Published in Nature on May 16, 2002
C-reactive protein: a critical update. J Clin Invest (2003) 11.77
The amyloid state of proteins in human diseases. Cell (2012) 4.53
Amyloidosis: pathogenesis and new therapeutic options. J Clin Oncol (2011) 2.82
Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nat Rev Drug Discov (2010) 2.58
Reduction of bleomycin-induced pulmonary fibrosis by serum amyloid P. J Immunol (2007) 2.02
Cardiovascular magnetic resonance and prognosis in cardiac amyloidosis. J Cardiovasc Magn Reson (2008) 2.01
Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys (2007) 1.97
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature (2010) 1.81
MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. Proc Natl Acad Sci U S A (2006) 1.61
Light chain (AL) amyloidosis: update on diagnosis and management. J Hematol Oncol (2011) 1.48
Anti-serum amyloid component P antibodies in patients with systemic lupus erythematosus correlate with disease activity. Ann Rheum Dis (2005) 1.48
Amyloid accomplices and enforcers. Protein Sci (2004) 1.36
Systemic amyloidosis and the gastrointestinal tract. Nat Rev Gastroenterol Hepatol (2009) 1.34
Al amyloidosis. Orphanet J Rare Dis (2012) 1.29
Amyloid in the cardiovascular system: a review. J Clin Pathol (2005) 1.24
Targeting TLR/IL-1R signalling in human diseases. Mediators Inflamm (2010) 1.09
Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro. Am J Pathol (2002) 1.06
Amyloid in surgical pathology. Virchows Arch (2003) 1.05
Current perspectives on cardiac amyloidosis. Am J Physiol Heart Circ Physiol (2011) 1.04
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc Natl Acad Sci U S A (2010) 1.02
Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination? Immunology (2004) 1.00
Update on treatment of light chain amyloidosis. Haematologica (2014) 1.00
Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component. Proc Natl Acad Sci U S A (2009) 0.99
An uncommon cause of bilateral pulmonary nodules in a long-term smoker. J Gen Intern Med (2007) 0.96
Existence of different structural intermediates on the fibrillation pathway of human serum albumin. Biophys J (2009) 0.95
Current treatment of AL amyloidosis. Haematologica (2009) 0.95
Pathophysiology and treatment of systemic amyloidosis. Nat Rev Nephrol (2013) 0.93
In vivo supramolecular templating enhances the activity of multivalent ligands: a potential therapeutic against the Escherichia coli O157 AB5 toxins. Proc Natl Acad Sci U S A (2008) 0.92
An insight into the changes in human plasma proteome on adaptation to hypobaric hypoxia. PLoS One (2013) 0.92
SAP suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice. Immunol Cell Biol (2011) 0.92
Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs. Heart Fail Rev (2015) 0.89
Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease. Cell Mol Neurobiol (2002) 0.86
Autoinflammation in 2010: expanding clinical spectrum and broadening therapeutic horizons. Nat Rev Rheumatol (2011) 0.86
Preventing beta-amyloid fibrillization and deposition: beta-sheet breakers and pathological chaperone inhibitors. BMC Neurosci (2008) 0.86
Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor protein transgenic mice. J Biol Chem (2014) 0.84
Investigating interactions of the pentraxins serum amyloid P component and C-reactive protein by mass spectrometry. Biochem J (2003) 0.84
Gastrointestinal Amyloidosis: Approach to Treatment. Curr Treat Options Gastroenterol (2003) 0.84
Laryngo-tracheobronchial amyloidosis: a case report and review of literature. Int J Clin Exp Pathol (2014) 0.83
A quantitative proteomic approach to prion disease biomarker research: delving into the glycoproteome. J Proteome Res (2011) 0.81
Protein folding and aggregation into amyloid: the interference by natural phenolic compounds. Int J Mol Sci (2013) 0.81
Inhibition of TTR aggregation-induced cell death--a new role for serum amyloid P component. PLoS One (2013) 0.81
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. J Immunol Methods (2012) 0.81
Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer's Disease? Neuron (2016) 0.81
Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology. Neurochem Res (2011) 0.80
The proteasome is involved in the degradation of different aquaporin-2 mutants causing nephrogenic diabetes insipidus. Am J Pathol (2003) 0.80
Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis. J Biol Chem (2016) 0.79
Anti-interleukin 1 treatment in secondary amyloidosis associated with autoinflammatory diseases. Pediatr Nephrol (2015) 0.79
Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo. Open Biol (2016) 0.78
Therapy effects of green tea in a patient with systemic light-chain amyloidosis. Clin Res Cardiol (2008) 0.77
