Published in Genetics on July 01, 2001
Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite. Genome Res (2003) 2.18
A likelihood ratio test for evolutionary rate shifts and functional divergence among proteins. Proc Natl Acad Sci U S A (2001) 1.56
Solution structure of Urm1 and its implications for the origin of protein modifiers. Proc Natl Acad Sci U S A (2006) 1.14
Molecular evolution of the ependymin protein family: a necessary update. BMC Evol Biol (2007) 1.09
Inferring functional constraints and divergence in protein families using 3D mapping of phylogenetic information. Nucleic Acids Res (2003) 1.06
Evolutionary modeling of rate shifts reveals specificity determinants in HIV-1 subtypes. PLoS Comput Biol (2008) 1.05
A phylogenetic study of cytochrome b561 proteins. Genome Biol (2003) 1.05
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One (2008) 1.05
Genomic background predicts the fate of duplicated genes: evidence from the yeast genome. Genetics (2004) 0.98
The genomic underpinnings of apoptosis in the silkworm, Bombyx mori. BMC Genomics (2010) 0.94
Rapid evolution through gene duplication and subfunctionalization of the testes-specific alpha4 proteasome subunits in Drosophila. Genetics (2004) 0.94
Identifying dramatic selection shifts in phylogenetic trees. BMC Evol Biol (2007) 0.90
Evolutionary dynamics of recently duplicated genes: Selective constraints on diverging paralogs in the Drosophila pseudoobscura genome. J Mol Evol (2009) 0.88
Hydroxycamptothecin-loaded Fe3O4 nanoparticles induce human lung cancer cell apoptosis through caspase-8 pathway activation and disrupt tight junctions. Cancer Sci (2011) 0.87
Large-scale analysis of orthologs and paralogs under covarion-like and constant-but-different models of amino acid evolution. Mol Biol Evol (2010) 0.87
Molecular evolution and functional divergence of the bestrophin protein family. BMC Evol Biol (2008) 0.86
En bloc duplications, mutation rates, and densities of amino acid changes clarify the evolution of vertebrate alpha-1,3/4-fucosyltransferases. J Mol Evol (2006) 0.82
Molecular evolution of the primate α-/θ-defensin multigene family. PLoS One (2014) 0.82
Evolution of Klk4 and enamel maturation in eutherians. Biol Chem (2014) 0.81
Evolution by gene duplication of Medicago truncatula PISTILLATA-like transcription factors. J Exp Bot (2016) 0.80
Unravelling selection shifts among foot-and-mouth disease virus (FMDV) serotypes. Evol Bioinform Online (2007) 0.80
In silico identification of functional divergence between the multiple groEL gene paralogs in Chlamydiae. BMC Evol Biol (2007) 0.80
Variation in DNA substitution rates among lineages erroneously inferred from simulated clock-like data. PLoS One (2010) 0.80
Proteases in malaria parasites - a phylogenomic perspective. Curr Genomics (2011) 0.79
Evolution of PAS domains and PAS-containing genes in eukaryotes. Chromosoma (2014) 0.78
Molecular evolution and functional divergence of the metallothionein gene family in vertebrates. J Mol Evol (2014) 0.78
Dissection of functional residues in receptor activity-modifying proteins through phylogenetic and statistical analyses. Evol Bioinform Online (2008) 0.77
Comparative analysis of vertebrate PEPT1 and PEPT2 genes. Genetica (2009) 0.77
Genomic characterization of the European sea bass Dicentrarchus labrax reveals the presence of a novel uncoupling protein (UCP) gene family member in the teleost fish lineage. BMC Evol Biol (2012) 0.77
Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Sci Rep (2015) 0.76
Evidence of functional divergence in MSP7 paralogous proteins: a molecular-evolutionary and phylogenetic analysis. BMC Evol Biol (2016) 0.75
Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates. PLoS One (2014) 0.75
Comparative Genomics and Systems Biology of Malaria Parasites Plasmodium. Curr Bioinform (2012) 0.75
The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol (1987) 266.90
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res (1997) 175.36
Caspases: enemies within. Science (1998) 19.45
Preservation of duplicate genes by complementary, degenerative mutations. Genetics (1999) 18.29
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (1995) 15.07
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell (1993) 10.35
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (1992) 9.96
An evolutionary trace method defines binding surfaces common to protein families. J Mol Biol (1996) 9.31
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature (1996) 7.27
