Molecular bases of odor discrimination: Reconstitution of olfactory receptors that recognize overlapping sets of odorants.

PubWeight™: 2.04‹?› | Rank: Top 2%

🔗 View Article (PMID 11487625)

Published in J Neurosci on August 15, 2001

Authors

K Kajiya1, K Inaki, M Tanaka, T Haga, H Kataoka, K Touhara

Author Affiliations

1: Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 113, Japan.

Articles citing this

The human olfactory receptor gene family. Proc Natl Acad Sci U S A (2004) 2.74

The mouse olfactory receptor gene family. Proc Natl Acad Sci U S A (2004) 2.34

Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori. Proc Natl Acad Sci U S A (2004) 2.29

Chemotopic odorant coding in a mammalian olfactory system. J Comp Neurol (2007) 2.13

Retracted Odor maps in the olfactory cortex. Proc Natl Acad Sci U S A (2005) 2.11

Silencing of odorant receptor genes by G protein βγ signaling ensures the expression of one odorant receptor per olfactory sensory neuron. Neuron (2014) 1.72

Olfactory receptor antagonism between odorants. EMBO J (2003) 1.66

Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells. Nat Protoc (2008) 1.54

Ric-8B promotes functional expression of odorant receptors. Proc Natl Acad Sci U S A (2006) 1.47

A pharmacological profile of the aldehyde receptor repertoire in rat olfactory epithelium. J Physiol (2004) 1.45

A large-scale analysis of odor coding in the olfactory epithelium. J Neurosci (2011) 1.44

The cell biology of smell. J Cell Biol (2010) 1.40

The dog and rat olfactory receptor repertoires. Genome Biol (2005) 1.37

Functional analysis of a mammalian odorant receptor subfamily. J Neurochem (2006) 1.30

The complete swine olfactory subgenome: expansion of the olfactory gene repertoire in the pig genome. BMC Genomics (2012) 1.23

Ultrasensitive detection of amines by a trace amine-associated receptor. J Neurosci (2013) 1.17

Selective imaging of presynaptic activity in the mouse olfactory bulb shows concentration and structure dependence of odor responses in identified glomeruli. Proc Natl Acad Sci U S A (2002) 1.16

Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor. Proc Natl Acad Sci U S A (2004) 1.14

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins. ACS Nano (2011) 1.11

Personal receptor repertoires: olfaction as a model. BMC Genomics (2012) 1.10

Heterodimerization and surface localization of G protein coupled receptors. Biochem Pharmacol (2006) 1.09

Olfactory receptors: G protein-coupled receptors and beyond. J Neurochem (2009) 1.08

Visualizing odorant receptor trafficking in living cells down to the single-molecule level. Proc Natl Acad Sci U S A (2006) 1.04

Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression. BMC Cell Biol (2004) 1.03

Mammalian olfactory receptors. Front Cell Neurosci (2009) 0.99

Odor concentration invariance by chemical ratio coding. Front Syst Neurosci (2008) 0.98

The state of the art of odorant receptor deorphanization: a report from the orphanage. J Gen Physiol (2014) 0.96

A broadly tuned mouse odorant receptor that detects nitrotoluenes. J Neurochem (2012) 0.95

From molecule to mind: an integrative perspective on odor intensity. Trends Neurosci (2014) 0.93

Human olfactory detection of homologous n-alcohols measured via concentration-response functions. Pharmacol Biochem Behav (2008) 0.93

Origin of basal activity in mammalian olfactory receptor neurons. J Gen Physiol (2010) 0.92

Test of the Binding Threshold Hypothesis for olfactory receptors: explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912-93. Protein Sci (2005) 0.92

Olfactory receptor patterning in a higher primate. J Neurosci (2014) 0.91

Chaperoning G protein-coupled receptors: from cell biology to therapeutics. Endocr Rev (2014) 0.91

Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules. J Gen Physiol (2003) 0.90

A cleavable N-terminal signal peptide promotes widespread olfactory receptor surface expression in HEK293T cells. PLoS One (2013) 0.88

In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors. J Neurosci (2014) 0.88

A framework for exploring functional variability in olfactory receptor genes. PLoS One (2007) 0.88

Generation and modulation of chemosensory behaviors in C. elegans. Pflugers Arch (2007) 0.88

The perception of odor objects in everyday life: a review on the processing of odor mixtures. Front Psychol (2014) 0.88

Identification and characterization of novel renal sensory receptors. PLoS One (2014) 0.87

Deep sequencing of the murine olfactory receptor neuron transcriptome. PLoS One (2015) 0.87

Analysis of cattle olfactory subgenome: the first detail study on the characteristics of the complete olfactory receptor repertoire of a ruminant. BMC Genomics (2013) 0.86

Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids. J Neurochem (2009) 0.86

Ligand specificity of odorant receptors. J Mol Model (2006) 0.85

Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo. Nat Neurosci (2015) 0.84

Ligand-selective activation of heterologously-expressed mammalian olfactory receptor. Cell Calcium (2014) 0.83

Glomerular input patterns in the mouse olfactory bulb evoked by retronasal odor stimuli. BMC Neurosci (2013) 0.82

Genomic drift and copy number variation of chemosensory receptor genes in humans and mice. Cytogenet Genome Res (2009) 0.81

Preferential binding of an odor within olfactory receptors: a precursor to receptor activation. Chem Senses (2014) 0.80

The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons. J Neurosci (2016) 0.78

Phosphoinositide 3-kinase dependent inhibition as a broad basis for opponent coding in Mammalian olfactory receptor neurons. PLoS One (2013) 0.77

Evaluation of the role of g protein-coupled receptor kinase 3 in desensitization of mouse odorant receptors in a Mammalian cell line and in olfactory sensory neurons. Chem Senses (2014) 0.76

A model for non-monotonic intensity coding. R Soc Open Sci (2015) 0.76

How does your kidney smell? Emerging roles for olfactory receptors in renal function. Pediatr Nephrol (2015) 0.76

Receptive range analysis of a mouse odorant receptor subfamily. J Neurochem (2015) 0.75

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles. Sci Rep (2015) 0.75

High-throughput analysis of mammalian olfactory receptors: measurement of receptor activation via luciferase activity. J Vis Exp (2014) 0.75

Eugenol inhibits the GABAA current in trigeminal ganglion neurons. PLoS One (2015) 0.75

Bioelectronic nose and its application to smell visualization. J Biol Eng (2016) 0.75

Neocortex expansion is linked to size variations in gene families with chemotaxis, cell-cell signalling and immune response functions in mammals. Open Biol (2016) 0.75

From Chemistry to Behavior. Molecular Structure and Bioactivity of Repellents against Ixodes ricinus Ticks. PLoS One (2013) 0.75

Mammalian odorant receptor tuning breadth persists across distinct odorant panels. PLoS One (2017) 0.75

Articles by these authors

The complete nucleotide sequence of the tobacco chloroplast genome: its gene organization and expression. EMBO J (1986) 19.59

Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res (2001) 15.22

Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23

Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment. J Clin Oncol (2001) 6.83

Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. Nature (1970) 5.65

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature (1989) 5.43

Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature (1986) 4.97

Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates. Antimicrob Agents Chemother (1992) 4.43

Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy. Ann Intern Med (1999) 4.38

Coding of modified body schema during tool use by macaque postcentral neurones. Neuroreport (1996) 3.78

Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis (2008) 3.77

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet (1989) 3.69

A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin. Biochem Biophys Res Commun (1985) 3.40

Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature (1985) 3.28

Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation (1995) 3.18

Necrotising fasciitis due to group A streptococci in western Norway: incidence and clinical features. Lancet (1994) 3.16

The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res (1995) 3.04

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci U S A (1996) 2.88

FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell (2000) 2.86

Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res (1995) 2.79

Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol (1994) 2.74

Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum (2000) 2.72

Risk of poliomyelitis importation and re-emergence in Laos. Lancet (2000) 2.64

Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature (1995) 2.64

Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds. Proc Natl Acad Sci U S A (1975) 2.60

Rapid identification of dengue virus serotypes by using polymerase chain reaction. J Clin Microbiol (1991) 2.60

Mitochondrial genotype associated with longevity. Lancet (1998) 2.58

In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity (1998) 2.54

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest (1997) 2.44

FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol (1998) 2.43

Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A (1997) 2.42

Expression of SR-PSOX, a novel cell-surface scavenger receptor for phosphatidylserine and oxidized LDL in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol (2001) 2.39

Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev (1996) 2.39

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. J Biol Chem (1995) 2.35

A TBP complex essential for transcription from TATA-less but not TATA-containing RNA polymerase III promoters is part of the TFIIIB fraction. Cell (1992) 2.32

Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J (1997) 2.28

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun (1989) 2.23

Six chloroplast genes (ndhA-F) homologous to human mitochondrial genes encoding components of the respiratory chain NADH dehydrogenase are actively expressed: determination of the splice sites in ndhA and ndhB pre-mRNAs. Mol Gen Genet (1987) 2.14

Function of Light in the Light-induced Geotropic Response in Zea Roots. Plant Physiol (1981) 2.13

Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med (1999) 2.13

Erythromycin reduces neutrophils and neutrophil-derived elastolytic-like activity in the lower respiratory tract of bronchiolitis patients. Am Rev Respir Dis (1992) 2.12

