infections and in vivo septic infections by Staphylococcus aureus. Infect Immun (2011) 1.00

Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis. Int J Mol Sci (2013) 1.00

Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Evid Based Complement Alternat Med (2012) 0.99

Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs. Arthritis Res Ther (2010) 0.96

Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis. Osteoarthritis Cartilage (2013) 0.95

Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int J Rheumatol (2011) 0.95

Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragments. Arthritis Rheum (2013) 0.91

Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus. Mol Pain (2012) 0.91

Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research. Endocr Rev (2012) 0.91

OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis. Osteoarthritis Cartilage (2015) 0.91

In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis. Arthritis Rheumatol (2014) 0.90

Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. Osteoarthritis Cartilage (2009) 0.90

p38gamma mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation. Osteoarthritis Cartilage (2010) 0.89

Fibronectin: functional character and role in alcoholic liver disease. World J Gastroenterol (2011) 0.89

Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther (2012) 0.89

Integrins and chondrocyte-matrix interactions in articular cartilage. Matrix Biol (2014) 0.87

Macrophages express membrane bound form of APRIL that can generate immunomodulatory signals. Immunology (2010) 0.87

Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes. Gene (2013) 0.86

Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells. J Cell Physiol (2012) 0.86

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways. Arthritis Res Ther (2013) 0.86

Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes. Arthritis Rheum (2009) 0.85

Coptisine Prevented IL-β-Induced Expression of Inflammatory Mediators in Chondrocytes. Inflammation (2016) 0.84

Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complement Altern Med (2011) 0.84

Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation. RMD Open (2015) 0.83

Intertwining threshold settings, biological data and database knowledge to optimize the selection of differentially expressed genes from microarray. PLoS One (2010) 0.83

Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes. J Cell Biochem (2012) 0.83

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities. Osteoarthritis Cartilage (2015) 0.83

Borrelia burgdorferi HtrA may promote dissemination and irritation. Mol Microbiol (2013) 0.81

Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes. Arthritis Res Ther (2015) 0.78

Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments. Arthritis Rheumatol (2016) 0.77

A novel rose hip preparation with enhanced anti-inflammatory and chondroprotective effects. Mediators Inflamm (2014) 0.77

Low oxygen tension increased fibronectin fragment induced catabolic activities--response prevented with biomechanical signals. Arthritis Res Ther (2013) 0.76

Basic science of osteoarthritis. J Exp Orthop (2016) 0.75

Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis. Exp Ther Med (2016) 0.75

Inflammatory conditions partly impair the mechanically mediated activation of Smad2/3 signaling in articular cartilage. Arthritis Res Ther (2016) 0.75

Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes. Open Access Rheumatol (2009) 0.75

Comprehensive Genome-Wide Transcriptomic Analysis of Immature Articular Cartilage following Ischemic Osteonecrosis of the Femoral Head in Piglets. PLoS One (2016) 0.75

Wnt5a Induces Catabolic Signaling and Matrix Metalloproteinase Production in Human Articular Chondrocytes. Osteoarthritis Cartilage (2017) 0.75

Articles cited by this

Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science (2000) 13.20

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell (1985) 8.55

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol (1989) 6.55

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest (2001) 3.86

The role of the chondrocyte in osteoarthritis. Arthritis Rheum (2000) 2.87

The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest (1996) 2.58

Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum (2003) 2.40

Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology (1997) 2.37

Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4. Arthritis Rheum (2002) 2.00

Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum (2001) 1.85

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. J Immunol (1990) 1.82

Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum (2002) 1.81

Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem (2003) 1.78

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis Rheum (2000) 1.72

Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem (2003) 1.56

Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines. Arthritis Rheum (2000) 1.41

Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum (2002) 1.38

Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes. J Immunol (1992) 1.36

IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. J Immunol (2003) 1.36

Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid. Osteoarthritis Cartilage (1998) 1.32

Mechanisms of chondrocyte apoptosis. Osteoarthritis Cartilage (1999) 1.31

Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines. Biochem J (1997) 1.26

Fibronectin fragments in osteoarthritic synovial fluid. J Rheumatol (1992) 1.25

Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture. J Biol Chem (1992) 1.21

