Published in Infect Immun on October 01, 2001
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ (2007) 7.74
Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect Immun (2004) 1.49
Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice. Infect Immun (2003) 1.22
CD4+ T cells and toll-like receptors recognize Salmonella antigens expressed in bacterial surface organelles. Infect Immun (2005) 1.20
The majority of in vitro macrophage activation exhibited by extracts of some immune enhancing botanicals is due to bacterial lipoproteins and lipopolysaccharides. Int Immunopharmacol (2008) 1.11
Infectious diarrhea: Cellular and molecular mechanisms. Gut Microbes (2010) 1.08
Role of Toll-like receptors in health and diseases of gastrointestinal tract. World J Gastroenterol (2006) 1.06
Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation. Immunology (2004) 1.00
Vesicle-independent extracellular release of a proinflammatory outer membrane lipoprotein in free-soluble form. BMC Microbiol (2008) 0.89
Induction of interleukin-8 in T84 cells by Vibrio cholerae. Infect Immun (2004) 0.89
Immunostimulation by synthetic lipopeptide-based vaccine candidates: structure-activity relationships. Front Immunol (2013) 0.86
Mycobacterium indicus pranii supernatant induces apoptotic cell death in mouse peritoneal macrophages in vitro. PLoS One (2011) 0.78
Function and activation of NF-kappa B in the immune system. Annu Rev Immunol (1994) 17.04
Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ (1999) 8.93
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science (1999) 8.63
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75
Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J Immunol (2000) 6.68
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature (1998) 6.49
Shigella sonnei plasmids: evidence that a large plasmid is necessary for virulence. Infect Immun (1981) 6.40
Shigella flexneri induces apoptosis in infected macrophages. Nature (1992) 6.26
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem (1999) 5.81
Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry (1976) 5.43
Synthesis and assembly of bacterial membrane components. A lipopolysaccharide-phospholipid-protein complex excreted by living bacteria. J Mol Biol (1969) 4.62
Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol (1999) 3.80
IpaB mediates macrophage apoptosis induced by Shigella flexneri. Mol Microbiol (1994) 3.27
A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J (1996) 3.16
Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr Opin Immunol (1999) 2.85
The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J (2000) 2.82
Endotoxin protein: a B-cell mitogen and polyclonal activator of C3H/HeJ lymphocytes. J Exp Med (1976) 2.77
Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis. Microbiol Rev (1996) 2.55
Release of outer membrane fragments from normally growing Escherichia coli. Biochim Biophys Acta (1976) 2.51
Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J Exp Med (1997) 2.33
A new ABC transporter mediating the detachment of lipid-modified proteins from membranes. Nat Cell Biol (2000) 2.16
Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol (2000) 2.16
Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct. J Immunol (1991) 2.09
Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis. J Clin Invest (1997) 2.03
Genetic determinants of Shigella pathogenicity. Annu Rev Microbiol (1988) 1.94
In vivo apoptosis in Shigella flexneri infections. Infect Immun (1996) 1.81
Infection of rabbit Peyer's patches by Shigella flexneri: effect of adhesive or invasive bacterial phenotypes on follicle-associated epithelium. Infect Immun (1996) 1.54
Stimulation of human and murine adherent cells by bacterial lipoprotein and synthetic lipopeptide analogues. Immunobiology (1988) 1.51
Fatty acids of Treponema pallidum and Borrelia burgdorferi lipoproteins. J Bacteriol (1994) 1.48
Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide. J Immunol (1998) 1.45
The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi. J Immunol (1998) 1.38
Structure and specific activity of macrophage-stimulating lipopeptides from Mycoplasma hyorhinis. Infect Immun (1998) 1.38
Borrelia burgdorferi upregulates expression of adhesion molecules on endothelial cells and promotes transendothelial migration of neutrophils in vitro. Infect Immun (1995) 1.33
Endotoxin-induced early gene expression in C3H/HeJ (Lpsd) macrophages. J Immunol (1994) 1.33
Identification of outer membrane proteins, including known lymphocyte mitogens, as the endotoxin protein of Escherichia coli 0111. J Immunol (1981) 1.27
Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever. Nat Med (1998) 1.12
A critical appraisal of "chronic Lyme disease". N Engl J Med (2007) 7.84
