Stress and neuroactive steroids.

The role of GABA(A) receptors in the development of alcoholism. Pharmacol Biochem Behav (2008) 1.82

Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy. J Physiol (2004) 1.66

Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin Neurosci (2011) 1.63

Neurosteroid regulation of GABA(A) receptors: Focus on the alpha4 and delta subunits. Pharmacol Ther (2007) 1.50

Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berl) (2006) 1.48

Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice. Alcohol Clin Exp Res (2005) 1.41

Steroid hormone fluctuations and GABA(A)R plasticity. Psychoneuroendocrinology (2009) 1.27

3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neuroscience (2005) 1.22

Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption. Alcohol Res (2012) 1.10

Luteal-phase accentuation of acoustic startle response in women with premenstrual dysphoric disorder. Neuropsychopharmacology (2007) 1.08

Juvenile offspring of rats exposed to restraint stress in late gestation have impaired cognitive performance and dysregulated progestogen formation. Stress (2010) 1.07

Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress. Front Neurosci (2011) 1.04

Basis of the gabamimetic profile of ethanol. Alcohol Clin Exp Res (2006) 1.03

Stress, ethanol, and neuroactive steroids. Pharmacol Ther (2007) 1.01

Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors. Horm Behav (2009) 1.01

Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice. Neuroscience (2007) 0.98

Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior. Proc Natl Acad Sci U S A (2005) 0.95

Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions. Psychoneuroendocrinology (2009) 0.94

Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder. J Neuroendocrinol (2012) 0.92

The relevance of neuroactive steroids in schizophrenia, depression, and anxiety disorders. Cell Mol Neurobiol (2007) 0.87

Effects of stress on responses to methamphetamine in humans. Psychopharmacology (Berl) (2003) 0.86

Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatr Dis Treat (2015) 0.86

S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice. Neuropharmacology (2010) 0.85

Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System. Evid Based Complement Alternat Med (2011) 0.85

Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor. Front Neurosci (2012) 0.85

Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression. Alcohol Clin Exp Res (2009) 0.85

Effects of acute progesterone administration upon responses to acute psychosocial stress in men. Exp Clin Psychopharmacol (2010) 0.85

Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis. Psychoneuroendocrinology (2012) 0.85

Beyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and Emotion. Front Endocrinol (Lausanne) (2011) 0.84

α4βδ GABAA receptors and tonic inhibitory current during adolescence: effects on mood and synaptic plasticity. Front Neural Circuits (2013) 0.84

Neurosteroid modulation of respiratory rhythm in rats during the perinatal period. J Physiol (2006) 0.83

Action by and sensitivity to neuroactive steroids in menstrual cycle related CNS disorders. Psychopharmacology (Berl) (2005) 0.83

Ovarian steroid regulation of the midbrain corticotropin releasing factor and urocortin systems in macaques. Neuroscience (2010) 0.83

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response. Front Neuroendocrinol (2014) 0.82

Differences in the reinstatement of ethanol seeking with ganaxolone and gaboxadol. Neuroscience (2014) 0.81

Unique responses of midbrain CART neurons in macaques to ovarian steroids. Brain Res (2008) 0.81

The influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptor. Neuroscience (2012) 0.81

The neuroenergetics of stress hormones in the hippocampus and implications for memory. Front Neurosci (2015) 0.80

Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. Psychopharmacology (Berl) (2008) 0.80

Environmental stressors influence limited-access ethanol consumption by C57BL/6J mice in a sex-dependent manner. Alcohol (2014) 0.79

Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity. Alcohol (2011) 0.79

Early postnatal stimulation alters pregnane neurosteroids in the hippocampus. Psychopharmacology (Berl) (2006) 0.78

Stress, rejection, and hormones: Cortisol and progesterone reactivity to laboratory speech and rejection tasks in women and men. F1000Res (2014) 0.78

Pregnane xenobiotic receptors and membrane progestin receptors: role in neurosteroid-mediated motivated behaviours. J Neuroendocrinol (2013) 0.77

Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal. Psychopharmacology (Berl) (2014) 0.77

Role of Glia in Stress-Induced Enhancement and Impairment of Memory. Front Integr Neurosci (2016) 0.77

Allopregnanolone's attenuation of the lordosis-inhibiting effects of restraint is blocked by the antiprogestin, CDB-4124. Pharmacol Biochem Behav (2014) 0.77

The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats. Front Syst Neurosci (2014) 0.76

Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress. Schizophr Res (2015) 0.76

Context-dependent memory following recurrent hypoglycaemia in non-diabetic rats is mediated via glucocorticoid signalling in the dorsal hippocampus. Diabetologia (2016) 0.75

