A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31.

PubWeight™: 1.25‹?› | Rank: Top 10%

🔗 View Article (PMID 11687974)

Published in Oncogene on October 18, 2001

Authors

Z Hu1, I Gomes, S K Horrigan, J Kravarusic, B Mar, Z Arbieva, B Chyna, N Fulton, S Edassery, A Raza, C A Westbrook

Author Affiliations

1: Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607-7170, USA.

Articles citing this

IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev (2008) 5.25

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev (2013) 2.31

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. PLoS One (2009) 1.53

Targeting Histone Demethylases: A New Avenue for the Fight against Cancer. Genes Cancer (2011) 1.47

A chemical probe toolbox for dissecting the cancer epigenome. Nat Rev Cancer (2017) 1.40

The roles of Jumonji-type oxygenases in human disease. Epigenomics (2014) 1.05

Histone demethylases and cancer. Adv Cancer Res (2009) 1.05

Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines. Proc Natl Acad Sci U S A (2013) 1.04

Regulation of mouse steroidogenesis by WHISTLE and JMJD1C through histone methylation balance. Nucleic Acids Res (2010) 1.02

New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma. Int J Med Sci (2015) 1.00

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation. PLoS One (2013) 0.99

KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia. Mol Cell Biol (2012) 0.98

Histone lysine demethylases in breast cancer. Crit Rev Oncol Hematol (2012) 0.87

The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function. Int J Biol Sci (2015) 0.81

The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma. Clin Cancer Res (2016) 0.77

Knockout of the Histone Demethylase Kdm3b Decreases Spermatogenesis and Impairs Male Sexual Behaviors. Int J Biol Sci (2015) 0.76

Histone demethylases and their roles in cancer epigenetics. J Med Oncol Ther (2016) 0.75

Articles by these authors

Localization of gelsolin proximal to ABL on chromosome 9. Am J Hum Genet (1988) 2.64

Is eLD an effective way of revising for FRCR 2A? Clin Radiol (2007) 2.60

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity. Nature (1985) 2.25

G-protein-coupled receptor dimerization: modulation of receptor function. Pharmacol Ther (2002) 2.18

DNA integrity in human spermatozoa: relationships with semen quality. J Androl (2000) 2.06

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci U S A (2000) 2.00

Understanding the nature and outcome of childhood wheezing. Eur Respir J (2009) 1.98

Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle. J Virol (1988) 1.92

Evidence for two distinct c-src loci on human chromosomes 1 and 20. Nature (1984) 1.91

Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders. Science (1986) 1.91

Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization. Science (1990) 1.90

Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci U S A (2001) 1.82

Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes. Leuk Res (1997) 1.81

Myotilin is mutated in limb girdle muscular dystrophy 1A. Hum Mol Genet (2000) 1.78

The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. Mol Cell Biol (1987) 1.73

Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases. Proc Natl Acad Sci U S A (1993) 1.56

Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (1988) 1.56

Trisomy 11 in myelodysplastic syndromes defines a unique group of disease with aggressive clinicopathologic features. Leukemia (2010) 1.51

Functional interactions between mu opioid and alpha 2A-adrenergic receptors. Mol Pharmacol (2003) 1.49

A low-cost intervention for cleaner drinking water in Karachi, Pakistan. Int J Infect Dis (2001) 1.48

Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates. J Immunol (2000) 1.48

Sequential activation of caspase-1 and caspase-3-like proteases during apoptosis in myelodysplastic syndromes. J Hematother Stem Cell Res (1999) 1.48

Mutation rates at Y chromosome specific microsatellites. Hum Mutat (2005) 1.48

Parallel studies of clonogenic leukaemia cells and the leukaemia cell population as a whole in acute myelogenous leukaemia. Eur J Cancer (1994) 1.39

Some reasons for the lack of progress in the treatment of acute myelogenous leukemia: a review of three consecutive trials of the treatment of poor prognosis patients. Leuk Res (1991) 1.38