Review of eprodisate for the treatment of renal disease in AA amyloidosis. Int J Nephrol Renovasc Dis (2012) 0.77
Bifunctional crosslinking ligands for transthyretin. Open Biol (2015) 0.77
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro. Sci Rep (2016) 0.77
A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex. J Physiol (2003) 0.77
Efflux transport of serum amyloid P component at the blood-brain barrier. Eur J Microbiol Immunol (Bp) (2013) 0.76
Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. PLoS One (2013) 0.76
A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases. Curr Opin Chem Biol (2016) 0.75
KTP Laser in Laryngeal Amyloidosis: Five Cases with Review of Literature. Indian J Otolaryngol Head Neck Surg (2012) 0.75
Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting. Front Mol Biosci (2016) 0.75
Target Mediated Drug Disposition Model of CPHPC in Patients with Systemic Amyloidosis. CPT Pharmacometrics Syst Pharmacol (2015) 0.75
Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC). Acta Crystallogr D Biol Crystallogr (2014) 0.75
Amyloidosis of the head and neck: a clinicopathological study of cases with long-term follow-up. Arch Med Sci (2014) 0.75
Amyloid diseases: small drugs lead the attack. Nature (2002) 0.75
Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. AIDS (2015) 0.75
[Amyloid centers in Europe: the EURAMY project]. Pathologe (2009) 0.75
Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (1991) 38.64
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet (2003) 18.67
Antisense transcription in the mammalian transcriptome. Science (2005) 15.69
The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med (1994) 8.10
Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A (1991) 8.04
Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy (2010) 7.10
Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc Natl Acad Sci U S A (1994) 6.96
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology (1990) 6.34
Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS). Lancet (2005) 6.18
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ (2000) 6.10
A role for glucagon-like peptide-1 in the central regulation of feeding. Nature (1996) 6.03
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature (1989) 5.86
Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis. Nature (1997) 5.47
Building large trees by combining phylogenetic information: a complete phylogeny of the extant Carnivora (Mammalia). Biol Rev Camb Philos Soc (1999) 4.80
How safe is general practitioner obstetrics? Lancet (1980) 4.51
A standard reference frame for the description of nucleic acid base-pair geometry. J Mol Biol (2001) 4.29
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology (2004) 4.24
Particulate air pollution is associated with an acute phase response in men; results from the MONICA-Augsburg Study. Eur Heart J (2001) 4.21
The PILATUS 1M detector. J Synchrotron Radiat (2006) 4.16
Detection of Lactobacillus, Pediococcus, Leuconostoc, and Weissella species in human feces by using group-specific PCR primers and denaturing gradient gel electrophoresis. Appl Environ Microbiol (2001) 4.11
IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03
Development of the new lung allocation system in the United States. Am J Transplant (2006) 4.02
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A (1986) 3.97
Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat Med (1999) 3.88
Cross-contamination potential with dental equipment. Lancet (1992) 3.55
Exercise-based rehabilitation for coronary heart disease. Cochrane Database Syst Rev (2001) 3.46
Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum-based chemotherapy. Cancer (2000) 3.46
A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin. Biochem Biophys Res Commun (1985) 3.40
Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci (2003) 3.38
Postal survey of bronchoscopic practice by physicians in the United Kingdom. Thorax (1986) 3.30
Bacterial genomic reorganization upon DNA replication. Science (2001) 3.25
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. Nat Genet (1999) 3.17
Clinical pharmacology and pharmacokinetics of clonidine. Clin Pharmacol Ther (1976) 3.13
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11
A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice. Dev Biol (1999) 3.11
Development of an MRI-compatible needle insertion manipulator for stereotactic neurosurgery. J Image Guid Surg (1995) 3.07
Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice. Neuroreport (2000) 3.04
Expression vector system based on the chicken beta-actin promoter directs efficient production of interleukin-5. Gene (1989) 3.00
