Intranasal vaccination with pneumococcal surface protein A and interleukin-12 augments antibody-mediated opsonization and protective immunity against Streptococcus pneumoniae infection.

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Published in Infect Immun on November 01, 2001

Authors

B P Arulanandam1, J M Lynch, D E Briles, S Hollingshead, D W Metzger

Author Affiliations

1: Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA. metzged@mail.amc.edu

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Subclass restriction of murine anti-carbohydrate antibodies. J Immunol (1978) 4.99

Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenylyltransferase. Plasmid (1985) 4.63

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The release of a platelet-activating factor by stimulated rabbit neutrophils. J Immunol (1979) 2.02

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Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response. Transplantation (2001) 1.90

Human neutrophil-derived platelet activating factor. J Immunol (1980) 1.82

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The primary effect of the Ity locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing. J Immunol (1990) 1.71

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Phytotoxicity of acetic acid produced in the anaerobic decomposition of wheat straw. J Appl Bacteriol (1977) 1.67

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Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults. Clin Pharmacol Ther (2007) 1.61

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Steroids and squalene in Methylococcus capsulatus grown on methane. Nature (1971) 1.60

Ascorbic acid for the common cold. A prophylactic and therapeutic trial. JAMA (1975) 1.56

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The hemolytic and complement-activating properties of pneumolysin do not contribute individually to virulence in a pneumococcal bacteremia model. Microb Pathog (1997) 1.55

Inhibition of specific immune responses by feeding protein antigens. Int Arch Allergy Appl Immunol (1977) 1.54

Variation in the molecular weight of PspA (pneumococcal surface protein A) among Streptococcus pneumoniae. Microb Pathog (1990) 1.53

Distinct functions of antigenic sites of the HN glycoprotein of Sendai virus. Virology (1987) 1.52

Genetic control of the susceptibility to pneumococcal infection. Curr Top Microbiol Immunol (1986) 1.50

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Inhibition of homocytotropic antibody responses in adult inbred mice by previous feeding of the specific antigen. J Allergy Clin Immunol (1977) 1.43

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Pseudobacteremia caused by Clostridium sordellii. Arch Intern Med (1980) 1.29

Resistance to Streptococcus pneumoniae is induced by a phosphocholine-protein conjugate. J Immunol (1983) 1.27

Isoelectric focusing of immunoglobulins: improved methodology. J Immunol Methods (1980) 1.26

Sharing of an idiotypic marker by monoclonal antibodies specific for distinct regions of hen lysozyme. Nature (1980) 1.25

Protein serotyping of Streptococcus pneumoniae based on reactivity to six monoclonal antibodies. Microb Pathog (1988) 1.25

Impact of Field Release of Genetically Modified Pseudomonas fluorescens on Indigenous Microbial Populations of Wheat. Appl Environ Microbiol (1995) 1.25

Clonal dominance. I. Restricted nature of the IgM antibody response to group A streptococcal carbohydrate in mice. J Exp Med (1975) 1.24

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Development of a multi-specificity opsonophagocytic killing assay. Vaccine (2000) 1.22

The purification and characterization of the poison produced by Gonyaulax catenella in axenic culture. Biochemistry (1966) 1.22

A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A. J Immunol (1998) 1.21

Physiological and performance responses to tournament wrestling. Med Sci Sports Exerc (2001) 1.20

Salmonella typhimurium virulence genes necessary to exploit the Itys/s genotype of the mouse. Infect Immun (1986) 1.20

A protective monoclonal antibody that reacts with a novel antigen of pneumococcal teichoic acid. Microb Pathog (1987) 1.18

Clones of Streptococcus pneumoniae isolated from nasopharyngeal carriage and invasive disease in young children in central Tennessee. J Infect Dis (2001) 1.18