Assessment of cell-cycle effects of cytokines in vivo. J Clin Oncol (1992) 1.38

Acute myelogenous leukemia with leukemia cutis. Eighteen cases seen between 1969 and 1986. Cancer (1989) 1.33

Delineation of a minimal interval and identification of 9 candidates for a tumor suppressor gene in malignant myeloid disorders on 5q31. Blood (2000) 1.26

Opioid receptor endocytosis and activation of MAP kinase pathway. Brain Res Mol Brain Res (2000) 1.19

Transmission-blocking antibodies against multiple, non-variant target epitopes of the Plasmodium falciparum gamete surface antigen Pfs230 are all complement-fixing. Parasite Immunol (1994) 1.18

Polymerase chain reaction-based diagnosis of del (5q) in acute myeloid leukemia and myelodysplastic syndrome identifies a minimal deletion interval. Blood (1996) 1.17

Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis. J Neurosci (1990) 1.17

Iatrogenic DNA damage induced in human spermatozoa during sperm preparation: protective significance of seminal plasma. Mol Hum Reprod (1998) 1.16

Loss of heterozygosity from the short arm of chromosome 8 is associated with invasive behavior in breast cancer. Genes Chromosomes Cancer (1996) 1.14

Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia. Nature (1985) 1.14

Purification and characterization of human T-lymphocyte-derived erythroid-potentiating activity. J Biol Chem (1984) 1.11

Culture-negative endocarditis probably due to Chlamydia pneumoniae. J Infect Dis (1990) 1.11

Operational calibration of Geostationary Operational Environmental Satellite-8 and-9 imagers and sounders. Appl Opt (1997) 1.11

Effect of rosuvastatin on low-density lipoprotein cholesterol in patients with hypercholesterolemia. Am J Cardiol (2001) 1.11

Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effectiveness of antioxidants. Hum Reprod (1998) 1.10

Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro. Am J Physiol (1995) 1.08

Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation. Endocrinology (2006) 1.07

Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility. Genes Immun (2002) 1.05

Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscul Disord (1995) 1.04

Evidence for a common molecular pathogenesis in colorectal, gastric, and pancreatic cancer. Genes Chromosomes Cancer (1991) 1.03

Successful establishment of long-term bone marrow cultures in 103 patients with myelodysplastic syndromes. Leuk Res (2001) 1.03

DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia. Blood Cancer J (2011) 1.03

Microbiologic effectiveness of hand washing with soap in an urban squatter settlement, Karachi, Pakistan. Epidemiol Infect (2001) 1.03

Expression of the aphthovirus RNA polymerase gene in Escherichia coli and its use together with other bioengineered nonstructural antigens in detection of late persistent infections. Virology (1991) 1.03

Refractory anemia with ringed sideroblasts associated with marked thrombocytosis harbors JAK2 mutation and shows overlapping myeloproliferative and myelodysplastic features. Leukemia (2006) 1.03

The clinical and biologic significance of abnormal lipid profiles in patients with myelodysplastic syndromes. J Hematother Stem Cell Res (2000) 1.03

Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study. Clin Exp Allergy (2010) 1.03

The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life. Clin Exp Allergy (2011) 1.02

The clinical and biological effects of thalidomide in patients with myelodysplastic syndromes. Br J Haematol (2001) 1.02

Assignment of the GM-CSF, CSF-1, and FMS genes to human chromosome 5 provides evidence for linkage of a family of genes regulating hematopoiesis and for their involvement in the deletion (5q) in myeloid disorders. Cold Spring Harb Symp Quant Biol (1986) 1.02

MDR1 transcript levels as an indication of resistant disease in acute myelogenous leukaemia. Br J Haematol (1990) 1.02

The two in situ techniques do not differentiate between apoptosis and necrosis but rather reveal distinct patterns of DNA fragmentation in apoptosis. Lab Invest (1995) 1.01

Clinical problems in hairy cell leukemia: diagnosis and management. Semin Oncol (1984) 1.01

Deletion mapping reveals two regions of chromosome 8 allele loss in colorectal carcinomas. Genes Chromosomes Cancer (1994) 0.99

