Published in J Mol Biol on January 13, 2009
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol (2012) 2.47
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80. EMBO J (2009) 2.14
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. Nat Chem Biol (2010) 2.09
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell (2013) 2.05
Mechanism of phospho-ubiquitin-induced PARKIN activation. Nature (2015) 2.02
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature (2013) 1.70
The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature (2012) 1.70
Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radic Biol Med (2011) 1.59
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3. EMBO J (2009) 1.48
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
Assembly, analysis and architecture of atypical ubiquitin chains. Nat Struct Mol Biol (2013) 1.27
Ubiquitin makes its mark on immune regulation. Immunity (2010) 1.25
Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin. J Biol Chem (2009) 1.13
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nat Struct Mol Biol (2013) 1.10
Mixed-linkage ubiquitin chains send mixed messages. Structure (2013) 1.09
Structure and recognition of polyubiquitin chains of different lengths and linkage. F1000 Biol Rep (2011) 1.08
Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest). Nat Protoc (2015) 1.08
OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3. Nat Commun (2013) 1.01
PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications. Cell Biochem Biophys (2011) 1.00
Structural and biochemical studies of the open state of Lys48-linked diubiquitin. Biochim Biophys Acta (2012) 0.97
OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer. Mol Cancer (2014) 0.94
OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance. Oncogene (2015) 0.92
Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks. Mutat Res (2013) 0.86
Activity-based diubiquitin probes for elucidating the linkage specificity of deubiquitinating enzymes. Chem Commun (Camb) (2014) 0.85
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1. World J Biol Chem (2014) 0.84
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination. EMBO Mol Med (2016) 0.82
The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways. Cell Signal (2014) 0.82
Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting. Biochem Biophys Res Commun (2015) 0.82
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. PLoS Biol (2016) 0.82
MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Mol Cell (2016) 0.81
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Sci Signal (2015) 0.79
Nonenzymatic rubylation and ubiquitination of proteins for structural and functional studies. Angew Chem Int Ed Engl (2014) 0.78
OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer. Oncotarget (2016) 0.78
Recent advances in polyubiquitin chain recognition. F1000 Biol Rep (2010) 0.78
Mechanisms for regulating deubiquitinating enzymes. Protein Sci (2014) 0.78
Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins. Angew Chem Int Ed Engl (2013) 0.77
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo. Acta Neuropathol (2017) 0.75
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog (2017) 0.75
Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB(+1). FEBS Lett (2016) 0.75
DNA repair: Blocking ubiquitin transfer. Nature (2010) 0.75
Opposing roles of RNF8/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice. J Radiat Res (2016) 0.75
Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTs. Mol Biol Cell (2017) 0.75
Ubiquitin Chain Enrichment Middle-Down Mass Spectrometry Enables Characterization of Branched Ubiquitin Chains in Cellulo. Anal Chem (2017) 0.75
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature (2004) 12.41
A proteomics approach to understanding protein ubiquitination. Nat Biotechnol (2003) 10.51
Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol (2004) 9.42
A genomic and functional inventory of deubiquitinating enzymes. Cell (2005) 9.36
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (2002) 7.49
Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol (2004) 7.10
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell (1999) 6.56
A cryptic protease couples deubiquitination and degradation by the proteasome. Nature (2002) 6.21
Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta (2004) 6.03
A new protease required for cell-cycle progression in yeast. Nature (1999) 5.44
Ubiquitin-binding domains. Biochem J (2006) 5.32
Ubiquitylation and cell signaling. EMBO J (2005) 4.65
Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta (2004) 4.54
Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Cell Host Microbe (2007) 4.14
DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 3.88
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome. Nature (1997) 3.47
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol (2002) 3.43
Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling. J Biol Chem (2003) 3.30
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
Ubiquitin enters the new millennium. Mol Cell (2001) 2.97
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains. Nature (2008) 2.94
Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome. J Biol Chem (2004) 2.85
Structural properties of polyubiquitin chains in solution. J Mol Biol (2002) 2.72
Lingering mysteries of ubiquitin-chain assembly. Cell (2006) 2.69
AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol (2004) 2.58
Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting. Proc Natl Acad Sci U S A (1996) 2.50
Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Mol Cell (2006) 2.41
A 25-kilodalton ubiquitin carrier protein (E2) catalyzes multi-ubiquitin chain synthesis via lysine 48 of ubiquitin. J Biol Chem (1990) 2.31
Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. Biochemistry (1995) 2.31
ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol Cell (2006) 2.26
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23
Structural basis and specificity of human otubain 1-mediated deubiquitination. Biochem J (2009) 2.12
A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Trends Biochem Sci (2000) 2.01
Structure of the A20 OTU domain and mechanistic insights into deubiquitination. Biochem J (2008) 1.94
Otubains: a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep (2003) 1.90
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J Mol Biol (2007) 1.82
Deubiquitinating enzymes--the importance of driving in reverse along the ubiquitin-proteasome pathway. Int J Biochem Cell Biol (2003) 1.80
UBPY: a growth-regulated human ubiquitin isopeptidase. EMBO J (1998) 1.76
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell (2007) 1.75
Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem (2008) 1.75
A novel type of deubiquitinating enzyme. J Biol Chem (2003) 1.57
Two isoforms of otubain 1 regulate T cell anergy via GRAIL. Nat Immunol (2003) 1.57
Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes. J Biol Chem (1997) 1.56
VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol (2004) 1.55
Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics. Hum Mol Genet (2003) 1.36
Crystal structure of human otubain 2. EMBO Rep (2004) 1.24
