Published in Proc Natl Acad Sci U S A on July 17, 2001
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol (2008) 1.87
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J (2003) 1.57
DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I. J Gerontol A Biol Sci Med Sci (2006) 1.19
Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study. J Gerontol A Biol Sci Med Sci (2009) 1.10
Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study. Rejuvenation Res (2010) 1.06
Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion. J Biol Chem (2008) 0.91
New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs. Front Neurosci (2012) 0.91
Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene. J Gerontol A Biol Sci Med Sci (2016) 0.77
Celecoxib influences steroid sulfonation catalyzed by human recombinant sulfotransferase 2A1. J Steroid Biochem Mol Biol (2015) 0.75
Leukocyte Telomere Length and Serum Levels of High-Molecular-Weight Adiponectin and Dehydroepiandrosterone-Sulfate Could Reflect Distinct Aspects of Longevity in Japanese Centenarians. Gerontol Geriatr Med (2017) 0.75
Prognostic Value of Dehydroepiandrosterone Sulfate for Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis. J Am Heart Assoc (2017) 0.75
Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab (1996) 2.44
Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med (1999) 2.13
Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res (1997) 1.80
Human growth hormone and human aging. Endocr Rev (1993) 1.80
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab (1994) 1.79
Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci U S A (1981) 1.78
Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem (1998) 1.76
Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. J Clin Endocrinol Metab (1992) 1.68
Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. J Clin Endocrinol Metab (1994) 1.66
Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology (1999) 1.57
A double-blind, placebo-controlled, clinical trial of dehydroepiandrosterone in severe systemic lupus erythematosus. Lupus (1999) 1.51
The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf) (1998) 1.45
Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab (1998) 1.40
Serum total IGF-I, free IGF-I, and IGFB-1 levels in an elderly population: relation to cardiovascular risk factors and disease. Arterioscler Thromb Vasc Biol (1998) 1.37
Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment. J Clin Endocrinol Metab (1998) 1.17
Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci U S A (2001) 1.17
Complex alteration of thyroid function in healthy centenarians. J Clin Endocrinol Metab (1993) 1.11
Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. Mol Pharmacol (1996) 1.10
DHEA and peripheral androgen and estrogen formation: intracinology. Ann N Y Acad Sci (1995) 1.09
Serum dehydroepiandrosterone sulfate levels as an individual marker. J Clin Endocrinol Metab (1994) 1.05
Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Am J Obstet Gynecol (1993) 1.03
Serum levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in healthy centenarians: relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function. J Clin Endocrinol Metab (1997) 1.03
Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study. J Clin Endocrinol Metab (2000) 1.02
Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. J Clin Endocrinol Metab (1997) 1.02
Three sulfate esters of 17-ketosteroids in the plasma of normal subjects and after administration of ACTH. J Clin Endocrinol Metab (1960) 1.00
Replacement of DHEA in aging men and women. Potential remedial effects. Ann N Y Acad Sci (1995) 0.99
The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. J Clin Endocrinol Metab (1996) 0.99
Dehydroepiandrosterone: biosynthesis and metabolism in the brain. Endocrinology (1999) 0.98
Identification and isolation of dehydroisoandrosterone from peripheral human plasma. J Biol Chem (1954) 0.95
A genetic component to the variation of dehydroepiandrosterone sulfate. Metabolism (1985) 0.95
Serum free IGF-I, total IGF-I, IGFBP-1 and IGFBP-3 levels in an elderly population: relation to age and sex steroid levels. Clin Endocrinol (Oxf) (1998) 0.94
Aging alters zonation in the adrenal cortex of men. J Clin Endocrinol Metab (1997) 0.93
IL-6, DHEA and the ageing process. Mech Ageing Dev (1997) 0.91
Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20-desmolase enzymatic activity. J Clin Endocrinol Metab (1990) 0.90
Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women. J Endocrinol (1996) 0.89
DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range. Am J Physiol (1995) 0.82
A single administration of dehydroepiandrosterone does not enhance memory performance in young healthy adults, but immediately reduces cortisol levels. Biol Psychiatry (1997) 0.79
Identification of fatty acid esters of pregnenolone and allopregnanolone from bovine corpora lutea. J Biol Chem (1980) 0.79