Studies on a wild strain of Schizophyllum commune: Cellulase and xylanase production and formation of the extracellular polysaccharide Schizophyllan. Biotechnol Bioeng (1987) 0.99

Loss of heterozygosity from the short arm of chromosome 8 is an early event in breast cancers. Genes Chromosomes Cancer (1995) 0.99

Trends in cutaneous sensitization in the first 18 years of life: results from the 1989 Isle of Wight birth cohort study. Clin Exp Allergy (2012) 0.98

c-src is consistently conserved in the chromosomal deletion (20q) observed in myeloid disorders. Proc Natl Acad Sci U S A (1985) 0.98

Primary cardiac ancient schwannoma. J Thorac Cardiovasc Surg (2003) 0.97

Environmental toxicant-induced germ cell apoptosis in the human fetal testis. Hum Reprod (2007) 0.96

Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia. Proc Natl Acad Sci U S A (1987) 0.96

Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Mol Cell Biol (1998) 0.95

Protooncogene c-ski is expressed in both proliferating and postmitotic neuronal populations. Dev Dyn (1994) 0.95

Diagnosis of persistent aphthovirus infection and its differentiation from vaccination response in cattle by use of enzyme-linked immunoelectrotransfer blot analysis with bioengineered nonstructural viral antigens. Am J Vet Res (1993) 0.95

The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors. Cancer (1997) 0.94

Modification of bacterial artificial chromosome clones using Cre recombinase: introduction of selectable markers for expression in eukaryotic cells. Genome Res (1998) 0.94

Genetic data of 10 X-STRs in a Spanish population sample. Forensic Sci Int (2007) 0.93

Recycling and resensitization of delta opioid receptors. DNA Cell Biol (2000) 0.93

Indication of an involvement of interleukin-1 beta converting enzyme-like protease in intramedullary apoptotic cell death in the bone marrow of patients with myelodysplastic syndromes. Blood (1996) 0.93

Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase. Leuk Res (1997) 0.92

Evidence for locus heterogeneity in autosomal dominant limb-girdle muscular dystrophy. Am J Hum Genet (1995) 0.92

Correlation of tumor necrosis factor alpha (TNF alpha) with high Caspase 3-like activity in myelodysplastic syndromes. Cancer Lett (1999) 0.92

Utility of PCR in diagnosis of problematic cases of typhoid. Jpn J Infect Dis (2001) 0.92

Heterogeneity of the polyribocytidilic acid tract in aphthovirus: changes in the size of the poly(C) of viruses recovered from persistently infected cattle. Virology (1988) 0.91

Autoimmune disease in hairy-cell leukaemia: clinical syndromes and treatment. Br J Haematol (1985) 0.91

Effect of green tea (Camellia sinensis) consumption on the components of metabolic syndrome in elderly. J Nutr Health Aging (2012) 0.91

Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine. Mol Reprod Dev (1997) 0.91

Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: apoptotic cells recovered from high-density fraction of bone marrow aspirates. Blood (2000) 0.90

Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors. Surgery (1993) 0.90

Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes. Genomics (1990) 0.90

Low intelligence but not attention deficit hyperactivity disorder is associated with resistance to thyroid hormone caused by mutation R316H in the thyroid hormone receptor beta gene. J Clin Endocrinol Metab (1994) 0.90

Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31. Leukemia (2000) 0.90

Two in situ labeling techniques reveal different patterns of DNA fragmentation during spontaneous apoptosis in vivo and induced apoptosis in vitro. Anticancer Res (1996) 0.90

Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34. Somat Cell Mol Genet (1997) 0.89

Measurement of mRNA expression for a variety of cytokines and its receptors in bone marrows of patients with myelodysplastic syndromes. Anticancer Res (2000) 0.89

Cytogenetic and molecular diagnosis of chromosome 5 deletions in myelodysplasia. Br J Haematol (2000) 0.89

In vivo determinations of labelling index of metastatic colorectal carcinoma and normal colonic mucosa using intravenous infusions of bromodeoxyuridine. J Surg Oncol (1988) 0.89