Published in Oncogene on November 22, 2001
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A (2004) 2.03
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol (2010) 1.91
Experimental mouse models for hepatocellular carcinoma research. Int J Exp Pathol (2009) 1.79
β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice. PLoS One (2012) 1.56
Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model. J Hepatol (2014) 1.50
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. Gastroenterology (2015) 1.20
Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome. Genome Biol (2012) 1.09
Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver. Nucleic Acids Res (2013) 1.07
Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice. Histochem Cell Biol (2010) 1.07
β-Catenin signaling in hepatocellular cancer: Implications in inflammation, fibrosis, and proliferation. Cancer Lett (2013) 0.94
Phenotype of single hepatocytes expressing an activated version of β-catenin in liver of transgenic mice. J Mol Histol (2011) 0.88
Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice. Toxicol Sci (2009) 0.86
Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol Sci (2013) 0.85
Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors. Toxicol Sci (2009) 0.84
Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. PLoS One (2014) 0.83
Accelerated hepatocellular carcinoma development in CUL4B transgenic mice. Oncotarget (2015) 0.80
Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer. Cancer Res (2016) 0.80
Effect of mutant β-catenin on liver growth homeostasis and hepatocarcinogenesis in transgenic mice. Liver Int (2011) 0.79
Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques. Toxicol Pathol (2008) 0.78
Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis. Nat Commun (2015) 0.78
Genetic ablation of β-catenin inhibits the proliferative phenotype of mouse liver adenomas. Br J Cancer (2014) 0.78
Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion. Nucleic Acids Res (2014) 0.76
Animal models of extracranial pediatric solid tumors. Oncol Lett (2012) 0.75
Experimental Hepatic Carcinogenesis: Oxidative Stress and Natural Antioxidants. Open Access Maced J Med Sci (2017) 0.75
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature (2004) 16.76
Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci U S A (2006) 9.26
Identification of a gene that causes primary open angle glaucoma. Science (1997) 8.14
Assessment of client/patient satisfaction: development of a general scale. Eval Program Plann (1979) 7.45
Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia. Proc Natl Acad Sci U S A (2005) 7.12
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry (2007) 6.72
Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med (1998) 5.79
Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia? J Virol (2005) 5.78
The molecular basis of lung morphogenesis. Mech Dev (2000) 4.87
Assessment of patient satisfaction: development and refinement of a service evaluation questionnaire. Eval Program Plann (1983) 3.91
Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abi1 and abi2 mutants. Plant Cell (1997) 3.62
Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam. Virology (2006) 3.59
Epiluminescence microscopy. A useful tool for the diagnosis of pigmented skin lesions for formally trained dermatologists. Arch Dermatol (1995) 3.34
The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms. Chem Biol (1998) 3.23
Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice. J Cyst Fibros (2008) 2.56
Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res (1983) 2.46
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. FEBS Lett (2000) 2.40
Genetic controls of meiotic recombination and somatic DNA metabolism in Drosophila melanogaster. Proc Natl Acad Sci U S A (1976) 2.39
Isolation and characterization of X-linked mutants of Drosophila melanogaster which are sensitive to mutagens. Genetics (1976) 2.28
Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J Virol (2007) 2.20
Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. Curr Biol (2001) 2.16
Ethnic populations in public mental health: services choice and level of use. Am J Public Health (1991) 2.13
Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam. J Clin Microbiol (1996) 2.12
Cystic fibrosis, Young's syndrome, and normal sweat chloride. Lancet (1998) 2.06
Preexistence and evolution of imatinib mesylate-resistant clones in chronic myelogenous leukemia detected by a PNA-based PCR clamping technique. Ann Hematol (2003) 2.01
Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product. Ophthalmologica (1997) 1.98
Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Mol Psychiatry (2008) 1.92
Genetic predisposition to adverse consequences of anti-cholinesterases in 'atypical' BCHE carriers. Nat Med (1995) 1.87
Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation. J Biol Chem (1996) 1.87
Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors. Circulation (1993) 1.86
The isolation of porcine ribonuclease, a glycoprotein, from pancreatic juice. J Biol Chem (1968) 1.83
Peripheral artery occlusive disease in chronic phase chronic myeloid leukemia patients treated with nilotinib or imatinib. Leukemia (2013) 1.77
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice. J Lipid Res (2001) 1.69
Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. J Clin Invest (1998) 1.68
Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitors. Blood (1998) 1.61
Bipolaron mechanism for organic magnetoresistance. Phys Rev Lett (2007) 1.60
Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis. Brain Res (1984) 1.59
Heparin inhibits ligand binding to the leukocyte integrin Mac-1 (CD11b/CD18). Circulation (1999) 1.58
A novel long-QT 5 gene mutation in the C-terminus (V109I) is associated with a mild phenotype. J Mol Med (Berl) (2001) 1.56
Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression. Proc Natl Acad Sci U S A (1990) 1.56
Recommendations for the classification of diseases as CFTR-related disorders. J Cyst Fibros (2011) 1.54
