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L Illum

Author PubWeight™ 79.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. J Control Release 1999 2.08
2 Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res 1994 1.61
3 Non-phagocytic uptake of intravenously injected microspheres in rat spleen: influence of particle size and hydrophilic coating. Biochem Biophys Res Commun 1991 1.50
4 Nanoparticles in drug delivery. Crit Rev Ther Drug Carrier Syst 1987 1.42
5 Carbohydrate biopolymers enhance antibody responses to mucosally delivered vaccine antigens. Infect Immun 2000 1.35
6 Evaluation of the clearance characteristics of bioadhesive systems in humans. Int J Pharm 1999 1.30
7 Chitosan as a nasal delivery system: the effect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers. J Pharm Sci 1997 1.28
8 Chitosan microspheres prepared by spray drying. Int J Pharm 1999 1.20
9 Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J Control Release 2001 1.20
10 The polyoxyethylene/polyoxypropylene block co-polymer poloxamer-407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow. FEBS Lett 1992 1.17
11 Transport of nanoparticles across the rat nasal mucosa. J Drug Target 2001 1.11
12 Preparation of biodegradable, surface engineered PLGA nanospheres with enhanced lymphatic drainage and lymph node uptake. Pharm Res 1997 1.08
13 Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum. Biochim Biophys Acta 1993 1.08
14 Immune responses and protection against Bordetella pertussis infection after intranasal immunization of mice with filamentous haemagglutinin in solution or incorporated in biodegradable microparticles. Vaccine 1995 1.08
15 Nasal delivery of insulin using novel chitosan based formulations: a comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles. Pharm Res 2002 1.08
16 Polylactide-poly(ethylene glycol) micellar-like particles as potential drug carriers: production, colloidal properties and biological performance. J Drug Target 2001 1.07
17 Preparation of sub-100 nm human serum albumin nanospheres using a pH-coacervation method. J Drug Target 1993 1.07
18 Lipid emulsions as drug delivery systems. Ann N Y Acad Sci 1987 1.07
19 Defining the drug incorporation properties of PLA-PEG nanoparticles. Int J Pharm 2000 1.06
20 Use of the ninhydrin assay to measure the release of chitosan from oral solid dosage forms. Int J Pharm 2004 1.05
21 A mucosal vaccine against diphtheria: formulation of cross reacting material (CRM(197)) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery. Vaccine 2000 1.04
22 An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen. Biochim Biophys Acta 1993 1.04
23 Polystyrene-poly (ethylene glycol) (PS-PEG2000) particles as model systems for site specific drug delivery. 2. The effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution. Pharm Res 1994 1.02
24 The organ uptake of intravenously administered colloidal particles can be altered using a non-ionic surfactant (Poloxamer 338). FEBS Lett 1984 1.00
25 Sustained release chitosan microspheres prepared by novel spray drying methods. J Microencapsul 1999 0.97
26 Sustained release hGH microsphere formulation produced by a novel supercritical fluid technology: in vivo studies. J Control Release 2009 0.95
27 Surface engineered nanospheres with enhanced drainage into lymphatics and uptake by macrophages of the regional lymph nodes. FEBS Lett 1994 0.92
28 Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS. J Control Release 1999 0.92
29 Preparation of surface-modified albumin nanospheres. Biomaterials 1997 0.91
30 Mice are protected against Bordetella pertussis infection by intra-nasal immunization with filamentous haemagglutinin. FEMS Microbiol Lett 1993 0.91
31 Preparation and characterisation of rose Bengal-loaded surface-modified albumin nanoparticles. J Control Release 2001 0.91
32 The effect of the nasal cycle on mucociliary clearance. Clin Otolaryngol Allied Sci 2001 0.90