Effects of adult exposure to bisphenol a on genes involved in the physiopathology of rat prefrontal cortex. PLoS One (2013) 0.75

Structure-activity relationship studies on neuroactive steroids in memory, alcohol and stress-related functions: a crucial benefit from endogenous level analysis. Psychopharmacology (Berl) (2014) 0.75

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev (1998) 4.37

Neuroactive steroids. FASEB J (1992) 3.41

Neurosteroids act on recombinant human GABAA receptors. Neuron (1990) 2.44

Free tryptophan in serum controls brain tryptophan level and serotonin synthesis. Life Sci II (1973) 1.80

Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem (2000) 1.78

Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites. Brain Res (1999) 1.72

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target. Cancer Res (1996) 1.65

Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice. Cancer Res (1998) 1.64

Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences. J Clin Endocrinol Metab (1998) 1.63

Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc Natl Acad Sci U S A (1998) 1.58

Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer. Lymphology (1999) 1.51

Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one. J Clin Endocrinol Metab (1996) 1.46

Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain. J Neurochem (2000) 1.45

[Cost-effectiveness analysis of serum ferritin screening in periodic physical examinations of women at the fertile age]. Med Clin (Barc) (1996) 1.39

Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress. Neuroendocrinology (1996) 1.36

Ethanol markedly increases "GABAergic" neurosteroids in alcohol-preferring rats. Eur J Pharmacol (1999) 1.32

Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Mol Pharmacol (1990) 1.29

Preparation of I-131-labeled human serum prealbumin and its metabolism in normal and sick patients. J Clin Invest (1965) 1.28

Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sci (1974) 1.26

Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids. Mol Pharmacol (1997) 1.24

Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex. Proc Natl Acad Sci U S A (1977) 1.23

Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes. Mol Pharmacol (1997) 1.21

EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations. J Clin Invest (1994) 1.20

Seroprevalence of and risk factors for HIV-1 infection among female commercial sex workers in South America. Sex Transm Infect (2006) 1.19

The neurosteroids, progesterone and 3alpha,5alpha-THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Res (1998) 1.18

Validation of a harmonized Spanish version of the IPSS: evidence of equivalence with the original American scale. International Prostate Symptom Score. Urology (1998) 1.17

Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors. J Med Chem (1998) 1.15

The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat. Behav Brain Res (1999) 1.14

Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal. J Pharmacol Exp Ther (1996) 1.12

The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. Eur J Pharmacol (1997) 1.12

Patients with premenstrual syndrome have a different sensitivity to a neuroactive steroid during the menstrual cycle compared to control subjects. Neuroendocrinology (1998) 1.11

Circulating levels of anxiolytic steroids in the luteal phase in women with premenstrual syndrome and in control subjects. J Clin Endocrinol Metab (1994) 1.10

Phosphorylation and dephosphorylation of histone (V (H5): controlled condensation of avian erythrocyte chromatin. Appendix: Phosphorylation and dephosphorylation of histone H5. II. Circular dichroic studies. Biochemistry (1977) 1.10

Selection of low investment in sex in a cyclically parthenogenetic rotifer. J Evol Biol (2009) 1.10

Phase II study of pemetrexed in combination with carboplatin in patients with malignant pleural mesothelioma (MPM). Ann Oncol (2007) 1.09

Predictors of adherence to tuberculosis treatment in a supervised therapy programme for prisoners before and after release. Study Group of Adherence to Tuberculosis Treatment of Prisoners. Eur Respir J (1998) 1.09

CD99 engagement: an effective therapeutic strategy for Ewing tumors. Cancer Res (2000) 1.08

Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers. Nutr Metab Cardiovasc Dis (2011) 1.08

Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone. J Pharmacol Exp Ther (2001) 1.07

Allopregnanolone synthesis in cerebellar granule cells: roles in regulation of GABA(A) receptor expression and function during progesterone treatment and withdrawal. Mol Pharmacol (2000) 1.07

How unspecified are disorders of children with a pervasive developmental disorder not otherwise specified? A study of social problems in children with PDD-NOS and ADHD. Eur Child Adolesc Psychiatry (2000) 1.07

Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry. Anal Biochem (2000) 1.07

Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons. Neurosci Lett (1992) 1.07

Effect of the oral administration of tryptophan-free amino acid mixtures on serum tryptophan, brain tryptophan and serotonin metabolism. J Neurochem (1974) 1.06

Selection on life-history traits and genetic population divergence in rotifers. J Evol Biol (2009) 1.06

