Published in N Engl J Med on July 31, 1997
Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features. Clin Microbiol Rev (1999) 4.63
VDRL test and its interpretation. Indian J Dermatol (2012) 2.29
Syphilis treatment response among HIV-discordant couples in Zambia and Rwanda. Clin Infect Dis (2013) 2.22
Predictors of serological cure and Serofast State after treatment in HIV-negative persons with early syphilis. Clin Infect Dis (2011) 1.88
Syphilis in adults. Sex Transm Infect (2005) 1.74
Syphilis. BMJ (2007) 1.69
Secondary syphilitic lesions. Clin Microbiol Rev (2005) 1.64
Serological response to treatment of syphilis according to disease stage and HIV status. Clin Infect Dis (2012) 1.62
Syphilis: using modern approaches to understand an old disease. J Clin Invest (2011) 1.58
Syphilitic uveitis in patients infected with human immunodeficiency virus. Graefes Arch Clin Exp Ophthalmol (2005) 1.51
Global challenge of antibiotic-resistant Treponema pallidum. Antimicrob Agents Chemother (2009) 1.30
Serological response to syphilis treatment in HIV-positive and HIV-negative patients attending sexually transmitted diseases clinics. Sex Transm Infect (2006) 1.28
The laboratory diagnosis of syphilis. Can J Infect Dis Med Microbiol (2005) 1.27
Don't forget syphilis. Syphilis outbreak is twice as big as reported. BMJ (2002) 1.16
Evaluation and treatment of chronic meningitis. Neurohospitalist (2014) 1.13
Antiretroviral therapy is associated with reduced serologic failure rates for syphilis among HIV-infected patients. Clin Infect Dis (2008) 1.07
The rash of secondary syphilis. CMAJ (2007) 1.04
Changing Epidemiology of Syphilis and Its Persistent Relationship with HIV. Curr Infect Dis Rep (2004) 1.03
Neurosyphilis: A Current Review. Curr Infect Dis Rep (2005) 1.03
Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis. PLoS Negl Trop Dis (2010) 0.99
Pathogen-pathogen interaction: a syndemic model of complex biosocial processes in disease. Virulence (2010) 0.98
Factors associated with serological cure and the serofast state of HIV-negative patients with primary, secondary, latent, and tertiary syphilis. PLoS One (2013) 0.97
Effects of various handling and storage conditions on stability of Treponema pallidum DNA in cerebrospinal fluid. J Clin Microbiol (1998) 0.96
Sexually Transmitted Diseases in Men Who Have Sex with Men: A Clinical Review. Curr Infect Dis Rep (2003) 0.95
Clinical prediction and diagnosis of neurosyphilis in HIV-infected patients with early Syphilis. J Clin Microbiol (2013) 0.94
Response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin. Clin Infect Dis (2012) 0.91
Neurosyphilis in a man with human immunodeficiency virus. J Clin Aesthet Dermatol (2014) 0.89
Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells? Am J Pathol (2010) 0.88
Predictors of serological failure after treatment in HIV-infected patients with early syphilis in the emerging era of universal antiretroviral therapy use. BMC Infect Dis (2013) 0.87
A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy. BMC Infect Dis (2015) 0.87
The 1998 CDC Sexually Transmitted Diseases Treatment Guidelines. Curr Infect Dis Rep (2000) 0.84
One dose versus three weekly doses of benzathine penicillin G for patients co-infected with HIV and early syphilis: a multicenter, prospective observational study. PLoS One (2014) 0.84
Late-stage neurosyphilis presenting with severe neuropsychiatric deficits: diagnosis, therapy, and course of three patients. J Neurol (2011) 0.83
Antimicrobial resistance in Neisseria gonorrhoeae and Treponema pallidum: evolution, therapeutic challenges and the need to strengthen global surveillance. Sex Transm Infect (2011) 0.82
Emerging trends and persistent challenges in the management of adult syphilis. BMC Infect Dis (2015) 0.82
Severe course of Lyme neuroborreliosis in an HIV-1 positive patient; case report and review of the literature. BMC Neurol (2010) 0.81
Repeat syphilis among men who have sex with men in California, 2002-2006: implications for syphilis elimination efforts. Am J Public Health (2011) 0.81
Cerebrospinal fluid human immunodeficiency virus viral load in patients with neurosyphilis. J Neurovirol (2010) 0.80
Current standards for diagnosis and treatment of syphilis: selection of some practical issues, based on the European (IUSTI) and U.S. (CDC) guidelines. Postepy Dermatol Alergol (2013) 0.79
Rapid Treponema pallidum clearance from blood and ulcer samples following single dose benzathine penicillin treatment of early syphilis. PLoS Negl Trop Dis (2015) 0.78
