Published in Toxicology on January 15, 2002
Coupling of receptor conformation and ligand orientation determine graded activity. Nat Chem Biol (2010) 1.25
Impact of polychlorinated biphenyls contamination on estrogenic activity in human male serum. Environ Health Perspect (2005) 1.09
Postweaning exposure to dietary zearalenone, a mycotoxin, promotes premature onset of puberty and disrupts early pregnancy events in female mice. Toxicol Sci (2013) 0.91
Evidence that 17alpha-estradiol is biologically active in the uterine tissue: antiuterotonic and antiuterotrophic action. Reprod Biol Endocrinol (2005) 0.88
Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates. Environ Health Perspect (2006) 0.86
OECD validation of the Hershberger assay in Japan: phase 2 dose response of methyltestosterone, vinclozolin, and p,p'-DDE. Environ Health Perspect (2003) 1.06
Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals. Toxicology (2003) 0.99
Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study. Toxicol Appl Pharmacol (2006) 0.99
Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Arch Toxicol (2002) 0.96
Relationship between the results of in vitro receptor binding assay to human estrogen receptor alpha and in vivo uterotrophic assay: comparative study with 65 selected chemicals. Toxicol In Vitro (2007) 0.88
Immature uterotrophic assay of estrogenic compounds in rats given diets of different phytoestrogen content and the ovarian changes with ICI 182,780 or antide. Arch Toxicol (2002) 0.85
Age-related changes of genital systems in the female Crj:CD (SD) IGS rats during sexual maturation. J Vet Med Sci (2002) 0.85
The efficacy of endocrine disruptor screening tests in detecting anti-estrogenic effects downstream of receptor-ligand interactions. Toxicol Lett (2002) 0.84
Uterotrophic and Hershberger assays for n-butylbenzene in rats. Arch Toxicol (2002) 0.83
Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology (2004) 0.83
Development and application of a stable HeLa cell line capable of site-specific transgenesis using the Cre-lox system: establishment and application of a stable TNFRI knockdown cell line to cytotoxicity assay. Toxicol In Vitro (2008) 0.81
Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity. Toxicol Lett (2004) 0.81
Evaluation of a rapid in vitro androgen receptor transcriptional activation assay using AR-EcoScreen cells. Toxicol In Vitro (2005) 0.81
Gene expression profile of brain regions reflecting aberrations in nervous system development targeting the process of neurite extension of rat offspring exposed developmentally to glycidol. J Appl Toxicol (2014) 0.80
Discrimination of carcinogens by hepatic transcript profiling in rats following 28-day administration. Cancer Inform (2009) 0.80
Quantitative proteomic analysis of rat liver for carcinogenicity prediction in a 28-day repeated dose study. Proteomics (2007) 0.79
Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro (2005) 0.78
A comparative study of gene expression profiles in rat liver after administration of alpha-hexachlorocyclohexane and lindane. J Toxicol Sci (2007) 0.78
Application of RNAi inducible TNFRI knockdown cells to the analysis of TNFalpha-induced cytotoxicity. Toxicol In Vitro (2006) 0.77
Development of a monoclonal antibody-based sandwich ELISA for detection of guinea pig interleukin-2. J Vet Med Sci (2006) 0.77
Effect of gonadotropin-releasing hormone antagonist on ovarian and uterine weights in immature female rats. Reprod Toxicol (2002) 0.77
Subacute oral toxicity study of diethylphthalate based on the draft protocol for "Enhanced OECD Test Guideline no. 407". Arch Toxicol (2005) 0.77
Changes of serum alpha 2u-globulin in the subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the 'Enhanced OECD Test Guideline No. 407'. Toxicology (2002) 0.77
Comparison of the reporter gene assay for ER-alpha antagonists with the immature rat uterotrophic assay of 10 chemicals. Toxicol Lett (2003) 0.76
New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats. Cancer Inform (2011) 0.75
Effects of 4-tert-pentylphenol on the gene expression of P450 11beta-hydroxylase in the gonad of medaka (Oryzias latipes). Aquat Toxicol (2004) 0.75
Effects of pentobarbital, isoflurane, or medetomidine-midazolam-butorphanol anesthesia on bronchoalveolar lavage fluid and blood chemistry in rats. J Toxicol Sci (2016) 0.75
Glycidol induces axonopathy by adult-stage exposure and aberration of hippocampal neurogenesis affecting late-stage differentiation by developmental exposure in rats. Toxicol Sci (2013) 0.75
Simpler alternative to CARCINOscreen(®) based on quantitative PCR (qPCR). J Toxicol Sci (2016) 0.75
Unique bioconcentration characteristics of new aryl fluoroalkyl ethers in common carp (Cyprinus carpio). Chemosphere (2003) 0.75
Comprehensive identification of cytochrome p450 isoforms from solubility-based fractionated rat liver microsomes. Drug Metab Lett (2007) 0.75
Evaluation for skin sensitization based on published literatures (existing information) of major PRTR designated chemical substances in Japan. Regul Toxicol Pharmacol (2009) 0.75
Inter-laboratory validation of the modified murine local lymph node assay based on 5-bromo-2'-deoxyuridine incorporation. J Appl Toxicol (2011) 0.75
Preliminary evaluation of an in utero-lactation assay using 6-n-propyl-2-thiouracil. Arch Toxicol (2005) 0.75
Investigation of the early-response genes in chemical-induced renal carcinogenicity for the prediction of chemical carcinogenicity in rats. J Toxicol Sci (2017) 0.75
Identification of sheep red blood cell (SRBC) surface immune-responsive peptides detected by antisera from SRBC-immunized rats. J Toxicol Sci (2016) 0.75
Interlaboratory validation of the modified murine local lymph node assay based on adenosine triphosphate measurement. J Pharmacol Toxicol Methods (2008) 0.75
Applicability of a gene expression based prediction method to SD and Wistar rats: an example of CARCINOscreen®. J Toxicol Sci (2015) 0.75
Ability of the Hershberger assay protocol to detect thyroid function modulators. Arch Toxicol (2005) 0.75
Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Arch Toxicol (2006) 0.75
Differences in gene expression profiles in liver caused by different types of anesthesia: cases of CO2-O2 and isoflurane. J Toxicol Sci (2015) 0.75
Methacarn as a whole brain fixative for gene and protein expression analyses of specific brain regions in rats. J Toxicol Sci (2013) 0.75
High-accuracy prediction of carcinogenicity by global quantitative analysis of post-translational modifications in a 28-day in vivo rat study. Cancer Genomics Proteomics (2008) 0.75
Gene expression changes induced by type IV allergy-inducible chemicals in dendritic cells. J Vet Med Sci (2008) 0.75
An evaluation of performance standards and non-radioactive endpoints for the local lymph node assay. The report and recommendations of ECVAM Workshop 65. Altern Lab Anim (2008) 0.75
Assessment of statistic analysis in non-radioisotopic local lymph node assay (non-RI-LLNA) with alpha-hexylcinnamic aldehyde as an example. Toxicology (2003) 0.75
CARCINOscreen®: New short-term prediction method for hepatocarcinogenicity of chemicals based on hepatic transcript profiling in rats. J Toxicol Sci (2014) 0.75