Published in AAPS PharmSci on January 01, 2001
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biol (2002) 2.40
The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. Plant Cell (2004) 2.05
Family-B G-protein-coupled receptors. Genome Biol (2001) 1.75
On the analysis of ligand-directed signaling at G protein-coupled receptors. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.24
Evolution of secretin family GPCR members in the metazoa. BMC Evol Biol (2006) 1.14
The KDEL receptor couples to Gαq/11 to activate Src kinases and regulate transport through the Golgi. EMBO J (2012) 1.12
Availability of short amino acid sequences in proteins. Protein Sci (2005) 1.03
GPR-4 is a predicted G-protein-coupled receptor required for carbon source-dependent asexual growth and development in Neurospora crassa. Eukaryot Cell (2006) 1.00
Construction of a sequence motif characteristic of aminergic G protein-coupled receptors. Protein Sci (2003) 0.92
Genetic variations in human G protein-coupled receptors: implications for drug therapy. AAPS PharmSci (2001) 0.86
Cross-Genome Clustering of Human and C. elegans G-Protein Coupled Receptors. Evol Bioinform Online (2012) 0.77
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Basic local alignment search tool. J Mol Biol (1990) 659.07
The Pfam protein families database. Nucleic Acids Res (2000) 42.28
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell (1991) 18.19
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (1995) 13.80
Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods. J Mol Biol (1998) 9.09
Principles governing amino acid composition of integral membrane proteins: application to topology prediction. J Mol Biol (1998) 7.72
Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships. Proc Natl Acad Sci U S A (1998) 7.18
IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices. Bioinformatics (1999) 6.91
Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J (1999) 6.25
A novel family of genes encoding putative pheromone receptors in mammals. Cell (1995) 4.88
Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell (1995) 4.67
Prediction of transmembrane segments in proteins utilising multiple sequence alignments. J Mol Biol (1994) 4.07
Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. Proc Natl Acad Sci U S A (1986) 4.07
GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res (1998) 3.94
The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene. Nucleic Acids Res (1985) 3.59
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature (1987) 3.33
Phylogenetic analysis using PHYLIP. Methods Mol Biol (2000) 3.27
odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell (1996) 3.22
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature (1997) 3.04
Applications of network BLAST server. Methods Enzymol (1996) 3.03
A human homologue of the yeast HDEL receptor. Nature (1990) 2.91
Hydrophobic organization of membrane proteins. Science (1989) 2.74
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell (1996) 2.58
A chemoattractant receptor controls development in Dictyostelium discoideum. Science (1988) 2.54
A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains. Nature (1989) 2.36
Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem (1995) 2.32
A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol Microbiol (1999) 2.23
GCRDb: a G-protein-coupled receptor database. Receptors Channels (1994) 2.23
Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein. Appl Environ Microbiol (1992) 2.18
The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell (1989) 2.10
Two large families of chemoreceptor genes in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae reveal extensive gene duplication, diversification, movement, and intron loss. Genome Res (1998) 2.03
The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins. Proc Natl Acad Sci U S A (1999) 2.01
Complete DNA sequence of yeast chromosome II. EMBO J (1994) 1.97
Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome. Nat Genet (1995) 1.95
The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein. EMBO J (1991) 1.89
Prediction of membrane protein topology utilizing multiple sequence alignments. J Protein Chem (1997) 1.56
Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol (1994) 1.56
Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor. Mol Cell Biol (1993) 1.53
