Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMID 20886225)

Published in Histochem Cell Biol on October 01, 2010

Authors

Albert Braeuning1, Yasmin Singh, Benjamin Rignall, Albrecht Buchmann, Seddik Hammad, Amnah Othman, Iris von Recklinghausen, Patricio Godoy, Stefan Hoehme, Dirk Drasdo, Jan G Hengstler, Michael Schwarz

Author Affiliations

1: Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, Wilhelmstr. 56, 72074, Tübingen, Germany.

Articles citing this

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis. Arch Toxicol (2014) 1.10

Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injury. Hepatology (2011) 1.08

A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration. Hepatology (2013) 1.00

Depletion of β-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development. Proc Natl Acad Sci U S A (2011) 0.99

Hepatocyte γ-catenin compensates for conditionally deleted β-catenin at adherens junctions. J Hepatol (2011) 0.94

Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration. Hear Res (2012) 0.89

Phenotype of single hepatocytes expressing an activated version of β-catenin in liver of transgenic mice. J Mol Histol (2011) 0.88

Pericentral activity of alpha-fetoprotein enhancer 3 and glutamine synthetase upstream enhancer in the adult liver are regulated by β-catenin in mice. Hepatology (2012) 0.80

Quantification of three-dimensional structures in liver tissue: bile canalicular and sinusoidal networks. EXCLI J (2014) 0.80

Genetic ablation of β-catenin inhibits the proliferative phenotype of mouse liver adenomas. Br J Cancer (2014) 0.78

Highlight report: Software for tissue analysis and reconstruction. EXCLI J (2015) 0.75

Advances in 2D and 3D in vitro systems for hepatotoxicity testing. EXCLI J (2013) 0.75

Signal integration by the CYP1A1 promoter--a quantitative study. Nucleic Acids Res (2015) 0.75

Histochemistry and cell biology: the annual review 2010. Histochem Cell Biol (2011) 0.75

Articles cited by this

A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61

Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer (2006) 10.05

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell (2001) 8.41

Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev (1998) 3.65

Focus on hepatocellular carcinoma. Cancer Cell (2004) 3.49

WNT/beta-catenin signaling in liver health and disease. Hepatology (2007) 3.26

Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology (2006) 2.54

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration. Proc Natl Acad Sci U S A (2010) 2.50

Functional specialization of different hepatocyte populations. Physiol Rev (1989) 2.45

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell (2006) 2.45

New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene (2002) 2.23

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A (2004) 2.03

Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr (1996) 2.03

Metabolic zonation of the liver: regulation and implications for liver function. Pharmacol Ther (1992) 2.02

Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res (2004) 2.01

Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology (2009) 1.86

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. EMBO J (1983) 1.84

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology (2009) 1.80

Zonal gene expression in murine liver: lessons from tumors. Hepatology (2006) 1.73

Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. Hepatology (2006) 1.69

Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res (2002) 1.62

Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy. Hepatology (2007) 1.40

Zonation of hepatic cytochrome P-450 expression and regulation. Biochem J (1998) 1.26

Zonation of metabolism and gene expression in liver. Histochem Cell Biol (1995) 1.24

Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology (2010) 1.23

Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res (2002) 1.19

Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene (2001) 1.14

A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. Carcinogenesis (2004) 1.09

Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver. Gen Pharmacol (1997) 1.09

Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology. Future Oncol (2008) 1.06

Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1. Drug Metab Dispos (2009) 1.02

Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers. Hepatology (2007) 1.01

Periportal and perivenous hepatocytes retain their zonal characteristics in primary culture. Biochem Biophys Res Commun (1986) 0.93

PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. Toxicol Sci (2006) 0.90

Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and beta-catenin mutated hepatomas. Drug Metab Dispos (2007) 0.89

Glutamine synthetase and hepatocarcinogenesis. Carcinogenesis (1995) 0.88

Expression of gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. J Gastroenterol (2004) 0.88

Position-specific gene expression in the liver lobule is directed by the microenvironment and not by the previous cell differentiation state. J Biol Chem (1999) 0.88

Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice. Cancer Res (2000) 0.86

Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver. Toxicol Sci (2010) 0.86

Evidence that interaction of hepatocytes with the collecting (hepatic) veins triggers position-specific transcription of the glutamine synthetase and ornithine aminotransferase genes in the mouse liver. Mol Cell Biol (1991) 0.84

Reestablishment of the heterogeneous distribution of hepatic glutamine synthetase during regeneration after CCl4-intoxication. Histochemistry (1990) 0.84

Induction of glutamine synthetase in periportal hepatocytes by cocultivation with a liver epithelial cell line. Eur J Cell Biol (1990) 0.82

beta-Catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver. Biol Chem (2010) 0.82

The RL-ET-14 cell line mediates expression of glutamine synthetase through the upstream enhancer/promoter region. J Hepatol (2005) 0.81

Zonal expression of hepatocytic marker enzymes during liver repopulation. Histochem Cell Biol (2007) 0.81

Roles of gap junctions and connexins in non-neoplastic pathological processes in which cell proliferation is involved. J Membr Biol (2007) 0.79

