Published in Oncogene on July 05, 2001
Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling. EMBO J (2012) 2.09
Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J (2002) 1.99
Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO Rep (2005) 1.62
Hyperphosphatemia, Phosphoprotein Phosphatases, and Microparticle Release in Vascular Endothelial Cells. J Am Soc Nephrol (2015) 1.43
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Genes Dev (2006) 1.35
Integrin signaling in cancer cell survival and chemoresistance. Chemother Res Pract (2012) 1.26
Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase. Mol Biol Cell (2006) 1.24
14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity. Mol Cell Biol (2002) 1.20
Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J (2003) 1.15
A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins. Cancer Metastasis Rev (2008) 1.14
KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs. Mol Cell Biol (2009) 1.10
The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Genes Dev (2006) 1.07
A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation. Mol Cell Biol (2003) 1.03
Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms. Mol Cell Biol (2002) 1.02
Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. EMBO J (2003) 1.01
Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation. J Biol Chem (2010) 0.98
A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. PLoS Biol (2014) 0.95
Palmitoylation of oncogenic NRAS is essential for leukemogenesis. Blood (2010) 0.95
How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches. Front Physiol (2012) 0.94
Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia. Proc Natl Acad Sci U S A (2008) 0.93
Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways. Endocrinology (2010) 0.93
Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A (2013) 0.93
Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells. J Biol Chem (2009) 0.91
"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway. FEBS Lett (2014) 0.91
A feedback circuit between miR-133 and the ERK1/2 pathway involving an exquisite mechanism for regulating myoblast proliferation and differentiation. Cell Death Dis (2013) 0.90
Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms. Mol Cell Biol (2006) 0.89
Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Proc Natl Acad Sci U S A (2005) 0.88
Identification of H-Ras-specific motif for the activation of invasive signaling program in human breast epithelial cells. Neoplasia (2011) 0.87
Phosphorylation of SET protein at Ser171 by protein kinase D2 diminishes its inhibitory effect on protein phosphatase 2A. PLoS One (2012) 0.86
Mathematical modelling of the MAP kinase pathway using proteomic datasets. PLoS One (2012) 0.86
PP2A as a master regulator of the cell cycle. Crit Rev Biochem Mol Biol (2016) 0.85
The HDAC inhibitor LBH589 induces ERK-dependent prometaphase arrest in prostate cancer via HDAC6 inactivation and down-regulation. PLoS One (2013) 0.85
Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics. Mol Cell Proteomics (2008) 0.84
Ras signaling through RASSF proteins. Semin Cell Dev Biol (2016) 0.82
Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device. Cell Cycle (2015) 0.81
Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway. Mol Cell Biol (2011) 0.80
INPP4B is an oncogenic regulator in human colon cancer. Oncogene (2015) 0.78
Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. J Clin Biochem Nutr (2011) 0.76
Assessment of Methods for the Intracellular Blockade of GABAA Receptors. PLoS One (2016) 0.75
Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation. Cell Death Differ (2016) 0.75
Cell Density-Dependent Increase in Tyrosine-Monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf. PLoS One (2016) 0.75
Decoding the full picture of Raf1 function based on its interacting proteins. Oncotarget (2017) 0.75
Activation of Raf as a result of recruitment to the plasma membrane. Science (1994) 6.97
Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nat Cell Biol (1999) 4.94
GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat Cell Biol (2001) 4.42
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product. Nature (1988) 4.33
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis. EMBO J (1989) 3.51
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol (2000) 3.24
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J Biol Chem (1998) 2.75
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization. Mol Cell Biol (1994) 1.92
Compartmentalization of Ras proteins. J Cell Sci (2001) 1.72
Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function. Mol Cell Biol (1993) 1.31
Ras signaling from plasma membrane and endomembrane microdomains. Biochim Biophys Acta (2005) 1.28
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. J Biol Chem (2000) 1.25
Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange. J Biol Chem (1994) 1.24
Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger. J Biol Chem (1997) 1.20
Post-translational processing of Schizosaccharomyces pombe YPT proteins. J Biol Chem (1992) 1.15
14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo. Mol Cell Biol (1998) 1.10
Targeting of oncoproteins to membranes by fatty acylation. J Cell Sci Suppl (1989) 1.02
Interactions of c-Raf-1 with phosphatidylserine and 14-3-3. Oncogene (1999) 1.01
Caveolin and Ras function. Methods Enzymol (2001) 0.95
The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization. Mol Cell Biol (1994) 0.94
Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase. J Biol Chem (1994) 0.94
DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18. Blood (1993) 0.93
Human papillomavirus type 6b virus-like particles are able to activate the Ras-MAP kinase pathway and induce cell proliferation. J Virol (2001) 0.92
Early-acting inbreeding depression and reproductive success in the highbush blueberry, Vaccinium corymbosum L. Theor Appl Genet (1990) 0.91
Purification of baculovirus-expressed recombinant Ras and Rap proteins. Methods Enzymol (1995) 0.85
Lipid modifications and function of the ras superfamily of proteins. Biochem Soc Trans (1992) 0.84
Expression of multiple endocrine neoplasia 2B RET in neuroblastoma cells alters cell adhesion in vitro, enhances metastatic behavior in vivo, and activates Jun kinase. Cancer Res (1997) 0.82
Sequence analysis of the 3' termini of RNA1 and RNA2 of blueberry leaf mottle virus. Virus Res (1994) 0.80
Haemorrhagic cystitis in bone marrow transplantation patients: possible increased risk associated with prior busulphan therapy. Bone Marrow Transplant (1987) 0.79
Six point mutations that cause factor XI deficiency. Blood (1995) 0.78
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Nature of 2n gamete formation and mode of inheritance in interspecific hybrids of diploid Vaccinium darrowi and tetraploid V. corymbosum. Theor Appl Genet (1995) 0.75
Conformational effects of nucleotide exchange in ras p21 proteins as studied by fluorescence spectroscopy. FEBS Lett (1990) 0.75
Selection versus recombination: what is maintaining identity in the 3' termini of blueberry leaf mottle nepovirus RNA1 and RNA2? J Gen Virol (1994) 0.75
Analysis of mammalian ras effector function. Cold Spring Harb Symp Quant Biol (1988) 0.75
Stimulation of nucleotide exchange on Ras- and Rho-related proteins by small GTP-binding protein GDP dissociation stimulator. Methods Enzymol (1995) 0.75