Published in Oncogene on October 01, 2001
Structural basis of protein kinase C isoform function. Physiol Rev (2008) 4.00
Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab (2009) 2.81
Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem J (2004) 2.70
CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J Cell Biol (2005) 2.47
Protein kinase C theta (PKCtheta): a key player in T cell life and death. Pharmacol Res (2007) 2.31
RACK1, A multifaceted scaffolding protein: Structure and function. Cell Commun Signal (2011) 2.16
Phototransduction and retinal degeneration in Drosophila. Pflugers Arch (2007) 2.15
Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell (2007) 2.03
RACK1 functions in rice innate immunity by interacting with the Rac1 immune complex. Plant Cell (2008) 1.70
Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy. J Cell Biol (2004) 1.62
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ Res (2012) 1.61
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Asc1p, a WD40-domain containing adaptor protein, is required for the interaction of the RNA-binding protein Scp160p with polysomes. Biochem J (2004) 1.46
Ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase C epsilon. J Neurosci (2008) 1.43
Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol (2007) 1.36
The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta. Mol Cell Biol (2002) 1.30
Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation. J Cereb Blood Flow Metab (2010) 1.21
Wealth of opportunity - the C1 domain as a target for drug development. Curr Drug Targets (2008) 1.21
Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK. Mol Biol Cell (2007) 1.20
Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing. J Biol Chem (2010) 1.19
Rationally designed peptide regulators of protein kinase C. Trends Endocrinol Metab (2008) 1.17
The RACK1 homologue from Trypanosoma brucei is required for the onset and progression of cytokinesis. J Biol Chem (2006) 1.14
P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras. PLoS One (2008) 1.12
RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. Mol Biol Cell (2008) 1.11
Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. Front Immunol (2012) 1.06
Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. IUBMB Life (2008) 1.06
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae. Eukaryot Cell (2006) 1.06
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation. Cell Microbiol (2008) 1.05
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem (2008) 1.04
The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation. Mol Cell Biol (2010) 1.03
PKCalpha: a versatile key for decoding the cellular calcium toolkit. J Cell Biol (2006) 1.01
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Biochem J (2006) 1.01
Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem (2011) 0.96
A spatiotemporally coordinated cascade of protein kinase C activation controls isoform-selective translocation. Mol Cell Biol (2006) 0.94
Rational design of drugs that induce human immunodeficiency virus replication. J Virol (2003) 0.93
Improved spatial learning in aged rats by genetic activation of protein kinase C in small groups of hippocampal neurons. Hippocampus (2009) 0.93
Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. J Biol Chem (2010) 0.93
Intracellular interaction of interleukin (IL)-32α with protein kinase Cε (PKCε ) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells. J Biol Chem (2012) 0.91
Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Int J Biochem Cell Biol (2010) 0.91
Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation. Cancer Res (2009) 0.90
RACK1, a PKC targeting protein, is exclusively localized to basal airway epithelial cells. J Histochem Cytochem (2007) 0.89
RACK-1 acts with Rac GTPase signaling and UNC-115/abLIM in Caenorhabditis elegans axon pathfinding and cell migration. PLoS Genet (2010) 0.88
RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. J Biol Chem (2008) 0.87
Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity. J Biol Chem (2008) 0.87
Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. J Biol Chem (2012) 0.86
Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface. Langmuir (2008) 0.85
Angiopoietin-like 4 regulates epidermal differentiation. PLoS One (2011) 0.85
Receptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction. J Biol Chem (2011) 0.85
Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome. J Struct Biol (2012) 0.85
Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. J Cell Mol Med (2008) 0.82
Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1. Small GTPases (2011) 0.82
Protein kinase C and acute respiratory distress syndrome. Shock (2013) 0.82
RACK-1 overexpression protects against goniothalamin-induced cell death. Toxicol Lett (2009) 0.82
Synthetic Lethality Induced by Loss of PKC δ and Mutated Ras. Genes Cancer (2010) 0.82
Interaction of MCM7 and RACK1 for activation of MCM7 and cell growth. Am J Pathol (2013) 0.81
Walleye dermal sarcoma virus Orf B functions through receptor for activated C kinase (RACK1) and protein kinase C. Virology (2008) 0.81
Sprouty2 interacts with protein kinase C delta and disrupts phosphorylation of protein kinase D1. J Biol Chem (2009) 0.80
The WD repeat protein FAN regulates lysosome size independent from abnormal downregulation/membrane recruitment of protein kinase C. Exp Cell Res (2007) 0.80
P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state. PLoS One (2009) 0.79
Function of RasGRP3 in the formation and progression of human breast cancer. Mol Cancer (2014) 0.78