Caspases: killer proteases. Trends Biochem Sci (1997) 7.07
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell (1994) 5.25
Structure and mechanism of interleukin-1 beta converting enzyme. Nature (1994) 4.44
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell (1998) 3.62
A method for detecting positive selection at single amino acid sites. Mol Biol Evol (1999) 3.58
Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev (1998) 3.24
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev Biol (1990) 3.11
Statistical methods for testing functional divergence after gene duplication. Mol Biol Evol (1999) 3.06
The domains of death: evolution of the apoptosis machinery. Trends Biochem Sci (1999) 2.56
ICE-like proteases in apoptosis. Trends Biochem Sci (1995) 2.48
The structural basis of molecular adaptation. Mol Biol Evol (1998) 2.24
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nat Struct Biol (1996) 2.17
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem (1996) 2.07
A simple method for estimating the parameter of substitution rate variation among sites. Mol Biol Evol (1997) 2.02
Function-structure analysis of proteins using covarion-based evolutionary approaches: Elongation factors. Proc Natl Acad Sci U S A (2001) 1.39
Evolutionary patterns of gene families generated in the early stage of vertebrates. J Mol Evol (2000) 1.24
Identification of functional residues and secondary structure from protein multiple sequence alignment. Methods Enzymol (1996) 1.18
Identification of a new caspase homologue: caspase-14. Cell Death Differ (1998) 1.03
Analysis of heregulin symmetry by weighted evolutionary tracing. Protein Eng (1999) 0.98
Measuring shifts in function and evolutionary opportunity using variability profiles: a case study of the globins. J Mol Evol (2000) 0.94
B cell apoptosis triggered by antigen receptor ligation proceeds via a novel caspase-dependent pathway. J Immunol (1999) 0.93
Changes in the prevalence of chronic disability in the United States black and nonblack population above age 65 from 1982 to 1999. Proc Natl Acad Sci U S A (2001) 5.85
Evolution by the birth-and-death process in multigene families of the vertebrate immune system. Proc Natl Acad Sci U S A (1997) 4.83
Epinephrine absorption in children with a history of anaphylaxis. J Allergy Clin Immunol (1998) 2.38
Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src. J Biol Chem (1999) 2.18
Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology (2000) 2.17
A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst. Biochemistry (1998) 2.12
Determination of the number of conserved chromosomal segments between species. Genetics (2001) 1.89
Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol (2001) 1.80
Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol (2000) 1.79
Transvenous closure of secundum atrial septal defects: preliminary results with a new self-expanding nitinol prosthesis in a swine model. Circulation (1997) 1.67
Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice. Invest Ophthalmol Vis Sci (2001) 1.57
Early metazoan divergence was about 830 million years ago. J Mol Evol (1998) 1.54
Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology (2001) 1.53
New self-expanding patent foramen ovale occlusion device. Catheter Cardiovasc Interv (1999) 1.50
Balance and physical impairments after stroke. Arch Phys Med Rehabil (1999) 1.42
Renal artery embolization with diluted hot contrast medium: an experimental study. J Vasc Interv Radiol (2001) 1.40
Sex differences in mutation rate in higher primates estimated from AMG intron sequences. J Mol Evol (1997) 1.36
On reporting fold differences. Pac Symp Biocomput (2001) 1.36
Striatal origin of the pathologic beta oscillations in Parkinson's disease. Proc Natl Acad Sci U S A (2011) 1.35
ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. J Biol Chem (2000) 1.33
The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form). J Mol Biol (1996) 1.30
Identification of a novel virus in pigs--Bungowannah virus: a possible new species of pestivirus. Virus Res (2007) 1.30
Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. J Biol Chem (1999) 1.28
Estimating the distribution of worm burden and egg excretion of Schistosoma japonicum by risk group in Sichuan Province, China. Parasitology (2002) 1.26
Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiol Biomarkers Prev (2000) 1.25
DeltaNp63 isoforms regulate CD44 and keratins 4, 6, 14 and 19 in squamous cell carcinoma of head and neck. J Pathol (2007) 1.24
