Published in Mol Cell Biol on September 01, 2001
Preventing re-replication of chromosomal DNA. Nat Rev Mol Cell Biol (2005) 5.82
Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev (2004) 4.19
Replication licensing--defining the proliferative state? Trends Cell Biol (2002) 2.91
Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol (2009) 2.67
ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase. Genes Dev (2002) 2.40
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev (2004) 2.36
The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein. Proc Natl Acad Sci U S A (2001) 1.64
Regulating DNA replication in eukarya. Cold Spring Harb Perspect Biol (2013) 1.52
SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast. Mol Biol Cell (2002) 1.40
Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites. Proc Natl Acad Sci U S A (2007) 1.33
Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage. Mol Biol Cell (2004) 1.26
Role for Cdk1 (Cdc2)/cyclin A in preventing the mammalian origin recognition complex's largest subunit (Orc1) from binding to chromatin during mitosis. Mol Cell Biol (2004) 1.23
Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant. Mol Biol Cell (2006) 1.23
Genomic instability in cancer. Cold Spring Harb Perspect Biol (2013) 1.23
Redundant control of rereplication in fission yeast. Proc Natl Acad Sci U S A (2001) 1.17
Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development. J Proteome Res (2013) 1.15
Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain. Mol Biol Cell (2008) 1.11
The chromosome cycle: coordinating replication and segregation. Second in the cycles review series. EMBO Rep (2005) 1.06
Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts. Nucleic Acids Res (2005) 1.03
Once in a lifetime: strategies for preventing re-replication in prokaryotic and eukaryotic cells. EMBO Rep (2008) 1.00
Different phenotypes in vivo are associated with ATPase motif mutations in Schizosaccharomyces pombe minichromosome maintenance proteins. Genetics (2002) 0.96
Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping. J Struct Biol (2008) 0.95
Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication. Cell Div (2012) 0.95
Putative subunits of the maize origin of replication recognition complex ZmORC1-ZmORC5. Nucleic Acids Res (2003) 0.93
The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication. Mol Cell Biol (2004) 0.91
Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins. J Biol Chem (2012) 0.86
A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication. PLoS Genet (2012) 0.86
Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants. Plant Physiol (2009) 0.86
The dual role of autonomously replicating sequences as origins of replication and as silencers. Curr Genet (2009) 0.84
Site-specific interaction of the murine pre-replicative complex with origin DNA: assembly and disassembly during cell cycle transit and differentiation. Nucleic Acids Res (2007) 0.83
Roles of the CDK phosphorylation sites of yeast Cdc6 in chromatin binding and rereplication. Mol Biol Cell (2007) 0.83
Checkpoint effects and telomere amplification during DNA re-replication in fission yeast. BMC Mol Biol (2007) 0.80
Mechanisms and regulation of DNA replication initiation in eukaryotes. Crit Rev Biochem Mol Biol (2017) 0.79
Regulation of DNA replication proteins in parasitic protozoans: possible role of CDK-like kinases. Curr Genet (2016) 0.76
Plasma membrane/cell wall perturbation activates a novel cell cycle checkpoint during G1 in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2016) 0.76
Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis. Mol Biol Cell (2013) 0.75
A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. BMC Syst Biol (2012) 0.75
A new role for Ran in ensuring precise duplication of chromosomal DNA. Cell (2003) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol (1991) 33.90
Universal control mechanism regulating onset of M-phase. Nature (1990) 19.11
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
MCM proteins in DNA replication. Annu Rev Biochem (1999) 13.88
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature (1992) 11.06
Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell (1997) 8.23
nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine. J Biol Chem (1990) 8.16
Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell (1998) 6.69
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science (2000) 6.48
Two steps in the assembly of complexes at yeast replication origins in vivo. Cell (1994) 6.42
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol (2001) 5.37
Regulation of p34cdc2 protein kinase during mitosis. Cell (1989) 5.33
Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell (1997) 5.15
The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization. Cell (1989) 4.95
The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell (1996) 4.80
Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature (1991) 4.60
Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev (1996) 4.26
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell (1995) 4.23
S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr Biol (1995) 4.20
Efficient targeted integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe. Genetics (1994) 3.92
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature (1996) 3.89
Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex. Cell (1994) 3.52
The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J (1997) 3.35
Subcellular localization of yeast CDC46 varies with the cell cycle. Genes Dev (1990) 3.34
Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science (1994) 3.16
The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev (1998) 3.15
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J (1999) 3.05
Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev (1998) 2.75
CLB5-dependent activation of late replication origins in S. cerevisiae. Mol Cell (1998) 2.72
The origin recognition complex in silencing, cell cycle progression, and DNA replication. Mol Biol Cell (1995) 2.67
A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. EMBO J (1996) 2.58
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol (1998) 2.54
Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Mol Cell (1998) 2.49
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Cell (1995) 2.48
Role for a Xenopus Orc2-related protein in controlling DNA replication. Nature (1996) 2.44
G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nat Cell Biol (1999) 2.39
Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev (1997) 2.34
Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7. Curr Biol (2000) 2.23
Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18. Genes Dev (1997) 2.16
Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis. Mol Biol Cell (1999) 2.07
A predictive scale for evaluating cyclin-dependent kinase substrates. A comparison of p34cdc2 and p33cdk2. J Biol Chem (1996) 2.01
Genetic analysis of an ARS element from the fission yeast Schizosaccharomyces pombe. EMBO J (1995) 1.99
Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. EMBO J (2000) 1.91
hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J (1995) 1.89
Putting it all together: building a prereplicative complex. Cell (1997) 1.86
Cdc7p-Dbf4p becomes famous in the cell cycle. J Cell Sci (2000) 1.83
Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature (1996) 1.82
Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins. Mol Cell Biol (1999) 1.79
Large, complex modular structure of a fission yeast DNA replication origin. Curr Biol (1996) 1.70
Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol Cell Biol (1996) 1.52
Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly. Mol Biol Cell (1999) 1.42
Negative regulation of Cdc18 DNA replication protein by Cdc2. Mol Biol Cell (1998) 1.41
Emerging mechanisms of eukaryotic DNA replication initiation. Curr Opin Cell Biol (1998) 1.39
Regulation of Cdc2 activity by phosphorylation at T14/Y15. Prog Cell Cycle Res (1996) 1.37
Cyclin-dependent kinase and initiation at eukaryotic origins: a replication switch? Curr Opin Cell Biol (1997) 1.33
Eukaryotic DNA replication: from pre-replication complex to initiation complex. Curr Opin Cell Biol (2000) 1.32
Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle. Genes Dev (2000) 1.32
Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Mol Cell Biol (1996) 1.23
Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs). Curr Biol (1999) 1.19
The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle. J Cell Sci (1999) 1.13
sud1(+) targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast. Proc Natl Acad Sci U S A (1998) 1.12
Schizosaccharomyces pombe Mcm3p, an essential nuclear protein, associates tightly with Nda4p (Mcm5p). Nucleic Acids Res (1998) 1.11
Functions of fission yeast orp2 in DNA replication and checkpoint control. Genetics (2000) 1.11
Fission yeast Nda1 and Nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins. J Cell Sci (1996) 1.09
The kinetics of the B cyclin p56cdc13 and the phosphatase p80cdc25 during the cell cycle of the fission yeast Schizosaccharomyces pombe. J Cell Sci (1996) 1.06
The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size. Mol Biol Cell (2000) 1.03
Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex. J Biol Chem (2000) 1.02
Intracellular location of the Saccharomyces cerevisiae CDC6 gene product. DNA Cell Biol (1996) 0.93
CDC7 kinase complex as a molecular switch for DNA replication. Front Biosci (1999) 0.93
The metazoan origin recognition complex. Front Biosci (1999) 0.90
Ribosomal-membrane interaction: in vitro binding of ribosomes to microsomal membranes. J Mol Biol (1974) 5.75
An amino-terminal fragment of GAL4 binds DNA as a dimer. J Mol Biol (1989) 3.65
A potent GAL4 derivative activates transcription at a distance in vitro. Science (1990) 2.15
Activation of yeast polymerase II transcription by herpesvirus VP16 and GAL4 derivatives in vitro. Mol Cell Biol (1989) 2.06
Characterization of the ribosomal binding site in rat liver rough microsomes: ribophorins I and II, two integral membrane proteins related to ribosome binding. J Supramol Struct (1978) 1.75
Negative regulation of Cdc18 DNA replication protein by Cdc2. Mol Biol Cell (1998) 1.41
Functions of fission yeast orp2 in DNA replication and checkpoint control. Genetics (2000) 1.11
Selective absorption of ultraviolet laser energy by human atherosclerotic plaque treated with tetracycline. Am J Cardiol (1985) 0.92
A 2-year open-label study of galantamine therapy in Chinese Alzheimer's disease patients in Hong Kong. Int J Clin Pract (2007) 0.85
Pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe. J Biol Chem (1997) 0.85
Cross-linked hemoglobins as potential plasma protein extenders. Fed Proc (1975) 0.83
Structural and functional aspects of the protein synthesizing apparatus in the rough endoplasmic reticulum. Adv Exp Med Biol (1975) 0.80
A comparison of the lytic properties of two ether-linked lipids, one with and one without antineoplastic activity. Biochem Cell Biol (1995) 0.76
Pretransplant coronary arteriography for diabetic renal transplant recipients. Transplant Proc (1987) 0.76
Where does DNA replication start in archaea? Genome Biol (2000) 0.75
Lottery play and problem gambling. J Gambl Stud (1990) 0.75
Tools for educating transcultural patients. ANNA J (1986) 0.75
Impact of religious beliefs on medical care. ANNA J (1986) 0.75
Forskolin inhibits platelet-activating factor binding to platelet receptors independently of adenylyl cyclase activation. Eur J Pharmacol (1993) 0.75