DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.

PubWeight™: 1.89‹?› | Rank: Top 3%

🔗 View Article (PMC 209436)

Published in J Clin Invest on November 01, 2001

Authors

E Olaso1, K Ikeda, F J Eng, L Xu, L H Wang, H C Lin, S L Friedman

Author Affiliations

1: Division of Liver Diseases and Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

Articles citing this

Liver fibrosis. J Clin Invest (2005) 17.27

Mechanisms of hepatic fibrogenesis. Gastroenterology (2008) 11.98

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev (2008) 10.28

Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut (2005) 5.39

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest (2007) 4.41

The origin of fibroblasts and mechanism of cardiac fibrosis. J Cell Physiol (2010) 2.18

Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev (2012) 1.96

Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Am J Pathol (2004) 1.39

Discoidin domain receptor functions in physiological and pathological conditions. Int Rev Cell Mol Biol (2014) 1.29

Structural basis of the collagen-binding mode of discoidin domain receptor 2. EMBO J (2007) 1.26

Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J Gastroenterol (2008) 1.23

Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver. Hepatology (2010) 1.20

Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta. J Biol Chem (2010) 1.19

Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Am J Physiol Gastrointest Liver Physiol (2010) 1.17

Reversibility of liver fibrosis. Fibrogenesis Tissue Repair (2012) 1.13

Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants. Biochem J (2013) 1.08

Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. J Biol Chem (2005) 1.04

Discoidin domain receptors in disease. Matrix Biol (2013) 1.01

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. J Proteome Res (2012) 1.00

DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1. J Exp Clin Cancer Res (2015) 0.99

Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator. Gastroenterology (2008) 0.99

Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice. PLoS One (2010) 0.96

Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention. J Surg Res (2009) 0.94

Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts. J Biol Chem (2011) 0.93

Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis. Gut (2006) 0.90

Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices. Fibrogenesis Tissue Repair (2012) 0.90

Impaired dermal wound healing in discoidin domain receptor 2-deficient mice associated with defective extracellular matrix remodeling. Fibrogenesis Tissue Repair (2011) 0.89

Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. Mol Med (2011) 0.89

Bioconjugation of oligonucleotides for treating liver fibrosis. Oligonucleotides (2007) 0.88

Phosphoproteomic analysis identifies insulin enhancement of discoidin domain receptor 2 phosphorylation. Cell Adh Migr (2012) 0.87

Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages. Am J Pathol (2011) 0.86

RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats. PLoS One (2013) 0.84

DDR2 polymorphisms and mRNA expression in lung cancers of Japanese patients. Oncol Lett (2012) 0.83

Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma. Cancer Biol Ther (2014) 0.82

Age-dependent expression of collagen receptors and deformation of type I collagen substrates by rat cardiac fibroblasts. Microsc Microanal (2011) 0.81

Role of methionine adenosyltransferase α2 and β phosphorylation and stabilization in human hepatic stellate cell trans-differentiation. J Cell Physiol (2015) 0.81

Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene, Ddr2, as a regulator of ovarian function. Physiol Genomics (2009) 0.81

Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. PLoS One (2014) 0.81

The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron (2011) 0.81

Discoidin domain receptor 1: isoform expression and potential functions in cirrhotic human liver. Am J Pathol (2011) 0.81

Versican: a novel modulator of hepatic fibrosis. Lab Invest (2016) 0.80

Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients. BMC Cancer (2014) 0.79

Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells. Comp Hepatol (2006) 0.78

Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol (2014) 0.78

The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. Dig Dis Sci (2007) 0.78

Evaluation of discoidin domain receptor-2 (DDR2) expression level in normal, benign, and malignant human prostate tissues. Res Pharm Sci (2015) 0.77

Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis. Antioxid Redox Signal (2015) 0.77

Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis. PeerJ (2015) 0.77

A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. Lab Chip (2016) 0.75

Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1. PLoS Genet (2015) 0.75

Abnormal Accumulation of Collagen Type I Due to the Loss of Discoidin Domain Receptor 2 (Ddr2) Promotes Testicular Interstitial Dysfunction. PLoS One (2015) 0.75

Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol (2017) 0.75

The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration. PLoS Genet (2016) 0.75

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways. World J Gastroenterol (2017) 0.75

A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis. Am J Hum Genet (2017) 0.75

Articles cited by this

Integrins: versatility, modulation, and signaling in cell adhesion. Cell (1992) 34.06

Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem (2000) 9.07

A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43

FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol (2000) 6.54

ECM and cell surface proteolysis: regulating cellular ecology. Cell (1997) 6.00

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci U S A (1985) 4.76

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J (1996) 4.26

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell (1995) 4.13

The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell (1997) 4.11

Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem (1995) 3.52

An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell (1997) 2.89

Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest (1990) 2.73

The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study. J Biol Chem (1998) 2.71

Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol (1984) 2.63

Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem (1989) 2.42

An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J Lipid Res (2000) 2.36

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem (2000) 2.12

High yield micronodular cirrhosis in the rat. Gastroenterology (1982) 1.97

Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest (1989) 1.95

Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest (1994) 1.91

Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene (1995) 1.81

Discoidin domain receptor 1 is activated independently of beta(1) integrin. J Biol Chem (2000) 1.64

Molecular regulation of hepatic fibrogenesis. J Hepatol (1998) 1.56

Signal transduction in hepatic stellate cells. Liver (1998) 1.55

MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Hepatology (1999) 1.39

Tissue inhibitor of metalloproteinases-2 (TIMP-2) suppresses TKR-growth factor signaling independent of metalloproteinase inhibition. J Biol Chem (2000) 1.39

Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43. Lab Invest (1993) 1.36

Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity. Biochem J (1992) 1.35

Evidence for a role of collagen synthesis in arterial smooth muscle cell migration. J Clin Invest (1998) 1.30

The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture. J Biol Chem (1997) 1.29

Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats. Hepatology (1995) 1.26

Tumor-dependent activation of rodent hepatic stellate cells during experimental melanoma metastasis. Hepatology (1997) 1.23

Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing. Oncogene (1998) 1.22

Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. Oncogene (1993) 1.22

Expression patterns of the novel receptor-like tyrosine kinase, DDR, in human breast tumours. Oncogene (1995) 1.21

In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology (1999) 1.17

Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation. Hepatology (1999) 1.16

Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes. Am J Pathol (1997) 1.10

Structure and expression of the Tyro 10 receptor tyrosine kinase. Oncogene (1994) 1.10

Plasma membrane-dependent activation of gelatinase A in human vascular endothelial cells. J Cell Physiol (1995) 1.07

Macrophage and perisinusoidal cell kinetics in acute liver injury. J Pathol (1992) 1.04

Fibroblast growth factor 2 and transforming growth factor beta 1 interactions in human liver myofibroblasts. Gastroenterology (1995) 0.95

Focal adhesion kinase and phospholipase C gamma involvement in adhesion and migration of human hepatic stellate cells. Gastroenterology (1997) 0.95

Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells. Gastroenterology (1996) 0.92

Liver fat storing cell proliferation is stimulated by epidermal growth factor/transforming growth factor alpha and inhibited by transforming growth factor beta. Biochem Biophys Res Commun (1989) 0.92

Articles by these authors

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell (1996) 11.02

DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell (1992) 10.48

Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end. J Virol (1975) 8.09

Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood (1998) 6.81

Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol (2000) 5.72

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med (2001) 5.54

Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut (2005) 5.39

Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci U S A (1985) 4.76

Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature (2001) 4.73

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature (1998) 4.68

Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology (1999) 4.59

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med (2000) 4.55

Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science (1998) 4.55

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev (2000) 4.38

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res (1991) 4.31

An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis Rheum (2008) 4.25

Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science (1998) 4.24

Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study. Gut (2008) 4.07

Structural insights into the evolution of an antibody combining site. Science (1997) 3.92

Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell (1999) 3.84

High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80

Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval. J Neurosci (1989) 3.78

Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 3.73

Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med (1997) 3.65

Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1. J Cell Biol (1983) 3.44

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res (1995) 3.38

Recombination between viral and cellular sequences generates transforming sarcoma virus. Proc Natl Acad Sci U S A (1978) 3.38

Possible temperature-dependent blockage of synaptic vesicle recycling induced by a single gene mutation in Drosophila. J Neurobiol (1983) 3.36

KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Science (2001) 3.22

Properties and location of poly(A) in Rous sarcoma virus RNA. J Virol (1974) 3.22

An improved DNA sequencing strategy. Anal Biochem (1985) 3.22

Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases. J Neurosci (2000) 3.14

Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase. Mol Cell Biol (1989) 3.13

Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res (2000) 3.03

Office of Rare Diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol (2002) 3.02

