Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit.

PubWeight™: 1.68‹?› | Rank: Top 3%

🔗 View Article (PMID 11575934)

Published in J Mol Biol on September 28, 2001

Authors

A G Evdokimov1, D E Anderson, K M Routzahn, D S Waugh

Author Affiliations

1: Protein Engineering Section Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. eudokima@ncifcrf.gov

Articles citing this

Process of protein transport by the type III secretion system. Microbiol Mol Biol Rev (2004) 3.31

Type III secretion systems and bacterial flagella: insights into their function from structural similarities. Proc Natl Acad Sci U S A (2003) 3.11

Yersinia type III secretion: send in the effectors. J Cell Biol (2002) 3.04

The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci U S A (2005) 2.71

Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature (2011) 2.12

Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics (2007) 1.80

Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J (2003) 1.78

The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense. Proc Natl Acad Sci U S A (2003) 1.72

A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases. Proc Natl Acad Sci U S A (2009) 1.70

Functional equivalence and evolutionary convergence in complex communities of microbial sponge symbionts. Proc Natl Acad Sci U S A (2012) 1.63

Ribonuclease inhibitor: structure and function. Prog Nucleic Acid Res Mol Biol (2005) 1.55

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome. Cell Host Microbe (2016) 1.45

Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites. J Biol Chem (2009) 1.41

Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Sci (2002) 1.39

Multiple functions of the leucine-rich repeat protein LrrA of Treponema denticola. Infect Immun (2004) 1.38

Computational prediction of type III and IV secreted effectors in gram-negative bacteria. Infect Immun (2010) 1.19

The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence. Infect Immun (2010) 1.14

Gr1+ cells control growth of YopM-negative yersinia pestis during systemic plague. Infect Immun (2009) 1.12

Delineation of regions of the Yersinia YopM protein required for interaction with the RSK1 and PRK2 host kinases and their requirement for interleukin-10 production and virulence. Infect Immun (2010) 1.12

Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins. Infect Immun (2003) 1.05

Yersinia virulence factor YopM induces sustained RSK activation by interfering with dephosphorylation. PLoS One (2010) 1.02

Modulation of innate immune responses by Yersinia type III secretion system translocators and effectors. Cell Microbiol (2013) 1.02

Application of a Saccharomyces cerevisiae model to study requirements for trafficking of Yersinia pestis YopM in eucaryotic cells. Infect Immun (2003) 1.00

Lifestyle evolution in cyanobacterial symbionts of sponges. MBio (2015) 1.00

IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM. MBio (2014) 0.99

Macromolecular complexes in crystals and solutions. Acta Crystallogr D Biol Crystallogr (2011) 0.98

Atomic interaction networks in the core of protein domains and their native folds. PLoS One (2010) 0.98

A multi-pronged search for a common structural motif in the secretion signal of Salmonella enterica serovar Typhimurium type III effector proteins. Mol Biosyst (2010) 0.97

Thermodynamics, kinetics, and salt dependence of folding of YopM, a large leucine-rich repeat protein. J Mol Biol (2008) 0.95

Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM. Infect Immun (2012) 0.94

C-terminal deletion of leucine-rich repeats from YopM reveals a heterogeneous distribution of stability in a cooperatively folded protein. Protein Sci (2009) 0.93

Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res (2016) 0.92

The streptococcal Blr and Slr proteins define a family of surface proteins with leucine-rich repeats: camouflaging by other surface structures. J Bacteriol (2006) 0.92

Genome-wide subcellular localization of putative outer membrane and extracellular proteins in Leptospira interrogans serovar Lai genome using bioinformatics approaches. BMC Genomics (2008) 0.90

Hal Is a Bacillus anthracis heme acquisition protein. J Bacteriol (2012) 0.88

Deletion of internal structured repeats increases the stability of a leucine-rich repeat protein, YopM. Biophys Chem (2011) 0.86

Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. Mol Cell Biol (2013) 0.85

Interactions of bacterial proteins with host eukaryotic ubiquitin pathways. Front Microbiol (2011) 0.84

A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. PLoS One (2011) 0.83

Toward a molecular pathogenic pathway for Yersinia pestis YopM. Front Cell Infect Microbiol (2012) 0.83

Caspase-3 mediates the pathogenic effect of Yersinia pestis YopM in liver of C57BL/6 mice and contributes to YopM's function in spleen. PLoS One (2014) 0.82

Comparative structural analysis of the binding domain of follicle stimulating hormone receptor. Proteins (2008) 0.81

Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC Genomics (2007) 0.81

Cytotoxic necrotizing factor-Y boosts Yersinia effector translocation by activating Rac protein. J Biol Chem (2013) 0.81

Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen. Biochem J (2002) 0.79

Homo-dimerization and ligand binding by the leucine-rich repeat domain at RHG1/RFS2 underlying resistance to two soybean pathogens. BMC Plant Biol (2013) 0.76

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells. PLoS Pathog (2016) 0.76

The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3. Cell Death Dis (2016) 0.76

Bacterial-derived cell-penetrating peptides deliver gentamicin to kill intracellular pathogens. Antimicrob Agents Chemother (2017) 0.75