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem (1999) 5.81
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci U S A (1999) 5.17
A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. N Engl J Med (1997) 4.11
Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins. Infect Immun (1990) 4.10
GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. Nature (1993) 3.49
A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J Clin Invest (1998) 3.41
Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites. Proc Natl Acad Sci U S A (1997) 3.25
A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J (1996) 3.16
Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda InCh, a simple Escherichia coli plasmid-chromosome shuttle system. J Bacteriol (2000) 3.14
Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis. J Immunol (2001) 3.06
A bacterial enhancer functions to tether a transcriptional activator near a promoter. Science (1990) 2.93
Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol (1995) 2.92
A diffusible cytotoxin of Haemophilus ducreyi. Proc Natl Acad Sci U S A (1997) 2.89
The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J (2000) 2.82
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity (2000) 2.81
Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J Biol Chem (1998) 2.75
Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin. Infect Immun (1993) 2.71
Prokaryotic transcriptional enhancers and enhancer-binding proteins. Trends Biochem Sci (1991) 2.56
Posttraumatic stress disorder and functioning and quality of life outcomes in a nationally representative sample of male Vietnam veterans. Am J Psychiatry (1997) 2.52
Sensitive detection of Treponema pallidum by using the polymerase chain reaction. J Clin Microbiol (1991) 2.51
The induction of apoptosis by bacterial pathogens. Annu Rev Microbiol (1999) 2.50
Estimating kinetic parameters for single channels with simulation. A general method that resolves the missed event problem and accounts for noise. Biophys J (1990) 2.36
Glutamate at the site of phosphorylation of nitrogen-regulatory protein NTRC mimics aspartyl-phosphate and activates the protein. J Mol Biol (1993) 2.24
Stoichiometry of a recombinant GABAA receptor. J Neurosci (1996) 2.23
Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun (1998) 2.23
Septal localization of FtsQ, an essential cell division protein in Escherichia coli. J Bacteriol (1999) 2.22
Use of polymerase chain reaction and rabbit infectivity testing to detect Treponema pallidum in amniotic fluid, fetal and neonatal sera, and cerebrospinal fluid. J Clin Microbiol (1991) 2.20
Problems in families of male Vietnam veterans with posttraumatic stress disorder. J Consult Clin Psychol (1992) 2.20
The Peritraumatic Distress Inventory: a proposed measure of PTSD criterion A2. Am J Psychiatry (2001) 2.19
Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family. Infect Immun (1999) 2.18
Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model. J Exp Med (2000) 2.18
Major integral membrane protein immunogens of Treponema pallidum are proteolipids. Infect Immun (1989) 2.15
Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames and a lipoprotein gene family. J Bacteriol (1996) 2.14
Domain-swapping analysis of FtsI, FtsL, and FtsQ, bitopic membrane proteins essential for cell division in Escherichia coli. J Bacteriol (1997) 2.07
Fractal models are inadequate for the kinetics of four different ion channels. Biophys J (1988) 2.06
Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks. Infect Immun (2000) 2.00
Cardiovascular syphilis. Am J Med (1989) 1.99
Channel opening locks agonist onto the GABAC receptor. Nat Neurosci (1999) 1.96
Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infect Immun (1997) 1.93
Limited surface exposure of Borrelia burgdorferi outer surface lipoproteins. Proc Natl Acad Sci U S A (1996) 1.90
Identifying kinetic gating mechanisms for ion channels by using two-dimensional distributions of simulated dwell times. Proc Biol Sci (1990) 1.89
Sleep disturbances in the Vietnam generation: findings from a nationally representative sample of male Vietnam veterans. Am J Psychiatry (1998) 1.89
Apoptosis induced by bacterial pathogens. Microb Pathog (1994) 1.89
The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum. Infect Immun (1992) 1.86
Pathogen-induced apoptosis of macrophages: a common end for different pathogenic strategies. Cell Microbiol (2000) 1.86
Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides. Infect Immun (1999) 1.84
Clinical manifestations of early syphilis by HIV status and gender: results of the syphilis and HIV study. Sex Transm Dis (2001) 1.82
Extracellular ATP as a trigger for apoptosis or programmed cell death. J Cell Biol (1991) 1.80
Purification and characterization of a cloned protease-resistant Treponema pallidum-specific antigen. Infect Immun (1984) 1.80