Biochemical analysis of the secreted and virion glycoproteins of Ebola virus. J Virol (1998) 2.99

Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science (2001) 2.98

p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med (1998) 2.91

Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet (2002) 2.90

Evolution of the dispersed SUC gene family of Saccharomyces by rearrangements of chromosome telomeres. Mol Cell Biol (1985) 2.88

Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family. J Virol (1985) 2.88

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell (2001) 2.87

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia (2006) 2.82

Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol (2000) 2.80

Serum lectin with known structure activates complement through the classical pathway. J Biol Chem (1987) 2.79

Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem (1996) 2.78

Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease? Clin Neuropathol (1985) 2.72

Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol (1992) 2.72

Paternal population history of East Asia: sources, patterns, and microevolutionary processes. Am J Hum Genet (2001) 2.71

Characterization of the transforming gene of Fujinami sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.68

Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Hepatology (1998) 2.67

Early dexamethasone therapy in preterm infants: a follow-up study. Pediatrics (1998) 2.65

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A (1997) 2.63

Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol (2005) 2.54

Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study. Arthritis Rheum (2001) 2.45

NAK is an IkappaB kinase-activating kinase. Nature (2000) 2.44

The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. Cell (2000) 2.41

RNA of replication-defective strains of Rous sarcoma virus. Proc Natl Acad Sci U S A (1975) 2.37

An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J Lipid Res (2000) 2.36

Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol (2012) 2.34

Distribution of envelope-specific and sarcoma-specific nucleotide sequences from different parents in the RNAs of avian tumor virus recombinants. Proc Natl Acad Sci U S A (1976) 2.32

Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan. Anal Biochem (1987) 2.31

Detection of retroviral antibodies in primary biliary cirrhosis and other idiopathic biliary disorders. Lancet (1998) 2.31

A panoramic code for sound location by cortical neurons. Science (1994) 2.30

Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes. Proc Natl Acad Sci U S A (1996) 2.29

A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ (2010) 2.25

Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Cell (1995) 2.25

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc Natl Acad Sci U S A (1999) 2.25

Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science (1999) 2.25

Feasibility of stomach exploration with a guided capsule endoscope. Endoscopy (2010) 2.20

Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci U S A (1988) 2.20

Lactation is associated with greater maternal bone size and bone strength later in life. Osteoporos Int (2011) 2.19

The ryanodine receptor-Ca2+ release channel complex of skeletal muscle sarcoplasmic reticulum. Evidence for a cooperatively coupled, negatively charged homotetramer. J Biol Chem (1989) 2.18

Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor). Biophys J (1995) 2.18

Novel mutations in the connexin 26 gene (GJB2) responsible for childhood deafness in the Japanese population. Am J Med Genet (2000) 2.17

PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Proc Natl Acad Sci U S A (2000) 2.17

Synaptic vesicles have two distinct recycling pathways. J Cell Biol (1996) 2.17

The long-term pathological evolution of chronic hepatitis C. Hepatology (1996) 2.15

Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity. J Virol (1982) 2.14

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res (2001) 2.11

Plasma endothelin levels in patients with cirrhosis and their relationships to the severity of cirrhosis and renal function. J Hepatol (1995) 2.10

Differential use of CREB binding protein-coactivator complexes. Science (1998) 2.10

Herpes zoster during varicella. Pediatr Infect Dis J (2001) 2.06

A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma. Ann Oncol (2011) 2.05

Six family genes--structure and function as transcription factors and their roles in development. Bioessays (2000) 2.03

Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy. J Gastroenterol Hepatol (1999) 2.02

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc Natl Acad Sci U S A (1998) 2.02

An Oral Health Survey in Southern China, 1997: background and methodology. J Dent Res (2001) 1.99

Changes in gene expression associated with induced differentiation of erythroleukemia: protooncogenes, globin genes, and cell division. Proc Natl Acad Sci U S A (1986) 1.99

The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA. Mol Cell Biol (1987) 1.98

Incidence of primary cholangiocellular carcinoma of the liver in japanese patients with hepatitis C virus-related cirrhosis. Cancer (2000) 1.98

Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science (1994) 1.98

Patterned neural activity of a mutant Drosophila melanogaster. Proc Natl Acad Sci U S A (1970) 1.97

Role for phospholipase D in receptor-mediated endocytosis. Mol Cell Biol (2001) 1.96

Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology (1994) 1.96

Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest (1989) 1.95

Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol Psychiatry (2004) 1.95