Visna virus-induced activation of MAPK is required for virus replication and correlates with virus-induced neuropathology.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMC 136850)

Published in J Virol on January 01, 2002

Authors

Sheila A Barber1, Linda Bruett, Brian R Douglass, David S Herbst, M Christine Zink, Janice E Clements

Author Affiliations

1: Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Articles citing this

Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity. J Virol (2003) 1.97

The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication. Biochem J (2004) 1.58

The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity. J Virol (2006) 1.15

Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway. J Virol (2006) 1.14

Effect of p38 mitogen-activated protein kinase on the replication of encephalomyocarditis virus. J Virol (2003) 1.09

Rabies virus stimulates nitric oxide production and CXC chemokine ligand 10 expression in macrophages through activation of extracellular signal-regulated kinases 1 and 2. J Virol (2004) 1.09

Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis. Infect Immun (2003) 1.07

Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection. J Virol (2004) 1.00

Japanese encephalitis virus induces matrix metalloproteinase-9 in rat brain astrocytes via NF-κB signalling dependent on MAPKs and reactive oxygen species. Br J Pharmacol (2010) 0.99

Activated Ras/MEK inhibits the antiviral response of alpha interferon by reducing STAT2 levels. J Virol (2009) 0.94

Influenza virus and cell signaling pathways. Med Sci Monit (2011) 0.93

Characterization of host microRNAs that respond to DNA virus infection in a crustacean. BMC Genomics (2012) 0.90

Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway. J Virol (2011) 0.90

Expanding possibilities for intervention against small ruminant lentiviruses through genetic marker-assisted selective breeding. Viruses (2013) 0.88

Progressive accumulation of activated ERK2 within highly stable ORF45-containing nuclear complexes promotes lytic gammaherpesvirus infection. PLoS Pathog (2014) 0.87

Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system. Mol Brain (2013) 0.86

Interferon gamma induces protective non-canonical signaling pathways in primary neurons. J Neurochem (2015) 0.83

Mapping of equine lentivirus receptor 1 residues critical for equine infectious anemia virus envelope binding. J Virol (2007) 0.83

Distinct roles for extracellular signal-regulated kinase 1 (ERK1) and ERK2 in the structure and production of a primate gammaherpesvirus. J Virol (2012) 0.79

The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71. PLoS Pathog (2015) 0.78

Exogenous avian leukosis virus-induced activation of the ERK/AP1 pathway is required for virus replication and correlates with virus-induced tumorigenesis. Sci Rep (2016) 0.78

Articles cited by this

Mammalian MAP kinase signalling cascades. Nature (2001) 18.89

CRM1 is an export receptor for leucine-rich nuclear export signals. Cell (1997) 18.60

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem (1995) 14.14

The MAPK signaling cascade. FASEB J (1995) 10.81

CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature (1997) 10.49

Exportin 1 (Crm1p) is an essential nuclear export factor. Cell (1997) 10.32

A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A (1995) 10.25

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. Proc Natl Acad Sci U S A (1989) 8.76

The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem (1995) 8.32

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med (1999) 7.97

Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature (1988) 6.28

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell (2000) 6.07

How MAP kinases are regulated. J Biol Chem (1995) 6.04

Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol (1996) 5.99

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol (1997) 5.49

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J Virol (1989) 5.07

The HIV-1 Rev protein. Annu Rev Microbiol (1998) 4.78

Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow. Proc Natl Acad Sci U S A (1985) 4.66

HIV chemotherapy. Nature (2001) 3.63

Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. J Virol (1986) 3.45

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell (1993) 3.27

Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs. Genes Dev (1991) 3.06

Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nat Cell Biol (2001) 2.93

The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs. Mol Cell Biol (1992) 2.83

Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. Mol Cell Biol (1993) 2.79

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci U S A (1994) 2.47

Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques. J Virol (1992) 2.30

Infectious leukoencephalomyelitis of young goats. J Infect Dis (1974) 2.23

Visna of sheep; a slow, demyelinating infection. Br J Exp Pathol (1958) 2.18

Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein. J Virol (1990) 2.17

Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals. J Virol (1996) 1.89

The ins and outs of HIV Rev. Arch Biochem Biophys (1999) 1.81

Virus mutation during 'slow infection': temporal development and characterization of mutants of visna virus recovered from sheep. J Gen Virol (1978) 1.80

Slow virus infection: replication and mechanisms of persistence of visna virus in sheep. J Infect Dis (1977) 1.78

Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression. J Virol (1997) 1.78

Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis. J Infect Dis (2001) 1.70

MAP kinase activation in macrophages. J Leukoc Biol (2001) 1.64

Phosphorylation of the rev gene product of human immunodeficiency virus type 1. J Virol (1988) 1.61

Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism. J Cell Biol (2000) 1.60

Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathway. J Virol (1999) 1.60

Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts. J Biol Chem (2000) 1.60

Visna virus encodes a post-transcriptional regulator of viral structural gene expression. Proc Natl Acad Sci U S A (1990) 1.55

Sequences in the visna virus long terminal repeat that control transcriptional activity and respond to viral trans-activation: involvement of AP-1 sites in basal activity and trans-activation. J Virol (1989) 1.54

Role of macrophage activation in the pathogenesis of Alzheimer's disease and human immunodeficiency virus type 1-associated dementia. Eur J Clin Invest (2000) 1.53

Biological characterization of the virus causing leukoencephalitis and arthritis in goats. J Gen Virol (1980) 1.53

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum. Proc Natl Acad Sci U S A (1994) 1.53

Maedi-visna virus infection in sheep: a review. Vet Res (1998) 1.42

Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins. J Virol (1991) 1.41

Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection. J Virol (1998) 1.41

Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation. Mol Cell Biol (1993) 1.34

A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp. J Biol Chem (2000) 1.31

Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro. Proc Natl Acad Sci U S A (1998) 1.21

The critical role of p38 MAP kinase in T cell HIV-1 replication. Mol Med (1997) 1.20

Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. J Immunol (2001) 1.18

Genetic variation among lentiviruses: homology between visna virus and caprine arthritis-encephalitis virus is confined to the 5' gag-pol region and a small portion of the env gene. J Virol (1984) 1.18

Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol Cell Biol (1996) 1.17

Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth. J Virol (2000) 1.11

Regulation of the visna virus long terminal repeat in macrophages involves cellular factors that bind sequences containing AP-1 sites. Mol Cell Biol (1989) 1.10

Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. Hepatology (2000) 1.09

Immune-mediated thrombocytopenia in horses infected with equine infectious anemia virus. J Virol (1991) 1.09

Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors. J Immunol (1998) 1.09

Cleavage of RasGAP and phosphorylation of mitogen-activated protein kinase in the course of coxsackievirus B3 replication. J Virol (1999) 1.07

Echovirus 1 infection induces both stress- and growth-activated mitogen-activated protein kinase pathways and regulates the transcription of cellular immediate-early genes. Virology (1998) 1.03

ERK/MAP kinase is chronically activated in human reactive astrocytes. Neuroreport (1999) 1.00

Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line. Cell Growth Differ (2000) 0.99

Both the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus induce constitutive activation of the Raf-1/mitogen-activated protein kinase signal transduction pathway. J Virol (1998) 0.98

Structural and functional analysis of the visna virus Rev-response element. J Virol (1992) 0.97

Site-specific phosphorylation of the human immunodeficiency virus type-1 Rev protein accelerates formation of an efficient RNA-binding conformation. Biochemistry (1997) 0.97

MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells. FEBS Lett (2000) 0.95

Unique features of HIV-1 Rev protein phosphorylation by protein kinase CK2 ('casein kinase-2'). FEBS Lett (2000) 0.94

Activation of the mitogen-activated protein kinase pathway in U937 leukemic cells induces phosphorylation of the amino terminus of the TATA-binding protein. Cell Growth Differ (1998) 0.93

Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells. J Biol Chem (2000) 0.93

Identification of cell membrane proteins that bind visna virus. J Virol (1991) 0.89

Phosphorylation of HIV-1 Rev protein: implication of protein kinase CK2 and pro-directed kinases. Biochem Biophys Res Commun (1996) 0.89

Involvement of FOS and JUN in the activation of visna virus gene expression in macrophages through an AP-1 site in the viral LTR. Virology (1992) 0.89

Lentivirus-induced interferon inhibits maturation and proliferation of monocytes and restricts the replication of caprine arthritis-encephalitis virus. J Virol (1989) 0.87

Animal models of demyelination. Brain Pathol (1996) 0.85

Targeting of the visna virus tat protein to AP-1 sites: interactions with the bZIP domains of fos and jun in vitro and in vivo. J Virol (1999) 0.84

The visna transcriptional activator Tat: effects on the viral LTR and on cellular genes. Virology (1993) 0.84

Lentivirus infection of macrophages. Immunol Ser (1994) 0.84

Integration of visna virus DNA occurs and may be necessary for productive infection. Virology (1997) 0.83

Cell type specific and viral regulation of visna virus gene expression. Virus Res (1990) 0.82

Characterization of a membrane-associated protein implicated in visna virus binding and infection. Virology (2000) 0.82

Involvement of a membrane-associated serine/threonine kinase complex in cellular binding of visna virus. Virology (2000) 0.81