The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors. AAPS PharmSci (1999) 1.47
Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes Dev (1990) 1.28
Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J Biol Chem (1998) 1.27
G-protein coupled receptor from yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun (1997) 1.19
alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. J Biol Chem (1998) 1.14
Olfactory receptors, vomeronasal receptors, and the organization of olfactory information. Cell (1997) 1.09
Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans. J Mol Neurosci (1997) 1.07
Calmodulin binding to G protein-coupling domain of opioid receptors. J Biol Chem (1999) 1.05
Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor. Biochem Biophys Res Commun (1993) 1.01
Evolutionary relationships among proteins probed by an iterative neighborhood cluster analysis (INCA). Alignment of bacteriorhodopsins with the yeast sequence YRO2. Pharm Res (1997) 1.00
Characterization of p40/GPR69A as a peripheral membrane protein related to the lantibiotic synthetase component C. Biochem Biophys Res Commun (2000) 0.98
Evidence for kinship between diverse G-protein coupled receptors. Gene (1999) 0.98
Evolutionary conservation of both the hydrophilic and hydrophobic nature of transmembrane residues. J Theor Biol (1995) 0.92
Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter. Mol Pharmacol (1995) 0.92
Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor. Biochim Biophys Acta (1998) 0.89
Distribution of the GABA(B) receptor subunit gb2 in rat CNS. Brain Res (2000) 0.88
Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family. Trends Pharmacol Sci (1998) 0.87
Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. Oncogene (1998) 0.84
Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors. Nucleic Acids Res (1990) 0.83
Studies on the light-transducing pigment bacteriorhodopsin. Cold Spring Harb Symp Quant Biol (1983) 0.81
Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae. Yeast (1995) 0.76
Pharmacogenomics: the promise of personalized medicine. AAPS PharmSci (2000) 2.63
Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells. J Neurochem (1995) 1.93
5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res (1998) 1.66
Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling. J Biol Chem (1993) 1.64
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. J Neurochem (2001) 1.53
Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR. Mol Psychiatry (2006) 1.27
Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. J Pharmacol Exp Ther (1996) 1.26
Determination of 5-fluorouracil (NSC-19893) plasma levels in rats and man by isotope dilution-mass fragmentography. Cancer Chemother Rep (1975) 1.24
Membrane topology of the human dipeptide transporter, hPEPT1, determined by epitope insertions. Biochemistry (1998) 1.23
[Spectrophotometric determination of 5-phenyl-1,4-benzodiazepine-derivatives and studies on metabolism of nitrazepam. 5. Chemistry and analytics of benzodiazepine-derivatives]. Arzneimittelforschung (1969) 1.22
Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture. Cancer Res (1985) 1.22
Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci (1994) 1.20
Determination of metronidazole and misonidazole and their metabolites in plasma and urine by high-performance liquid chromatography. J Chromatogr (1978) 1.18
Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5. Eur J Biochem (1999) 1.12
G-protein coupling of mu-opioid receptors (OP3): elevated basal signalling activity. Biochem J (2000) 1.10
Multiple dose kinetics of spironolactone and canrenoate-potassium in cardiac and hepatic failure. Eur J Clin Pharmacol (1974) 1.08
Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding. J Biol Chem (2001) 1.06
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells. J Neurochem (1990) 1.06
Pharmacokinetics of spironolactone, canrenone and canrenoate-K in humans. J Pharmacol Exp Ther (1973) 1.05
An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. Cancer Res (1998) 1.05
Calmodulin binding to G protein-coupling domain of opioid receptors. J Biol Chem (1999) 1.05
Buprenorphine: differential interaction with opiate receptor subtypes in vivo. J Pharmacol Exp Ther (1982) 1.04
