Published in Biochem J on September 01, 2001
Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter. Vitam Horm (2008) 1.05
The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer. Drug Metab Dispos (2014) 0.89
Characterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods. Biochem J (2003) 0.87
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr (2014) 0.85
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. Biotechniques (1990) 13.62
Homocysteine and cardiovascular disease. Annu Rev Med (1998) 4.69
The biological chemistry of folate receptors. Blood (1992) 2.27
Carrier-mediated membrane transport of folates in mammalian cells. Annu Rev Nutr (1999) 1.53
Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro. J Biol Chem (1982) 1.52
Role of the charge pair aspartic acid-237-lysine-358 in the lactose permease of Escherichia coli. Biochemistry (1993) 1.44
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem (1995) 1.42
Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli. Proc Natl Acad Sci U S A (1992) 1.37
The cellular pharmacology of methotrexate. Pharmacol Ther (1985) 1.31
Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer. Cancer Res (1985) 1.30
Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier. J Biol Chem (1999) 1.29
A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem (1994) 1.23
Folate: effects on carcinogenesis and the potential for cancer chemoprevention. Oncology (Williston Park) (1996) 1.23
Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res (1995) 1.20
Molecular cloning of the human placental folate transporter. Biochem Biophys Res Commun (1995) 1.15
Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. J Biol Chem (1999) 1.11
Folic acid and the prevention of birth defects. Annu Rev Nutr (1996) 1.10
Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition. J Biol Chem (1997) 1.08
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J Biol Chem (1998) 1.08
Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport. Cancer Res (1991) 1.07
Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J Biol Chem (1995) 1.07
Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier. Biochim Biophys Acta (1998) 1.05
Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J Biol Chem (1994) 1.00
Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity. Biochem Pharmacol (1997) 1.00
Salt bridge interactions: stability of the ionic and neutral complexes in the gas phase, in solution, and in proteins. Proteins (1998) 0.95
Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line. J Biol Chem (1995) 0.94
Evidence for a salt bridge between transmembrane segments 5 and 6 of the yeast plasma-membrane H+-ATPase. J Biol Chem (1998) 0.90
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function. J Biol Chem (1998) 0.90
Charge pair interactions stabilizing ferredoxin-ferredoxin reductase complexes. Identification by complementary site-specific mutations. J Biol Chem (1993) 0.87
Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate. J Biol Chem (1998) 0.85
A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate. J Biol Chem (1998) 0.83
Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis. Mol Pharmacol (1999) 0.82
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. Leukemia (2009) 1.45
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem (1995) 1.42
The cellular pharmacology of methotrexate. Pharmacol Ther (1985) 1.31
Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier. J Biol Chem (1999) 1.29
Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci (2002) 1.22
Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. Am J Physiol Cell Physiol (2000) 1.18
Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy. Clin Cancer Res (1998) 1.13
Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier. Biochim Biophys Acta (1998) 1.05
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. Leukemia (2007) 1.04
Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity. Biochem Pharmacol (1997) 1.00
Transcriptional regulation of the human cystathionine beta-synthase -1b basal promoter: synergistic transactivation by transcription factors NF-Y and Sp1/Sp3. Biochem J (2001) 0.97
In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells. Cancer Res (1983) 0.94
The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. Basis for tissue-specific gene expression. J Biol Chem (2000) 0.93
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue. J Biol Chem (1987) 0.92
Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers. Clin Cancer Res (2001) 0.91
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line. J Biol Chem (1988) 0.90
Transcriptional regulation of cell-specific expression of the human cystathionine beta -synthase gene by differential binding of Sp1/Sp3 to the -1b promoter. J Biol Chem (2001) 0.89
P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene. Int J Cancer (1998) 0.88
Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells. Biochem Pharmacol (1998) 0.87
Enhanced polyglutamylation of aminopterin relative to methotrexate in the Ehrlich ascites tumor cell in vitro. Cancer Res (1985) 0.87
Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons. Biochem J (1998) 0.86
Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia: a report from the Children's Oncology Group. Oncogene (2008) 0.86
Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells. Cancer Res (1986) 0.84
Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-D-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: a model of leukemia in Down syndrome. Cancer Res (2000) 0.84
Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate reductase by 5-formyltetrahydrofolate in Ehrlich ascites tumor cells in vitro. Cancer Res (1983) 0.83
Synthesis and properties of 7-hydroxymethotrexate polyglutamyl derivatives in Ehrlich ascites tumor cells in vitro. J Biol Chem (1984) 0.83
Repression of human reduced folate carrier gene expression by wild type p53. J Biol Chem (2000) 0.83
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin. J Med Chem (1994) 0.82
Substrate-mediated inactivation of urocanase from Pseudomonas putida. Evidence for an essential sulfhydryl group. Biochemistry (1980) 0.80
Structure and organization of the human reduced folate carrier gene. Biochim Biophys Acta (1998) 0.80
The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells. Leukemia (2006) 0.79
Mechanism of urocanase as studied by deuterium isotope effects and labeling patterns. Biochemistry (1981) 0.78
Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells. Br J Cancer (1997) 0.78
Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. Biochem Pharmacol (2001) 0.78
A covalent nicotinamide adenine dinucleotide intermediate in the urocanase reaction. Biochemistry (1982) 0.78
Role of the cellular oxidation-reduction state in methotrexate binding to dihydrofolate reductase and dissociation induced by reduced folates. Cancer Res (1984) 0.77
Increased expression of human reduced folate carrier in fetal Down syndrome brain. J Neural Transm Suppl (2003) 0.77
Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells. Leukemia (2002) 0.77
Identification of the enol tautomer of imidazolone propionate as the urocanase reaction product. Arch Biochem Biophys (1983) 0.76
High frequency of the 844ins68 cystathionine-beta-synthase gene variant in Down syndrome children with acute myeloid leukemia. Leukemia (2002) 0.75
Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier. J Biol Chem (1989) 0.75
Interactions between 7-hydroxymethotrexate and methotrexate at the cellular level in the Ehrlich ascites tumor in vitro. Cancer Res (1984) 0.75
Transient-state kinetic analysis of urocanase. Biochemistry (1982) 0.75
Relationship of p15 and p16 gene alterations to elevated dihydrofolate reductase in childhood acute lymphoblastic leukaemia. Br J Haematol (2001) 0.75
Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia. Leukemia (2002) 0.75
Rates of development of methotrexate resistance in heterogeneous mouse mammary tumor cell cultures. J Exp Ther Oncol (1996) 0.75
Role of USF1 in the differential expression of the human deoxycytidine kinase gene in acute myeloid leukemia. Leukemia (2005) 0.75