Published in Eur J Biochem on July 15, 1975
A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway. Proc Natl Acad Sci U S A (1988) 1.40
Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region. Proc Natl Acad Sci U S A (1984) 1.31
Guinea pig preproinsulin gene: an evolutionary compromise? Proc Natl Acad Sci U S A (1984) 1.24
Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin. Proc Natl Acad Sci U S A (1980) 1.16
Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers. J Cell Biol (1991) 1.01
Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin. Biochem J (1986) 0.86
Sequence of a New World primate insulin having low biological potency and immunoreactivity. Proc Natl Acad Sci U S A (1987) 0.82
Inactive conformation of an insulin despite its wild-type sequence. Protein Sci (1997) 0.80
The solution structure of a superpotent B-chain-shortened single-replacement insulin analogue. Protein Sci (1999) 0.80
Chemical reactivity of the functional groups of insulin. Concentration-dependence studies. Biochem J (1984) 0.79
Structure-function relationships in the free insulin monomer. Biochem J (1986) 0.79
Side-chain mobility and the calculation of tyrosyl circular dichroism of proteins. Implications of a test with insulin and des-B1-phenylalanine insulin. Biophys J (1977) 0.79
Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptors. Proc Natl Acad Sci U S A (1981) 0.78
Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61
FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties. J Mol Biol (2001) 10.02
HOMSTRAD: a database of protein structure alignments for homologous families. Protein Sci (1998) 5.62
The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein. Plant Cell (1999) 4.54
JOY: protein sequence-structure representation and analysis. Bioinformatics (1998) 4.10
Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming. J Mol Biol (1990) 4.02
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature (2000) 3.90
Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures. Protein Eng (1989) 3.79
The structure of 2Zn pig insulin crystals at 1.5 A resolution. Philos Trans R Soc Lond B Biol Sci (1988) 3.30
A database of globular protein structural domains: clustering of representative family members into similar folds. Fold Des (1996) 3.23
Knowledge-based prediction of protein structures and the design of novel molecules. Nature (1987) 2.99
Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering. J Mol Biol (1989) 2.86
Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature (2002) 2.71
The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure (1999) 2.64
Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds. Protein Sci (1992) 2.61
A six-stranded double-psi beta barrel is shared by several protein superfamilies. Structure (1999) 2.57
Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction. Proc Biol Sci (1990) 2.53
New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature (1991) 2.47
Structural evidence for gene duplication in the evolution of the acid proteases. Nature (1978) 2.47
I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat Biotechnol (1997) 2.47
Atomic positions in rhombohedral 2-zinc insulin crystals. Nature (1971) 2.31
X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins. Nature (1990) 2.21
Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. Protein Eng (2000) 2.20
Location of a folding protein and shape changes in GroEL-GroES complexes imaged by cryo-electron microscopy. Nature (1994) 2.19
Receptor-binding region of insulin. Nature (1976) 2.14
Crystal structure of an Xrcc4-DNA ligase IV complex. Nat Struct Biol (2001) 2.07
Structure of pentameric human serum amyloid P component. Nature (1994) 2.07
HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families. Bioinformatics (2001) 1.97
Alignment and searching for common protein folds using a data bank of structural templates. J Mol Biol (1993) 1.97
Yeast hexokinase. 3. Sulfhydryl groups and protein dissociation. Biochemistry (1968) 1.89
Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing. Nat Struct Biol (1998) 1.89
Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling. Protein Eng (1987) 1.81
Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist. Thyroid (2005) 1.76
Hormone families: pancreatic hormones and homologous growth factors. Nature (1980) 1.71
Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables. Protein Eng (1997) 1.69
Knowledge-based protein modeling. Crit Rev Biochem Mol Biol (1994) 1.65
Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell (1992) 1.62
ATP induces large quaternary rearrangements in a cage-like chaperonin structure. Curr Biol (1993) 1.62
Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature (1998) 1.61
Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables. J Mol Biol (1993) 1.60
Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains. Protein Eng (1989) 1.58
Epidermal growth factor binding induces a conformational change in the external domain of its receptor. EMBO J (1989) 1.56
