Published in Circulation on October 30, 2001
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci U S A (2002) 4.03
Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci U S A (2008) 2.65
Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol (2010) 2.18
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov (2009) 2.10
HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest (2003) 1.99
HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood (2007) 1.87
Metabolic shifts in immunity and inflammation. J Immunol (2010) 1.45
Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism. PLoS One (2016) 1.40
Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor. Kidney Int (2017) 1.38
Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface. Trends Cardiovasc Med (2008) 1.36
Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterology (2011) 1.26
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation (2010) 1.20
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev (2014) 1.09
HIF hydroxylase pathways in cardiovascular physiology and medicine. Circ Res (2015) 1.00
Angiogenesis: a curse or cure? Postgrad Med J (2005) 0.97
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell (2016) 0.93
Hypoxia and Mucosal Inflammation. Annu Rev Pathol (2016) 0.87
Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury. Int Immunol (2009) 0.86
Metabolic regulation of intestinal epithelial barrier during inflammation. Tissue Barriers (2015) 0.85
Conditional knockout of prolyl hydroxylase domain protein 2 attenuates high fat-diet-induced cardiac dysfunction in mice. PLoS One (2014) 0.81
Tissue inhibitor of matrix metalloproteinase-3 or vascular endothelial growth factor transfection of aged human mesenchymal stem cells enhances cell therapy after myocardial infarction. Rejuvenation Res (2012) 0.81
PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban. J Clin Invest (2015) 0.79
Physiological Implications of Myocardial Scar Structure. Compr Physiol (2015) 0.78
Incorporation of a prolyl hydroxylase inhibitor into scaffolds: a strategy for stimulating vascularization. Tissue Eng Part A (2015) 0.75
Systems biology-opportunities and challenges: the application of proteomics to study the cardiovascular extracellular matrix. Cardiovasc Res (2016) 0.75
Prolyl 4 hydroxylase: a critical target in the pathophysiology of diseases. Korean J Physiol Pharmacol (2013) 0.75
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell (1999) 11.59
Mutation detection and single-molecule counting using isothermal rolling-circle amplification. Nat Genet (1998) 9.84
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med (2001) 6.97
Revealing the maximum strength in nanotwinned copper. Science (2009) 6.27
Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc Natl Acad Sci U S A (2001) 5.08
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell (1996) 3.55
Quantitative interpretation of magnetization transfer. Magn Reson Med (1993) 3.55
Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci U S A (2000) 3.47
A prognostic score for patients with lower risk myelodysplastic syndrome. Leukemia (2007) 3.45
TGF-beta is a critical mediator of acute lung injury. J Clin Invest (2001) 3.29
Smoking duration, intensity, and risk of Parkinson disease. Neurology (2010) 3.19
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene (2006) 3.10
Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays. Genome Res (2000) 2.79
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem (1998) 2.78
The fibronectin type III domain as a scaffold for novel binding proteins. J Mol Biol (1998) 2.65
Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J (1999) 2.50
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J (2001) 2.41
Watching the growth of bulk grains during recrystallization of deformed metals. Science (2004) 2.38
Measles, mumps, and rubella (MMR) vaccine and autism. Ecological studies cannot answer main question. BMJ (2001) 2.15
Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process. Biochemistry (1995) 2.13
Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Neuron (2000) 2.12
Prognostic factors for progression-free and overall survival with sunitinib targeted therapy and with cytokine as first-line therapy in patients with metastatic renal cell carcinoma. Ann Oncol (2010) 2.06
Context sequences of translation initiation codon in plants. Plant Mol Biol (1997) 2.05
A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles. J Am Chem Soc (2001) 1.99
Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans. J Exp Med (1993) 1.94
Residue-based control of helix shape in beta-peptide oligomers. Nature (1997) 1.94
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil (2011) 1.93
Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes (1996) 1.85
The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther (1994) 1.82
Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. J Neurochem (2000) 1.82
Architecture for a Web-based clinical information system that keeps the design open and the access closed. Proc AMIA Symp (1998) 1.79
Vascular endothelial growth factor as a marker of tumor endothelium. Cancer Res (1998) 1.78
Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci U S A (1993) 1.72
Induction of type I diabetes by interferon-alpha in transgenic mice. Science (1993) 1.68
The diagnosis and treatment of dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg (2009) 1.67
Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest (1997) 1.66
An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways. Leukemia (2011) 1.61
Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase. Nat Genet (1995) 1.61
Chromosomal instability and cytoskeletal defects in oral cancer cells. Proc Natl Acad Sci U S A (2000) 1.60
Hypoxia-associated induction of early growth response-1 gene expression. J Biol Chem (1999) 1.60
