A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum.

PubWeight™: 2.25‹?› | Rank: Top 2%

🔗 View Article (PMC 2950895)

Published in Cell Death Differ on June 25, 2010

Authors

J Lian1, X Wu, F He, D Karnak, W Tang, Y Meng, D Xiang, M Ji, T S Lawrence, L Xu

Author Affiliations

1: Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Articles citing this

Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood (2011) 1.91

Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice. Gastroenterology (2014) 1.85

Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther (2011) 1.55

BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells. PLoS One (2014) 1.50

Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol (2011) 1.47

Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res (2012) 1.43

Autophagy and cancer therapy. Cancer Biol Ther (2011) 1.32

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy. Oncogene (2015) 1.11

Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB. PLoS One (2010) 1.07

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis (2013) 1.03

HAb18G/CD147 promotes pSTAT3-mediated pancreatic cancer development via CD44s. Clin Cancer Res (2013) 1.00

The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. Autophagy (2010) 0.98

Caloric restriction: is mammalian life extension linked to p53? Aging (Albany NY) (2012) 0.94

(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. Mol Cancer Ther (2011) 0.94

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis (2013) 0.93

Autophagy modulation as a target for anticancer drug discovery. Acta Pharmacol Sin (2013) 0.93

Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells. PLoS One (2012) 0.92

Bcl-2 antagonists: a proof of concept for CLL therapy. Invest New Drugs (2013) 0.92

Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem Biol (2015) 0.92

Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer. Am J Cancer Res (2011) 0.91

Autophagy: cancer's friend or foe? Adv Cancer Res (2013) 0.89

RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. Oncotarget (2014) 0.89

Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors. Commun Integr Biol (2012) 0.88

Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. Mol Cancer Ther (2012) 0.88

Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. Oncotarget (2014) 0.86

Convallatoxin, a dual inducer of autophagy and apoptosis, inhibits angiogenesis in vitro and in vivo. PLoS One (2014) 0.84

Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. Mol Oncol (2015) 0.83

Nanomaterials and autophagy: new insights in cancer treatment. Cancers (Basel) (2013) 0.83

Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer (2015) 0.82

Antiproliferative and apoptotic effects of a specific antiprostate stem cell single chain antibody on human prostate cancer cells. J Oncol (2013) 0.81

The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells. Br J Cancer (2012) 0.80

Roles of autophagy induced by natural compounds in prostate cancer. Biomed Res Int (2015) 0.80

Autophagy induced by tumor necrosis factor α mediates intrinsic apoptosis in trophoblastic cells. Reprod Sci (2013) 0.79

The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. Oncotarget (2015) 0.79

Identification of novel small molecule Beclin 1 mimetics activating autophagy. Oncotarget (2017) 0.76

Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737. World J Urol (2015) 0.75

BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition. Am J Cancer Res (2016) 0.75

Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a. Biomed Res Int (2014) 0.75

Anti-proliferative Effects of Androctonus amoreuxi Scorpion and Cerastes cerastes Snake Venoms on Human Prostate Cancer Cells. J Cancer Prev (2017) 0.75

Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. Biomed Res Int (2014) 0.75

Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Sci Rep (2016) 0.75

Ginsenoside Rg1 protects starving H9c2 cells by dissociation of Bcl-2-Beclin1 complex. BMC Complement Altern Med (2016) 0.75

Autophagy in Cancer Therapy. Front Oncol (2017) 0.75

Beclin-1 suppresses gastric cancer progression by promoting apoptosis and reducing cell migration. Oncol Lett (2017) 0.75

Articles cited by this

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Autophagy in health and disease: a double-edged sword. Science (2004) 13.69

The role of autophagy in cancer development and response to therapy. Nat Rev Cancer (2005) 8.18

A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res (2001) 5.92

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood (2007) 4.91

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res (2009) 4.53

Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42

MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One (2009) 3.66

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis (1996) 3.40

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08

The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ (2009) 2.85

Autophagy: many paths to the same end. Mol Cell Biochem (2004) 2.79

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem (2003) 2.64

Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood (2008) 2.20

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability. Hum Pathol (2008) 2.18

Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. Mol Cancer Ther (2008) 1.95

Autophagy: an emerging target for cancer therapy. Autophagy (2008) 1.94

Management of hormone refractory prostate cancer: current standards and future prospects. J Urol (1998) 1.91

Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. Autophagy (2008) 1.86

In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res (2004) 1.55

Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model. Clin Cancer Res (2009) 1.53

(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther (2005) 1.46

Targeting the Bcl-2 family of proteins in Hodgkin lymphoma: in vitro cytotoxicity, target modulation and drug combination studies of the Bcl-2 homology 3 mimetic ABT-737. Leuk Lymphoma (2009) 1.45

Beclin 1 bridges autophagy, apoptosis and differentiation. Autophagy (2008) 1.41

BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. Mol Pharmacol (2009) 1.38

Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene (2006) 1.33

Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Mol Pharmacol (2009) 1.29

Lineage relationship between LNCaP and LNCaP-derived prostate cancer cell lines. Prostate (2004) 1.14

In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia (2007) 1.10

Targeting the Bcl-2. Curr Opin Oncol (2009) 1.08

A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy (2009) 1.02

Small molecule inhibition of the Bcl-X(L)-BH3 protein-protein interaction: proof-of-concept of an in vivo chemopotentiator ABT-737. Curr Top Med Chem (2007) 0.98

Management of Hormone-Sensitive and Hormone-Refractory Metastatic Prostate Cancer. Cancer Control (1998) 0.94

Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. Autophagy (2008) 0.93

The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. Anticancer Res (2002) 0.93

Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. Biochem Pharmacol (2008) 0.91

Novel therapeutic strategies for androgen-independent prostate cancer: an update. Semin Oncol (2004) 0.87

Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. Biochem Biophys Res Commun (2010) 0.81

Articles by these authors

(truncated to the top 100)

CHARMM: the biomolecular simulation program. J Comput Chem (2009) 27.71

An STS-based map of the human genome. Science (1995) 17.72

A gene map of the human genome. Science (1996) 14.32

A physical map of 30,000 human genes. Science (1998) 12.43

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell (1996) 11.02

DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell (1992) 10.48

Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood (1998) 6.81

Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120. J Virol (2000) 6.71

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med (2001) 5.54

Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature (1997) 5.08

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78

Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology (1999) 4.59

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med (2000) 4.55

Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science (1998) 4.55

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci U S A (1998) 4.40

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev (1994) 4.30

Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science (1998) 4.24

Transient simulation of last deglaciation with a new mechanism for Bolling-Allerod warming. Science (2009) 4.20

Chalcones: an update on cytotoxic and chemoprotective properties. Curr Med Chem (2005) 3.97

Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC) Science (1998) 3.86

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood (1996) 3.81

High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80

Long-range incommensurate charge fluctuations in (Y,Nd)Ba2Cu3O(6+x). Science (2012) 3.73

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56

Loss of function of a rice brassinosteroid insensitive1 homolog prevents internode elongation and bending of the lamina joint. Plant Cell (2000) 3.56

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res (1995) 3.38

The highly reduced genome of an enslaved algal nucleus. Nature (2001) 3.31

DNA structure-dependent requirements for yeast RAD genes in gene conversion. Nature (1995) 3.15

Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases. J Neurosci (2000) 3.14

Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'-->2') oligonucleotide system. Science (2000) 3.11

Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res (2000) 3.03

Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia (2003) 3.00

Biochemical analysis of the secreted and virion glycoproteins of Ebola virus. J Virol (1998) 2.99

Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet (2002) 2.90

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell (2001) 2.87

Longitudinal pattern of regional brain volume change differentiates normal aging from MCI. Neurology (2009) 2.84

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia (2006) 2.82

Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol (2000) 2.80

Coronary calcium does not accurately predict near-term future coronary events in high-risk adults. Circulation (1999) 2.80

