Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMID 10801774)

Published in J Biol Chem on June 30, 2000

Authors

M P Cuajungco1, L E Goldstein, A Nunomura, M A Smith, J T Lim, C S Atwood, X Huang, Y W Farrag, G Perry, A I Bush

Author Affiliations

1: Laboratory for Oxidation Biology, Genetics and Aging Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

Articles citing this

Regional brain hypometabolism is unrelated to regional amyloid plaque burden. Brain (2015) 1.58

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J Alzheimers Dis (2010) 1.54

Copper in the brain and Alzheimer's disease. J Biol Inorg Chem (2009) 1.40

Metals and amyloid-beta in Alzheimer's disease. Int J Exp Pathol (2005) 1.19

Mysterious oligomerization of the amyloidogenic proteins. FEBS J (2010) 1.14

A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation. Chembiochem (2010) 1.12

Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology. J Nutr Health Aging (2006) 1.09

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease. Neuroimage (2009) 1.07

Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Dis (2009) 1.06

The galvanization of beta-amyloid in Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 1.05

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochim Biophys Acta (2008) 1.01

Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide. Biophys J (2007) 0.98

Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol (2013) 0.97

Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies. Drugs Aging (2010) 0.95

Cu(II) mediates kinetically distinct, non-amyloidogenic aggregation of amyloid-beta peptides. J Biol Chem (2011) 0.94

Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective? Int J Exp Pathol (2005) 0.94

Promotion of oxidative lipid membrane damage by amyloid beta proteins. Biochemistry (2005) 0.93

Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis. Expert Rev Neurother (2010) 0.93

Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease. Mol Neurodegener (2013) 0.92

Effect of zinc binding on β-amyloid structure and dynamics: implications for Aβ aggregation. Biophys J (2011) 0.90

Ab initio modelling of the structure and redox behaviour of copper(I) bound to a His-His model peptide: relevance to the beta-amyloid peptide of Alzheimer's disease. J Biol Inorg Chem (2006) 0.89

FoxO mediates APP-induced AICD-dependent cell death. Cell Death Dis (2014) 0.88

Effect of metals on kinetic pathways of amyloid-β aggregation. Biomolecules (2014) 0.87

Zinc and its effects on oxidative stress in Alzheimer's disease. Neurol Sci (2014) 0.85

Biometals and their therapeutic implications in Alzheimer's disease. Neurotherapeutics (2015) 0.85

β-amyloid fibrils in Alzheimer disease are not inert when bound to copper ions but can degrade hydrogen peroxide and generate reactive oxygen species. J Biol Chem (2014) 0.84

Frontiers in Alzheimer's disease therapeutics. Ther Adv Chronic Dis (2011) 0.84

Novel therapeutics for Alzheimer's disease: an update. Curr Opin Drug Discov Devel (2010) 0.84

Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons. J Biol Chem (2012) 0.83

The mechanism for heme to prevent Aβ(1-40) aggregation and its cytotoxicity. J Biol Inorg Chem (2011) 0.82

Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain. PLoS One (2010) 0.82

The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons. PLoS One (2010) 0.82

Links between copper and cholesterol in Alzheimer's disease. Front Physiol (2013) 0.81

Protein phosphatase 5 protects neurons against amyloid-beta toxicity. J Neurochem (2009) 0.80

Early onset Alzheimer's disease and oxidative stress. Oxid Med Cell Longev (2014) 0.79

Alzheimer's Disease: Mechanism and Approach to Cell Therapy. Int J Mol Sci (2015) 0.79

Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim. J Neural Transm (Vienna) (2011) 0.79

Zinc and the aging brain. Genes Nutr (2013) 0.77

Amyloid-modifying therapies for Alzheimer's disease: therapeutic progress and its implications. Age (Dordr) (2010) 0.77

A potential role for zinc alterations in the pathogenesis of Alzheimer's disease. Biofactors (2012) 0.77

Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer's disease that exhibit neurodegeneration. Biomed Spectrosc Imaging (2013) 0.77

Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds. Oxid Med Cell Longev (2015) 0.77

Endogenous zinc in neurological diseases. J Clin Neurol (2005) 0.76

Metals and Neurodegeneration. F1000Res (2016) 0.76

Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides. Inorg Chem (2016) 0.75

Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer's Amyloid-β Peptides. PLoS One (2016) 0.75

Cyclic peptidomimetic lead compounds to reduce neurotoxicity and associated oxidative stress in Alzheimer's disease. Int J Biomed Sci (2010) 0.75

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson's disease. Sci Rep (2016) 0.75

The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer's Disease. Evid Based Complement Alternat Med (2016) 0.75

How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study. Dalton Trans (2016) 0.75

Divalent copper ion bound amyloid-β(40) and amyloid-β(42) alloforms are less preferred than divalent zinc ion bound amyloid-β(40) and amyloid-β(42) alloforms. J Biol Inorg Chem (2016) 0.75

Amyloid plaques beyond Aβ: a survey of the diverse modulators of amyloid aggregation. Biophys Rev (2017) 0.75

Articles by these authors

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell (1999) 11.59

Mutation detection and single-molecule counting using isothermal rolling-circle amplification. Nat Genet (1998) 9.84

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol (1999) 7.69

B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med (2001) 6.97

Revealing the maximum strength in nanotwinned copper. Science (2009) 6.27

Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA (1996) 5.31

Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc Natl Acad Sci U S A (2001) 5.08

Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol (2001) 4.80

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42

Mitochondrial abnormalities in Alzheimer's disease. J Neurosci (2001) 4.39

Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell (2001) 4.21

New ages for the last Australian megafauna: continent-wide extinction about 46,000 years ago. Science (2001) 3.91

Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83

Early care limitations independently predict mortality after intracerebral hemorrhage. Neurology (2007) 3.73

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell (1996) 3.55

Quantitative interpretation of magnetization transfer. Magn Reson Med (1993) 3.55

Multidimensional model of racial identity: a reconceptualization of African American racial identity. Pers Soc Psychol Rev (1998) 3.54

Copernicus revisited: amyloid beta in Alzheimer's disease. Neurobiol Aging (2001) 3.48

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci U S A (1997) 3.47

Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci U S A (2000) 3.47

A prognostic score for patients with lower risk myelodysplastic syndrome. Leukemia (2007) 3.45

Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ Res (1997) 3.41

The family health worker. Am J Public Health Nations Health (1968) 3.34

TGF-beta is a critical mediator of acute lung injury. J Clin Invest (2001) 3.29

Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality. J Natl Cancer Inst (1999) 3.25

Smoking duration, intensity, and risk of Parkinson disease. Neurology (2010) 3.19

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene (2006) 3.10

Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci (1997) 3.08

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc Natl Acad Sci U S A (1987) 2.97

Projected costs of ischemic stroke in the United States. Neurology (2006) 2.93

Upright tilt testing in evaluating syncope: a comprehensive literature review. Am J Med (1994) 2.90

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci (1999) 2.86

Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc Natl Acad Sci U S A (1985) 2.86

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature (1997) 2.86

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem (1997) 2.80

Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays. Genome Res (2000) 2.79

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem (1998) 2.78

Late mortality after surgery for peptic ulcer. N Engl J Med (1982) 2.73

Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging (1997) 2.69

The fibronectin type III domain as a scaffold for novel binding proteins. J Mol Biol (1998) 2.65

The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry (1999) 2.58

Oxidative damage in Alzheimer's. Nature (1996) 2.55

Ricinoleic acid biosynthesis and triacylglycerol assembly in microsomal preparations from developing castor-bean (Ricinus communis) endosperm. Biochem J (1991) 2.53

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci (2000) 2.52

Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J (1999) 2.50

Direction of reading of the genetic message. J Biol Chem (1965) 2.43

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J (2001) 2.41

Watching the growth of bulk grains during recrystallization of deformed metals. Science (2004) 2.38

Cancer surveillance series: recent trends in childhood cancer incidence and mortality in the United States. J Natl Cancer Inst (1999) 2.38

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell (1995) 2.37

Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J Surg Pathol (1996) 2.36

Serum transaminases during salicylate therapy. Br Med J (1971) 2.34

Radical AGEing in Alzheimer's disease. Trends Neurosci (1995) 2.32

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol (1999) 2.31

The rational clinical examination. Does this patient have strep throat? JAMA (2000) 2.30

Lead exposure and children's intellectual performance. Int J Epidemiol (1987) 2.30

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem (1999) 2.30

Total body calcium in rheumatoid arthritis: effects of disease activity and corticosteroid treatment. Br Med J (Clin Res Ed) (1982) 2.24

National cancer clinical trials: children have equal access; adolescents do not. J Adolesc Health (1997) 2.17

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J Biol Chem (1990) 2.16

Measles, mumps, and rubella (MMR) vaccine and autism. Ecological studies cannot answer main question. BMJ (2001) 2.15

Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process. Biochemistry (1995) 2.13

Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Neuron (2000) 2.12

Identification of agrin, a synaptic organizing protein from Torpedo electric organ. J Cell Biol (1987) 2.11

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol (2000) 2.11

The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition. Ann Neurol (1989) 2.07

Efficacy of pneumococcal vaccination in adults. A meta-analysis of randomized controlled trials. Arch Intern Med (1995) 2.07

Prognostic factors for progression-free and overall survival with sunitinib targeted therapy and with cytokine as first-line therapy in patients with metastatic renal cell carcinoma. Ann Oncol (2010) 2.06

Context sequences of translation initiation codon in plants. Plant Mol Biol (1997) 2.05

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases. Proc Natl Acad Sci U S A (1988) 2.04

Ancient hematoma: a unifying concept for a post-traumatic lesion mimicking an aggressive soft tissue neoplasm. Mod Pathol (1997) 2.04

A systematic review of the precision and accuracy of dose measurements in photon radiotherapy using polymer and Fricke MRI gel dosimetry. Phys Med Biol (2002) 1.99

A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles. J Am Chem Soc (2001) 1.99

Flat feet in children. BMJ (1990) 1.94

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans. J Exp Med (1993) 1.94

Residue-based control of helix shape in beta-peptide oligomers. Nature (1997) 1.94

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil (2011) 1.93

Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci U S A (1994) 1.91

Prepregnancy body mass index and pregnancy weight gain: associations with preterm delivery. The NMIHS Collaborative Study Group. Obstet Gynecol (2000) 1.91

Factors protecting children living in disharmonious homes: maternal reports. J Am Acad Child Adolesc Psychiatry (1990) 1.86