Adhesion events in angiogenesis.

Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell (2009) 4.02

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75

Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone. Breast Cancer Res (2006) 1.88

The role of VEGF receptors in angiogenesis; complex partnerships. Cell Mol Life Sci (2006) 1.63

Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med (2006) 1.56

Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. J Exp Med (2010) 1.41

Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. Development (2008) 1.41

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J Biol Chem (2008) 1.40

Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci U S A (2006) 1.39

Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis. Sci Signal (2009) 1.34

Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia. Mol Cell Neurosci (2008) 1.20

The emergence of integrins: a personal and historical perspective. Matrix Biol (2004) 1.18

Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. EMBO J (2003) 1.17

Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds. Adv Mater (2014) 1.16

Inhibition of pathologic retinal neovascularization by alpha-defensins. Blood (2005) 1.13

The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J Cell Biol (2008) 1.11

Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A (2005) 1.10

Perlecan and tumor angiogenesis. J Histochem Cytochem (2003) 1.09

HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. Mol Biol Cell (2006) 1.09

Integrins and bone metastasis: integrating tumor cell and stromal cell interactions. Bone (2010) 1.09

Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Mol Cell Biol (2002) 1.08

The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood (2005) 1.07

Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment. Breast Cancer Res (2003) 1.07

Correlating global gene regulation to angiogenesis in the developing chick extra-embryonic vascular system. PLoS One (2009) 1.05

Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces. Integr Biol (Camb) (2011) 1.03

A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. Mol Cell Biol (2004) 1.01

α(V)β(3) integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug. ACS Nano (2012) 1.00

Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome. Surgery (2010) 0.98

Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis. Dev Dyn (2009) 0.98

Angiogenesis in differentiated placental multipotent mesenchymal stromal cells is dependent on integrin alpha5beta1. PLoS One (2009) 0.95

Correlation between the tumoral expression of beta3-integrin and outcome in cervical cancer patients who had undergone radiotherapy. Br J Cancer (2005) 0.94

VEGF-initiated angiogenesis and the uPA/uPAR system. Cell Adh Migr (2012) 0.94

Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers. Acta Biomater (2011) 0.90

Absence of the alpha v beta 3 integrin dictates the time-course of angiogenesis in the hypoxic central nervous system: accelerated endothelial proliferation correlates with compensatory increases in alpha 5 beta 1 integrin expression. J Cereb Blood Flow Metab (2010) 0.88

Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol (2013) 0.87

Pathophysiology of tumor neovascularization. Vasc Health Risk Manag (2005) 0.86

Role of integrins in regulating proteases to mediate extracellular matrix remodeling. Cancer Microenviron (2012) 0.85

How do cells make decisions: engineering micro- and nanoenvironments for cell migration. J Oncol (2010) 0.84

Expression of integrins in human proliferative diabetic retinopathy membranes. Can J Ophthalmol (2008) 0.84

Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis. Br J Cancer (2003) 0.81

Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo. J Biol Chem (2013) 0.81

SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression. Clin Exp Metastasis (2013) 0.79

Expression of integrins on human choroidal neovascular membranes. J Ocul Biol Dis Infor (2009) 0.77

A tumor-penetrating peptide modification enhances the antitumor activity of thymosin alpha 1. PLoS One (2013) 0.76

Effect of Thyrotropin on Osteopontin, Integrin αvβ3, and VCAM-1 in the Endothelium via Activation of Akt. Int J Mol Sci (2016) 0.75

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell (1993) 13.21

Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science (1994) 12.83

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell (1994) 9.51

Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol (1997) 7.14

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell (1996) 6.52

Definition of two angiogenic pathways by distinct alpha v integrins. Science (1995) 6.00

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell (1999) 4.55

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol (1998) 4.22

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci U S A (1987) 4.17

Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med (1998) 3.85

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest (1995) 3.69

Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. J Cell Biol (1994) 3.42

Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface. J Cell Biol (1991) 3.00

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol (2001) 2.99

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity. J Clin Invest (1992) 2.92

Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell (1998) 2.89

The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest (1999) 2.88

Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol (1998) 2.87

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. Proc Natl Acad Sci U S A (1996) 2.67

Integrins and cancer. Curr Opin Cell Biol (1996) 2.44

An antagonist of integrin alpha v beta 3 prevents maturation of blood vessels during embryonic neovascularization. J Cell Sci (1995) 2.38

Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol (1993) 2.38

Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. J Clin Invest (1991) 2.32

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci U S A (1994) 2.30

Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery. Neurosurgery (2001) 2.30

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption. J Biol Chem (1993) 2.27

Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin. J Biol Chem (1990) 2.27

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro. J Clin Invest (1995) 2.23

Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase. J Virol (1998) 2.20

Vitronectin and its receptors. Curr Opin Cell Biol (1993) 2.17

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat Med (2001) 2.16

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest (1996) 2.10

Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol (1994) 2.08

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin. J Cell Biol (1990) 2.07

Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem (1999) 2.04

Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. J Clin Invest (1999) 2.03

Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res (1984) 2.01

Integrins and angiogenesis. Curr Top Dev Biol (2004) 2.00

Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. Clin Cancer Res (2000) 2.00

Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit. J Biol Chem (1987) 1.93

Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery (2001) 1.90

Induction of the angiogenic phenotype by Hox D3. J Cell Biol (1997) 1.84

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J Cell Biol (1995) 1.81

Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer. Clin Cancer Res (1998) 1.80

Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proc Natl Acad Sci U S A (2001) 1.79

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J Cell Biol (1992) 1.78

Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2. Proc Natl Acad Sci U S A (2000) 1.76

Integrin alpha(v)beta1 is an adenovirus coreceptor. J Virol (2001) 1.72

Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene (2006) 1.71

Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth. Cancer Res (1987) 1.68

Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. Am J Pathol (1996) 1.67

Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. Cancer Res (1999) 1.66

The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit. J Biol Chem (1988) 1.59

Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration. J Biol Chem (1996) 1.55

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest (1997) 1.53

Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor. J Biol Chem (1990) 1.52

RGD-dependent linkage between plant cell wall and plasma membrane: consequences for growth. J Cell Biol (1989) 1.51

Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3. J Cell Biol (1996) 1.50

cDNA sequence of the human integrin beta 5 subunit. J Biol Chem (1990) 1.49

Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J Cell Biol (1996) 1.48

Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18. Cancer Res (1989) 1.45

Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1. J Biol Chem (1996) 1.42

Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins. J Cell Biol (1986) 1.42

Role of alpha v integrins during angiogenesis. Cancer J (2000) 1.41

Use of the 10-day-old chick embryo model for studying angiogenesis. Methods Mol Biol (1999) 1.40

Localization of the gangliosides GD2 and GD3 in adhesion plaques and on the surface of human melanoma cells. Proc Natl Acad Sci U S A (1984) 1.39

O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant. Science (1984) 1.38

Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits. J Biol Chem (1990) 1.36

A monoclonal antibody recognizes an O-acylated sialic acid in a human melanoma-associated ganglioside. J Biol Chem (1984) 1.31

Integrins, angiogenesis and vascular cell survival. Chem Biol (1996) 1.30

Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. J Cell Sci (1995) 1.29

Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel. Blood (1991) 1.28

Cell adhesion and angiogenesis. Trends Cell Biol (1996) 1.27

A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins. J Cell Biol (1997) 1.26

Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. J Clin Invest (1992) 1.26

Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging. Mol Ther (2001) 1.25

Arginine-glycine-aspartic acid binding leading to molecular stabilization between integrin alpha v beta 3 and its ligand. J Biol Chem (1991) 1.24

Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectin. Development (1994) 1.22

Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem (1990) 1.21

Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies. J Immunol (1987) 1.17

Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression. Mol Biol Cell (1995) 1.16

Human tumor antigens. Adv Immunol (1987) 1.14

Adenovirus entry into host cells: a role for alpha(v) integrins. Trends Cell Biol (1994) 1.12

Isolation and characterization of a platelet membrane protein related to the vitronectin receptor. J Biol Chem (1989) 1.12

Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene (2011) 1.11

Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol (1996) 1.09

Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol (1999) 1.08

Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells. J Cell Biol (1991) 1.07

Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments. J Biol Chem (1992) 1.06

Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases. Proc Natl Acad Sci U S A (1999) 1.05

Regulation of adenovirus membrane penetration by the cytoplasmic tail of integrin beta5. J Virol (2000) 1.05

The role of alphav integrins during angiogenesis. Mol Med (1998) 1.03

REVIEW: the integrin alpha V beta 3: angiogenesis and apoptosis. Cell Adhes Commun (1995) 1.03

Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. Proc Natl Acad Sci U S A (1985) 1.01

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene (2011) 1.00

Extracellular matrix and integrin composition of the normal bladder wall. World J Urol (1996) 0.98

Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia. Am J Pathol (1996) 0.98

Design, synthesis and biological evaluation of nonpeptide integrin antagonists. Bioorg Med Chem (1998) 0.97

Interaction of an acute phase reactant, alpha 1-acid glycoprotein (orosomucoid), with the lymphoid cell surface: a model for non-specific immune suppression. Immunology (1984) 0.96

Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3). J Am Chem Soc (2001) 0.96