Tumor promotion in liver of mice with a conditional Cx26 knockout. Toxicol Sci (2008) 0.78

Cell-cell interactions in the regulation of the expression of hepatic enzymes. Cell Biol Toxicol (1997) 0.76

Articles by these authors

Drought sensitivity of the Amazon rainforest. Science (2009) 7.27

The humoral immune system has a key prognostic impact in node-negative breast cancer. Cancer Res (2008) 5.69

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet (2010) 3.93

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev (2007) 2.69

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Nat Genet (2010) 2.56

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration. Proc Natl Acad Sci U S A (2010) 2.50

Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers. PLoS One (2012) 2.38

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17

Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Gastroenterology (2008) 2.07

Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers. Gut (2006) 1.96

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration. Hepatology (2014) 1.93

The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+ -antiporter active in proanthocyanidin-accumulating cells of the seed coat. Plant Cell (2007) 1.87

A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors. Clin Cancer Res (2012) 1.83

Drought-mortality relationships for tropical forests. New Phytol (2010) 1.82

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo. Nature (2012) 1.82

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology (2009) 1.80

Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs". Arch Toxicol (2011) 1.77

Zonal gene expression in murine liver: lessons from tumors. Hepatology (2006) 1.73

Do normal D-dimer levels reliably exclude cerebral sinus thrombosis? Stroke (2004) 1.70

Molecular modes of action of artesunate in tumor cell lines. Mol Pharmacol (2003) 1.66

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice. Hepatology (2014) 1.65

A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice. Cancer Res (2004) 1.64

Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation. Clin Cancer Res (2012) 1.63

Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro. Biophys J (2004) 1.61

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene. Hum Mol Genet (2011) 1.58

Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach. Biophys J (2008) 1.57

SEURAT-1 liver gold reference compounds: a mechanism-based review. Arch Toxicol (2014) 1.50

Individual-based and continuum models of growing cell populations: a comparison. J Math Biol (2008) 1.49

Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis. Phys Biol (2009) 1.49

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol (2011) 1.46

Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol (2014) 1.43

ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction. Clin Cancer Res (2010) 1.41

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci U S A (2012) 1.41

Differential gene expression in periportal and perivenous mouse hepatocytes. FEBS J (2006) 1.41

Low-dose extrapolation in toxicology: an old controversy revisited. Arch Toxicol (2009) 1.39

Mathematical modelling of liver regeneration after intoxication with CCl(4). Chem Biol Interact (2007) 1.35

A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage. Oncogene (2002) 1.35

Characteristics of infection with Candida species in patients with necrotizing pancreatitis. World J Surg (2001) 1.33

Present status and perspectives of cell-based therapies for liver diseases. J Hepatol (2006) 1.33

Loss of tumor suppressor protein PTEN during renal carcinogenesis. Int J Cancer (2002) 1.31

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer. Breast Cancer Res (2010) 1.30

Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer. Clin Cancer Res (2008) 1.28

A microfluidic array with cellular valving for single cell co-culture. Lab Chip (2010) 1.27

Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype. Pharmacogenet Genomics (2011) 1.27

Pathways of proliferation and antiapoptosis driven in breast cancer stem cells by stem cell protein piwil2. Cancer Res (2010) 1.26

Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology (2005) 1.26

β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One (2011) 1.25

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes. Hepatology (2010) 1.25

Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res (2005) 1.23

Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis. Cancer Res (2010) 1.23

The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis. Hepatology (2009) 1.21

Consensus report on the future of animal-free systemic toxicity testing. ALTEX (2014) 1.20

Cerebral aspergillosis caused by Neosartorya hiratsukae, Brazil. Emerg Infect Dis (2002) 1.20

Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective. Toxicol Lett (2004) 1.20

Intraspecific molecular phylogeny, genetic variation and phylogeography of Reticulitermes speratus (Isoptera: Rhinotermitidae). Mol Cells (2006) 1.19

Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res (2002) 1.19

Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology (2007) 1.19

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes. Arch Toxicol (2012) 1.18

Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes. BMC Bioinformatics (2010) 1.16

Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure. Pharmacogenet Genomics (2009) 1.15

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. ALTEX (2012) 1.15

Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration. Regen Med (2008) 1.14

The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins. Mol Cell Biol (2009) 1.10

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis. Arch Toxicol (2014) 1.10

A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. Carcinogenesis (2004) 1.09

IGKC and prognosis in breast cancer. Clin Cancer Res (2012) 1.09

Transdermal rotigotine for the perioperative management of Parkinson's disease. J Neural Transm (Vienna) (2010) 1.08

NAT2 and bladder cancer--letter. Cancer Epidemiol Biomarkers Prev (2013) 1.08

ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions. Cancer Res (2006) 1.06

Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytes. Biol Chem (2010) 1.06

Re: Caroline E. Weibull, Sandra Eloranta, Daniel Altman, Anna L.V. Johansson, Mats Lambe. Childbearing and the risk of bladder cancer: a nationwide population-based cohort study. Eur Urol 2013;63:733-8. Eur Urol (2013) 1.06

Tracking of human cells in mice. Histochem Cell Biol (2008) 1.06