Low-energy He/Ne laser in the prevention of radiation-induced mucositis. A multicenter phase III randomized study in patients with head and neck cancer. Support Care Cancer (1999) 1.51
A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly. EMBO J (2000) 1.48
Late evaluation of pulmonary function after acute exposure to chlorine gas. Am Rev Respir Dis (1969) 1.46
Retrovirus-induced insertional mutation in Mov13 mice affects collagen I expression in a tissue-specific manner. Cell (1989) 1.46
Evidence for a non-orthostatic origin of orthostatic tremor. J Neurol Neurosurg Psychiatry (1999) 1.43
Determination of the X(3872) meson quantum numbers. Phys Rev Lett (2013) 1.42
Epidermal growth factor receptor of the intestinal enterocyte. Localization to laterobasal but not brush border membrane. J Biol Chem (1989) 1.41
Deafferentation pain after local treatment in non-metastatic breast carcinoma. Pain (1994) 1.39
Evaluation of different tubing geometries for high-speed counter-current chromatography. J Chromatogr A (2001) 1.39
[Cerebral angiitis or central side effects after lumbar myelography (with intracerebral vascular spasm)]. Nervenarzt (1994) 1.38
Amplification refractory mutation system for prenatal diagnosis and carrier assessment in cystic fibrosis. Lancet (1990) 1.36
Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers. J Clin Oncol (1998) 1.34
Genetic selection of mutations in the high affinity K+ transporter HKT1 that define functions of a loop site for reduced Na+ permeability and increased Na+ tolerance. J Biol Chem (1999) 1.34
High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr Biol (1997) 1.33
Prevalence of antibodies to West Nile fever, sandfly fever Sicilian, and sandfly fever Naples viruses in healthy adults in Israel. Public Health Rev (1999) 1.33
GLC1A mutations point to regions of potential functional importance on the TIGR/MYOC protein. Mol Vis (1998) 1.32
Age is not a limiting factor for radical radiotherapy in pelvic malignancies. Radiother Oncol (1997) 1.29
Localization of the stress proteins alpha B-crystallin and trabecular meshwork inducible glucocorticoid response protein in normal and glaucomatous trabecular meshwork. Invest Ophthalmol Vis Sci (1998) 1.29
Precision grip and Parkinson's disease. Brain (1998) 1.29
Magnetic resonance imaging contrast agent targeted toward activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis. Circulation (2008) 1.28
Nonrandom induction of pyrimidine-pyrimidone (6-4) photoproducts in ultraviolet-irradiated human chromatin. J Biol Chem (1990) 1.27
Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene. Hum Genet (1992) 1.27
Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission. Neurotox Res (2006) 1.25
Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc Natl Acad Sci U S A (1997) 1.25
CSF shunt infections in children. Infection (1993) 1.22
Different mechanisms underlie the long-latency stretch reflex response of active human muscle at different joints. J Physiol (1991) 1.21
First observation of CP violation in the decays of B(s)0 mesons. Phys Rev Lett (2013) 1.21
Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase. Carcinogenesis (1984) 1.20
The role of the human thalamus in processing corollary discharge. Brain (2005) 1.19
Comparative analytical sensitivities of six rapid influenza A antigen detection test kits for detection of influenza A subtypes H1N1, H3N2 and H5N1. J Clin Virol (2006) 1.19
Purification, physical characterization, and NH2-terminal sequence of glutamine synthetase from the cyanobacterium Anabaena 7120. J Biol Chem (1981) 1.18
Expression of hypoxia-inducible genes in tumor cells. J Cancer Res Clin Oncol (1998) 1.18
Halictine social evolution: the Australian enigma. Science (1976) 1.17
Clinic experience of prenatal diagnosis of cystic fibrosis by use of linked DNA probes. Lancet (1987) 1.15
In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials. Acta Trop (1997) 1.15
Coronary MR angiography: selection of acquisition window of minimal cardiac motion with electrocardiography-triggered navigator cardiac motion prescanning--initial results. Radiology (2001) 1.14
Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/Smad pathway in human glioblastoma cells. Oncogene (2009) 1.13
[Securing the airway in children with the Morquio-Brailsford syndrome]. Anaesthesist (1993) 1.13
Gender-related differences in bile acid and sterol metabolism in outbred CD-1 mice fed low- and high-cholesterol diets. Hepatology (1998) 1.13
Botulinum toxin treatment of synkinesia and hyperlacrimation after facial palsy. J Neurol Neurosurg Psychiatry (1998) 1.13
The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiol Dis (1999) 1.12
Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol (1996) 1.12
Homozygotes carrying an autosomal dominant TIGR mutation do not manifest glaucoma. Nat Genet (1998) 1.11
IFN-gamma-independent IgG2a production in mice infected with viruses and parasites. Int Immunol (2000) 1.10
The b-wave of the electroretinogram as an index of retinal ischemia. Gen Pharmacol (1998) 1.10
Nonidentical induction of the guanylate binding protein and the 56K protein by type I and type II interferons. J Interferon Res (1986) 1.09
Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation. Circulation (1994) 1.09
[Typhoid fever in South Vietnam, 1990-1993]. Bull Soc Pathol Exot (1993) 1.08
Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis. Proc Natl Acad Sci U S A (1991) 1.08
Stress-controlled viscoelastic tensile response of bovine cornea. J Biomech (2007) 1.08
Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter with the severity of primary open-angle glaucoma. Clin Genet (2001) 1.07
Social outcome in adults with maple syrup urine disease (MSUD). J Inherit Metab Dis (2007) 1.07
Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current. Receptors Channels (1999) 1.07
Learned changes of feeding behavior in Aplysia in response to edible and inedible foods. J Neurosci (1986) 1.06
The bisphosphonate ibandronate improves implant integration in osteopenic ovariectomized rats. Bone (2005) 1.06
Recommendations for quality improvement in genetic testing for cystic fibrosis. European Concerted Action on Cystic Fibrosis. Eur J Hum Genet (2000) 1.06