Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11beta-hydroxysteroid dehydrogenase.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMID 11733403)

Published in Circulation on December 04, 2001

Authors

P W Hadoke1, C Christy, Y V Kotelevtsev, B C Williams, C J Kenyon, J R Seckl, J J Mullins, B R Walker

Author Affiliations

1: Endocrinology, Endothelial Cell Biology, and Molecular Physiology groups, University of Edinburgh, Edinburgh, UK. phadoke@srv0.med.ed.ac.uk

Articles citing this

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest (2003) 1.95

11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. Physiol Rev (2013) 1.60

Preventing local regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 enhances angiogenesis. Proc Natl Acad Sci U S A (2005) 1.26

Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease. Br J Pharmacol (2009) 1.18

Glucocorticoid response elements and 11 beta-hydroxysteroid dehydrogenases in the regulation of endothelial nitric oxide synthase expression. Cardiovasc Res (2008) 1.15

Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11betaHSD1-deficient mice post-MI. Cardiovasc Res (2010) 1.03

A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess. J Am Soc Nephrol (2007) 1.01

Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice. Hypertension (2012) 0.89

11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice. PLoS One (2013) 0.89

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis. FASEB J (2013) 0.88

Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome. Cardiovasc Res (2010) 0.85

VEGF-mediated fusion in the generation of uniluminal vascular spheroids. Dev Dyn (2008) 0.85

Contribution of endogenous glucocorticoids and their intravascular metabolism by 11β-HSDs to postangioplasty neointimal proliferation in mice. Endocrinology (2012) 0.81

11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol. Biochimie (2012) 0.80

Articles by these authors

DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli. Proc Natl Acad Sci U S A (1980) 7.87

A transgenic model of visceral obesity and the metabolic syndrome. Science (2001) 6.22

Molecular basis of human hypertension: role of angiotensinogen. Cell (1992) 6.07

Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension? Lancet (1993) 4.59

Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli. Proc Natl Acad Sci U S A (1981) 4.09

Adult cardiovascular risk factors in premature babies. Lancet (2000) 3.95

Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation (2002) 3.63

Glucocorticoid exposure in utero: new model for adult hypertension. Lancet (1993) 3.47

ZW10 helps recruit dynactin and dynein to the kinetochore. J Cell Biol (1998) 3.38

Expression of the E. coli uvrA gene is inducible. Nature (1981) 3.18

Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol (2001) 3.04

11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci U S A (1997) 3.00

Intramuscular versus oral antibiotic therapy for the prevention of meningitis and other bacterial sequelae in young, febrile children at risk for occult bacteremia. J Pediatr (1994) 2.79

Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci (Lond) (1999) 2.71

A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans. Nature (1995) 2.61

Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome? J Clin Endocrinol Metab (1998) 2.60

Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens (1993) 2.59

Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. J Cell Biol (1999) 2.41

Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab (1998) 2.41

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest (1998) 2.36

Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev Neurosci (1996) 2.34

Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab (2001) 2.33

Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action. Endocrinology (2001) 2.21

The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk. J Endocrinol (2004) 2.20

Role of a new Rho family member in cell migration and axon guidance in C. elegans. Cell (1997) 2.18

Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. N Engl J Med (1999) 2.17

Prenatal programming of hepatocyte nuclear factor 4alpha in the rat: A key mechanism in the 'foetal origins of hyperglycaemia'? Diabetologia (2006) 2.16

Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem (2001) 2.11

Enlarged perivascular spaces are associated with cognitive function in healthy elderly men. J Neurol Neurosurg Psychiatry (2004) 2.11

Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol (1996) 2.10

Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. J Immunol (1999) 2.09

Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans. J Neurosci (1993) 2.03

Population-based assessment of childhood blindness in southern India. Arch Ophthalmol (1998) 1.97

Intracranial capacity and brain volumes are associated with cognition in healthy elderly men. Neurology (2002) 1.95

Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology (1996) 1.88

Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab (1998) 1.80

Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat. Placenta (1996) 1.75

Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: evidence for an intraocular renin-angiotensin system. Br J Ophthalmol (1996) 1.74

Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control study. Heart (2004) 1.69

