The structural basis of molecular adaptation.

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Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene. Proc Natl Acad Sci U S A (2003) 1.17

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Multiple mechanisms promote the retained expression of gene duplicates in the tetraploid frog Xenopus laevis. PLoS Genet (2006) 1.11

A systematic search for positive selection in higher plants (Embryophytes). BMC Plant Biol (2006) 1.10

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Rapid evolution by positive selection and gene gain and loss: PLA(2) venom genes in closely related Sistrurus rattlesnakes with divergent diets. J Mol Evol (2008) 1.05

Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors. Proc Natl Acad Sci U S A (2013) 1.03

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Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. PLoS Genet (2012) 0.96

Was "molecular opportunism" a factor in the evolution of different photosynthetic light-harvesting pigment systems? Proc Natl Acad Sci U S A (2001) 0.94

Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin. Mol Biol Evol (2015) 0.93

Molecular variation at a candidate gene implicated in the regulation of fire ant social behavior. PLoS One (2007) 0.91

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Genome-wide evidence for positive selection and recombination in Actinobacillus pleuropneumoniae. BMC Evol Biol (2011) 0.88

Positive Darwinian selection drives the evolution of the morphology-related gene, EPCAM, in particularly species-rich lineages of African cichlid fishes. J Mol Evol (2011) 0.86

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Positive Darwinian selection at single amino acid sites conferring plant virus resistance. J Mol Evol (2008) 0.85

Tracking recent adaptive evolution in microbial species using TimeZone. Nat Protoc (2013) 0.85

An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases. Elife (2014) 0.84

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Adaptive evolutionary paths from UV reception to sensing violet light by epistatic interactions. Sci Adv (2015) 0.79

Evolution of new function through a single amino acid change in the yeast repressor Sum1p. Mol Cell Biol (2008) 0.78

Adaptive evolution of the STRA6 genes in mammalian. PLoS One (2014) 0.78

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Natural selection during functional divergence to LMP7 and proteasome subunit X (PSMB5) following gene duplication. J Mol Evol (2005) 0.77

Molecular evolution of HR, a gene that regulates the postnatal cycle of the hair follicle. Sci Rep (2011) 0.77

Molecular adaptation in plant hemoglobin, a duplicated gene involved in plant-bacteria symbiosis. J Mol Evol (2004) 0.76

Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases. Protein Sci (2016) 0.76

Structure of a Highly Active Cephalopod S-crystallin Mutant: New Molecular Evidence for Evolution from an Active Enzyme into Lens-Refractive Protein. Sci Rep (2016) 0.75

A non-synonymous SNP with the allele frequency correlated with the altitude may contribute to the hypoxia adaptation of Tibetan chicken. PLoS One (2017) 0.75

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Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution. Proc Natl Acad Sci U S A (2000) 2.20

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Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase. Protein Sci (1996) 0.94

Structural constraints in protein engineering--the coenzyme specificity of Escherichia coli isocitrate dehydrogenase. Eur J Biochem (1997) 0.82

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Nucleotide variations in the lxd region of Drosophila melanogaster: characterization of a candidate modifier of lifespan. Gene (2002) 0.76