The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro. Arthritis Rheum (2002) 1.17

Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint. Arthritis Rheum (2001) 1.15

Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1. Arthritis Rheum (1995) 1.13

Chemokine production by human chondrocytes. J Rheumatol (1999) 1.12

Subtyping of osteoarthritic synoviopathy. Clin Exp Rheumatol (2002) 1.12

Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy. Arthritis Rheum (2003) 1.08

Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis. FEBS Lett (1999) 1.07

Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysis. Arch Biochem Biophys (1994) 1.06

Functional genomic analysis in arthritis-affected cartilage: yin-yang regulation of inflammatory mediators by alpha 5 beta 1 and alpha V beta 3 integrins. J Immunol (2000) 1.04

Characterization of synovial fluid fibronectin from patients with rheumatic inflammatory diseases and healthy subjects. Arthritis Rheum (1984) 1.01

Induction of synthesis and release of interleukin-8 from human articular chondrocytes and cartilage explants. Arthritis Rheum (1992) 0.97

Characterization of cells from pannus-like tissue over articular cartilage of advanced osteoarthritis. Osteoarthritis Cartilage (2004) 0.93

Growth-related oncogene alpha induction of apoptosis in osteoarthritis chondrocytes. Arthritis Rheum (2002) 0.88

Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cell Immunol (2001) 0.86

Down-modulation of chemokine receptor cartilage expression in inflammatory arthritis. Rheumatology (Oxford) (2003) 0.85

Fibronectin fragments alter matrix protein synthesis in cartilage tissue cultured in vitro. Arch Biochem Biophys (1993) 0.85

Articles by these authors

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85

Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum (2004) 6.46

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature (2002) 6.22

Draft genome of the filarial nematode parasite Brugia malayi. Science (2007) 5.28

The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode. PLoS Biol (2005) 4.28

Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol (2006) 3.63

The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. Cancer Res (2009) 3.42

Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA (2013) 3.38

A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study. J Am Coll Cardiol (2003) 3.29

CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci U S A (2008) 3.04

Maternal exposure to magnetic fields during pregnancy in relation to the risk of asthma in offspring. Arch Pediatr Adolesc Med (2011) 2.90

Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med (2014) 2.90

Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol (2006) 2.62

Virologically confirmed population-based burden of hospitalization caused by influenza A and B among children in Hong Kong. Clin Infect Dis (2009) 2.60

Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52

Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr (2004) 2.37

Nanomagnetic actuation of receptor-mediated signal transduction. Nat Nanotechnol (2007) 2.22

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A (2010) 2.16

The interaction of attention and action: from seeing action to acting on perception. Br J Psychol (2009) 2.14

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09

A case-control study of long-term exposure to ambient volatile organic compounds and lung cancer in Toronto, Ontario, Canada. Am J Epidemiol (2013) 2.05

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2002) 2.04

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum (2009) 2.02

Genetic diversity and multiple infections of Plasmodium vivax malaria in Western Thailand. Am J Trop Med Hyg (2003) 1.98

Tumor necrosis factor receptor levels are associated with carotid atherosclerosis. Stroke (2002) 1.94

The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem (2005) 1.93

Quantitative evaluation of AgNORs in bone tumours. Pathology (2003) 1.92

Independent regulation of tumor cell migration by matrix stiffness and confinement. Proc Natl Acad Sci U S A (2012) 1.89

Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem (2002) 1.87

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87

The NOD2 defect in Blau syndrome does not result in excess interleukin-1 activity. Arthritis Rheum (2009) 1.87

Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives. Chem Pharm Bull (Tokyo) (2008) 1.83

Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum (2002) 1.81

Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem (2007) 1.80

A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci U S A (2002) 1.78

Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem (2003) 1.78

Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis Rheum (2010) 1.75

Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices. Biomaterials (2009) 1.72

Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity (Silver Spring) (2006) 1.72

Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide. Arthritis Rheum (2006) 1.71

The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. J Biol Chem (2002) 1.68

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness. Integr Biol (Camb) (2011) 1.68

Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal (2010) 1.68

Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67

Average gene length is highly conserved in prokaryotes and eukaryotes and diverges only between the two kingdoms. Mol Biol Evol (2006) 1.67

The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol (2011) 1.67

Infection with cytomegalovirus in patients with inflammatory bowel disease: prevalence, clinical significance and outcome. J Med Microbiol (2004) 1.67

Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum (2006) 1.65

Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum (2005) 1.65

Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem (2010) 1.64

Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum (2002) 1.63

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature (2013) 1.61

Time to disease-modifying antirheumatic drug treatment in rheumatoid arthritis and its predictors: a national, multicenter, retrospective cohort. J Rheumatol (2012) 1.60

Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem (2009) 1.60

Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. Arthritis Rheum (2003) 1.59

Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem (2003) 1.56

Postmenopausal breast cancer is associated with exposure to traffic-related air pollution in Montreal, Canada: a case-control study. Environ Health Perspect (2010) 1.56

Chondrocyte BMP2 signaling plays an essential role in bone fracture healing. Gene (2012) 1.56

Indian doctor in protest after using Viagra to save "blue babies". BMJ (2002) 1.54

Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. J Biol Chem (2003) 1.54

Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Gene (2005) 1.53

Topiramate use in pregnancy and the birth prevalence of oral clefts. Pharmacoepidemiol Drug Saf (2014) 1.52

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest (2015) 1.52

4-Des-oxy-4β-[(5-meth-oxy-1H-indol-3-yl)oxalylamino]podophyllotoxin methanol solvate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.51

IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem J (2005) 1.51

Transurethral vapor enucleation and resection of the prostate with plasma vaporization button electrode for the treatment of benign prostatic hyperplasia: a feasibility study. J Endourol (2012) 1.50

Structural basis for peptidoglycan binding by peptidoglycan recognition proteins. Proc Natl Acad Sci U S A (2004) 1.50

Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. J Hypertens (2003) 1.49

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest (2008) 1.49

Ascorbic acid deficiency activates cell death and disease resistance responses in Arabidopsis. Plant Physiol (2005) 1.49

A current review of molecular mechanisms regarding osteoarthritis and pain. Gene (2013) 1.48

GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood (2005) 1.47

Scientists accuse animal rights activists of stifling research. BMJ (2002) 1.46

Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology (2005) 1.45

The ENTH domain. FEBS Lett (2002) 1.45

Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene (2008) 1.45

Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. J Biol Chem (2007) 1.44

Early management of newly diagnosed rheumatoid arthritis by Canadian rheumatologists: a national, multicenter, retrospective cohort. J Rheumatol (2011) 1.43

Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosis. Cardiovasc Res (2009) 1.43

Dental treatment intensity in frail older adults in the last year of life. J Am Dent Assoc (2013) 1.42

Analyses of 2-DEG characteristics in GaN HEMT with AlN/GaN super-lattice as barrier layer grown by MOCVD. Nanoscale Res Lett (2012) 1.41

Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels. Arthritis Rheum (2003) 1.41

Effects of aging on articular cartilage homeostasis. Bone (2012) 1.40

Combination of balanced ultrafiltration with modified ultrafiltration attenuates pulmonary injury in patients undergoing open heart surgery. Chin Med J (Engl) (2003) 1.40

Ratio of girls to boys in India continues to decline. BMJ (2003) 1.40

Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol (2010) 1.40

Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer. Clin Cancer Res (2004) 1.39

Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes. Arthritis Rheum (2005) 1.38

Therapeutic potential of mesenchymal stem cells producing interferon-alpha in a mouse melanoma lung metastasis model. Stem Cells (2008) 1.38

Millions more at risk of arsenic poisoning than previously thought. BMJ (2003) 1.38

MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene (2011) 1.38

Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage. Mol Cell Biol (2005) 1.37

Aspiration cytology of epidermoid cyst of terminal phalanx. Diagn Cytopathol (2002) 1.37

Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep (2013) 1.36

Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation. Biochem J (2007) 1.34

Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology. PLoS One (2009) 1.34