Published in Curr Pharm Des on November 01, 2001
Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110. Mol Cell Biol (2004) 1.33
ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. J Biol Chem (2009) 1.10
Protein kinase C and cancer: what we know and what we do not. Oncogene (2013) 1.09
Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. J Biol Chem (2011) 0.97
Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha. Mol Pharmacol (2010) 0.96
Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. PLoS One (2012) 0.87
Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene (2011) 0.87
A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-{kappa}B activities. Carcinogenesis (2011) 0.84
Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line. Cancer Cell Int (2003) 0.84
Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. BMC Complement Altern Med (2014) 0.83
Protein kinase Cα mediates erlotinib resistance in lung cancer cells. Mol Pharmacol (2015) 0.82
Enhanced PKCδ and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF. PLoS One (2012) 0.81
PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. Mol Vis (2011) 0.79
A randomized phase II evaluation of bryostatin-1 (NSC #339555) in recurrent or persistent platinum-sensitive ovarian cancer: a Gynecologic Oncology Group Study. Invest New Drugs (2003) 0.77
Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse. J Neurosci (2016) 0.75
Effect of TPA and HTLV-1 Tax on BRCA1 and ERE controlled genes expression. Cell Cycle (2017) 0.75
KLF5 promotes apoptosis induced by phorbol ester as an effector of the autocrine factor TNFα in LNCaP prostate cancer cells. Oncol Lett (2017) 0.75
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem (1993) 7.16
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell (1995) 3.08
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem (1993) 2.62
New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J (1999) 2.39
Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta. J Biol Chem (1993) 1.51
Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem (1996) 1.49
Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. J Biol Chem (2000) 1.49
Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated protein kinase-dependent pathway. J Biol Chem (1999) 1.21
Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry (1996) 1.20
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proc Natl Acad Sci U S A (1999) 1.19
Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. J Biol Chem (2001) 1.13
Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells. J Biol Chem (1993) 1.12
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol (1994) 1.05
Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors. J Biol Chem (1994) 1.03
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells. J Biol Chem (2000) 1.03
Phosphorylation of the gamma chain of the high affinity receptor for immunoglobulin E by receptor-associated protein kinase C-delta. J Biol Chem (1994) 1.03
Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun. Proc Natl Acad Sci U S A (1994) 1.02
Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters. J Biol Chem (1997) 1.01
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes. Cell Growth Differ (1995) 0.94
Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent. J Biol Chem (2001) 0.94
The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta. Gene (1992) 0.93
The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review). Oncol Rep (1999) 0.91
Protein kinase C in cell signaling: strategies for the development of selective inhibitors. Agents Actions Suppl (1995) 0.90
Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene (2011) 0.87
Atypical protein kinase Czeta suppresses migration of mouse melanoma cells. Cell Growth Differ (2001) 0.85
Differential activation of PKC isozymes by 14-3-3 zeta protein. Biochem Biophys Res Commun (1995) 0.84
Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis. Cell Growth Differ (2001) 0.83
Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C. J Med Chem (1996) 0.81
The lipid second messenger diacylglycerol as a negative regulator of Rac signalling. Biochem Soc Trans (2006) 0.81
Biochemical and immunological studies of protein kinase C from Trypanosoma cruzi. Int J Parasitol (1999) 0.80
Recombinant C1b domain of PKCdelta triggers meiotic maturation upon microinjection in Xenopus laevis oocytes. FEBS Lett (2000) 0.79
Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-delta. J Med Chem (2001) 0.78
Conformationally constrained analogues of diacylglycerol (DAG)--II. Differential interaction of delta-lactones and gamma-lactones with protein kinase C (PK-C). Bioorg Med Chem (1993) 0.78
Protein kinase C in signal transduction and carcinogenesis. Prog Clin Biol Res (1994) 0.78
Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells. Endocrinology (2000) 0.77
Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. Bioorg Med Chem Lett (2001) 0.77
Interaction between beta 2- and alpha 2-adrenoceptor responses in the vascular system: effect of clenbuterol. Eur J Pharmacol (1986) 0.75
Pressor response induced by clenbuterol treatment in immobilized normotensive rats. J Cardiovasc Pharmacol (1989) 0.75
Beta-adrenoceptor desensitization by/clenbuterol in rat uterus. Gen Pharmacol (1993) 0.75