Derivitization of the C-terminus of ubiquitin and ubiquitin-like proteins using intein chemistry: methods and uses. Methods Enzymol (2005) 1.23
14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase. Exp Cell Res (2007) 1.10
Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor. J Biol Chem (2005) 0.93
Expression and accurate processing of yeast penta-ubiquitin in Escherichia coli. J Biol Chem (1987) 0.93
Cyclization of polyubiquitin by the E2-25K ubiquitin conjugating enzyme. J Biol Chem (2000) 0.91
Deubiquitinating enzymes: their roles in development, differentiation, and disease. Int Rev Cytol (2003) 0.88
Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol (2004) 7.10
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem (2009) 6.23
A cryptic protease couples deubiquitination and degradation by the proteasome. Nature (2002) 6.21
Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol (2004) 5.14
Atom-by-atom analysis of global downhill protein folding. Nature (2006) 4.50
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
The biochemistry of sirtuins. Annu Rev Biochem (2006) 4.32
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab (2007) 4.16
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep (2009) 3.94
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation. Nat Struct Mol Biol (2006) 3.71
Designing superoleophobic surfaces. Science (2007) 3.56
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol (2002) 3.43
Total synthesis of a functional designer eukaryotic chromosome. Science (2014) 3.31
Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling. J Biol Chem (2003) 3.30
Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat Struct Mol Biol (2005) 3.27
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain. Mol Cell (2005) 2.92
A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal. Nature (2002) 2.86
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res (2008) 2.81
Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol (2004) 2.76
Structural properties of polyubiquitin chains in solution. J Mol Biol (2002) 2.72
A core nucleosome surface crucial for transcriptional silencing. Nat Genet (2002) 2.67
Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. J Biol Chem (2003) 2.57
Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science (2004) 2.50
Robust omniphobic surfaces. Proc Natl Acad Sci U S A (2008) 2.41
Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80. Mol Cell (2009) 2.39
A conserved catalytic residue in the ubiquitin-conjugating enzyme family. EMBO J (2003) 2.37
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell (2005) 2.31
Noncarious cervical lesions and abfractions: a re-evaluation. J Am Dent Assoc (2003) 2.28
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH. J Mol Biol (2006) 2.22
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J Biol Chem (2003) 2.21
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J (2009) 2.17
Protein partners of deubiquitinating enzymes. Biochem J (2008) 2.15
Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure (2008) 2.12
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem (2008) 2.09
The etiology and prevalence of gingival recession. J Am Dent Assoc (2003) 2.06
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nat Struct Mol Biol (2006) 2.03
Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol Cell (2002) 2.00
N-lysine propionylation controls the activity of propionyl-CoA synthetase. J Biol Chem (2007) 1.95
Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+]. Genetics (2004) 1.90
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev (2003) 1.82
The structure and conformation of Lys63-linked tetraubiquitin. J Mol Biol (2009) 1.77
The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases. Trends Cell Biol (2004) 1.76
Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A. J Mol Biol (2004) 1.76
Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem (2008) 1.75
Structural insights into the assembly and function of the SAGA deubiquitinating module. Science (2010) 1.74
Characterization of the overall and local dynamics of a protein with intermediate rotational anisotropy: Differentiating between conformational exchange and anisotropic diffusion in the B3 domain of protein G. J Biomol NMR (2003) 1.72
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem (2003) 1.72
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Mol Cell (2008) 1.71
Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains. J Mol Biol (2007) 1.71
The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature (2012) 1.70
Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool. J Biol Chem (2003) 1.69
SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J Cell Biol (2006) 1.67
A model of interdomain mobility in a multidomain protein. J Am Chem Soc (2007) 1.66
Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure (2006) 1.66
Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase. EMBO J (2006) 1.64
Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. J Biol Chem (2008) 1.64
Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene (2005) 1.64
Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nat Methods (2012) 1.62
Identification and characterization of DEN1, a deneddylase of the ULP family. J Biol Chem (2003) 1.62
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J (2003) 1.61
Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains. Structure (2013) 1.61
Analyses of the effects of all ubiquitin point mutants on yeast growth rate. J Mol Biol (2013) 1.59
Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol Cell (2009) 1.57
Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis. EMBO J (2005) 1.56
Interdomain mobility in di-ubiquitin revealed by NMR. Proteins (2006) 1.55
Antibacterial properties of Ag nanoparticle loaded multilayers and formation of magnetically directed antibacterial microparticles. Langmuir (2005) 1.52
Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A (2009) 1.49
Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. EMBO Rep (2011) 1.47
Together, Rpn10 and Dsk2 can serve as a polyubiquitin chain-length sensor. Mol Cell (2009) 1.47
An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Mol Cell (2006) 1.46
Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways. J Biol Chem (2003) 1.44
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. Sci Signal (2012) 1.40
How does the histone code work? Biochem Cell Biol (2005) 1.40
The structural basis of sirtuin substrate affinity. Biochemistry (2006) 1.40
Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. J Virol (2007) 1.39
Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain. Mol Cell Biol (2006) 1.39
Structural basis for the mechanism and regulation of Sir2 enzymes. Mol Cell (2004) 1.37
Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains. Nat Struct Mol Biol (2009) 1.35
Transparent superhydrophobic films based on silica nanoparticles. Langmuir (2007) 1.34
The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling. Oncogene (2005) 1.33
Distribution and paralogue specificity of mammalian deSUMOylating enzymes. Biochem J (2010) 1.33
Controlled drug release from porous polyelectrolyte multilayers. Biomacromolecules (2006) 1.33