Published in Nature on July 26, 2001
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell (2008) 7.63
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev (2011) 3.47
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The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants. Proc Natl Acad Sci U S A (2003) 1.42
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Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. Mol Cell Biol (2004) 1.31
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Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol (2012) 1.30
Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication. Mol Cell Biol (2002) 1.30
Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition. J Biol Chem (2008) 1.28
Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast. Nucleic Acids Res (2004) 1.28
DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol (2015) 1.27
The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. J Biol Chem (2009) 1.27
Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway. J Biol Chem (2009) 1.27
SCFhFBH1 can act as helicase and E3 ubiquitin ligase. Nucleic Acids Res (2004) 1.25
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J (2013) 1.25
The fission yeast pfh1(+) gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase. Nucleic Acids Res (2002) 1.25
Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2008) 1.24
Mechanisms and regulation of DNA end resection. EMBO J (2010) 1.22
Flap endonuclease 1. Annu Rev Biochem (2013) 1.21
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Tripartite structure of Saccharomyces cerevisiae Dna2 helicase/endonuclease. Nucleic Acids Res (2001) 1.16
DNA replication: a complex matter. EMBO Rep (2003) 1.15
Roles of SGS1, MUS81, and RAD51 in the repair of lagging-strand replication defects in Saccharomyces cerevisiae. Curr Genet (2005) 1.14
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Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading. J Biol Chem (2010) 1.09
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Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev (2009) 1.05
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A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability. Mol Cell Biol (2014) 1.00
DNA double-strand break processing: the beginning of the end. Genes Dev (2008) 0.99
Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases. J Biol Chem (2010) 0.99
Regulation of the DNA replication fork: a way to fight genomic instability. Chromosoma (2004) 0.98
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem (2012) 0.98
Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol (2002) 0.98
Genetic instability induced by overexpression of DNA ligase I in budding yeast. Genetics (2005) 0.98
Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates. Nucleic Acids Res (2009) 0.97
The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing. J Biol Chem (2009) 0.97
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An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase. J Biol Chem (2010) 0.97
Differential processing of leading- and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nuclease. Genetics (2002) 0.96
Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2009) 0.96
The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1. Mol Cell Biol (2008) 0.95
In vivo and in vitro studies of Mgs1 suggest a link between genome instability and Okazaki fragment processing. Nucleic Acids Res (2005) 0.95
Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity. Proc Natl Acad Sci U S A (2013) 0.93
A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation. Nucleic Acids Res (2003) 0.93
Genetic and functional interactions between Mus81-Mms4 and Rad27. Nucleic Acids Res (2010) 0.92
Enzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2. Nucleic Acids Res (2005) 0.92
Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron-sulfur cluster domain. Nucleic Acids Res (2012) 0.91
Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol Biol (2013) 0.91
TbPIF5 is a Trypanosoma brucei mitochondrial DNA helicase involved in processing of minicircle Okazaki fragments. PLoS Pathog (2009) 0.90
Telomerase is essential to alleviate pif1-induced replication stress at telomeres. Genetics (2009) 0.90
Four pillars of the S-phase checkpoint. Genes Dev (2013) 0.89
Genetics of lagging strand DNA synthesis and maturation in fission yeast: suppression analysis links the Dna2-Cdc24 complex to DNA polymerase delta. Nucleic Acids Res (2004) 0.89
Dna2 exhibits a unique strand end-dependent helicase function. J Biol Chem (2010) 0.89
Mechanism and regulation of DNA end resection in eukaryotes. Crit Rev Biochem Mol Biol (2016) 0.88
Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex. EMBO J (2015) 0.88
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Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. Nucleic Acids Res (2012) 0.86
Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins. Proc Natl Acad Sci U S A (2016) 0.85
Reconstitution of eukaryotic lagging strand DNA replication. Methods (2010) 0.84
Yet another job for Dna2: Checkpoint activation. DNA Repair (Amst) (2015) 0.84
Human replication factor C stimulates flap endonuclease 1. J Biol Chem (2009) 0.84
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The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication. Nucleic Acids Res (2015) 0.84
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