Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profile.

PubWeight™: 1.38‹?› | Rank: Top 10%

🔗 View Article (PMC 56949)

Published in Proc Natl Acad Sci U S A on August 28, 2001

Authors

A M Fahrer1, Y Konigshofer, E M Kerr, G Ghandour, D H Mack, M M Davis, Y H Chien

Author Affiliations

1: Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.

Articles citing this

Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity (2008) 4.21

Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A (2002) 2.69

Epithelial decision makers: in search of the 'epimmunome'. Nat Immunol (2010) 2.19

Gamma delta T cells provide an early source of interferon gamma in tumor immunity. J Exp Med (2003) 1.99

Immunology of gut mucosal vaccines. Immunol Rev (2011) 1.59

The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer. J Exp Med (2003) 1.51

Reciprocal interactions between commensal bacteria and gamma delta intraepithelial lymphocytes during mucosal injury. J Immunol (2009) 1.46

Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease. Proc Natl Acad Sci U S A (2013) 1.36

Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm. Trends Immunol (2003) 1.27

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol (2012) 1.24

T-cell activation in the intestinal mucosa. Immunol Rev (2007) 1.20

Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite. J Exp Med (2003) 1.07

A microarray screen for novel candidate genes in coeliac disease pathogenesis. Gut (2004) 1.02

Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease. J Immunol (2009) 1.02

gammadelta T lymphocytes-selectable cells within the innate system? J Clin Immunol (2007) 0.97

Cross-talk between intraepithelial γδ T cells and epithelial cells. J Leukoc Biol (2013) 0.92

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation. PLoS One (2013) 0.89

Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection. Biochem Biophys Res Commun (2006) 0.88

Human small intestinal mucosa harbours a small population of cytolytically active CD8+ alphabeta T lymphocytes. Immunology (2002) 0.83

Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge. PLoS One (2013) 0.83

Phenotypic profile and functional characterization of rat lymph node-derived gammadelta T cells: implication in the immune response to cytomegalovirus. Immunology (2003) 0.81

Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance. Nat Commun (2015) 0.81

Selective upregulation of immune regulatory and effector cytokine synthesis by intestinal intraepithelial lymphocytes following CD43 costimulation. Biochem Biophys Res Commun (2005) 0.81

The aryl hydrocarbon receptor in innate T cell immunity. Semin Immunopathol (2013) 0.79

Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol Sci (2008) 0.79

Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets. J Leukoc Biol (2007) 0.78

In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ. PLoS One (2013) 0.77

Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy. Cancer Lett (2016) 0.77

LAG3 (CD223) as a cancer immunotherapy target. Immunol Rev (2017) 0.77

Intraepithelial gamma delta T cells exposed by functional genomics. Genome Biol (2001) 0.76

γδ T cells in homeostasis and host defence of epithelial barrier tissues. Nat Rev Immunol (2017) 0.75

Articles cited by this

High density synthetic oligonucleotide arrays. Nat Genet (1999) 29.99

PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature (2000) 5.48

Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science (2000) 5.10

[gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol (2000) 5.01

Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen. Nature (1993) 3.47

Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science (1994) 3.21

In vivo modulation of cytolytic activity and Thy-1 expression in TCR-gamma delta+ intraepithelial lymphocytes. Science (1989) 2.88

2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J Exp Med (1998) 2.48

Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A (1995) 2.21

Diversity of gamma delta T-cell receptors on murine intestinal intra-epithelial lymphocytes. Nature (1989) 2.21

Local hormone networks and intestinal T cell homeostasis. Science (1997) 1.95

Immune protection and control of inflammatory tissue necrosis by gamma delta T cells. J Immunol (1994) 1.92

T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc Natl Acad Sci U S A (1996) 1.92

Recognition by gamma/delta T cells. Annu Rev Immunol (1996) 1.82

gamma/delta and other unconventional T lymphocytes: what do they see and what do they do? Proc Natl Acad Sci U S A (1996) 1.73

Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells. Nature (1989) 1.73

Membrane rafts and signaling by the multichain immune recognition receptors. Curr Opin Immunol (2000) 1.62

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature (2000) 1.50

Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia. J Immunol (1996) 1.49

A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule. Science (2000) 1.49

RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes. Immunity (1999) 1.48

Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J Exp Med (1992) 1.48

Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell. J Immunol (1994) 1.36

Tumour necrosis factor-alpha and interferon-gamma synergistically activate the RANTES promoter through nuclear factor kappaB and interferon regulatory factor 1 (IRF-1) transcription factors. Biochem J (2000) 1.36

Intraepithelial lymphocytes and the immune system. Adv Immunol (1995) 0.96

Articles by these authors

Phenotypic analysis of antigen-specific T lymphocytes. Science (1996) 24.26

Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (1998) 18.23

The immunological synapse: a molecular machine controlling T cell activation. Science (1999) 17.41

DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science (1988) 13.46

Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain. Science (1989) 9.01

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature (1984) 8.89

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med (1999) 6.09

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature (1984) 6.08

Identification of human immunodeficiency virus sequences by using in vitro enzymatic amplification and oligomer cleavage detection. J Virol (1987) 5.27

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev (2000) 5.04

Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell (1994) 4.60

The immunological synapse. Annu Rev Immunol (2001) 4.45

Somatic recombination in a murine T-cell receptor gene. Nature (1984) 4.21

Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes. Nature (1984) 4.15

Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature (1992) 4.01

An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature (1980) 3.99

A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity (1999) 3.88

Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays. Genome Res (1998) 3.85

A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science (1998) 3.76

DNA sequences mediating class switching in alpha-immunoglobulins. Science (1980) 3.70

