Published in J Cell Sci on July 01, 1995
Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol (1997) 7.14
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest (1999) 5.65
Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer (2008) 4.27
Synergistic control of cell adhesion by integrins and syndecans. Nat Rev Mol Cell Biol (2007) 3.21
Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. Am J Pathol (2000) 3.18
The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest (1999) 2.88
Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. Proc Natl Acad Sci U S A (1996) 2.67
Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol (1999) 2.67
NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival. J Cell Biol (1998) 2.49
Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. Am J Pathol (1996) 2.42
Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins. Proc Natl Acad Sci U S A (1997) 2.32
Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest (1996) 2.10
Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. J Clin Invest (1999) 2.03
Integrin signaling is critical for pathological angiogenesis. J Exp Med (2006) 1.91
Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization. Proc Natl Acad Sci U S A (1995) 1.88
The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol (2002) 1.75
The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Mol Biol Cell (2011) 1.70
Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. Genes Dev (1998) 1.69
Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia. J Clin Invest (1998) 1.68
RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha(v)beta(3) and alpha(5)beta(1) integrins. Am J Pathol (2000) 1.68
Inhibition of endothelial cell survival and angiogenesis by protein kinase A. J Clin Invest (2002) 1.67
Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1. J Cell Biol (2005) 1.61
Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme. Expert Opin Investig Drugs (2008) 1.56
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol (2002) 1.55
Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling. Dev Cell (2011) 1.55
Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. J Exp Med (2010) 1.41
Integrin targeted therapeutics. Theranostics (2011) 1.36
αV integrins in angiogenesis and cancer. Cold Spring Harb Perspect Med (2011) 1.33
Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo. Proc Natl Acad Sci U S A (2002) 1.31
Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade. Am J Pathol (2007) 1.29
Molecular framework for angiogenesis: a complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines. Am J Pathol (1996) 1.26
Radiolabeled Cyclic RGD Peptides as Radiotracers for Imaging Tumors and Thrombosis by SPECT. Theranostics (2011) 1.25
Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis. Cold Spring Harb Perspect Med (2012) 1.21
Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells. J Cell Biol (2000) 1.20
Integrin affinity modulation in angiogenesis. Cell Cycle (2007) 1.17
Roles of integrins in tumor angiogenesis and lymphangiogenesis. Lymphat Res Biol (2008) 1.16
Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. J Biol Chem (2010) 1.08
Matrix metalloproteinase 2-integrin alpha(v)beta3 binding is required for mesenchymal cell invasive activity but not epithelial locomotion: a computational time-lapse study. Mol Biol Cell (2008) 1.05
Tumor angiogenesis: insights and innovations. J Oncol (2010) 1.04
The role of alphav integrins during angiogenesis. Mol Med (1998) 1.03
Role of the cytoskeleton in formation and maintenance of angiogenic sprouts. J Vasc Res (2011) 1.01
Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer. Clin Cancer Res (2011) 1.01
FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcription. Mol Cell Biol (2013) 1.00
Cell adhesion and angiogenesis. J Clin Invest (1997) 0.98
Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras. Am J Pathol (1997) 0.96
Tubulogenesis during blood vessel formation. Semin Cell Dev Biol (2011) 0.94
Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition. J Bioenerg Biomembr (2012) 0.92
Role of the beta3 integrin subunit in human primary melanoma progression: multifunctional activities associated with alpha(v)beta3 integrin expression. Am J Pathol (1998) 0.92
Antiangiogenic therapy for glioma. J Signal Transduct (2012) 0.89
Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. Theranostics (2015) 0.88
MVL-PLA2, a snake venom phospholipase A2, inhibits angiogenesis through an increase in microtubule dynamics and disorganization of focal adhesions. PLoS One (2010) 0.87
Angiogenesis in cancer: Anti-VEGF escape mechanisms. Transl Lung Cancer Res (2012) 0.87
Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells. Cell Commun Signal (2005) 0.87
Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer. J Biomed Sci (2008) 0.86
Genetic and epigenetic mechanisms in the early development of the vascular system. J Anat (2006) 0.84
Expression of integrins in human proliferative diabetic retinopathy membranes. Can J Ophthalmol (2008) 0.84
The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis. Pharmaceuticals (Basel) (2010) 0.80
Research advances on structure and biological functions of integrins. Springerplus (2016) 0.79
Angiostatin inhibits acute lung injury in a mouse model. Am J Physiol Lung Cell Mol Physiol (2013) 0.78
Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin. J Biol Chem (2016) 0.77
Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo. Histochem Cell Biol (2003) 0.77
Imaging of angiogenesis in cardiology. Eur J Nucl Med Mol Imaging (2007) 0.76
Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice. Dis Model Mech (2012) 0.75
Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model. Reprod Biol Endocrinol (2017) 0.75
Tension in Cancer. Int J Mol Sci (2016) 0.75
Combinatorial Extracellular Matrix Microenvironments for Probing Endothelial Differentiation of Human Pluripotent Stem Cells. Sci Rep (2017) 0.75
Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell (1993) 13.21
Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science (1994) 12.83
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell (1994) 9.51
Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol (1997) 7.14
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell (1996) 6.52
Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature (1984) 6.23
Definition of two angiogenic pathways by distinct alpha v integrins. Science (1995) 6.00
Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell (1999) 4.55
CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol (1998) 4.22
Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci U S A (1987) 4.17
Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med (1998) 3.85
Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest (1995) 3.69
Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. J Cell Biol (1994) 3.42
Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface. J Cell Biol (1991) 3.00
Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol (2001) 2.99
Involvement of integrin alpha V gene expression in human melanoma tumorigenicity. J Clin Invest (1992) 2.92