Crystal structure of an engineered YopM-InlB hybrid protein. BMC Struct Biol (2014) 0.75

Distribution and Evolution of Yersinia Leucine-Rich Repeat Proteins. Infect Immun (2016) 0.75

Articles by these authors

Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency. Protein Eng (2001) 5.71

Escherichia coli maltose-binding protein is uncommonly effective at promoting the solubility of polypeptides to which it is fused. Protein Sci (1999) 5.43

Genetic epidemiology of breast cancer: segregation analysis of 200 Danish pedigrees. Genet Epidemiol (1984) 3.11

Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance. Methods Enzymol (1989) 2.95

Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Science (1992) 2.89

GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis. J Clin Microbiol (1996) 2.60

Problems created for ice arenas by engine exhaust. Am Ind Hyg Assoc J (1971) 2.49

Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients. J Clin Microbiol (1998) 2.47

Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage. Structure (2001) 2.40

Tick-borne diseases in the United States. N Engl J Med (1993) 2.39

Controlled intracellular processing of fusion proteins by TEV protease. Protein Expr Purif (2000) 2.38

The 8-nucleotide-long RNA:DNA hybrid is a primary stability determinant of the RNA polymerase II elongation complex. J Biol Chem (2000) 2.35

Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme. Biochemistry (1991) 2.31

Identification and molecular cloning of a gene encoding a fibronectin-binding protein (CadF) from Campylobacter jejuni. Mol Microbiol (1997) 2.17

Treatment of Bacillary (Flexner) Dysentery with Sulphanilylguanidine. Br Med J (1941) 2.15

Hereditary aspects of malignant melanoma. JAMA (1967) 1.98

Heredity and cancer in man. Prog Med Genet (1973) 1.91

Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J Immunol (1998) 1.82

Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry (1991) 1.79

Bimodal activation of SMC ATPase by intra- and inter-molecular interactions. EMBO J (2001) 1.78

Some characteristics of familial breast cancer. Cancer (1971) 1.67

Genetic study of breast cancer: identification of a high risk group. Cancer (1974) 1.66

Cancer risk and diet in India. J Postgrad Med (2003) 1.62

Tick-borne relapsing fever in the northwestern United States and southwestern Canada. Clin Infect Dis (1998) 1.59

Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology (1999) 1.46

Effects of phenylbutazone on bone activity and formation in horses. Am J Vet Res (2000) 1.45

Pre-weaning morbidity and mortality of llamas and alpacas. Aust Vet J (2009) 1.44

Articular fractures of the distal portion of the humerus in Vietnamese pot-bellied pigs: six cases (1988-1992) J Am Vet Med Assoc (1995) 1.41

A versatile plasmid expression vector for the production of biotinylated proteins by site-specific, enzymatic modification in Escherichia coli. Gene (1996) 1.40

Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. J Immunol (2001) 1.39

Catalysis by RNA. Bioessays (1986) 1.36

A genetic study of human breast cancer. J Natl Cancer Inst (1972) 1.34

Single amino acid substitutions on the surface of Escherichia coli maltose-binding protein can have a profound impact on the solubility of fusion proteins. Protein Sci (2001) 1.34

Clinical characteristics of the genetic variety of cutaneous melanoma in man. Cancer (1971) 1.33

IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol (1996) 1.32

Stenotrophomonas maltophilia: emergence of multidrug-resistant strains during therapy and in an in vitro pharmacodynamic chamber model. Antimicrob Agents Chemother (1996) 1.28

Breast cancer in families. Cancer (1977) 1.27

Site-specific, enzymatic biotinylation of recombinant proteins in Spodoptera frugiperda cells using biotin acceptor peptides. Anal Biochem (1998) 1.27

The nevoid basal cell carcinoma syndrome. Am J Hum Genet (1967) 1.26

Distal deletion of chromosome Ip in ductal carcinoma of the breast. Am J Hum Genet (1989) 1.25

Heredity and intraocular malignant melanoma. Study of two families and review of forty-five cases. Cancer (1968) 1.21

Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface. Biochemistry (1995) 1.21

Crystal structure of plant aspartic proteinase prophytepsin: inactivation and vacuolar targeting. EMBO J (1999) 1.18

Structural basis for oligosaccharide recognition by Pyrococcus furiosus maltodextrin-binding protein. J Mol Biol (2001) 1.06

Risk of familial breast cancer. Cancer (1985) 1.05

Xeroderma pigmentosum, malignant melanoma, and congenital ichthyosis. A family study. Arch Dermatol (1967) 1.05

Linkage analysis of the nevoid basal cell carcinoma syndrome. Ann Hum Genet (1968) 1.04

Sustained increased cerebral blood flow with prophylactic hypertensive hypervolemic hemodilution ("triple-H" therapy) after subarachnoid hemorrhage. Neurosurgery (1990) 1.03

Endogenous marinobufagenin-like immunoreactive factor and Na+, K+ ATPase inhibition during voluntary hypoventilation. Hypertension (1995) 1.02

