Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease.

PubWeight™: 2.48‹?› | Rank: Top 2%

🔗 View Article (PMID 11565535)

Published in N Engl J Med on September 20, 2001

Authors

A Chrysostomou, G Becker

Associated clinical trials:

Using the Drug Spironolactone to Test If It Reduces Protein Leakage From the Kidney | NCT00106561

Articles citing this

Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. J Am Soc Nephrol (2008) 1.93

The RAAS in the pathogenesis and treatment of diabetic nephropathy. Nat Rev Nephrol (2010) 1.65

The role of mineralocorticoid receptor expression in brain remodeling after cerebral ischemia. Endocrinology (2008) 1.61

Aldosterone and glomerular podocyte injury. Clin Exp Nephrol (2008) 1.07

Effect of aldosterone and mineralocorticoid receptor blockade on vascular inflammation. Heart Fail Rev (2005) 1.05

Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats. J Pharmacol Exp Ther (2009) 0.98

Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium. J Am Soc Nephrol (2008) 0.94

The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease. Br J Clin Pharmacol (2012) 0.92

Aldosterone induces mesangial cell apoptosis both in vivo and in vitro. Am J Physiol Renal Physiol (2008) 0.89

The effect of aldosterone blockade in patients with Alport syndrome. Pediatr Nephrol (2006) 0.87

Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1. Clin Exp Nephrol (2011) 0.87

Endothelin receptor antagonists in proteinuric renal disease: every rose has its thorn. J Am Soc Nephrol (2010) 0.86

Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. J Hypertens (2011) 0.86

Effect of aldosterone and MR blockade on the brain and the kidney. Heart Fail Rev (2005) 0.84

Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury. Int J Obes (Lond) (2011) 0.83

Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial. Clin Exp Nephrol (2015) 0.82

The necessity and effectiveness of mineralocorticoid receptor antagonist in the treatment of diabetic nephropathy. Hypertens Res (2015) 0.81

Effect of spironolactone on diabetic nephropathy compared to the combination of spironolactone and losartan. Nephrourol Mon (2014) 0.81

Comparison of spironolactone and trichlormethiazide as add-on therapy to renin-angiotensin blockade for reduction of albuminuria in diabetic patients. J Diabetes Investig (2013) 0.81

Management of hyperkalaemia consequent to mineralocorticoid-receptor antagonist therapy. Nat Rev Nephrol (2012) 0.80

Aldosterone and TGF-β1 synergistically increase PAI-1 expression in hepatic stellate cells of rats. Int J Clin Exp Pathol (2015) 0.78

Endogenous cardiotonic steroids in kidney failure: a review and an hypothesis. Adv Chronic Kidney Dis (2015) 0.78

Novel drugs and intervention strategies for the treatment of chronic kidney disease. Br J Clin Pharmacol (2013) 0.78

Role of aldosterone in the progression of chronic kidney disease and potential use of aldosterone blockade in children. Pediatr Nephrol (2009) 0.77

Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. Mol Med Rep (2016) 0.76

Spironolactone and ACE inhibition in chronic renal failure. N Engl J Med (2002) 0.75

Spironolactone and ACE inhibition in chronic renal failure. N Engl J Med (2002) 0.75

An additive effect of eplerenone to ACE inhibitor on slowing the progression of diabetic nephropathy in the db/db mice. Am J Transl Res (2016) 0.75

Mineralocorticoid receptor blockade-a novel approach to fight hyperkalaemia in chronic kidney disease. Clin Kidney J (2013) 0.75

Spironolactone Plus Full-Dose ACE Inhibition in Patients with Idiopathic Membranous Nephropathy and Nephrotic Syndrome: Does It Really Work? Pharmaceuticals (Basel) (2010) 0.75

Targeting the renin-angiotensin system in patients with renal disease. J R Soc Med (2002) 0.75

Effects of RAAS Inhibitors in Patients with Kidney Disease. Curr Hypertens Rep (2017) 0.75

Articles by these authors

(truncated to the top 100)

Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data. Ann Intern Med (2001) 6.22