33 Gastrointestinal transit of dosage forms in the pig. J Pharm Pharmacol 2001 0.89
34 The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer--poloxamine 908. Life Sci 1987 0.89
35 Stimulation of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan in mice. Vaccine 1998 0.89
36 Clearance characteristics of chitosan based formulations in the sheep nasal cavity. Int J Pharm 2001 0.89
37 Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine. Crit Rev Ther Drug Carrier Syst 1990 0.89
38 Lymph node localisation of biodegradable nanospheres surface modified with poloxamer and poloxamine block co-polymers. FEBS Lett 1997 0.88
39 Preparation of sterically stabilized human serum albumin nanospheres using a novel Dextranox-MPEG crosslinking agent. Pharm Res 1994 0.87
40 Polymeric microspheres as drug carriers. Biomaterials 1988 0.87
41 Targeting of colloidal particles to the bone marrow. Life Sci 1987 0.87
42 Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation. J Control Release 2002 0.87
43 Distribution and clearance of bioadhesive formulations from the olfactory region in man: effect of polymer type and nasal delivery device. Eur J Pharm Sci 2006 0.87
44 Nasal delivery of chitosan-DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice. Vaccine 2003 0.86
45 Attachment of monoclonal antibodies to microspheres. Methods Enzymol 1985 0.86
46 Polymeric lamellar substrate particles for intranasal vaccination. Adv Drug Deliv Rev 2001 0.86
47 Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages. Biomaterials 1987 0.85
48 Vaginal immunization of rats with a synthetic peptide from human immunodeficiency virus envelope glycoprotein. J Gen Virol 1992 0.84
49 Preparation and in vitro characterization of HSA-mPEG nanoparticles. Int J Pharm 1999 0.83
50 Preparation of human serum albumin microspheres by a novel acetone-heat denaturation method. J Microencapsul 1994 0.83
51 Human serum albumin as a probe for surface conditioning (opsonization) of block copolymer-coated microspheres. Biomaterials 1992 0.83
52 Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system. Vaccine 1993 0.83
53 Human serum albumin as a probe for protein adsorption to nanoparticles: relevance to biodistribution. J Drug Target 1997 0.82
54 Nasal absorption in the rat. III. Effect of lysophospholipids on insulin absorption and nasal histology. Pharm Res 1994 0.82
55 The effect of surface coverage and conformation of poly(ethylene oxide) (PEO) chains of poloxamer 407 on the biological fate of model colloidal drug carriers. Biochim Biophys Acta 2001 0.82
56 Hydrodynamic characterization of chitosans varying in degree of acetylation. Int J Biol Macromol 1993 0.82
57 In vitro displacement by rat serum of adsorbed radiolabeled poloxamer and poloxamine copolymers from model and biodegradable nanospheres. J Pharm Sci 1998 0.81
58 Physiopathological and physicochemical considerations in targeting of colloids and drug carriers to the bone marrow. Crit Rev Ther Drug Carrier Syst 1990 0.81
59 Influence of block copolymers on the adsorption of plasma proteins to microspheres. Biomaterials 1993 0.81
60 Tissue distribution of poly(hexyl 2-cyanoacrylate) nanoparticles coated with monoclonal antibodies in mice bearing human tumor xenografts. J Pharmacol Exp Ther 1984 0.80
61 Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system. J Pharm Pharmacol 1994 0.80
62 Intranasal absorption of granulocyte-colony stimulating factor (G-CSF) from powder formulations, in sheep. Eur J Pharm Sci 1998 0.80
63 Biodegradable polymeric microparticles for drug delivery and vaccine formulation: the surface attachment of hydrophilic species using the concept of poly(ethylene glycol) anchoring segments. Biomaterials 1997 0.80
64 Drug-polyionic block copolymer interactions for micelle formation: physicochemical characterisation. J Control Release 2001 0.80
65 Recent advances in the use of microspheres for targeted therapy. Drugs Exp Clin Res 1985 0.80