Immunofluorescence studies on sera of patients with breast carcinoma. Cancer (1971) 1.02

Simian papovavirus 40 transformation of cells from cancer patient with XY-XXY mosaic Klinefelter's syndrome. Cancer Res (1970) 1.01

Refinements using free-tissue transfer for complex cranial base reconstruction. Plast Reconstr Surg (1993) 1.01

Plasma marinobufagenin-like and ouabain-like immunoreactivity during saline volume expansion in anesthetized dogs. Cardiovasc Res (1996) 1.01

Escherichia coli O157:H7 hemorrhagic colitis. N Engl J Med (1988) 1.01

Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease. Biochemistry (1998) 1.01

Penetrance and expressivity of the chromosome 9p melanoma susceptibility locus (MLM). Cancer Res (1994) 1.00

Jaw cysts and the basal cell nevus syndrome. J Oral Surg (1966) 1.00

Blood type A and familial breast cancer. Cancer (1984) 0.99

Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. J Neuroimmunol (1998) 0.99

Effect of Mannheimia haemolytica pneumonia on behavior and physiologic responses of calves during high ambient environmental temperatures. J Anim Sci (2013) 0.98

"The basal-cell nevus" by Howell and Caro, January 1959. Commentary: The nevoid basal cell carcinoma syndrome. Arch Dermatol (1982) 0.98

Performance of respirator expiratory valves. Am Ind Hyg Assoc J (1967) 0.98

Tick paralysis: 33 human cases in Washington State, 1946-1996. Clin Infect Dis (1999) 0.97

The nevoid basal cell carcinoma syndrome. Autopsy findings. Arch Dermatol (1968) 0.97

Disseminated superficial actinic porokeratosis. Genetic aspects. Arch Dermatol (1969) 0.97

An inherited form of large bowel cancer: Muir's syndrome. Cancer (1980) 0.96

Neurological involvement in the nevoid basal cell carcinoma syndrome. J Neurosurg (1971) 0.96

Structure of the N-terminal domain of Yersinia pestis YopH at 2.0 A resolution. Acta Crystallogr D Biol Crystallogr (2001) 0.95

Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP. J Biol Chem (1994) 0.95

A genetic linkage study of familial breast-ovarian cancer. Cancer Genet Cytogenet (1989) 0.94

Familial cancer and cancer families. Semin Oncol (1978) 0.94

Synovial fluid analysis in cattle: a review of 130 cases. Vet Surg (2000) 0.93

Ambulatory monitoring of respiration in anxiety. Anxiety (1996) 0.92

Survival in familial breast cancer patients. Cancer (1986) 0.92

Nitrogen dioxide poisoning due to metal-cutting with oxyacetylene torch. J Occup Med (1966) 0.90

The kinetics of specific immune responses in rhesus monkeys inoculated with live recombinant BCG expressing SIV Gag, Pol, Env, and Nef proteins. Virology (2000) 0.90

G.-6-P.D. deficiency and cancer. Lancet (1970) 0.89

Interaction of NaCl and behavioral stress on endogenous sodium pump ligands in rats. Am J Physiol Regul Integr Comp Physiol (2001) 0.89

High-resolution structure of the temperature-sensitive mutant of phage lysozyme, Arg 96----His. Biochemistry (1989) 0.89

Data-based cancer control programs: a public health response. Wis Med J (1991) 0.89

Comparison of various in vitro susceptibility methods for testing Stenotrophomonas maltophilia. Diagn Microbiol Infect Dis (1998) 0.89

Molecular targets for nutrients involved with cancer prevention. Nutr Cancer (2001) 0.89

Nutrition and eye cancer in cattle. J Natl Cancer Inst (1970) 0.89

Time course of glycogen accumulation after eccentric exercise. J Appl Physiol (1985) (1992) 0.88

Immunological studies on human breast carcinoma and mouse mammary tumors. J Natl Cancer Inst (1972) 0.88

Intraoperative electromyographic assessment of recurrent laryngeal nerve stress and pharyngeal injury during anterior cervical spine surgery with Caspar instrumentation. J Neurosurg (1999) 0.88

Evaluation of intraocular pressure in eyes of clinically normal llamas and alpacas. Am J Vet Res (2000) 0.87

Plasma marinobufagenin-like and ouabain-like immunoreactivity in adrenocorticotropin-treated rats. Am J Hypertens (1998) 0.87

Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. J Immunol (1997) 0.87

Structure and catalytic function in ribonuclease P. Cold Spring Harb Symp Quant Biol (1987) 0.87

Disseminated superficial actinic porokeratosis. Clinical studies and experimental production of lesions. Arch Dermatol (1969) 0.87

Bilaterality in familial breast cancer patients. Cancer (1985) 0.86

Localization of the 9p melanoma susceptibility locus (MLM) to a 2-cM region between D9S736 and D9S171. Genomics (1994) 0.86

Molecular pathogenesis of multiple sclerosis. J Neuroimmunol (1999) 0.85

In vitro dose-dependent effects of enrofloxacin on equine articular cartilage. Am J Vet Res (1999) 0.85