Hm1 muscarinic cholinergic receptor internalization requires a domain in the third cytoplasmic loop. J Biol Chem (1992) 1.03
A constitutively internalizing and recycling mutant of the mu-opioid receptor. J Neurochem (1997) 1.02
Efficacy and tolerance of narcotic analgesics at the mu opioid receptor in differentiated human neuroblastoma cells. J Pharmacol Exp Ther (1988) 1.01
Evolutionary relationships among proteins probed by an iterative neighborhood cluster analysis (INCA). Alignment of bacteriorhodopsins with the yeast sequence YRO2. Pharm Res (1997) 1.00
Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane. Biochemistry (1998) 0.98
Inhibition of mouse melanoma cell proliferation by corticotropin-releasing hormone and its analogs. Anticancer Res (2001) 0.98
Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors. J Biol Chem (1993) 0.95
Compartmentation of guanine nucleotide precursors for DNA synthesis. Biochem J (1986) 0.95
Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. AAPS PharmSci (2000) 0.95
Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant. AAPS PharmSci (2001) 0.94
In vivo opiate receptor binding of oripavines to mu, delta and kappa sites in rat brain as determined by an ex vivo labeling method. Eur J Pharmacol (1985) 0.93
Expression of neurotransmitter receptors and myc protooncogenes in subclones of a human neuroblastoma cell line. Cancer Res (1987) 0.93
Morphine persistence in rat brain and serum after single doses. J Pharmacol Exp Ther (1979) 0.93
Human membrane transporter database: a Web-accessible relational database for drug transport studies and pharmacogenomics. AAPS PharmSci (2000) 0.93
Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors. J Biol Chem (1995) 0.93
Incorporation of nucleotide tracers into nucleic acids in permeabilized cells and cellular homogenates. Biochem J (1986) 0.92
Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase (beta-adrenergic-receptor kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites. Eur J Biochem (1994) 0.92
A human neuroblastoma cell line expresses mu and delta opioid receptor sites. J Biol Chem (1986) 0.92
Guanine ribonucleotide depletion in mammalian cells. A target of purine antimetabolites. Cancer Chemother Pharmacol (1983) 0.91
Sequence alignments of the H(+)-dependent oligopeptide transporter family PTR: inferences on structure and function of the intestinal PET1 transporter. Pharm Res (1997) 0.90
Neuronal cell differentiation of human neuroblastoma cells by retinoic acid plus herbimycin A. Cancer Res (1988) 0.90
[3H]-etorphine and [3H]-diprenorphine receptor binding in vitro and in vivo: differential effect of Na+ and guanylyl imidodiphosphate. Brain Res (1982) 0.90
Nuclear Ca2+/calmodulin translocation activated by mu-opioid (OP3) receptor. J Neurochem (2000) 0.90
Differentiation of human neuroblastoma cells: marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid. J Neurochem (1988) 0.87
Pharmacokinetics and metabolism of ftorafur in man. Cancer Treat Rep (1979) 0.86
3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice. Eur J Pharmacol (1999) 0.86
A synthetic human Agouti-related protein-(83-132)-NH2 fragment is a potent inhibitor of melanocortin receptor function. FEBS Lett (1998) 0.86
Differential regulation of the mu-, delta-, and kappa-opiate receptor subtypes by guanyl nucleotides and metal ions. J Neurosci (1982) 0.86
Rapid measurements of intracellular calcium using a fluorescence plate reader. Biotechniques (1999) 0.86
Dynorphin peptides: antagonists of melanocortin receptors. Pharm Res (1997) 0.85
Mapping the ligand binding pocket of the human muscarinic cholinergic receptor Hm1: contribution of tyrosine-82. Pharm Res (1992) 0.85
Discrimination of three types of opioid binding sites in rat brain in vivo. Mol Pharmacol (1984) 0.85
Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes. Role of third intracellular m2 loop and G protein-coupled receptor kinase 2. J Biol Chem (1998) 0.85
Opiate antagonist receptor binding in vivo: evidence for a new receptor binding model. Brain Res (1980) 0.85
Metabolic activation of ftorafur [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil]: the microsomal oxidative pathway. Biochem Pharmacol (1982) 0.84
Internalization of the Hm1 muscarinic cholinergic receptor involves the third cytoplasmic loop. FEBS Lett (1990) 0.84
Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain. Eur J Pharmacol (1999) 0.84
Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist. J Med Chem (2003) 0.84
Tolerance to morphine at the mu-opioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine. Eur J Pharmacol (2000) 0.84
Interaction among mu-opioid receptors and alpha 2-adrenoceptors on SH-SY5Y human neuroblastoma cells. Eur J Pharmacol (1992) 0.84
Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor. J Neurochem (1997) 0.83
Structure and function of G protein coupled receptors. Pharm Res (1990) 0.83
Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther (1999) 0.83
Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors. Neurosci Lett (1986) 0.83
Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell. J Neurochem (2000) 0.83
Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes. Cancer Res (1983) 0.83
Interaction among the distinct effects of adenine and guanine depletion in mouse lymphoma cells. Cancer Res (1984) 0.82
Distinct effects of adenine and guanine starvation on DNA synthesis associated with different pool sizes of nucleotide precursors. Cancer Res (1987) 0.82
Molecular modeling of G-protein coupled receptor kinase 2: docking and biochemical evaluation of inhibitors. AAPS PharmSci (2000) 0.81
Buprenorphine is an Antagonist at the ϰ Opioid Receptor. Pharm Res (1985) 0.81
Differential expression of alpha-subunits of G-proteins in human neuroblastoma-derived cell clones. FEBS Lett (1987) 0.81
Cerebral uptake of a 3 H-labelled spirolactone compound in the dog. Eur J Pharmacol (1973) 0.81
Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent. FEBS Lett (1996) 0.81
Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1. Pharmacogenomics J (2005) 0.81
Delta opioid receptors in human neuroblastoma cell lines. Brain Res (1986) 0.80
In vivo receptor binding of opioid drugs at the mu site. J Pharmacol Exp Ther (1985) 0.80
Analysis of purine ribonucleotides and deoxyribonucleotides in cell extracts by high-performance liquid chromatography. J Chromatogr (1980) 0.80
Hydroxylated metabolies of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) in rats and rabbits. Cancer Res (1978) 0.80
In vivo characterization of four types of opioid binding sites in rat brain. Life Sci (1983) 0.80
[3H]diprenorphine receptor binding in vivo and in vitro. Eur J Pharmacol (1982) 0.79
Morphine impurity with opioid activity is identified as 10 alpha-hydroxymorphine. Pharm Res (1990) 0.79
Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res (1996) 0.79
Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor. Biochem Biophys Res Commun (1992) 0.79
5-Fluorouracil concentrations in human plasma following R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) administration. Cancer Res (1979) 0.79
Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone. Cancer Res (1980) 0.79
[3H]Etorphine receptor binding in vivo. Small fractional occupancy elicits analgesia. Mol Pharmacol (1982) 0.79
Overlapping multi-site domains of the muscarinic cholinergic Hm1 receptor involved in signal transduction and sequestration. J Biol Chem (1994) 0.79
Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil). Cancer Chemother Pharmacol (1981) 0.78
Biological consequences of guanine starvation. Basic Life Sci (1985) 0.78
Improved radioreceptor assay of opiate narcotics in human serum: application to fentanyl and morphine metabolism. Pharm Res (1987) 0.78
Modulation of 6-thioguanine activity by guanine in human promyelocytic leukemia HL-60 cells. Cancer Res (1988) 0.78
In vivo binding of benzomorphans to mu, delta and kappa opioid receptors: comparison with urine output in the rat. J Pharmacol Exp Ther (1985) 0.77
Basal signaling activity of human dopamine D2L receptor demonstrated with an ecdysone-inducible mammalian expression system. J Neurosci Methods (2000) 0.77
Functional vasoactive intestinal polypeptide (VIP) receptors in human neuroblastoma subclones that contain VIP precursor mRNA and release VIP-like substances. J Biol Chem (1989) 0.77
Antineoplastic agents: high-dose methotrexate and citrovorum factor rescue. Ther Drug Monit (1980) 0.77
Methotrexate and 7-hydroxymethotrexate: serum level monitoring by high-performance liquid chromatography. Cancer Treat Rep (1980) 0.77
The fluoropyrimidines: biochemical mechanisms and design of clinical trials. Cancer Chemother Pharmacol (1978) 0.77