5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events. Mol Endocrinol (2000) 1.69

Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice. EMBO J (1989) 1.68

Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure. J Clin Invest (1997) 1.65

Conservation of the centromere/kinetochore protein ZW10. J Cell Biol (1997) 1.64

Do corticosteroids damage the brain? J Neuroendocrinol (2006) 1.64

Regulation of damage-inducible genes in Escherichia coli. J Mol Biol (1982) 1.63

Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience (2001) 1.60

Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations. Hypertension (2000) 1.60

L-NMMA increases blood pressure in man. Lancet (1993) 1.60

Idiopathic intracranial hypertension: can studies of obesity provide the key to understanding pathogenesis? Br J Neurosurg (2008) 1.60

Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. J Clin Endocrinol Metab (2001) 1.58

Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clin Endocrinol (Oxf) (1997) 1.58

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. J Clin Invest (1999) 1.55

Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology (2000) 1.54

Role of endothelin in intermittent hypoxia-induced hypertension. Hypertension (2001) 1.52

Microvascular correlates of blood pressure, plasma glucose, and insulin resistance in health. Cardiovasc Res (2002) 1.51

Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Diabetologia (1996) 1.49

A short water deprivation test incorporating urinary arginine vasopressin estimations for the investigation of posterior pituitary function in children. Acta Endocrinol (Copenh) (1988) 1.48

High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J (1992) 1.48

Molecular cloning of two distinct renin genes from the DBA/2 mouse. EMBO J (1982) 1.48

Measures for detecting systemic bioactivity with inhaled and intranasal corticosteroids. Thorax (1997) 1.48

Comparative antihypertensive effects of guanabenz and clonidine. J Int Med Res (1982) 1.47

Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology. Am J Physiol Endocrinol Metab (2004) 1.47

Renal versus hindquarter hemodynamic responses to vasopressin in conscious rats. J Cardiovasc Pharmacol (1990) 1.44

Conditional transgenic technologies. J Endocrinol (2001) 1.44

11beta-hydroxysteroid dehydrogenase type 1: a new regulator of fetal lung maturation. Horm Metab Res (2002) 1.41

Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease. J Biol Chem (2001) 1.41

A rational approach for assessing the hypothalamo-pituitary-adrenal axis. Lancet (1988) 1.40

Letter re: HPA axis testing after pituitary surgery. J Clin Endocrinol Metab (2005) 1.40

Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Eur J Neurosci (2000) 1.40

Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. J Biol Chem (1990) 1.39

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology (1995) 1.38

Angiotensinogen: a candidate gene involved in preeclampsia? Nat Genet (1993) 1.37

Inhibition of 11-beta-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertension (1996) 1.37

The ontogeny of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. Endocrinology (1996) 1.35

Postnatal handling increases the expression of cAMP-inducible transcription factors in the rat hippocampus: the effects of thyroid hormones and serotonin. J Neurosci (2000) 1.35

11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome. J Clin Endocrinol Metab (1995) 1.33

Programming hyperglycaemia in the rat through prenatal exposure to glucocorticoids-fetal effect or maternal influence? J Endocrinol (2001) 1.32

Genes affecting sensitivity to serotonin in Caenorhabditis elegans. Genetics (1996) 1.31

Maintained endothelium-dependent pulmonary vasodilation following chronic hypoxia in the rat. J Appl Physiol (1985) (1993) 1.29

Is there a relationship between attending physicians' and residents' teaching skills and students' examination scores? Acad Med (2000) 1.29

Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol (1997) 1.29

Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice. Endocrinology (2001) 1.28

Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese, young south african adults: early programming of cortisol axis. J Clin Endocrinol Metab (2000) 1.26

Double-blind clinical trials of oral cyclacillin and ampicillin. Antimicrob Agents Chemother (1979) 1.25

Initial emergency department diagnosis and return visits: risk versus perception. Ann Emerg Med (1998) 1.23

Additional value of measurement of urinary cortisone and unconjugated cortisol metabolites in assessing the activity of 11 beta-hydroxysteroid dehydrogenase in vivo. Clin Endocrinol (Oxf) (1997) 1.21

Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques. Nucleic Acids Res (2007) 1.20