X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone. Proc Natl Acad Sci U S A (1981) 1.56
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology. Tuberculosis (Edinb) (2003) 1.55
Modeling alpha-helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues. Protein Sci (1993) 1.53
CODA: a combined algorithm for predicting the structurally variable regions of protein models. Protein Sci (2001) 1.53
X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution. J Mol Biol (1990) 1.52
A variable gap penalty function and feature weights for protein 3-D structure comparisons. Protein Eng (1992) 1.51
Determination of interspin distances between spin labels attached to insulin: comparison of electron paramagnetic resonance data with the X-ray structure. Biophys J (1997) 1.48
Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site. Nature (1992) 1.48
A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism. Biochemistry (2001) 1.47
Characterization and modelling of VanT: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174. Mol Microbiol (1999) 1.42
High resolution structure of an oligomeric eye lens beta-crystallin. Loops, arches, linkers and interfaces in beta B2 dimer compared to a monomeric gamma-crystallin. J Mol Biol (1991) 1.40
Pressure sore prevention in hospital patients: a clinical audit. J Wound Care (1999) 1.40
Is the evolution of insulin Darwinian or due to selectively neutral mutation? Nature (1975) 1.38
From comparisons of protein sequences and structures to protein modelling and design. Trends Biochem Sci (1990) 1.37
Molecular recognition in protein families: a database of aligned three-dimensional structures of related proteins. Biochem Soc Trans (1993) 1.37
Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites. Blood (1996) 1.37
CAMPASS: a database of structurally aligned protein superfamilies. Structure (1998) 1.33
Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding. Proc Natl Acad Sci U S A (1978) 1.32
X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase. Nat Struct Biol (1997) 1.30
Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP). Protein Sci (1994) 1.29
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor. EMBO J (2001) 1.28
Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function. Thyroid (2004) 1.28
Fibroblast growth factor receptors: lessons from the genes. Trends Biochem Sci (1998) 1.26
High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes. Nature (1987) 1.25
Getting knotted: a model for the structure and activation of Spätzle. Trends Biochem Sci (1998) 1.24
A novel superfamily of enzymes that catalyze the modification of guanidino groups. Trends Biochem Sci (2001) 1.24
An automatic method involving cluster analysis of secondary structures for the identification of domains in proteins. Protein Sci (1995) 1.23
Conformational analysis and clustering of short and medium size loops connecting regular secondary structures: a database for modeling and prediction. Protein Sci (1996) 1.22
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding. Science (1986) 1.22
Incorporating knowledge-based biases into an energy-based side-chain modeling method: application to comparative modeling of protein structure. Biopolymers (2001) 1.22
Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase. Trends Biochem Sci (1998) 1.21
Properties of polyproline II, a secondary structure element implicated in protein-protein interactions. Proteins (2005) 1.20
Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases. Protein Sci (1992) 1.20
Structural variation in mammalian gamma-crystallins based on computer graphics analyses of human, rat and calf sequences. 1. Core packing and surface properties. Exp Eye Res (1986) 1.20
Insulin release from mouse islets. Effect of glucose and hormones on adenylate cyclase. Biochem J (1972) 1.20
Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors. Structure (1993) 1.20
An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure. Protein Eng (1993) 1.17
Sequence-structure homology recognition by iterative alignment refinement and comparative modeling. Proteins (2001) 1.17
Carbonyl-carbonyl interactions stabilize the partially allowed Ramachandran conformations of asparagine and aspartic acid. Protein Eng (1999) 1.17
X-ray analysis and the structure of insulin. Recent Prog Horm Res (1971) 1.16
Domain flexibility in aspartic proteinases. Proteins (1992) 1.15
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding. Nat Struct Biol (1999) 1.14
Molecular anatomy: phyletic relationships derived from three-dimensional structures of proteins. J Mol Evol (1990) 1.14
Surface interactions of gamma-crystallins in the crystal medium in relation to their association in the eye lens. Proteins (1988) 1.14
Structure and evolution of insulins: implications for receptor binding. Bioessays (1992) 1.14
X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution. J Mol Biol (1990) 1.14