Evolutionary patterns of gene families generated in the early stage of vertebrates. J Mol Evol (2000) 1.24
Patterns of biosynthesis and accumulation of hydrocarbons and contact sex pheromone in the female German cockroach, Blattella germanica. Arch Insect Biochem Physiol (1994) 1.22
Correlation between the substitution rate and rate variation among sites in protein evolution. Genetics (1998) 1.21
Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. J Biol Chem (2001) 1.19
The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target. Oncogene (2012) 1.17
Enzymatic mechanism of tRNA (m5U54)methyltransferase. Biochimie (1994) 1.16
Identification of two Escherichia coli pseudouridine synthases that show multisite specificity for 23S RNA. Biochemistry (1998) 1.14
Oncogenic driver mutations in patients with non-small-cell lung cancer at various clinical stages. Ann Oncol (2012) 1.13
Perventricular [correction of Periventricular] closure of ventricular septal defects without cardiopulmonary bypass. Ann Thorac Surg (1999) 1.11
p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia (2011) 1.09
Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells. J Biol Chem (2000) 1.08
Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease. Neuroscience (2008) 1.08
The alpha v beta 6 integrin induces gelatinase B secretion in colon cancer cells. Int J Cancer (1999) 1.04
Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. Cancer Res (2001) 1.03
Green and yellow vegetables can maintain body stores of vitamin A in Chinese children. Am J Clin Nutr (1999) 1.03
Epinephrine for the out-of-hospital (first-aid) treatment of anaphylaxis in infants: is the ampule/syringe/needle method practical? J Allergy Clin Immunol (2001) 1.01
Action potentials, calcium transients and the control of differentiation of excitable cells. Curr Opin Neurobiol (1994) 1.00
Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. J Clin Pharm Ther (2013) 1.00
In silico analysis indicates a similar gene expression pattern between human brain and testis. Cytogenet Genome Res (2003) 0.99
Structure of double-shelled rice dwarf virus. J Virol (1998) 0.99
A preliminary study on interruption of HBV transmission in uterus. Chin Med J (Engl) (1997) 0.98
Expression of folate receptor alpha in the mammalian retinol pigmented epithelium and retina. Invest Ophthalmol Vis Sci (1999) 0.98
Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: clinical results. Int J Radiat Oncol Biol Phys (2001) 0.97
Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis. Diabetes Obes Metab (2010) 0.96
Rapid monitoring of site-specific glycosylation microheterogeneity of recombinant human interferon-gamma. Anal Chem (1996) 0.96
Neurofibromin is enriched in the endoplasmic reticulum of CNS neurons. J Neurosci (1993) 0.95
Solution structure of the major alpha-amylase inhibitor of the crop plant amaranth. J Biol Chem (1999) 0.95
Behavioral plasticity in honey bees is associated with differences in brain microRNA transcriptome. Genes Brain Behav (2012) 0.95
Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells. Virology (1997) 0.93
Specific frequencies of spontaneous Ca2+ transients upregulate GAD 67 transcripts in embryonic spinal neurons. Mol Cell Neurosci (2000) 0.93
Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development. J Clin Invest (2001) 0.93
Pain in hospitalized patients with medical illnesses. J Pain Symptom Manage (1993) 0.93
Integrin-mediated signalling of gelatinase B secretion in colon cancer cells. Biochem Biophys Res Commun (1998) 0.93
Diversity and evolution of T-cell receptor variable region genes in mammals and birds. Immunogenetics (1999) 0.92
Seizures increase acetylcholine and choline concentrations in rat brain regions. Neurochem Res (1991) 0.92
Skin concentrations of H1-receptor antagonists. J Allergy Clin Immunol (2001) 0.90
A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements? Gene (2000) 0.89
Modulation of VEGF production by pH and glucose in retinal Müller cells. Curr Eye Res (1998) 0.89
Corneal endothelial modulation: a factor released by leukocytes induces basic fibroblast growth factor that modulates cell shape and collagen. Invest Ophthalmol Vis Sci (1993) 0.89
A genome-wide survey of copy number variation regions in various chicken breeds by array comparative genomic hybridization method. Anim Genet (2012) 0.88
Hypoxia-inducible factor-1alpha: molecular-targeted therapy for hepatocellular carcinoma. Mini Rev Med Chem (2013) 0.88
