Published in Life Sci on January 01, 1995
A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group. N Engl J Med (2000) 4.54
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc Natl Acad Sci U S A (1994) 3.95
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci U S A (2001) 3.28
Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol (2000) 3.13
Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Natl Acad Sci U S A (1999) 2.44
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J Neurosci (2000) 2.20
A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. J Biol Chem (1996) 2.16
A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. J Biol Chem (1997) 2.03
Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene (2001) 1.99
C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo. J Biol Chem (1995) 1.82
Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res (1994) 1.82
The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon. J Biol Chem (1997) 1.76
Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J Biol Chem (1998) 1.74
An autoregulatory region in protein kinase C: the pseudoanchoring site. Proc Natl Acad Sci U S A (1995) 1.67
Domain structure and phosphorylation of protein kinase C. J Biol Chem (1987) 1.65
Peptide modulators of protein-protein interactions in intracellular signaling. Nat Biotechnol (1998) 1.62
Topotecan versus observation after cisplatin plus etoposide in extensive-stage small-cell lung cancer: E7593--a phase III trial of the Eastern Cooperative Oncology Group. J Clin Oncol (2001) 1.58
Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chem Biol (2001) 1.58
Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer. Eastern Cooperative Oncology Group. Ann Thorac Surg (2000) 1.50
Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C. J Biol Chem (2001) 1.50
An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia. J Biol Chem (1999) 1.42
Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity. Proc Natl Acad Sci U S A (1986) 1.40
Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. J Biol Chem (1997) 1.40
Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes. J Mol Cell Cardiol (1999) 1.33
Induction chemotherapy with docetaxel, cisplatin, fluorouracil, and leucovorin for squamous cell carcinoma of the head and neck: a phase I/II trial. J Clin Oncol (1998) 1.33
Phase II trial of docetaxel, cisplatin, fluorouracil, and leucovorin as induction for squamous cell carcinoma of the head and neck. J Clin Oncol (1999) 1.28
RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry (1999) 1.27
Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage. Biochem Soc Trans (2007) 1.24
Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C. Proc Natl Acad Sci U S A (1999) 1.23
Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells. J Cell Biol (1994) 1.23
An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research. Circ Res (1996) 1.17
The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury. Biochem Soc Trans (2007) 1.17
Agonists and antagonists of protein kinase C function, derived from its binding proteins. J Biol Chem (1994) 1.14
Opposing effects of delta and xi PKC in ethanol-induced cardioprotection. J Mol Cell Cardiol (2001) 1.13
The HIV nef protein associates with protein kinase C theta. J Biol Chem (1996) 1.12
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. Proc Natl Acad Sci U S A (1995) 1.10
Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme. Circ Res (1995) 1.09
A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase. J Biol Chem (2001) 1.08
Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation. Pharmacol Res (1999) 1.06
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry (1987) 1.06
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels. Am J Physiol Heart Circ Physiol (2000) 1.04
Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis. J Cell Biol (1996) 1.04
C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels. Circ Res (1997) 1.03
Monoclonal anti-acetylcholine-receptor antibodies directed against the cholinergic binding site. Biochemistry (1981) 1.03
Localization, anchoring, and functions of protein kinase C isozymes in the heart. J Mol Cell Cardiol (2001) 1.02
Genome-wide pathway analysis and visualization using gene expression data. Pac Symp Biocomput (2002) 1.01
Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme. Biochem Biophys Res Commun (1992) 1.01
An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters. J Biol Chem (1997) 1.01
Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. Oncogene (2010) 1.00
Regulation of the properties of the heme-NO complexes in nitric-oxide synthase by hydrogen bonding to the proximal cysteine. J Biol Chem (2001) 1.00
Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain. Proc Natl Acad Sci U S A (1987) 0.99
Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption. Proc Natl Acad Sci U S A (1998) 0.97