Circular polarization in star-formation regions: implications for biomolecular homochirality. Science (1998) 2.38

Relation between antral motility and gastric emptying of solids and liquids in humans. Am J Physiol (1985) 1.81

Clusterin (Apo J) protects against in vitro amyloid-beta (1-40) neurotoxicity. J Neurochem (1996) 1.70

The correlation between ventricular diameter measured by transcranial sonography and clinical disability and cognitive dysfunction in patients with multiple sclerosis. Arch Neurol (2000) 1.55

Brain iron pathways and their relevance to Parkinson's disease. J Neurochem (2001) 1.55

The Kidney Disease: improving Global Outcomes website: comparison of guidelines as a tool for harmonization. Kidney Int (2007) 1.53

Superficial siderosis of the central nervous system: pathogenetic heterogeneity and therapeutic approaches. Acta Neurol Scand (2003) 1.49

Differentiation between intracerebral hemorrhage and ischemic stroke by transcranial color-coded duplex-sonography. Stroke (1998) 1.45

The effects of gender-specific diagnosis on men's and women's response to infertility. Fertil Steril (1992) 1.44

[Emergency rescue in accidents with HDR afterloading units]. Strahlenther Onkol (1999) 1.39

Stereotactic fractionated irradiation of optic nerve sheath meningioma: a new treatment alternative. Br J Ophthalmol (2002) 1.28

Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings. J Neurol (2001) 1.27

Vulnerability of the nigrostriatal system as detected by transcranial ultrasound. Neurology (1999) 1.27

High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study. J Neural Transm (Vienna) (2004) 1.26

Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol (1999) 1.23

Effects of amiloride and ouabain on short-chain fatty acid transport in guinea-pig large intestine. J Physiol (1993) 1.21

Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation. Neurogastroenterol Motil (2014) 1.19

Differentiation of Parkinson's disease and atypical parkinsonian syndromes by transcranial ultrasound. J Neurol Neurosurg Psychiatry (2005) 1.16

Lenticular nucleus lesion in idiopathic dystonia detected by transcranial sonography. Neurology (1996) 1.15

Transcranial color-coded real-time sonography in adults. Stroke (1990) 1.12

Specific antibodies elicited by antigen covalently linked to a synthetic adjuvant. Immunobiology (1985) 1.12

Role of activator site position and a distal UP-element half-site for sigma factor selectivity at a CRP/H-NS-activated sigma(s)-dependent promoter in Escherichia coli. Mol Microbiol (2001) 1.10

Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma. Am J Pathol (1998) 1.10

Clinical markers of asthma severity and risk: importance of subjective as well as objective factors. Heart Lung (1992) 1.09

Old age, rehabilitation, and research: a review of the issues. Gerontologist (1988) 1.08

Endocytosis in Chinese hamster fibroblasts. Inhibition by glucose. Exp Cell Res (1973) 1.08

Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic cervical dystonia: a SPECT study using [123I] epidepride and [123I] beta-CIT. Mov Disord (1998) 1.07

Clinical features of Fabry's disease in Australian patients. Intern Med J (2002) 1.06

Parkinson's disease and depression: evidence for an alteration of the basal limbic system detected by transcranial sonography. J Neurol Neurosurg Psychiatry (1997) 1.05

Use of a microscope photometer to analyze in vivo fluorescence intensity of epilithic microalgae grown on artificial substrata. Appl Environ Microbiol (1997) 1.05

Mutation frequency in human lymphocytes increases with age. Mech Ageing Dev (1984) 1.05

p16/MTS1 inactivation in ovarian carcinomas: high frequency of reduced protein expression associated with hyper-methylation or mutation in endometrioid and mucinous tumors. Int J Cancer (1998) 1.04

Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease. Neurology (2004) 1.03

Cloning, structure, cellular localization, and possible function of the tumor suppressor gene lethal(3)malignant blood neoplasm-1 of Drosophila melanogaster. Dev Biol (1994) 1.00

Reasons for delay in seeking treatment for acute asthma: the patient's perspective. J Asthma (1998) 1.00

