Published in Crit Rev Biochem Mol Biol on February 24, 2016
Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization. Protein Cell (2016) 0.81
Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development. Int J Mol Sci (2016) 0.76
Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity. Vaccines (Basel) (2016) 0.75
FAM122A, a new endogenous inhibitor of protein phosphatase 2A. Oncotarget (2016) 0.75
A mathematical model of endothelial nitric oxide synthase activation with time delay exhibiting Hopf bifurcation and oscillations. Math Biosci (2016) 0.75
The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation. Mol Cell Biol (2017) 0.75
Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays. J Vis Exp (2017) 0.75
The protein kinase complement of the human genome. Science (2002) 35.36
mTOR signaling in growth control and disease. Cell (2012) 29.21
Towards a proteome-scale map of the human protein-protein interaction network. Nature (2005) 24.76
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
Wnt/β-catenin signaling and disease. Cell (2012) 16.05
Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 15.88
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature (1994) 11.50
Identification of FAP locus genes from chromosome 5q21. Science (1991) 11.41
Defining the human deubiquitinating enzyme interaction landscape. Cell (2009) 11.39
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature (1992) 11.06
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J (2001) 9.40
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell (1995) 9.27
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell (2006) 8.61
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A (1998) 8.03
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell (2006) 7.49
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta (2006) 7.33
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (1993) 7.20
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell (1993) 6.44
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell (1991) 6.32
Serine/threonine phosphatases: mechanism through structure. Cell (2009) 6.19
Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem (1999) 6.14
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell (2009) 5.97
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science (1990) 5.76
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell (2005) 5.60
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science (1992) 5.55
A dimerization-dependent mechanism drives RAF catalytic activation. Nature (2009) 5.39
CIP2A inhibits PP2A in human malignancies. Cell (2007) 5.28
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell (2003) 5.21
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene (2007) 5.14
The Rb/E2F pathway and cancer. Hum Mol Genet (2001) 4.98
PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov (2014) 4.81
The Cdt1 protein is required to license DNA for replication in fission yeast. Nature (2000) 4.46
Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell (1995) 4.23
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature (2006) 4.23
From promiscuity to precision: protein phosphatases get a makeover. Mol Cell (2009) 4.17
Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science (1995) 4.15
The BioGRID interaction database: 2015 update. Nucleic Acids Res (2014) 4.06
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell (2006) 3.88
Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux. Cell (2007) 3.84
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem (2003) 3.83
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev (2002) 3.80
Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta (2008) 3.74
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol (1997) 3.52
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc Natl Acad Sci U S A (1999) 3.49
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell (2010) 3.44
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene (1999) 3.36
Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol (2014) 3.36
Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol (2007) 3.32
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell (2005) 3.29
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell (2005) 3.24
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat Methods (2005) 3.11
Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science (2010) 3.10
Structure of the protein phosphatase 2A holoenzyme. Cell (2006) 3.07
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J (1999) 3.05
Functional proteomics mapping of a human signaling pathway. Genome Res (2004) 3.04
PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). Trends Biochem Sci (2008) 3.04
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol Cell (2006) 3.00
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
The origin recognition complex: from simple origins to complex functions. Genes Dev (2002) 2.98
Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J (1997) 2.97
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev (2004) 2.96
An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Mol Syst Biol (2009) 2.92
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol (2010) 2.91
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Nature (2006) 2.87
Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol (2000) 2.84
Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J (2009) 2.78
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science (1999) 2.76
The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J Biol Chem (1996) 2.73
Orchestrating nuclear envelope disassembly and reassembly during mitosis. Nat Rev Mol Cell Biol (2009) 2.66
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell (2004) 2.62
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell (2010) 2.59
Condensin and cohesin: more than chromosome compactor and glue. Nat Rev Genet (2003) 2.56
Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase. Cell (1990) 2.47
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol (1993) 2.40
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J Biol Chem (2007) 2.36
Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev (1997) 2.34
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J (2003) 2.33
Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J Biol Chem (1997) 2.32
Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry. Cell (2011) 2.28
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. EMBO J (2004) 2.19
Phosphatases: providing safe passage through mitotic exit. Nat Rev Mol Cell Biol (2011) 2.19
Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases. EMBO J (1998) 2.18
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol (2010) 2.18
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Mol Cell (2003) 2.16
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. Nat Cell Biol (2006) 2.16
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15