Neurocognitive and psychiatric changes as the initial presentation of neurosyphilis. CMAJ (2013) 0.78
Cost-effectiveness of enhanced syphilis screening among HIV-positive men who have sex with men: a microsimulation model. PLoS One (2014) 0.78
Managing Syphilis in the HIV-infected Patient. Curr Infect Dis Rep (2004) 0.77
Treponemal tests for neurosyphilis--less accurate than what we thought? Sex Transm Dis (2012) 0.77
Syphilis in the HIV era. Emerg Infect Dis (2004) 0.76
Tracing the origin of Treponema pallidum in China using next-generation sequencing. Oncotarget (2016) 0.75
Rheumatoid arthritis and tabetic arthropathy: physiopathological link or simple association? Eur J Rheumatol (2015) 0.75
Rate of Decline in Nontreponemal Antibody Titers and Seroreversion After Treatment of Early Syphilis. Sex Transm Dis (2017) 0.75
Evaluation of treponemal serum tests performed on cerebrospinal fluid for diagnosis of neurosyphilis. Am J Clin Pathol (2015) 0.75
Could lengthening minocycline therapy better treat early syphilis? Medicine (Baltimore) (2016) 0.75
A 27-Year-Old Man With Right-Sided Hemiparesis and Dysarthria. Neurohospitalist (2016) 0.75
Response of HIV-infected patients with syphilis to therapy with penicillin or intravenous ceftriaxone. Eur J Med Res (2011) 0.75
The immunological response to syphilis differs by HIV status; a prospective observational cohort study. BMC Infect Dis (2017) 0.75
Treatment of early syphilis. N Engl J Med (1997) 0.75
Syphilis and neurosyphilis: HIV-coinfection and value of diagnostic parameters in cerebrospinal fluid. Eur J Med Res (2015) 0.75
Current concepts in bacterial sexually transmitted diseases. Korean J Urol (2011) 0.75
Cerebral syphilitic gumma mimicking a brain tumor in the relapse of secondary syphilis in a human immunodeficiency virus-negative patient. J Korean Neurosurg Soc (2013) 0.75
Neurocognitive impairment in HIV-infected individuals with previous syphilis. Int J STD AIDS (2013) 0.75
Acute syphilitic chorioretinitis after a missed primary diagnosis: a case report. J Med Case Rep (2008) 0.75
Treatment of early syphilis. N Engl J Med (1997) 0.75
Factors associated with syphilis treatment failure and reinfection: a longitudinal cohort study in Shenzhen, China. BMC Infect Dis (2017) 0.75
[Bilateral panuveitis with papillary swelling]. Ophthalmologe (2009) 0.75
Decline in the workload associated with the serodiagnosis of syphilis in a general hospital: 1994-2004. Eur J Clin Microbiol Infect Dis (2008) 0.75
Hierarchical clustering schemes. Psychometrika (1967) 8.37
A critical appraisal of "chronic Lyme disease". N Engl J Med (2007) 7.84
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75
Condom use to prevent incident STDs: the validity of self-reported condom use. Sex Transm Dis (1995) 5.94
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem (1999) 5.81
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins. Infect Immun (1990) 4.10
The association between genital ulcer disease and acquisition of HIV infection in homosexual men. JAMA (1988) 3.73
Does measured behavior reflect STD risk? An analysis of data from a randomized controlled behavioral intervention study. Project RESPECT Study Group. Sex Transm Dis (2000) 3.60
A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J Clin Invest (1998) 3.41
Noninvasive tests for diagnosis of Chlamydia trachomatis infection: application of ligase chain reaction to first-catch urine specimens of women. J Infect Dis (1995) 3.28
Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis. J Immunol (2001) 3.06
Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol (1995) 2.92
A diffusible cytotoxin of Haemophilus ducreyi. Proc Natl Acad Sci U S A (1997) 2.89
Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life. AJNR Am J Neuroradiol (1995) 2.80
Neurological manifestations of intracranial dural arteriovenous malformations. J Neurosurg (1986) 2.72
Comparison of Chlamydia trachomatis serovars causing rectal and cervical infections. J Infect Dis (1987) 2.66
Confirmatory assay increases specificity of the chlamydiazyme test for Chlamydia trachomatis infection of the cervix. J Clin Microbiol (1990) 2.65
The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res (1976) 2.60
UK National Guidelines on the Management of Syphilis 2008. Int J STD AIDS (2008) 2.53
Sensitive detection of Treponema pallidum by using the polymerase chain reaction. J Clin Microbiol (1991) 2.51