Iron accumulation in the substantia nigra in rats visualized by ultrasound. Ultrasound Med Biol (1999) 0.99

Echogenicity of substantia nigra determined by transcranial ultrasound correlates with severity of parkinsonian symptoms induced by neuroleptic therapy. Biol Psychiatry (2001) 0.98

ELISA technique for quantification of surfactant protein B (SP-B) in bronchoalveolar lavage fluid. Am J Respir Crit Care Med (1995) 0.98

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients. Neuroreport (2000) 0.98

Interleukin-10 (IL-10) augments allograft arterial disease: paradoxical effects of IL-10 in vivo. Am J Pathol (1999) 0.98

Correlation of intra-operative ultrasound with histopathologic findings after tumour resection in supratentorial gliomas. A method to improve gross total tumour resection. Acta Neurochir (Wien) (1996) 0.98

Depression in Parkinson's disease: brainstem midline alteration on transcranial sonography and magnetic resonance imaging. J Neurol (1999) 0.98

Do urinary tract infections trigger chronic kidney transplant rejection in man? J Urol (1998) 0.97

Pattern of graft- and host-specific MHC class II expression in long-term murine cardiac allografts: origin of inflammatory and vascular wall cells. Am J Pathol (1998) 0.96

Multiple false-positive serologic tests for HIV, HTLV-1, and hepatitis C following influenza vaccination, 1991. JAMA (1992) 0.96

Lesion pattern in patients with multiple sclerosis and depression. Mult Scler (2000) 0.96

[Is the pharmacological treatment of constipation in palliative care evidence based? : a systematic literature review]. Schmerz (2012) 0.95

Stigma, disclosure, and family functioning among parents of children conceived through donor insemination. Fertil Steril (1997) 0.94

An insoluble Ca 2+ -binding factor from rat liver mitochondria. Biochem Biophys Res Commun (1972) 0.94

Prevalence of HPV DNA in cervical specimens in women with renal transplants: a comparison with dialysis-dependent patients and patients with renal impairment. Nephrol Dial Transplant (1994) 0.93

Functional role of bicarbonate in propionate transport across guinea-pig isolated caecum and proximal colon. J Physiol (1994) 0.93

The basal ganglia in haemochromatosis. Neuroradiology (2000) 0.93

Frontal brain asymmetry and affective style: a conceptual replication. Psychophysiology (1998) 0.92

Multiple unilateral schwannomas: segmental neurofibromatosis type 2 or schwannomatosis? Br J Dermatol (2003) 0.92

The disclosure decision: concerns and issues of parents of children conceived through donor insemination. Am J Obstet Gynecol (1998) 0.92

Interferon-gamma-secreting T-cell populations in rejecting murine cardiac allografts: assessment by flow cytometry. Am J Pathol (1998) 0.92

Ultrasound derived imaging and quantification of cell adhesion molecules in experimental autoimmune encephalomyelitis (EAE) by Sensitive Particle Acoustic Quantification (SPAQ). Neuroimage (2005) 0.91

Ethnicity and lupus nephritis: an Australian single centre study. Intern Med J (2011) 0.90

Stroke: health care on the periphery. Soc Sci Med (1986) 0.90

Relationship of substantia nigra echogenicity and motor function in elderly subjects. Neurology (2001) 0.89

Sonographic imaging of the brain parenchyma. Eur J Ultrasound (2002) 0.89

Neurology of Fabry disease. Intern Med J (2007) 0.89

Cardiovascular testing in Fabry disease: exercise capacity reduction, chronotropic incompetence and improved anaerobic threshold after enzyme replacement. Intern Med J (2008) 0.89

Psychopathological symptoms of depression in Parkinson's disease compared to major depression. Psychopathology (2003) 0.89

Myofibroblasts and arteriolar sclerosis in human diabetic nephropathy. Am J Kidney Dis (1997) 0.89

Potentiation of leukotriene production following sequestration of neutrophils in isolated lungs: indirect evidence for intercellular leukotriene A4 transfer. Blood (1988) 0.88

[Effect of magnetic fields on the orientation behavior of goldfishes]. Naturwissenschaften (1974) 0.88

Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis. J Immunol (1990) 0.88

Clinical indications and biological mechanisms of splenic irradiation in chronic leukaemias and myeloproliferative disorders. Radiother Oncol (2001) 0.87

Opioid-induced constipation in advanced illness: safety and efficacy of methylnaltrexone bromide. Clin Med Insights Oncol (2011) 0.87

High yield enzymatic conversion of intravascular leukotriene A4 in blood-free perfused lungs. J Immunol (1988) 0.87

Continuous ambulatory peritoneal dialysis. Med J Aust (1982) 0.87

An improved percutaneous jetting system for use during microlaryngeal operations. Can Anaesth Soc J (1977) 0.86

Dependency of the [18F]fluoromisonidazole uptake on oxygen delivery and tissue oxygenation in the porcine liver. Nucl Med Biol (2000) 0.86

Percutaneous transhepatic drainage for malignant biliary obstruction. Am Surg (1984) 0.86

Using temporal information to construct, update, and retrieve situation models of narratives. J Exp Psychol Learn Mem Cogn (2001) 0.86

Omega-oxidized leukotriene B4 detected in the broncho-alveolar lavage fluid of patients with non-cardiogenic pulmonary edema, but not in those with cardiogenic edema. Intensive Care Med (1991) 0.85

Human papillomavirus detection in cervical adenocarcinoma by polymerase chain reaction. Hum Pathol (1993) 0.85

Low-temperature preservation of mammalian cells in tissue culture with polyvinylpyrrolidone (PVP), dextrans, and hydroxyethyl starch (HES). Cryobiology (1972) 0.85

Chemical preservation of urine sediment for phase-contrast microscopic examination. Nephron (1994) 0.85

Stereotactic radiotherapy in the liver hilum. Basis for future studies. Strahlenther Onkol (2011) 0.84

Diagnostic and clinical outcome of neurogenic tumours in the head and neck area. ORL J Otorhinolaryngol Relat Spec (1996) 0.84

[Heidelberg Centenarian Study: theoretical and methodological principles for social science research of the oldest old]. Z Gerontol Geriatr (2001) 0.84

Combination of celecoxib with percutaneous radiotherapy in patients with localised prostate cancer - a phase I study. Radiat Oncol (2006) 0.84

Syphilitic hearing loss. South Med J (1979) 0.84

Introducing fluorine-18 fluoromisonidazole positron emission tomography for the localisation and quantification of pig liver hypoxia. Eur J Nucl Med (1999) 0.84

Clinical indications and biological mechanisms of splenic irradiation in autoimmune diseases. Strahlenther Onkol (2001) 0.84

[Early symptoms and findings in optic nerve meningiomas]. Klin Monbl Augenheilkd (2009) 0.84

Genetic and molecular analysis of six tumor suppressor genes in Drosophila melanogaster. Environ Health Perspect (1990) 0.84

Differentiation of parkinsonian syndromes according to differences in executive functions. J Neural Transm (Vienna) (2003) 0.84

Spinal canal stenosis in L-2-hydroxyglutaric aciduria. Arch Neurol (2000) 0.83

Arachidonic acid lipoxygenase pathways and increased vascular permeability in isolated rabbit lungs. Am Rev Respir Dis (1987) 0.83

Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy. Gene Ther (2002) 0.83

Computer systems and mechanical tools for stereotactically guided conformation therapy with linear accelerators. Int J Radiat Oncol Biol Phys (1992) 0.83

Parasympathetic but not sympathetic cardiac dysfunction at early stages of Parkinson's disease. Clin Res Cardiol (2010) 0.83

Influence of an infectious disease consulting service on quality and costs of antibiotic prescriptions in a university hospital. Scand J Infect Dis (2001) 0.83

Plasma exchange in progressive IgA nephropathy. J Clin Apher (1990) 0.82

Decreased cloning of lymphocytes from elderly individuals. Scand J Immunol (1984) 0.82

Substantia nigra echomorphology in the healthy very old: Correlation with motor slowing. Neuroimage (2006) 0.82