A case-management system for coronary risk factor modification after acute myocardial infarction. Ann Intern Med (1994) 3.61

Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity (2000) 3.49

Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43

The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes. Nature (1988) 3.43

Antigen-specific development of primary and memory T cells in vivo. Science (1995) 3.41

Structural gene sets active in embryos and adult tissues of the sea urchin. Cell (1976) 3.38

CDR3 length in antigen-specific immune receptors. J Exp Med (1994) 3.35

Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J Immunol (1999) 3.33

Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo. J Exp Med (2000) 3.32

Differential clustering of CD4 and CD3zeta during T cell recognition. Science (2000) 3.30

Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci U S A (1999) 3.30

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell (1989) 3.29

A third type of murine T-cell receptor gene. Nature (1984) 3.24

A human T cell-specific molecule is a member of a new gene family. J Immunol (1988) 3.21

Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A (1979) 3.19

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature (1987) 3.08

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc Natl Acad Sci U S A (1994) 3.07

Low affinity interaction of peptide-MHC complexes with T cell receptors. Science (1991) 2.89

Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART). J Immunol (1999) 2.89

T-cell receptor delta gene rearrangements in early thymocytes. Nature (1988) 2.88

New approaches for computer analysis of nucleic acid sequences. Proc Natl Acad Sci U S A (1983) 2.85

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat Med (2000) 2.78

Structure, expression and divergence of T-cell receptor beta-chain variable regions. Nature (1984) 2.71

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity (1996) 2.69

Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. Proc Natl Acad Sci U S A (1998) 2.69

The nature of major histocompatibility complex recognition by gamma delta T cells. Cell (1994) 2.64

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells. J Exp Med (1994) 2.61

Expression of T cell antigen receptor heterodimers in a lipid-linked form. Science (1990) 2.56

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]. Immunity (1998) 2.52

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription. EMBO J (1992) 2.45

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature (1995) 2.45

Detection of hepatitis B virus sequences in serum by using in vitro enzymatic amplification. J Virol Methods (1988) 2.36

Kinetic discrimination in T-cell activation. Proc Natl Acad Sci U S A (1996) 2.17

Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). J Immunol (1994) 2.15

Genome-wide detection of allelic imbalance using human SNPs and high-density DNA arrays. Genome Res (2000) 2.13

Getting heavier, younger: trajectories of obesity over the life course. Int J Obes (Lond) (2009) 2.09

Identification of self through two-dimensional chemistry and synapses. Annu Rev Cell Dev Biol (2001) 1.99

Localization of a T-cell receptor diversity-region element. Nature (1984) 1.96

Molecular components of T-cell recognition. Annu Rev Immunol (1992) 1.96

Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP. J Cell Biol (1991) 1.93

Not without my permission: parents' willingness to permit use of newborn screening samples for research. Public Health Genomics (2009) 1.92

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH. J Exp Med (1991) 1.92

B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays. Immunol Rev (2000) 1.89

Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc Natl Acad Sci U S A (2001) 1.85

Identification and sequence of a fourth human T cell antigen receptor chain. Nature (1988) 1.81

Molecular genetics of the T cell-receptor beta chain. Annu Rev Immunol (1985) 1.76

A comprehensive management system for heart failure improves clinical outcomes and reduces medical resource utilization. Am J Cardiol (1997) 1.75

Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity (1998) 1.74

T cell assays and MIATA: the essential minimum for maximum impact. Immunity (2012) 1.74

Efficient algorithms for molecular sequence analysis. Proc Natl Acad Sci U S A (1988) 1.72

Rearrangements of genes for the antigen receptor on T cells as markers of lineage and clonality in human lymphoid neoplasms. N Engl J Med (1985) 1.65

Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity (1996) 1.64

Experience with juvenile polyps in North American children: the need for pancolonoscopy. Am J Gastroenterol (2001) 1.61

Ligand-specific oligomerization of T-cell receptor molecules. Nature (1997) 1.58

The effects of MHC gene dosage and allelic variation on T cell receptor selection. Cell (1990) 1.58

Formation of a highly peptide-receptive state of class II MHC. Immunity (1998) 1.58

Expression of genes of the T-cell antigen receptor complex in precursor thymocytes. Nature (1985) 1.57

A murine T cell receptor gene complex: isolation, structure and rearrangement. Immunol Rev (1984) 1.56

T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med (1990) 1.55

A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity (1997) 1.55

Kinetics and extent of T cell activation as measured with the calcium signal. J Exp Med (1997) 1.51

GROUP MEDICINE. Am J Public Health (N Y) (1919) 1.50

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature (2000) 1.50

Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning. Proc Natl Acad Sci U S A (1999) 1.47

Immunoglobulin class switching: developmentally regulated DNA rearrangements during differentiation. Cell (1980) 1.46

A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia. Cancer Res (1999) 1.45

Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection. Nature (1989) 1.44

Helper and killer T cells do not express B cell immunoglobulin joining and constant region gene segments. J Exp Med (1980) 1.42

C. M. A. DEPARTMENT OF PUBLIC RELATIONS: DO CORPORATIONS PRACTICE MEDICINE? Cal West Med (1932) 1.41

Increased apoptosis induction by 121F mutant p53. EMBO J (1999) 1.41

Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond. Cancer Immunol Immunother (2010) 1.36

pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule. EMBO J (1992) 1.36

A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity (2001) 1.32

Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies. J Immunol (2000) 1.32

T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen. J Exp Med (1993) 1.31

Activation and differentiation requirements of primary T cells in vitro. Proc Natl Acad Sci U S A (1993) 1.29