A Rev protein is expressed in caprine arthritis encephalitis virus (CAEV)-infected cells and is required for efficient viral replication. Virology (1994) 0.80

The leucine domain of the visna virus Tat protein mediates targeting to an AP-1 site in the viral long terminal repeat. J Virol (1996) 0.80

The Rev protein of visna virus is localized to the nucleus of infected cells. Virology (1994) 0.79

Pathogenesis of ovine lentiviral encephalitis: derivation of a neurovirulent strain by in vivo passage. J Neurovirol (1997) 0.79

Rev-dependency of expression of human immunodeficiency virus type 1 gag and env genes. FEBS Lett (1995) 0.77

Articles by these authors

A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy. J Virol (2009) 2.10

The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection. J Infect Dis (2002) 1.90

Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapy. J Virol (2003) 1.89

Minocycline attenuates HIV infection and reactivation by suppressing cellular activation in human CD4+ T cells. J Infect Dis (2010) 1.70

Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients. Retrovirology (2012) 1.62

MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response. J Immunol (2010) 1.61

The central nervous system is a viral reservoir in simian immunodeficiency virus--infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapy. J Neurovirol (2005) 1.56

The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: from mechanism to treatment. J Neurovirol (2008) 1.54

Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.50

Wounding: the primary mode of Seoul virus transmission among male Norway rats. Am J Trop Med Hyg (2004) 1.50

Coordinated regulation of SIV replication and immune responses in the CNS. PLoS One (2009) 1.49

Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection. J Virol (2007) 1.47

Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism. J Neurosci (2011) 1.43

A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease. J Neurovirol (2002) 1.41

Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA. J Infect Dis (2010) 1.37

Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host. Proc Natl Acad Sci U S A (2007) 1.28

Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model. J Infect Dis (2006) 1.19

Searching for clues: tracking the pathogenesis of human immunodeficiency virus central nervous system disease by use of an accelerated, consistent simian immunodeficiency virus macaque model. J Infect Dis (2002) 1.18

Novel pathway for induction of latent virus from resting CD4(+) T cells in the simian immunodeficiency virus/macaque model of human immunodeficiency virus type 1 latency. J Virol (2006) 1.16

Innate immune responses and control of acute simian immunodeficiency virus replication in the central nervous system. J Neurovirol (2004) 1.14

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. J Neurovirol (2014) 1.11

Advancing translational research. Science (2011) 1.11

Eradication of HIV from the brain: reasons for pause. AIDS (2011) 1.10

A plasma microRNA signature of acute lentiviral infection: biomarkers of central nervous system disease. AIDS (2011) 1.10

Role of microglial cells in selective replication of simian immunodeficiency virus genotypes in the brain. J Virol (2003) 1.10

From mice to macaques--animal models of HIV nervous system disease. Curr HIV Res (2006) 1.09

miRNA profiles of monocyte-lineage cells are consistent with complicated roles in HIV-1 restriction. Viruses (2012) 1.09

Expression of simian immunodeficiency virus (SIV) nef in astrocytes during acute and terminal infection and requirement of nef for optimal replication of neurovirulent SIV in vitro. J Virol (2003) 1.08

Central nervous system correlates of behavioral deficits following simian immunodeficiency virus infection. J Neurovirol (2003) 1.08

Longitudinal analysis of simian immunodeficiency virus (SIV) replication in the lungs: compartmentalized regulation of SIV. J Infect Dis (2006) 1.06

Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal ganglia. J Neuropathol Exp Neurol (2007) 1.05

Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages. J Immunol (2010) 1.05

Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis. Am J Pathol (2004) 1.04

Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection. J Leukoc Biol (2012) 1.03

Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasma. PLoS One (2012) 1.01

CUGBP1 is required for IFNbeta-mediated induction of dominant-negative CEBPbeta and suppression of SIV replication in macrophages. J Immunol (2007) 1.00

Hydrogen bonding at a conserved threonine in lentivirus capsid is required for virus replication. J Virol (2003) 0.99

Mechanisms of minocycline-induced suppression of simian immunodeficiency virus encephalitis: inhibition of apoptosis signal-regulating kinase 1. J Neurovirol (2008) 0.95

Progressive selection for neurovirulent genotypes in the brain of SIV-infected macaques. AIDS (2006) 0.92

Replication-competent simian immunodeficiency virus (SIV) Gag escape mutations archived in latent reservoirs during antiretroviral treatment of SIV-infected macaques. J Virol (2011) 0.92

Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection. J Immunol (2011) 0.91

An internal ribosome entry site promotes translation of a novel SIV Pr55(Gag) isoform. Virology (2006) 0.90