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell (1998) 2.89
The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest (1999) 2.88
Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol (1998) 2.87
Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. Proc Natl Acad Sci U S A (1996) 2.67
Integrins and cancer. Curr Opin Cell Biol (1996) 2.44
Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol (1993) 2.38
Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. J Clin Invest (1991) 2.32
Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci U S A (1994) 2.30
Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery. Neurosurgery (2001) 2.30
Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption. J Biol Chem (1993) 2.27
Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin. J Biol Chem (1990) 2.27
The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro. J Clin Invest (1995) 2.23
Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase. J Virol (1998) 2.20
Vitronectin and its receptors. Curr Opin Cell Biol (1993) 2.17
Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat Med (2001) 2.16
Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest (1996) 2.10
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol (1994) 2.08
The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin. J Cell Biol (1990) 2.07
Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem (1999) 2.04
Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. J Clin Invest (1999) 2.03
Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res (1984) 2.01
Integrins and angiogenesis. Curr Top Dev Biol (2004) 2.00
Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. Clin Cancer Res (2000) 2.00
Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit. J Biol Chem (1987) 1.93
Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery (2001) 1.90
Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization. Proc Natl Acad Sci U S A (1995) 1.88
Induction of the angiogenic phenotype by Hox D3. J Cell Biol (1997) 1.84
Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J Cell Biol (1995) 1.81
Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer. Clin Cancer Res (1998) 1.80
Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proc Natl Acad Sci U S A (2001) 1.79
Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J Cell Biol (1992) 1.78
Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2. Proc Natl Acad Sci U S A (2000) 1.76
Integrin alpha(v)beta1 is an adenovirus coreceptor. J Virol (2001) 1.72
Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene (2006) 1.71
Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth. Cancer Res (1987) 1.68
Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. Am J Pathol (1996) 1.67
Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. Cancer Res (1999) 1.66
The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit. J Biol Chem (1988) 1.59
Adhesion events in angiogenesis. Curr Opin Cell Biol (2001) 1.59
Multi-field 3D scanning light microscopy of early embryogenesis. J Microsc (2002) 1.57
TAL1/SCL is expressed in endothelial progenitor cells/angioblasts and defines a dorsal-to-ventral gradient of vasculogenesis. Dev Biol (1997) 1.55
Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration. J Biol Chem (1996) 1.55
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest (1997) 1.53
Developmental biology of the vascular smooth muscle cell: building a multilayered vessel wall. J Vasc Res (1999) 1.53
Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor. J Biol Chem (1990) 1.52
RGD-dependent linkage between plant cell wall and plasma membrane: consequences for growth. J Cell Biol (1989) 1.51
Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3. J Cell Biol (1996) 1.50
cDNA sequence of the human integrin beta 5 subunit. J Biol Chem (1990) 1.49
Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J Cell Biol (1996) 1.48
Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18. Cancer Res (1989) 1.45
Laminin receptors for neurite formation. Proc Natl Acad Sci U S A (1988) 1.43
Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1. J Biol Chem (1996) 1.42
Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins. J Cell Biol (1986) 1.42
Role of alpha v integrins during angiogenesis. Cancer J (2000) 1.41
Use of the 10-day-old chick embryo model for studying angiogenesis. Methods Mol Biol (1999) 1.40
The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study. J Histochem Cytochem (1995) 1.39
Localization of the gangliosides GD2 and GD3 in adhesion plaques and on the surface of human melanoma cells. Proc Natl Acad Sci U S A (1984) 1.39
O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant. Science (1984) 1.38
Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits. J Biol Chem (1990) 1.36
Development of the aortic vessel wall as defined by vascular smooth muscle and extracellular matrix markers. Dev Biol (1996) 1.34
Antibodies to beta 1-integrins cause alterations of aortic vasculogenesis, in vivo. Dev Dyn (1992) 1.33
A monoclonal antibody recognizes an O-acylated sialic acid in a human melanoma-associated ganglioside. J Biol Chem (1984) 1.31
Integrins, angiogenesis and vascular cell survival. Chem Biol (1996) 1.30
Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. J Cell Sci (1995) 1.29
Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel. Blood (1991) 1.28
Cell adhesion and angiogenesis. Trends Cell Biol (1996) 1.27
Production and characterization of a monoclonal antibody to chicken type I collagen. Proc Natl Acad Sci U S A (1979) 1.27
A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins. J Cell Biol (1997) 1.26
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. J Clin Invest (1992) 1.26
Organized type I collagen influences endothelial patterns during "spontaneous angiogenesis in vitro": planar cultures as models of vascular development. In Vitro Cell Dev Biol Anim (1995) 1.25
Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging. Mol Ther (2001) 1.25
Arginine-glycine-aspartic acid binding leading to molecular stabilization between integrin alpha v beta 3 and its ligand. J Biol Chem (1991) 1.24
Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectin. Development (1994) 1.22
Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem (1990) 1.21
VEGF regulates cell behavior during vasculogenesis. Dev Biol (2000) 1.20
Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies. J Immunol (1987) 1.17
Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression. Mol Biol Cell (1995) 1.16
Human tumor antigens. Adv Immunol (1987) 1.14
Masking of extracellular collagen and the co-distribution of collagen and fibronectin during matrix formation by cultured embryonic fibroblasts. J Cell Sci (1982) 1.12
VEGF and vascular fusion: implications for normal and pathological vessels. J Histochem Cytochem (1999) 1.12
Adenovirus entry into host cells: a role for alpha(v) integrins. Trends Cell Biol (1994) 1.12
Isolation and characterization of a platelet membrane protein related to the vitronectin receptor. J Biol Chem (1989) 1.12
Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene (2011) 1.11