Potentiation of morphine analgesia by muscimol. Neuropharmacology (1977) 1.06

Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. Histol Histopathol (2004) 1.05

Giant cell tumor of bone: a model for the in vitro human osteoclast characterization. Tumori (1989) 1.05

Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy. Pharmacogenomics J (2011) 1.05

Approaching oropharyngeal dysphagia. Rev Esp Enferm Dig (2004) 1.04

Progesterone, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-5alpha-pregnane-20-one in specific regions of the human female brain in different endocrine states. Brain Res (1997) 1.04

Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol training dose and dosing procedure. J Pharmacol Exp Ther (1999) 1.03

Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: structure-activity studies. J Pharmacol Exp Ther (1994) 1.03

Documentation of subtype C HIV Type 1 strains in Argentina, Paraguay, and Uruguay. AIDS Res Hum Retroviruses (2004) 1.03

Social isolation-induced changes in the hypothalamic-pituitary-adrenal axis in the rat. Stress (2005) 1.03

Paradoxical reactions elicited by diazepam in children with classic autism. Funct Neurol (1988) 1.03

Discriminative stimulus effects of ethanol and 3 alpha-hydroxy-5 alpha-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys (Macaca fascicularis). Psychopharmacology (Berl) (1997) 1.02

Climbing fiver activation and 3', 5'-cyclic guanosine monophosphate (cGMP) content in cortex and deep nuclei of cerebellum. Brain Res (1976) 1.02

Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem (1989) 1.02

Chronic ethanol intoxication induces differential effects on GABAA and NMDA receptor function in the rat brain. Alcohol Clin Exp Res (1993) 1.01

Clinical relevance of Ki-67 expression in bone tumors. Cancer (1995) 1.00

Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol (1993) 1.00

Actions of the general anesthetic propofol on recombinant human GABAA receptors: influence of receptor subunits. J Pharmacol Exp Ther (1995) 1.00

Dissolution properties and anticonvulsant activity of phenytoin-polyethylene glycol 6000 and -polyvinylpyrrolidone K-30 solid dispersions. Int J Pharm (2001) 1.00

Aging is associated with changes in allopregnanolone concentrations in brain, endocrine glands and serum in male rats. Eur J Endocrinol (1998) 1.00

Ethanol-like discriminative stimulus effects of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology (Berl) (1996) 1.00

Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution. Eur J Cell Biol (1995) 0.99

P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy. J Orthop Res (1999) 0.99

Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. Cancer Genet Cytogenet (2000) 0.98

Molecular and functional adaptation of the GABA(A) receptor complex during pregnancy and after delivery in the rat brain. Eur J Neurosci (1998) 0.98

Neurochemical action of the general anaesthetic propofol on the chloride ion channel coupled with GABAA receptors. Brain Res (1991) 0.97

Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function. Pharmacol Biochem Behav (1993) 0.97

Geometry and charge determine pharmacological effects of steroids on N-methyl-D-aspartate receptor-induced Ca(2+) accumulation and cell death. J Pharmacol Exp Ther (2000) 0.97

Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. Am J Pathol (1996) 0.97

Ewing's sarcoma family tumours. Differences in clinicopathological characteristics at presentation between localised and metastatic tumours. J Bone Joint Surg Br (2007) 0.96

The general anesthetic propofol enhances the function of gamma-aminobutyric acid-coupled chloride channel in the rat cerebral cortex. J Neurochem (1990) 0.96

Stress-induced increase in brain neuroactive steroids: antagonism by abecarnil. Pharmacol Biochem Behav (1996) 0.96

Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers. Neuroendocrinology (1993) 0.96

Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites. Eur J Pharmacol (1999) 0.96

Social isolation stress and neuroactive steroids. Eur Neuropsychopharmacol (2006) 0.96

Increase of brain tryptophan and stimulation of serotonin synthesis by salicylate. J Neurochem (1973) 0.95

Redundancy of autocrine loops in human osteosarcoma cells. Int J Cancer (1999) 0.95

The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations. Br J Pharmacol (1997) 0.95

Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain. Anesthesiology (1991) 0.94

The molecular mechanisms responsible for resistance to ET-743 (Trabectidin; Yondelis) in the Ewing's sarcoma cell line, TC-71. Int J Oncol (2005) 0.94

Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function. Mol Pharmacol (1994) 0.93

Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma. Cancer Genet Cytogenet (1998) 0.93

Changes in GABAA receptor gamma 2 subunit gene expression induced by long-term administration of oral contraceptives in rats. Neuropharmacology (2002) 0.93