Trypanosomatid RACK1 orthologs show functional differences associated with translation despite similar roles in Leishmania pathogenesis. PLoS One (2011) 0.78
The Novel PKCθ from Benchtop to Clinic. J Immunol Res (2015) 0.78
PKCη/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis. PLoS Pathog (2015) 0.78
Alcohol binding in the C1 (C1A+C1B) domain of protein kinase C epsilon. Biochim Biophys Acta (2015) 0.76
Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1. PLoS One (2014) 0.76
Protein kinase C: an attractive target for cancer therapy. Cancers (Basel) (2011) 0.75
Kidney kinase network regulates renal ion cotransport. J Clin Invest (2007) 0.75
Thienoquinolines as novel disruptors of the PKCε/RACK2 protein-protein interaction. J Med Chem (2014) 0.75
Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens. J Neurosci Res (2016) 0.75
Quantitative Proteomic Profiling of Low-Dose Ionizing Radiation Effects in a Human Skin Model. Proteomes (2014) 0.75
Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors. Int J Parasitol Drugs Drug Resist (2016) 0.75
Rational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changes. Sci Rep (2016) 0.75
Spatio-Temporal Regulation of PKC Isoforms Imparts Signaling Specificity. Front Immunol (2016) 0.75
Multiple signals regulate phospholipase CBeta3 in human myometrial cells. Biol Reprod (2008) 0.75
Specific subcellular targeting of PKCalpha and PKCepsilon in normal and tumoral lactotroph cells by PMA-mitogenic stimulus. J Mol Histol (2010) 0.75
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Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci U S A (2001) 3.28
Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol (2000) 3.13
Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Natl Acad Sci U S A (1999) 2.44
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J Neurosci (2000) 2.20
A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. J Biol Chem (1996) 2.16
A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. J Biol Chem (1997) 2.03
C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo. J Biol Chem (1995) 1.82
Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res (1994) 1.82
The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon. J Biol Chem (1997) 1.76
Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J Biol Chem (1998) 1.74
An autoregulatory region in protein kinase C: the pseudoanchoring site. Proc Natl Acad Sci U S A (1995) 1.67
Domain structure and phosphorylation of protein kinase C. J Biol Chem (1987) 1.65
Peptide modulators of protein-protein interactions in intracellular signaling. Nat Biotechnol (1998) 1.62
Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chem Biol (2001) 1.58
Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C. J Biol Chem (2001) 1.50
An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia. J Biol Chem (1999) 1.42
Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity. Proc Natl Acad Sci U S A (1986) 1.40
Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. J Biol Chem (1997) 1.40
Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes. J Mol Cell Cardiol (1999) 1.33
RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry (1999) 1.27
Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage. Biochem Soc Trans (2007) 1.24
Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C. Proc Natl Acad Sci U S A (1999) 1.23
Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells. J Cell Biol (1994) 1.23
An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research. Circ Res (1996) 1.17
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Opposing effects of delta and xi PKC in ethanol-induced cardioprotection. J Mol Cell Cardiol (2001) 1.13
The HIV nef protein associates with protein kinase C theta. J Biol Chem (1996) 1.12
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. Proc Natl Acad Sci U S A (1995) 1.10
Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme. Circ Res (1995) 1.09
Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation. Pharmacol Res (1999) 1.06
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An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters. J Biol Chem (1997) 1.01
Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. Oncogene (2010) 1.00
Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain. Proc Natl Acad Sci U S A (1987) 0.99
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Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells. Cell Growth Differ (1994) 0.93
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channels. Am J Physiol Cell Physiol (2001) 0.92
Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis. J Biol Chem (1999) 0.91
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Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C. Cardiovasc Res (2001) 0.90
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Exposure of HeLa DNA polymerase alpha to protein kinase C affects its catalytic properties. J Biol Chem (1987) 0.89
The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae. Proc Biol Sci (1991) 0.88
Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene (2011) 0.87
Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C. Proc Natl Acad Sci U S A (1994) 0.87
The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism. Ann N Y Acad Sci (1991) 0.86
Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C. FEBS Lett (1999) 0.86
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Islet cell survival during isolation improved through protein kinase C epsilon activation. Transplant Proc (2008) 0.82
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