Published in Proc Natl Acad Sci U S A on January 27, 2005
Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berl) (2006) 1.48
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The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors. J Pharmacol Exp Ther (2010) 1.10
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Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proc Natl Acad Sci U S A (2001) 1.41
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Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss. Neuropharmacology (1999) 1.23
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The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Res Brain Res Rev (2001) 1.19
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Progesterone receptors mediate male aggression toward infants. Proc Natl Acad Sci U S A (2003) 1.17
In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci U S A (2003) 1.14
Neurosteroids, GABAA receptors, and escalated aggressive behavior. Horm Behav (2003) 1.14
On the putative physiological role of allopregnanolone on GABA(A) receptor function. Neuropharmacology (2003) 1.13
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Brain allopregnanolone regulates the potency of the GABA(A) receptor agonist muscimol. Neuropharmacology (2000) 1.03
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Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain. FASEB J (2003) 1.00
The development of standard stimulus animals for mouse (Mus musculus) aggression testing by means of olfactory bulbectomy. Anim Behav (1973) 0.97
Physical provocation potentiates aggression in male rats receiving anabolic androgenic steroids. Horm Behav (2002) 0.95
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Development of a quantitative RT-PCR method to study 5alpha-reductase mRNA isozymes in rat prostate in different androgen status. Prostate (2003) 0.86
Effect of anabolic steroids on behavior and physiological characteristics of female mice. Physiol Behav (1996) 0.83
Precise quantitation of 5alpha-reductase type 1 mRNA by RT-PCR in rat liver and its positive regulation by testosterone and dihydrotestosterone. Biochem Biophys Res Commun (2003) 0.80
Effects of prolonged exposure to anabolic steroids on the behavior of male and female mice. Pharmacol Biochem Behav (1996) 0.80
Glucocorticoids and anabolic/androgenic steroids inhibit the synthesis of GABAergic steroids in rat cortex. Neuropsychobiology (1997) 0.78
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Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A (2005) 3.12
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A (2006) 2.01
DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol (2006) 1.95
GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon. Psychopharmacology (Berl) (2005) 1.82
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry (2005) 1.74
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1. Proc Natl Acad Sci U S A (2005) 1.72
Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics (2007) 1.70
On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res (2002) 1.69
Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berl) (2006) 1.48
The dynamics of DNA methylation in schizophrenia and related psychiatric disorders. Neuropsychopharmacology (2012) 1.40
A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proc Natl Acad Sci U S A (2003) 1.38
Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. Schizophr Res (2007) 1.34
The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia. Pharmacol Ther (2006) 1.32
DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures. Proc Natl Acad Sci U S A (2005) 1.26
Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proc Natl Acad Sci U S A (2007) 1.23
The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes. Mol Pharmacol (2008) 1.22
Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proc Natl Acad Sci U S A (2008) 1.22
Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Neuropharmacology (2012) 1.21
Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics (2010) 1.20
Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry (2006) 1.19
Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population. Schizophr Res (2006) 1.18
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends Pharmacol Sci (2008) 1.17
Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis. Neuropsychopharmacology (2011) 1.17
S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. Neuroreport (2007) 1.17
Histone deacetylase inhibitors decrease reelin promoter methylation in vitro. J Neurochem (2005) 1.16
SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Curr Opin Pharmacol (2009) 1.15
Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function. Neuropharmacology (2004) 1.15
In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci U S A (2003) 1.14
In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas. J Comp Neurol (2002) 1.07
Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochem Res (2008) 1.03
The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics. Curr Opin Pharmacol (2002) 1.02
Reelin down-regulation in mice and psychosis endophenotypes. Neurosci Biobehav Rev (2006) 0.99
Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice. Neuropsychopharmacology (2011) 0.99
Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. Stress (2005) 0.98
Olfactory discrimination learning deficit in heterozygous reeler mice. Brain Res (2003) 0.98
Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proc Natl Acad Sci U S A (2010) 0.97
Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain. Mol Pharmacol (2011) 0.97
GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert Rev Neurother (2009) 0.96
From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia. Epigenetics (2009) 0.96
Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc Natl Acad Sci U S A (2004) 0.95
Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention? Mol Interv (2003) 0.95
GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability. Crit Rev Neurobiol (2003) 0.94
Chromatin, DNA methylation and neuron gene regulation--the purpose of the package. J Psychiatry Neurosci (2005) 0.91
Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc Natl Acad Sci U S A (2006) 0.91
Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. Toxicology (2008) 0.88
Histone methylation at H3K9: evidence for a restrictive epigenome in schizophrenia. Schizophr Res (2013) 0.88
Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem. Neuropharmacology (2008) 0.87
DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain. J Comp Neurol (2012) 0.86
Advancing drug discovery for schizophrenia. Ann N Y Acad Sci (2011) 0.86
Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons. Neuropsychopharmacology (2011) 0.86
Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation. Epigenomics (2009) 0.84
The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. Proc Natl Acad Sci U S A (2008) 0.84
Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity. Neuropharmacology (2004) 0.83
Brain neurosteroids in gender-related aggression induced by social isolation. Crit Rev Neurobiol (2004) 0.83
L-methionine decreases dendritic spine density in mouse frontal cortex. Neuroreport (2010) 0.80
Acute imidazenil treatment after the onset of DFP-induced seizure is more effective and longer lasting than midazolam at preventing seizure activity and brain neuropathology. Toxicol Sci (2010) 0.80
Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives. Pharmacol Biochem Behav (2010) 0.79
Should allosteric positive modulators of GABA(A) receptors be tested in the treatment of schizophrenia? Schizophr Res (2005) 0.79
5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients. Psychopharmacology (Berl) (2014) 0.78
Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage. Neuropharmacology (2011) 0.78
Varenicline treatment decreases DNMT1 mRNA expression in lymphocytes of schizophrenic patients who are cigarette smokers. Schizophr Res (2010) 0.77
Gene profiling of laser-microdissected brain regions and individual cells in drug abuse and schizophrenia research. Methods Mol Biol (2012) 0.77
Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review. Curr Neuropharmacol (2016) 0.76
Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepam. Neuropharmacology (2005) 0.76