BMI from 3-6 y of age is predicted by TV viewing and physical activity, not diet. Int J Obes (Lond) (2005) 2.99
Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease. J Clin Invest (1993) 2.92
Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J Immunol (1997) 2.86
A defined range of guard cell calcium oscillation parameters encodes stomatal movements. Nature (2001) 2.82
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Human lysozyme gene mutations cause hereditary systemic amyloidosis. Nature (1993) 2.78
Assessment of antipyrine kinetics by measurement in saliva. Br J Clin Pharmacol (1976) 2.78
Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet (2001) 2.71
Structure of slow-reacting substance of anaphylaxis from guinea-pig lung. Nature (1980) 2.69
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther (1997) 2.68
The impact of long-term acute-care facilities on the outcome and cost of care for patients undergoing prolonged mechanical ventilation. Crit Care Med (2000) 2.66
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med (2001) 2.66
The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure (1999) 2.64
Association between C-reactive protein and features of the metabolic syndrome: a population-based study. Diabetes Care (2000) 2.63
Relations between song repertoire size and the volume of brain nuclei related to song: comparative evolutionary analyses amongst oscine birds. Proc Biol Sci (1993) 2.63
Bacterial infection in cystic fibrosis. Arch Dis Child (1972) 2.58
Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium. Infect Immun (1988) 2.56
Radiological versus histological diagnosis in UIP and NSIP: survival implications. Thorax (2003) 2.54
Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest (1999) 2.53
Comparative methods for explaining adaptations. Nature (1991) 2.51
Chemical structure of the morphogen differentiation inducing factor from Dictyostelium discoideum. Nature (1987) 2.49
Nasal acquisition of Staphylococcus aureus in a subdivided and mechanically ventilated ward: endemic prevalence of a single staphylococcal strain. J Hyg (Lond) (1970) 2.48
A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA. EMBO J (1998) 2.48
Upper gastrointestinal tract safety profile of alendronate: the fracture intervention trial. Arch Intern Med (2000) 2.46
Prevention of nonvertebral fractures by alendronate. A meta-analysis. Alendronate Osteoporosis Treatment Study Groups. JAMA (1997) 2.46
A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia. Gastroenterology (2000) 2.44
Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents. Br J Psychiatry (2000) 2.43
The association of pre-treatment neutrophil to lymphocyte ratio with overall survival in patients with glioblastoma multiforme. J Neurooncol (2013) 2.41
Calculating life years from transplant (LYFT): methods for kidney and kidney-pancreas candidates. Am J Transplant (2008) 2.39
Spectrodensitometric determination of trichothecene mycotoxins with 4-(p-nitrobenzyl)pyridine on silica gel thin-layer chromatograms. J Chromatogr (1979) 2.38
Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res (2005) 2.38
Amyloidosis and the respiratory tract. Thorax (1999) 2.36
Mutually exclusive expression of odorant receptor transgenes. Nat Neurosci (2000) 2.36
Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans. Neuron (2001) 2.36
Screening for colorectal cancer with flexible sigmoidoscopy by nonphysician endoscopists. Am J Med (1999) 2.35
Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet (1999) 2.32
Physiological role of silent receptors of atrial natriuretic factor. Science (1987) 2.31
Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum (1997) 2.31
Serum insulin-like growth factor-1 in centenarians: implications of IGF-1 as a rapid turnover protein. J Gerontol A Biol Sci Med Sci (2001) 2.27
Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. Science (1997) 2.27
Targeted integration of DNA using mutant lox sites in embryonic stem cells. Nucleic Acids Res (1997) 2.27
Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science (1999) 2.25
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia (2009) 2.24
Is colonoscopy indicated for small adenomas found by screening flexible sigmoidoscopy? Ann Intern Med (1998) 2.24
'SPKK' motifs prefer to bind to DNA at A/T-rich sites. EMBO J (1989) 2.24
The fast-slow continuum in mammalian life history: an empirical reevaluation. Am Nat (2007) 2.23
Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression. J Bacteriol (2000) 2.23
Endogenous steroids and financial risk taking on a London trading floor. Proc Natl Acad Sci U S A (2008) 2.22
Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int J Radiat Oncol Biol Phys (1999) 2.19