Prevalence and causes of albuminuria in non-insulin-dependent diabetic patients. Kidney Int (1992) 2.51
Infections with Mycobacterium chelonei in patients receiving dialysis and using processed hemodialyzers. J Infect Dis (1985) 2.39
Pneumococcal vaccine efficacy in selected populations in the United States. Ann Intern Med (1986) 2.26
Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun (1998) 2.23
Automation of sample mounting for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2006) 2.22
Differences in the temporal trends of HIV seroincidence and seroprevalence among sexually transmitted disease clinic patients, 1989-1998: application of the serologic testing algorithm for recent HIV seroconversion. Am J Epidemiol (2001) 2.22
Use of polymerase chain reaction and rabbit infectivity testing to detect Treponema pallidum in amniotic fluid, fetal and neonatal sera, and cerebrospinal fluid. J Clin Microbiol (1991) 2.20
Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family. Infect Immun (1999) 2.18
A transmissible feline fibrosarcoma of viral origin. Cancer Res (1971) 2.17
Hippocampal volume in normal aging and traumatic brain injury. AJNR Am J Neuroradiol (1997) 2.17
Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study. Neurology (1999) 2.15
Major integral membrane protein immunogens of Treponema pallidum are proteolipids. Infect Immun (1989) 2.15
Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames and a lipoprotein gene family. J Bacteriol (1996) 2.14
Antiretroviral regimen complexity, self-reported adherence, and HIV patients' understanding of their regimens: survey of women in the her study. J Acquir Immune Defic Syndr (2001) 2.13
Major outer membrane protein variants of Chlamydia trachomatis are associated with severe upper genital tract infections and histopathology in San Francisco. J Infect Dis (1995) 2.12
Patient perspective of hand osteoarthritis in relation to concepts covered by instruments measuring functioning: a qualitative European multicentre study. Ann Rheum Dis (2008) 2.10
Emotional, behavioral, and HIV risks associated with sexual abuse among adult homosexual and bisexual men. Child Abuse Negl (1994) 2.09
The response of symptomatic neurosyphilis to high-dose intravenous penicillin G in patients with human immunodeficiency virus infection. N Engl J Med (1994) 2.08
Does warm-up using mental practice improve crisis resource management performance? A simulation study. Br J Anaesth (2012) 2.02
Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks. Infect Immun (2000) 2.00
Cardiovascular syphilis. Am J Med (1989) 1.99
Syphilis-associated perinatal and infant mortality in rural Malawi. Bull World Health Organ (1993) 1.96
Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infect Immun (1997) 1.93
Limited surface exposure of Borrelia burgdorferi outer surface lipoproteins. Proc Natl Acad Sci U S A (1996) 1.90
The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum. Infect Immun (1992) 1.86
Isolation of "Campylobacter hyointestinalis" from a human. J Clin Microbiol (1986) 1.85
Neurosyphilis during the AIDS epidemic, San Francisco, 1985-1992. J Infect Dis (1998) 1.85
Causes of albuminuria in patients with type 2 diabetes without diabetic retinopathy. Kidney Int (2000) 1.85
Cytobrush in collection of cervical specimens for detection of Chlamydia trachomatis. J Clin Microbiol (1989) 1.84
Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides. Infect Immun (1999) 1.84
Clinical manifestations of early syphilis by HIV status and gender: results of the syphilis and HIV study. Sex Transm Dis (2001) 1.82
Purification and characterization of a cloned protease-resistant Treponema pallidum-specific antigen. Infect Immun (1984) 1.80
A temperature-dependent rabbit model for production of dermal lesions by Haemophilus ducreyi. J Infect Dis (1991) 1.77
Femoral vessel depth and the implications for groin node radiation. Int J Radiat Oncol Biol Phys (1993) 1.75
Syphilis serology in human immunodeficiency virus infection: evidence for false-negative fluorescent treponemal testing. J Infect Dis (1997) 1.74
Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals. Infect Immun (2001) 1.73
Use of urine polymerase chain reaction to define the prevalence and clinical presentation of Trichomonas vaginalis in men attending an STD clinic. Sex Transm Infect (2003) 1.72
Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words: an fMRI study. Brain (1999) 1.71