Early and late long-term effects of vasectomy on serum testosterone, dihydrotestosterone, luteinizing hormone and follicle-stimulating hormone levels. J Urol (1995) 1.59
Structural features of peptide analogs of human histocompatibility leukocyte antigen class I epitopes that are more potent and immunogenic than wild-type peptide. J Exp Med (2001) 1.57
COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem (1999) 1.57
Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects. Kidney Int (2006) 1.50
On the relationship between human all-cause mortality and age. Eur J Epidemiol (2003) 1.49
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. J Biol Chem (1999) 1.48
A reversible structural interconversion involving [M(H2pdc)2(H2O)2] . 2H2O (M = Mn, Fe, Co, Ni, Zn, H3pdc = 3,5-pyrazoledicarboxylic acid) and the role of a reactive intermediate [Co(H2pdc)2]. Chemistry (2001) 1.47
Tetracycline-regulated cardiac gene expression in vivo. J Clin Invest (1994) 1.46
Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. J Cell Sci (2001) 1.46
A new procedure for correction of severe inverted nipple with two triangular areolar dermofibrous flaps. Aesthetic Plast Surg (2008) 1.46
A three-dimensional analysis of a bioprosthetic heart valve. J Biomech (1991) 1.43
The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia (2011) 1.43
Up-regulation of macrophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitis. Histopathology (2005) 1.42
Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice. Am J Physiol Gastrointest Liver Physiol (2007) 1.42
Physical activities and future risk of Parkinson disease. Neurology (2010) 1.42
Cytogenetical diagnosis in paraffin-embedded fetoplacental tissue using comparative genomic hybridization. Prenat Diagn (2000) 1.39
Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation. Cytometry A (2003) 1.37
Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets. Am J Hum Genet (1997) 1.37
An efficient intermolecular palladium-catalyzed synthesis of aryl ethers. J Am Chem Soc (2001) 1.37
Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Curr Biol (2001) 1.36
beta-adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. Am J Physiol (1998) 1.35
Induction of H2AX phosphorylation in pulmonary cells by tobacco smoke: a new assay for carcinogens. Cell Cycle (2004) 1.33
Hormonal modulation of a gene injected into rat heart in vivo. Proc Natl Acad Sci U S A (1991) 1.31
Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake. J Lipid Res (1997) 1.30
High-resolution three-dimensional partially coherent diffraction imaging. Nat Commun (2012) 1.29
Adult acute erythroleukemia: an analysis of 91 patients treated at a single institution. Leukemia (2009) 1.28
Experimental demonstration of isotropic negative permeability in a three-dimensional dielectric composite. Phys Rev Lett (2008) 1.27
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126. Biochemistry (2001) 1.26
Nodular fasciitis in the orofacial region. Int J Oral Maxillofac Surg (2006) 1.25
Communication signals and sound production mechanisms of mormyrid electric fish. J Exp Biol (1999) 1.25
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc. J Biol Chem (2000) 1.24
Microtubule contribution to the reflectance of the retinal nerve fiber layer. Invest Ophthalmol Vis Sci (1998) 1.21
Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J Neurochem (1996) 1.21
Anoikis and metastatic potential of cloudman S91 melanoma cells. Cancer Res (2001) 1.21
Loss of atm radiosensitizes multiple p53 null tissues. Cancer Res (1998) 1.20
Role of air distribution in SARS transmission during the largest nosocomial outbreak in Hong Kong. Indoor Air (2005) 1.20
A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology. BMC Public Health (2001) 1.20
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis. Cell Prolif (2006) 1.19
The effect of pH on the dimensionality of coordination polymers. Inorg Chem (2001) 1.19
Measurement of the negative muon anomalous magnetic moment to 0.7 ppm. Phys Rev Lett (2004) 1.19
Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol (1989) 1.18
T-bet expression is upregulated in active Behçet's disease. Br J Ophthalmol (2003) 1.18
Myeloblasts from Down syndrome children with acute myeloid leukemia have increased in vitro sensitivity to cytosine arabinoside and daunorubicin. Leukemia (1997) 1.18
Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study. J Mol Biol (1996) 1.17
Molecular and phenotypic mapping of the short arm of chromosome 5: sublocalization of the critical region for the cri-du-chat syndrome. Hum Mol Genet (1994) 1.16
PKC-beta is not necessary for cardiac hypertrophy. Am J Physiol Heart Circ Physiol (2001) 1.16
Effects of reactive oxygen species from activated leucocytes on human sperm motility, viability and morphology. Andrologia (2011) 1.15
Response of avian embryonic brain to spatially segmented x-ray microbeams. Cell Mol Biol (Noisy-le-grand) (2001) 1.15
Arsenic trioxide induces multiple myeloma cell apoptosis via disruption of mitochondrial transmembrane potentials and activation of caspase-3. Chin Med J (Engl) (2001) 1.15
A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy (2011) 1.14
Serodiagnosis of Toxoplasma gondii infection in cats by enzyme-linked immunosorbent assay using recombinant SAG1. Vet Parasitol (2001) 1.14
Enzyme-linked immunosorbent assay for microcystins in blue-green algal blooms. J Assoc Off Anal Chem (1990) 1.14
Cardiac adaptations to chronic exercise in mice. Am J Physiol (1994) 1.13
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry (2000) 1.13
Three-dimensional orientation mapping in the transmission electron microscope. Science (2011) 1.13
Novel production of interleukin-1 receptor antagonist peptides in normal human cornea. J Clin Invest (1995) 1.13
Task specific influences of Parkinson's disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries. Neuroscience (2007) 1.12