Published in Mol Cell on September 01, 2001
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol (2004) 8.94
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol (2006) 3.97
Functional proteomic analysis of human nucleolus. Mol Biol Cell (2002) 3.07
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol (2007) 3.03
Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog (2009) 2.94
Identification, analysis, and prediction of protein ubiquitination sites. Proteins (2010) 2.53
Ubiquitination in signaling to and activation of IKK. Immunol Rev (2012) 2.28
Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev (2003) 2.24
Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation. EMBO J (2002) 2.23
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23
Dual mode of degradation of Cdc25 A phosphatase. EMBO J (2002) 1.95
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. Proc Natl Acad Sci U S A (2004) 1.85
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82
Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol Cell Biol (2006) 1.80
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Mol Cell (2008) 1.71
Small ubiquitin-like modifier modulates abscisic acid signaling in Arabidopsis. Plant Cell (2003) 1.70
Regulation of jasmonate-mediated plant responses in arabidopsis. Ann Bot (2003) 1.65
Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. J Biol Chem (2008) 1.64
blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. J Neurosci (2003) 1.57
Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev (2002) 1.57
The genome of canarypox virus. J Virol (2004) 1.56
E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia (2006) 1.49
Ubiquitination of inducible nitric oxide synthase is required for its degradation. Proc Natl Acad Sci U S A (2002) 1.45
Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. J Cell Biol (2005) 1.41
Molecular and cellular mechanisms of skeletal muscle atrophy: an update. J Cachexia Sarcopenia Muscle (2012) 1.40
The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases. Biochemistry (2006) 1.38
The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. EMBO J (2006) 1.38
Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein. EMBO J (2004) 1.38
Involvement of the DNA repair protein hHR23 in p53 degradation. Mol Cell Biol (2003) 1.38
Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome. J Cell Biol (2002) 1.36
Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments. J Virol (2002) 1.36
BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks. Mol Cell Biol (2003) 1.34
Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Mol Cell Biol (2005) 1.33
Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome. J Virol (2005) 1.32
Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover. PLoS Biol (2007) 1.24
The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology (2003) 1.24
Role of Annexin-II in GI cancers: interaction with gastrins/progastrins. Cancer Lett (2006) 1.22
Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11. J Biol Chem (2008) 1.22
Ubiquitin in NF-kappaB signaling. Chem Rev (2009) 1.20
Structural basis for the activation and inhibition of the UCH37 deubiquitylase. Mol Cell (2015) 1.20
Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A (2002) 1.20
Cullin-RING Ligases as attractive anti-cancer targets. Curr Pharm Des (2013) 1.19
Prediction of ubiquitination sites by using the composition of k-spaced amino acid pairs. PLoS One (2011) 1.18
Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Plant Cell (2008) 1.17
Regulation of abiotic stress signal transduction by E3 ubiquitin ligases in Arabidopsis. Mol Cells (2011) 1.16
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. Biochem J (2003) 1.12
Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer Targets. Genes Cancer (2010) 1.09
OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer. Cell Death Dis (2011) 1.06
c-Fos proto-oncoprotein is degraded by the proteasome independently of its own ubiquitinylation in vivo. Mol Cell Biol (2003) 1.06
Viral and cellular MARCH ubiquitin ligases and cancer. Semin Cancer Biol (2008) 1.05
RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Mol Cell (2013) 1.05
FOXP3+ regulatory T cells and their functional regulation. Cell Mol Immunol (2015) 1.02
Autophagy and polyglutamine diseases. Prog Neurobiol (2011) 1.02
Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases. Mol Biol Cell (2004) 1.01
Degradation or maintenance: actions of the ubiquitin system on eukaryotic chromatin. Eukaryot Cell (2002) 1.00
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol (2008) 0.98
Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics (2009) 0.97
Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. Oncogenesis (2013) 0.96
Posttranslational modifications of proteins in the pathobiology of medically relevant fungi. Eukaryot Cell (2011) 0.96
Correlation between recombinase activating gene 1 ubiquitin ligase activity and V(D)J recombination. Immunology (2009) 0.95
Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans. Mol Biol Cell (2011) 0.94
A Method to Identify p62's UBA Domain Interacting Proteins. Biol Proced Online (2003) 0.94
Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis. J Cancer Res Clin Oncol (2013) 0.91
An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. Cell (2016) 0.90
The ubiquitin signal: assembly, recognition and termination. Symposium on ubiquitin and signaling. EMBO Rep (2005) 0.90
Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach. J Proteome Res (2010) 0.90
Protein dynamics in supercooled water: the search for slow motional modes. J Biomol NMR (2002) 0.89
CC2D1A, a DM14 and C2 domain protein, activates NF-kappaB through the canonical pathway. J Biol Chem (2010) 0.89
Prediction of lysine ubiquitylation with ensemble classifier and feature selection. Int J Mol Sci (2011) 0.89
Regulation of gene expression by the ubiquitin-proteasome system. Semin Cell Dev Biol (2012) 0.89
Lessons from viral manipulation of protein disposal pathways. J Clin Invest (2002) 0.88
Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation. J Virol (2005) 0.87
Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model. Neurosci Lett (2011) 0.87
Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP. Biochem J (2011) 0.86
Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents. Cancer Chemother Pharmacol (2009) 0.86
Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway. Dev Biol (2006) 0.85
The ubiquitin proteasome system in Caenorhabditis elegans and its regulation. Redox Biol (2014) 0.84
Signaling pathways that control mRNA turnover. Cell Signal (2013) 0.84
Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer. J Carcinog (2010) 0.84
Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. Proc Natl Acad Sci U S A (2011) 0.83
Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases. Transl Oncol (2012) 0.82
Non-covalent interaction between polyubiquitin and GTP cyclohydrolase 1 dictates its degradation. PLoS One (2012) 0.82
Targeting ubiquitination for cancer therapies. Future Med Chem (2015) 0.82
Characterization of a UBC13 kinase in Plasmodium falciparum. Proc Natl Acad Sci U S A (2007) 0.81
Structural insights into interactions between ubiquitin specific protease 5 and its polyubiquitin substrates by mass spectrometry and ion mobility spectrometry. Protein Sci (2015) 0.79
The ubiquitin-conjugating system: multiple roles in viral replication and infection. Cells (2014) 0.79
Degradation of retinoid X receptor alpha by TPA through proteasome pathway in gastric cancer cells. World J Gastroenterol (2003) 0.79
Disassembly of the self-assembled, double-ring structure of proteasome α7 homo-tetradecamer by α6. Sci Rep (2015) 0.78
Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. Cell Death Dis (2014) 0.77
Chemical and functional aspects of posttranslational modification of proteins. Acta Naturae (2009) 0.77
A Synthetic Interaction between CDC20 and RAD4 in Saccharomyces cerevisiae upon UV Irradiation. Mol Biol Int (2014) 0.75
COP1 Controls Abiotic Stress Responses by Modulating AtSIZ1 Function through Its E3 Ubiquitin Ligase Activity. Front Plant Sci (2016) 0.75
Molecular identification and interaction assay of the gene (OsUbc13) encoding a ubiquitin-conjugating enzyme in rice. J Zhejiang Univ Sci B (2014) 0.75
Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells. Biochem J (2007) 0.75
Arabidopsis ubiquitin-conjugating enzyme UBC22 is required for female gametophyte development and likely involved in Lys11-linked ubiquitination. J Exp Bot (2016) 0.75
Post-translational modifications of Arabidopsis E3 SUMO ligase AtSIZ1 are controlled by environmental conditions. FEBS Open Bio (2017) 0.75
Expression of p97/VCP and ubiquitin during postnatal development of the degenerating rat retina. J Mol Histol (2011) 0.75
Ubiquitination-mediated interaction among domains is responsible for inhibition of RNA endonuclease activity of mRNA cycling sequence binding protein from L. donovani (LdCSBP). Parasitol Res (2014) 0.75
Up-regulation of SUMO E3 ligases during lung schistosomula and adult worm stages. Parasitol Res (2014) 0.75
The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease. Front Mol Neurosci (2017) 0.75