Peritraumatic dissociation and posttraumatic stress in male Vietnam theater veterans. Am J Psychiatry (1994) 1.79
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. J Neurosci (1997) 1.78
A temperature-dependent rabbit model for production of dermal lesions by Haemophilus ducreyi. J Infect Dis (1991) 1.77
The selC-associated SHI-2 pathogenicity island of Shigella flexneri. Mol Microbiol (1999) 1.74
Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals. Infect Immun (2001) 1.73
Isolation of integral membrane proteins by phase partitioning with Triton X-114. Methods Enzymol (1994) 1.70
Use of electroporation to construct isogenic mutants of Haemophilus ducreyi. J Bacteriol (1992) 1.61
The surface of virulent Treponema pallidum: resistance to antibody binding in the absence of complement and surface association of recombinant antigen 4D. Infect Immun (1986) 1.61
A hemoglobin-binding outer membrane protein is involved in virulence expression by Haemophilus ducreyi in an animal model. Infect Immun (1996) 1.60
Evaluation of molecular methodologies and rabbit infectivity testing for the diagnosis of congenital syphilis and neonatal central nervous system invasion by Treponema pallidum. J Infect Dis (1993) 1.60
Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone. Nat Struct Biol (1999) 1.60
Impact of Event Scale: a cross-validation study and some empirical evidence supporting a conceptual model of stress response syndromes. J Consult Clin Psychol (1982) 1.58
Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine. Biophys J (1999) 1.57
Localization of FtsL to the Escherichia coli septal ring. Mol Microbiol (1999) 1.57
Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect Immun (1997) 1.57
The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity. J Exp Med (2001) 1.57
Homomeric rho 1 GABA channels: activation properties and domains. Receptors Channels (1994) 1.55
Treponema pallidum in gel microdroplets: a novel strategy for investigation of treponemal molecular architecture. Mol Microbiol (1995) 1.54
Acylation of the 47-kilodalton major membrane immunogen of Treponema pallidum determines its hydrophobicity. Infect Immun (1989) 1.53
AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death Differ (2012) 1.50
Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Biol Psychiatry (2001) 1.49
Fatty acids of Treponema pallidum and Borrelia burgdorferi lipoproteins. J Bacteriol (1994) 1.48
Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity. Infect Immun (1993) 1.47
Localization of outer surface proteins A and B in both the outer membrane and intracellular compartments of Borrelia burgdorferi. J Bacteriol (1991) 1.46
Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide. J Immunol (1998) 1.45
Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes. Exp Cell Res (1991) 1.43
The 34-kilodalton membrane immunogen of Treponema pallidum is a lipoprotein. Infect Immun (1990) 1.42
The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages. Infect Immun (1997) 1.40
The cosleeping habits of military children. Mil Med (1992) 1.40
Psychological trauma and PTSD in HIV-positive women: a meta-analysis. AIDS Behav (2012) 1.39
Native surface association of a recombinant 38-kilodalton Treponema pallidum antigen isolated from the Escherichia coli outer membrane. Infect Immun (1986) 1.39
Antigenic interrelationship between endoflagella of Treponema phagedenis biotype Reiter and Treponema pallidum (Nichols): molecular characterization of endoflagellar proteins. Infect Immun (1986) 1.39
Analysis of a flawed double-blind, placebo-controlled, clinical trial of patients claimed to have persistent Lyme disease following treatment. Minerva Med (2009) 1.38
Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297. Infect Immun (2000) 1.38
Cloning and expression in Escherichia coli of the gene encoding the heat-modifiable major outer membrane protein of Haemophilus influenzae type b. Infect Immun (1987) 1.37
Molecular characterization of the pathogen-specific, 34-kilodalton membrane immunogen of Treponema pallidum. Infect Immun (1989) 1.37
Molecular cloning and DNA sequence analysis of the 37-kilodalton endoflagellar sheath protein gene of Treponema pallidum. Infect Immun (1989) 1.37
Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin. Receptors Channels (1995) 1.36
Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins. J Immunol (1999) 1.36
IpaB, a Shigella flexneri invasin, colocalizes with interleukin-1 beta-converting enzyme in the cytoplasm of macrophages. Infect Immun (1997) 1.36
Virulent Treponema pallidum activates human vascular endothelial cells. J Infect Dis (1992) 1.33
The major outer membrane protein of Haemophilus ducreyi consists of two OmpA homologs. J Bacteriol (1997) 1.33