66 Effect of a selected suppression of the reticuloendothelial system on the distribution of model carrier particles. J Pharm Sci 1986 0.80
67 Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene oxide) copolymer. Biomaterials 1997 0.79
68 Enhanced hepatic clearance of intravenously administered sterically stabilized microspheres in zymosan-stimulated rats. J Leukoc Biol 1993 0.79
69 CriticalSorb™ promotes permeation of flux markers across isolated rat intestinal mucosae and Caco-2 monolayers. Pharm Res 2012 0.79
70 Modification of the copolymers poloxamer 407 and poloxamine 908 can affect the physical and biological properties of surface modified nanospheres. Pharm Res 1998 0.79
71 The effect of block co-polymers on the uptake of model polystyrene microspheres by Kupffer cells--in vitro and in vivo studies. Biochem Soc Trans 1991 0.79
72 Nasal administration of an angiotensin antagonist in the rat model: effect of bioadhesive formulations on the distribution of drugs to the systemic and central nervous systems. Int J Pharm 2007 0.79
73 Egg albumin microspheres containing paracetamol for oral administration. I. In vitro characterization. J Microencapsul 1991 0.78
74 Single shot tetanus vaccine manufactured by a supercritical fluid encapsulation technology. Int J Pharm 2011 0.78
75 Di-iodo-L-tyrosine-labelled dextrans as molecular size markers of nasal absorption in the rat. J Pharm Pharmacol 1992 0.78
76 Potential of polymeric lamellar substrate particles (PLSP) as adjuvants for vaccines. Vaccine 1999 0.78
77 Complex formation between the anionic polymer (PAA) and a cationic drug (procaine HCI): characterization by microcalorimetric studies. Pharm Res 1999 0.78
78 Measurement of nasal mucociliary transport rates on the isolated human inferior turbinate. Clin Otolaryngol Allied Sci 1995 0.78
79 Resorbable polymeric microspheres for drug delivery--production and simultaneous surface modification using PEO-PPO surfactants. Biomaterials 1994 0.77
80 Evaluation of bioadhesive polymers as delivery systems for nose to brain delivery: in vitro characterisation studies. J Control Release 2006 0.77
81 A poly(D,L-lactide-co-glycolide) microsphere depot system for delivery of haloperidol. J Control Release 1998 0.77
82 Activation of the mononuclear phagocyte system by poloxamine 908: its implications for targeted drug delivery. Pharm Res 1997 0.77
83 Development and validation of a pig model for colon-specific drug delivery. J Pharm Pharmacol 1996 0.76
84 The effect of infused fat emulsions on reticuloendothelial function in the rabbit. Clin Nutr 1990 0.76
85 Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Pharm Res 1992 0.76
86 Nasal absorption enhancers for biosynthetic human growth hormone in rats. Pharm Res 1990 0.75
87 Schizophrenia and drug delivery systems. J Drug Target 2000 0.75
88 The targeting of drugs parenterally by use of microspheres. J Parenter Sci Technol 1983 0.75
89 Microspheres as drug carriers. Horiz Biochem Biophys 1989 0.75
90 Human serum albumin as a probe for surface conditioning--a study of the ageing effect. J Drug Target 1997 0.75
91 Effect of splenic congestion associated with haemolytic anaemia on filtration of 'spleen-homing' microspheres. Clin Sci (Lond) 1993 0.75
92 In vivo evaluation of protein adsorption to sterically stabilised colloidal carriers. J Biomed Mater Res 1993 0.75
93 Poly(organo phosphazene) nanoparticles surface modified with poly(ethylene oxide). Biotechnol Bioeng 1996 0.75
94 Differences in the adsorption behaviour of poly(ethylene oxide) copolymers onto model polystyrene nanoparticles assessed by isothermal titration microcalorimetry correspond to the biological differences. J Drug Target 2005 0.75
95 Egg albumin microspheres containing paracetamol for oral administration. II. In vivo investigation. J Microencapsul 1991 0.75
96 Drug delivery systems. Practitioner 1983 0.75
97 The effect of lymphatic oedema on the uptake of colloids to the lymph nodes. Biopharm Drug Dispos 1998 0.75