Altered cutaneous nerve regeneration in a simian immunodeficiency virus / macaque intracutaneous axotomy model. J Comp Neurol (2009) 0.90

SIV replication is directly downregulated by four antiviral miRNAs. Retrovirology (2013) 0.89

Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease. J Neuroimmune Pharmacol (2011) 0.88

Canonical type I IFN signaling in simian immunodeficiency virus-infected macrophages is disrupted by astrocyte-secreted CCL2. J Immunol (2012) 0.88

Induction of innate immune responses by SIV in vivo and in vitro: differential expression and function of RIG-I and MDA5. J Infect Dis (2011) 0.87

HIV life cycle, innate immunity and autophagy in the central nervous system. Curr Opin HIV AIDS (2014) 0.87

Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. J Neurovirol (2015) 0.87

Evidence for miRNA expression differences of HIV-1-positive, treatment-naive patients and elite suppressors: a re-analysis. Blood (2012) 0.87

Dose-dependent protection against or exacerbation of disease by a polylactide glycolide microparticle-adsorbed, alphavirus-based measles virus DNA vaccine in rhesus macaques. Clin Vaccine Immunol (2008) 0.86

Serum albumin and body weight as biomarkers for the antemortem identification of bone and gastrointestinal disease in the common marmoset. PLoS One (2013) 0.86

Regulation of CCL2 expression by an upstream TALE homeodomain protein-binding site that synergizes with the site created by the A-2578G SNP. PLoS One (2011) 0.86

Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system. Mol Brain (2013) 0.86

Initiation of HAART during acute simian immunodeficiency virus infection rapidly controls virus replication in the CNS by enhancing immune activity and preserving protective immune responses. J Neurovirol (2010) 0.86

Placental malaria and mother-to-child transmission of human immunodeficiency virus-1 in rural Rwanda. Am J Trop Med Hyg (2011) 0.84

PrPC, the cellular isoform of the human prion protein, is a novel biomarker of HIV-associated neurocognitive impairment and mediates neuroinflammation. Am J Pathol (2010) 0.84

Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells. J Biol Chem (2011) 0.83

Multiplex GPCR assay in reverse transfection cell microarrays. J Biomol Screen (2004) 0.83

CD4-independent entry and replication of simian immunodeficiency virus in primary rhesus macaque astrocytes are regulated by the transmembrane protein. J Virol (2005) 0.83

Impaired performance on the object retrieval-detour test of executive function in the SIV/macaque model of AIDS. AIDS Res Hum Retroviruses (2006) 0.83

Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease. J Neurovirol (2014) 0.82

14-3-3 protein in CSF: an early predictor of SIV CNS disease. J Neuropathol Exp Neurol (2005) 0.81

SIV-specific T lymphocyte responses in PBMC and lymphoid tissues of SIV-infected pigtailed macaques during suppressive combination antiretroviral therapy. J Med Primatol (2005) 0.81

Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol (2015) 0.81

Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques. AIDS (2017) 0.80

SIV/macaque model of HIV infection in cocaine users: minimal effects of cocaine on behavior, virus replication, and CNS inflammation. J Neuroimmune Pharmacol (2011) 0.80

Quantitation of gene expression in formaldehyde-fixed and fluorescence-activated sorted cells. PLoS One (2013) 0.80

Sequence variation in the CC-chemokine ligand 2 promoter of pigtailed macaques is not associated with the incidence or severity of neuropathology in a simian immunodeficiency virus model of human immunodeficiency virus central nervous system disease. J Neurovirol (2006) 0.80

Tissue-specific interferon alpha subtype response to SIV infection in brain, spleen, and lung. J Interferon Cytokine Res (2012) 0.80

Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol (2014) 0.79

Phosphorylation and proteolytic cleavage of gag proteins in budded simian immunodeficiency virus. J Virol (2005) 0.79

Early emergence and selection of a SIV-LTR C/EBP site variant in SIV-infected macaques that increases virus infectivity. PLoS One (2012) 0.79

RON receptor tyrosine kinase, a negative regulator of inflammation, is decreased during simian immunodeficiency virus-associated central nervous system disease. J Immunol (2013) 0.79

A quantitative measurement of antiviral activity of anti-human immunodeficiency virus type 1 drugs against simian immunodeficiency virus infection: dose-response curve slope strongly influences class-specific inhibitory potential. J Virol (2012) 0.79

Regulation of SIV mac 239 basal long terminal repeat activity and viral replication in macrophages: functional roles of two CCAAT/enhancer-binding protein beta sites in activation and interferon beta-mediated suppression. J Biol Chem (2009) 0.78

Induction of antibody-mediated neutralization in SIVmac239 by a naturally acquired V3 mutation. Virology (2010) 0.78