New device for closure of muscular ventricular septal defects in a canine model. Circulation (1999) 0.88
Studies on immunopathogenesis in epidemic hemorrhagic fever: sequential observations on activation of the first complement component in sera from patients with epidemic hemorrhagic fever. J Immunol (1981) 0.88
Karyotype relationships of six bat species (Chiroptera, Vespertilionidae) from China revealed by chromosome painting and G-banding comparison. Cytogenet Genome Res (2006) 0.88
HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population. Tissue Antigens (1999) 0.87
Can epinephrine inhalations be substituted for epinephrine injection in children at risk for systemic anaphylaxis? Pediatrics (2000) 0.87
Pentoxifylline suppression of TNF-alpha mediated axonal degeneration in the rabbit optic nerve. Neurol Res (1997) 0.86
The common variants of E-selectin gene in Graves' disease. Genes Immun (2007) 0.86
Characterization of surface accumulation and release of nanosilica during irradiation of polymer nanocomposites by ultraviolet light. J Nanosci Nanotechnol (2012) 0.86
Recombinant human endostatin combined with definitive chemoradiotherapy as primary treatment for patients with unresectable but without systemic metastatic squamous cell carcinoma of the oesophagus. Br J Radiol (2012) 0.85
Estimating evolutionary distances between DNA sequences. Methods Enzymol (1996) 0.85
Gamma-interferon production and quality in stoichiometric fed-batch cultures of Chinese hamster ovary (CHO) cells under serum-free conditions. Biotechnol Bioeng (1997) 0.85
Corneal endothelial modulation: bFGF as direct mediator and corneal endothelium modulation factor as inducer. Invest Ophthalmol Vis Sci (1994) 0.85
Sequence variation in ZFX introns in human populations. Mol Biol Evol (1998) 0.85
Experimental evaluation of a new self-expanding patent ductus arteriosus occluder in a canine model. J Vasc Interv Radiol (1997) 0.85
Infertility and venereal disease in cattle inseminated with semen containing bovine herpesvirus type 5. Vet Rec (2009) 0.84
Inherent temperature compensation of fiber-optic current sensors employing spun highly birefringent fiber. Opt Express (2016) 0.84
Two novel mutations in phenylalanine hydroxylase gene and in vitro expression analysis on mutation Arg252Gln. Chin Med Sci J (1997) 0.84
Highly simplified device for ultrashort-pulse measurement. Opt Lett (2001) 0.84
Spontaneous calcium transients regulate neuronal plasticity in developing neurons. J Neurobiol (1995) 0.84
Three-dimensional structure of Selenocosmia huwena lectin-I (SHL-I) from the venom of the spider Selenocosmia huwena by 2D-NMR. J Protein Chem (1999) 0.84
Motor unit properties of nerve-intact extensor digitorum longus muscle grafts in young and old rats. J Gerontol A Biol Sci Med Sci (2001) 0.84
Purification and characterization of CMP-N-acetylneuraminic acid:lactosylceramide (alpha 2-3) sialyltransferase (GM3-synthase) from rat brain. J Biol Chem (1993) 0.84
Lung cancer among tin miners in southeast China: silica exposure, silicosis, and cigarette smoking. Am J Ind Med (1994) 0.84
Enhanced therapeutic effect against liver W256 carcinosarcoma with temperature-sensitive liposomal adriamycin administered into the hepatic artery. Cancer Res (1993) 0.83
A new magnetic resonance imaging scoring system for perilymphatic space appearance after intratympanic gadolinium injection, and its clinical application. J Laryngol Otol (2012) 0.83
Structural analysis of free and enzyme-bound amaranth alpha-amylase inhibitor: classification within the knottin fold superfamily and analysis of its functional flexibility. Protein Eng (2001) 0.83
Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice. Neuroscience (2013) 0.83
Glycine-valine dimorphism at the 86th amino acid of HLA-DRB1 influenced the prognosis of postschistosomal hepatic fibrosis. J Infect Dis (1998) 0.83
Biological treatment of dye wastewaters using an anaerobic-oxic system. Chemosphere (1996) 0.83
Parametric amplification of few-cycle carrier-envelope phase-stable pulses at 2.1 microm. Opt Lett (2006) 0.83
A protocol for geographically randomized snail surveys in schistosomiasis fieldwork using the global positioning system. Am J Trop Med Hyg (2001) 0.83
The alphaVbeta6 integrin regulates its own expression with cell crowding: implications for tumour progression. Int J Cancer (2001) 0.83
Postoperative radiotherapy for stage I thymoma: a prospective randomized trial in 29 cases. Chin Med J (Engl) (1999) 0.82