Convulsions after ropivacaine 300 mg for brachial plexus block. Br J Anaesth (2008) 2.09

Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res (1998) 2.08

Concordance between telepathologic diagnosis and conventional histopathologic diagnosis: a multiobserver store-and-forward study on 20 skin specimens. Arch Dermatol (2002) 2.07

A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate. J Bacteriol (1983) 2.06

International transmission of uncompressed endoscopic surgery images via superfast broadband Internet connections. Surg Endosc (2005) 2.05

Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology (1999) 2.05

New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol (2000) 2.05

Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med (2000) 2.05

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence. FEBS Lett (1986) 2.03

Poly(L-proline)-binding proteins from chick embryos are a profilin and a profilactin. Eur J Biochem (1985) 2.01

The internal biliary fistula--reappraisal of incidence, type, diagnosis and management of 33 consecutive cases. HPB Surg (1997) 2.00

Symptomatic myopathy associated with interferon therapy for chronic hepatitis C. Lancet (1995) 1.99

Internet-based program for automatic discrimination of dermoscopic images between melanomas and Clark naevi. Br J Dermatol (2004) 1.99

Erythroid cell differentiation: murine erythroleukemia cell variant with unique pattern of induction by polar compounds. Proc Natl Acad Sci U S A (1976) 1.99

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum Mol Genet (2000) 1.99

Mitochondrial mutation in fatal infantile cardiomyopathy. Lancet (1990) 1.98

Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med (2001) 1.98

Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Neuron (1998) 1.96

Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J Cell Biol (1999) 1.96

Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc Natl Acad Sci U S A (1999) 1.96

Impact of cerebral microcirculatory changes on cerebral blood flow during cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke (2000) 1.94

Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene (1995) 1.94

Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer. Cancer Res (1991) 1.92

Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene (1999) 1.91

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Biochem Biophys Res Commun (1995) 1.90

Choline uptake systems of rat brain synaptosomes. Biochim Biophys Acta (1973) 1.88

Physical and functional mapping of Tn2603, a transposon encoding ampicillin, streptomycin, sulfonamide, and mercury resistance. Mol Gen Genet (1981) 1.88

Resistance of Fc receptor- deficient mice to fatal glomerulonephritis. J Clin Invest (1998) 1.88

IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol (2000) 1.86

A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer. Br J Cancer (2009) 1.84

Genes for the eight ribosomal proteins are clustered on the chloroplast genome of tobacco (Nicotiana tabacum): similarity to the S10 and spc operons of Escherichia coli. Proc Natl Acad Sci U S A (1986) 1.83

Transposition of the oxacillin-hydrolyzing penicillinase gene. J Bacteriol (1981) 1.82

Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med (1997) 1.80

Structures of mollusc shell framework proteins. Nature (1997) 1.80

A tobacco chloroplast DNA sequence possibly coding for a polypeptide similar to E. coli RNA polymerase beta-subunit. FEBS Lett (1986) 1.79

Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein. Circ Res (1998) 1.78

When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. J Cell Biol (1998) 1.78

Type II topoisomerase mutations in fluoroquinolone-resistant clinical strains of Pseudomonas aeruginosa isolated in 1998 and 1999: role of target enzyme in mechanism of fluoroquinolone resistance. Antimicrob Agents Chemother (2001) 1.77

Apoptosis of medial smooth muscle cells in the development of saccular cerebral aneurysms in rats. Stroke (1998) 1.77

Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages. J Biol Chem (2000) 1.76

Evolution of complex resistance transposons from an ancestral mercury transposon. J Bacteriol (1983) 1.76

Normotensive salt sensitivity: effects of race and dietary potassium. Hypertension (1999) 1.74

Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells. J Biol Chem (1977) 1.71

Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment. Genes Dev (1993) 1.71

Three-dimensional melanin distribution of acral melanocytic nevi is reflected in dermoscopy features: analysis of the parallel pattern. Dermatology (2008) 1.71

Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy. Biochem Biophys Res Commun (1991) 1.70

Non-steroidal anti-inflammatory drugs as a possible cause of collagenous colitis: a case-control study. Gut (1992) 1.70

Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol Cell Biol (1996) 1.69

Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. Clin Cancer Res (2001) 1.67

Internal jugular vein catheterization in infants undergoing cardiovascular surgery: an analysis of the factors influencing successful catheterization. Anesth Analg (1992) 1.66

Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts. Transplantation (2000) 1.66

Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis. Blood (1999) 1.63

Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J Neurochem (2000) 1.63

Supported membranes on soft polymer cushions: fabrication, characterization and applications. Trends Biotechnol (2000) 1.63

Neuronal circuitries involved in thermoregulation. Auton Neurosci (2000) 1.61