Interaction of monoclonal antibodies to Torpedo acetylcholine receptor with the receptor of skeletal muscle. Muscle Nerve (1983) 0.93
Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells. Cell Growth Differ (1994) 0.93
Hypothyroidism incidence after multimodality treatment for stage III and IV squamous cell carcinomas of the head and neck. Int J Radiat Oncol Biol Phys (2001) 0.92
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channels. Am J Physiol Cell Physiol (2001) 0.92
Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis. J Biol Chem (1999) 0.91
Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic. Biochem Soc Trans (2007) 0.90
Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C. Cardiovasc Res (2001) 0.90
Exposure of HeLa DNA polymerase alpha to protein kinase C affects its catalytic properties. J Biol Chem (1987) 0.89
Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs. J Membr Biol (1983) 0.89
The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae. Proc Biol Sci (1991) 0.88
Phase I/II trial of outpatient docetaxel, cisplatin, 5-fluorouracil, leucovorin (opTPFL) as induction for squamous cell carcinoma of the head and neck (SCCHN). Am J Clin Oncol (2002) 0.88
A phase II study of gemcitabine and 5-fluorouracil in metastatic pancreatic cancer: an Eastern Cooperative Oncology Group Study (E3296). Oncology (2000) 0.88
Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C. Proc Natl Acad Sci U S A (1994) 0.87
Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene (2011) 0.87
Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C. FEBS Lett (1999) 0.86
The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism. Ann N Y Acad Sci (1991) 0.86
DeltaPKC-mediated activation of epsilonPKC in ethanol-induced cardiac protection from ischemia. J Mol Cell Cardiol (2005) 0.83
The influence of gender on survival and tumor recurrence following adjuvant therapy of completely resected stages II and IIIa non-small cell lung cancer. Lung Cancer (2002) 0.83
Chronic ethanol-induced heterologous desensitization is mediated by changes in adenosine transport. Biochem Soc Symp (1990) 0.83
Quality of life assessment in advanced non-small-cell lung cancer patients undergoing an accelerated radiotherapy regimen: report of ECOG study 4593. Eastern Cooperative Oncology Group. Int J Radiat Oncol Biol Phys (2001) 0.83
A phase II study of combined oral uracil and ftorafur with leucovorin for patients with squamous cell carcinoma of the head and neck. Cancer (2001) 0.82
Islet cell survival during isolation improved through protein kinase C epsilon activation. Transplant Proc (2008) 0.82
An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin. FEBS Lett (1983) 0.82
Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes. J Mol Cell Cardiol (1995) 0.82
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase. J Biol Chem (1999) 0.81
Antigenic specificity of acetylcholine receptor in developing muscle. Studies with monoclonal antibodies. J Neuroimmunol (1985) 0.81
A phase II trial of palliative docetaxel plus 5-fluorouracil for squamous-cell cancer of the head and neck. Ann Oncol (2000) 0.80
Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation. J Neurosci (1992) 0.80
Mechanism of inhibition of horseradish peroxidase-catalysed iodide oxidation by EDTA. Biochem J (1994) 0.80
Acetylcholine receptor: molecular dissection and monoclonal antibodies in the study of experimental myasthenia. Ann N Y Acad Sci (1981) 0.79
Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia. J Mol Cell Cardiol (2000) 0.79
Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells. J Invest Dermatol (1996) 0.79
Characterization of sheep lacrimal-gland peroxidase and its major physiological electron donor. Biochem J (1996) 0.79
Phase II trial of hyperfractionated accelerated radiation therapy for nonresectable non-small-cell lung cancer: results of Eastern Cooperative Oncology Group 4593. J Clin Oncol (1998) 0.78
Developmental expression of protein kinase C subspecies in rat brain-pituitary axis. Mol Cell Endocrinol (1994) 0.77
Mechanism-based inactivation of lacrimal-gland peroxidase by phenylhydrazine: a suicidal substrate to probe the active site. Biochem J (1997) 0.75
Immune regulation of experimental myasthenia. J Neurol Neurosurg Psychiatry (1980) 0.75
Modification of acetylcholine receptor: chemical and immunological characterization of polyalanyl acetylcholine receptor. FEBS Lett (1980) 0.75
Molecular aspects of experimental autoimmune myasthenia gravis. Prog Clin Biol Res (1981) 0.75
Survival analysis with time-varying relative risks: a tree-based approach. Methods Inf Med (2001) 0.75
Molecular genetic approaches. II. Expression-interaction cloning. Methods Mol Biol (1998) 0.75
Comparison of the QTDT analysis for IgE in the CSGA data set. Genet Epidemiol (2001) 0.75