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol (1996) 2.78

Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem (1996) 2.78

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol (1999) 2.78

Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser. J Microsc (2003) 2.74

Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71

Paternal population history of East Asia: sources, patterns, and microevolutionary processes. Am J Hum Genet (2001) 2.71

Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst (1999) 2.68

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A (1997) 2.63

Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Mol Cell Biol (2000) 2.59

Different forms of TFIIH for transcription and DNA repair: holo-TFIIH and a nucleotide excision repairosome. Cell (1995) 2.58

Sublingual capnometry: a new noninvasive measurement for diagnosis and quantitation of severity of circulatory shock. Crit Care Med (1999) 2.54

Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol (2005) 2.54

Past adult lead exposure is linked to neurodegeneration measured by brain MRI. Neurology (2006) 2.52

Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study. Arthritis Rheum (2001) 2.45

CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J (1998) 2.44

The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. Cell (2000) 2.41

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J Natl Cancer Inst (1999) 2.41

Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. Cancer Res (2001) 2.37

Individual patient diagnosis of AD and FTD via high-dimensional pattern classification of MRI. Neuroimage (2008) 2.36

Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34

Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. Mol Cell (2000) 2.33

Detection of retroviral antibodies in primary biliary cirrhosis and other idiopathic biliary disorders. Lancet (1998) 2.31

Charge order driven by Fermi-arc instability in Bi2Sr(2-x)La(x)CuO(6+δ). Science (2013) 2.31

A panoramic code for sound location by cortical neurons. Science (1994) 2.30

JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev (1998) 2.29

Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes. Proc Natl Acad Sci U S A (1996) 2.29

Nonsense-mediated mRNA decay in yeast. Prog Nucleic Acid Res Mol Biol (1994) 2.25

Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro. Nucleic Acids Res (2000) 2.25

The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures. J Virol (1995) 2.25

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc Natl Acad Sci U S A (1999) 2.25

Electron beam computed tomographic coronary calcium as a predictor of coronary events: comparison of two protocols. Circulation (1997) 2.24

DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae. Mol Cell Biol (1993) 2.23

Lactation is associated with greater maternal bone size and bone strength later in life. Osteoporos Int (2011) 2.19

Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol (2001) 2.18

The ryanodine receptor-Ca2+ release channel complex of skeletal muscle sarcoplasmic reticulum. Evidence for a cooperatively coupled, negatively charged homotetramer. J Biol Chem (1989) 2.18

Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor). Biophys J (1995) 2.18

Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication. Br J Surg (2012) 2.17

PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Proc Natl Acad Sci U S A (2000) 2.17

Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients. J Natl Cancer Inst (1998) 2.16

Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies. J Clin Oncol (2000) 2.14

Gastric intramural PCO2 during peritonitis and shock. Chest (1993) 2.13

Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas. Cancer Res (2001) 2.13

Function of hexameric RNA in packaging of bacteriophage phi 29 DNA in vitro. Mol Cell (1998) 2.13

Specificity of DNA lesion bypass by the yeast DNA polymerase eta. J Biol Chem (2000) 2.12

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res (2001) 2.11

The human REV1 gene codes for a DNA template-dependent dCMP transferase. Nucleic Acids Res (1999) 2.10

Differential use of CREB binding protein-coactivator complexes. Science (1998) 2.10

Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota. Mol Cell Biol (2000) 2.08

Transmission of hormonal stimulation by cell-to-cell communication. Nature (1978) 2.08

Error-prone lesion bypass by human DNA polymerase eta. Nucleic Acids Res (2000) 2.07

Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. J Biol Chem (2001) 2.06

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem (2001) 2.06

A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma. Ann Oncol (2011) 2.05

The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains. J Cell Biol (2001) 2.05

The function of adipocytes in the bone marrow stroma: an update. Bone (1996) 2.01

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA (2000) 2.01

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci U S A (2001) 2.00

Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. Oncogene (1997) 1.97

Racial differences in the significance of coronary calcium in asymptomatic black and white subjects with coronary risk factors. J Am Coll Cardiol (1999) 1.97

Role for phospholipase D in receptor-mediated endocytosis. Mol Cell Biol (2001) 1.96