Isolation of integral membrane proteins by phase partitioning with Triton X-114. Methods Enzymol (1994) 1.70
Trans-isolate medium: a new medium for primary culturing and transport of Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. J Clin Microbiol (1984) 1.70
Patients attending STD clinics in an evolving health care environment. Demographics, insurance coverage, preferences for STD services, and STD morbidity. Sex Transm Dis (1997) 1.69
Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model. Br J Cancer (2005) 1.68
Sensitivity of treponemal tests for detecting prior treated syphilis during human immunodeficiency virus infection. J Infect Dis (1990) 1.67
Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase. Biochemistry (2000) 1.67
Factors influencing the sample size, exemplified by studies on gastroduodenal tolerability of drugs. Scand J Gastroenterol (1985) 1.67
Growth of colorectal polyps: recovery and evaluation of unresected polyps of less than 10 mm, 1 year after detection. Scand J Gastroenterol (1994) 1.66
Double-blind, placebo-controlled trial of the pain-relieving effects of the implantation of gold beads into dogs with hip dysplasia. Vet Rec (2006) 1.63
Commonly used diagnostic criteria for pelvic inflammatory disease have poor sensitivity for plasma cell endometritis. Sex Transm Dis (1996) 1.63
Use of electroporation to construct isogenic mutants of Haemophilus ducreyi. J Bacteriol (1992) 1.61
The surface of virulent Treponema pallidum: resistance to antibody binding in the absence of complement and surface association of recombinant antigen 4D. Infect Immun (1986) 1.61
A hemoglobin-binding outer membrane protein is involved in virulence expression by Haemophilus ducreyi in an animal model. Infect Immun (1996) 1.60
Evaluation of molecular methodologies and rabbit infectivity testing for the diagnosis of congenital syphilis and neonatal central nervous system invasion by Treponema pallidum. J Infect Dis (1993) 1.60
Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone. Nat Struct Biol (1999) 1.60
Like father, like son: young children's understanding of how and why offspring resemble their parents. Child Dev (1996) 1.58
Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect Immun (1997) 1.57
The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity. J Exp Med (2001) 1.57
Oestrogen-responsive human breast cancer in long term tissue culture. Nature (1975) 1.56
Relative efficiency of chlamydia screening in non-clinical settings in two California counties. Int J STD AIDS (2010) 1.56
Treatment of the restless legs syndrome with carbamazepine: a double blind study. Br Med J (Clin Res Ed) (1984) 1.56
Rhamnogalacturonan acetylesterase elucidates the structure and function of a new family of hydrolases. Structure (2000) 1.54
2014 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol (2014) 1.54
Treponema pallidum in gel microdroplets: a novel strategy for investigation of treponemal molecular architecture. Mol Microbiol (1995) 1.54
Blood lead-blood pressure relations: alcohol intake and hemoglobin as confounders. Am J Epidemiol (1989) 1.53
Acylation of the 47-kilodalton major membrane immunogen of Treponema pallidum determines its hydrophobicity. Infect Immun (1989) 1.53
Laser resurfacing-induced hypopigmentation: histologic alterations and repigmentation with topical photochemotherapy. Dermatol Surg (2001) 1.51
High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline. Acta Crystallogr D Biol Crystallogr (2006) 1.50
Growth of colorectal polyps: redetection and evaluation of unresected polyps for a period of three years. Gut (1996) 1.50
PACs: classifying ambulatory care patients and services for clinical and financial management. J Ambul Care Manage (1988) 1.48
Neuropsychiatric reaction induced by clarithromycin in a patient on highly active antiretroviral therapy (HAART). Sex Transm Infect (2001) 1.48
Fatty acids of Treponema pallidum and Borrelia burgdorferi lipoproteins. J Bacteriol (1994) 1.48
Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity. Infect Immun (1993) 1.47
Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition. Neurology (1997) 1.47
Localization of outer surface proteins A and B in both the outer membrane and intracellular compartments of Borrelia burgdorferi. J Bacteriol (1991) 1.46
Bolus i.v. nitroglycerin treatment of ischemic chest pain in the ED. Am J Emerg Med (1994) 1.46
Evaluation of covert video surveillance in the diagnosis of munchausen syndrome by proxy: lessons from 41 cases. Pediatrics (2000) 1.46