Published in Proc Natl Acad Sci U S A on December 26, 2001
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI) | NCT01044758
Medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol (2004) 4.89
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology (2005) 3.90
Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study. BMJ (2006) 2.79
Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med (2010) 2.77
Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation. Neuroimage (2003) 2.55
fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease. J Neurol Neurosurg Psychiatry (2003) 2.49
Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline. Neurology (2010) 2.25
Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies. Neuropsychologia (2007) 1.81
Energetics of neuronal signaling and fMRI activity. Proc Natl Acad Sci U S A (2007) 1.65
Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging. Behav Neurol (2009) 1.58
Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease. NeuroRx (2005) 1.58
Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. Neuroimage (2010) 1.57
Impairments in memory and hippocampal function in HIV-positive vs HIV-negative women: a preliminary study. Neurology (2009) 1.47
Brain imaging in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.37
Enhanced cue reactivity and fronto-striatal functional connectivity in cocaine use disorders. Drug Alcohol Depend (2011) 1.21
Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease. J Neurol Neurosurg Psychiatry (2002) 1.14
Cholinergic modulation of cognition: insights from human pharmacological functional neuroimaging. Prog Neurobiol (2011) 1.08
Cholinergic enhancement reduces spatial spread of visual responses in human early visual cortex. Neuron (2008) 1.07
The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation. Pharmacol Biochem Behav (2011) 1.07
Cholinergic enhancement of episodic memory in healthy young adults. Psychopharmacology (Berl) (2005) 1.06
Nicotinic versus muscarinic blockade alters verbal working memory-related brain activity in older women. Am J Geriatr Psychiatry (2008) 1.00
Potential of functional MRI as a biomarker in early Alzheimer's disease. Neurobiol Aging (2011) 0.99
Quantitative fMRI and oxidative neuroenergetics. Neuroimage (2012) 0.98
Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium. BMC Neurosci (2008) 0.94
Lorazepam dose-dependently decreases risk-taking related activation in limbic areas. Psychopharmacology (Berl) (2006) 0.93
Multivariate decoding of brain images using ordinal regression. Neuroimage (2013) 0.91
Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials. Arch Neurol (2011) 0.91
Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults. Hum Brain Mapp (2011) 0.90
Donepezil improves episodic memory in young individuals vulnerable to the effects of sleep deprivation. Sleep (2009) 0.87
Cholinergic blockade under working memory demands encountered by increased rehearsal strategies: evidence from fMRI in healthy subjects. Eur Arch Psychiatry Clin Neurosci (2011) 0.86
Decreasing task-related brain activity over repeated functional MRI scans and sessions with no change in performance: implications for serial investigations. Exp Brain Res (2008) 0.84
Associations between a neurophysiological marker of central cholinergic activity and cognitive functions in young and older adults. Behav Brain Funct (2012) 0.84
Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: a pilot study. Menopause (2010) 0.83
Hyperactivation of the cognitive control network in cocaine use disorders during a multisensory Stroop task. Drug Alcohol Depend (2013) 0.82
Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease. Neurodegener Dis (2012) 0.81
Estrogen-cholinergic interactions: Implications for cognitive aging. Horm Behav (2015) 0.80
Cognitive control network function in alcohol use disorder before and during treatment with lorazepam. Subst Use Misuse (2014) 0.80
Using arterial spin labeling perfusion MRI to explore how midazolam produces anterograde amnesia. Neurosci Lett (2012) 0.79
Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol (2016) 0.79
Altered memory-related functional connectivity of the anterior and posterior hippocampus in older adults at increased genetic risk for Alzheimer's disease. Hum Brain Mapp (2015) 0.78
Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram. Psychopharmacology (Berl) (2014) 0.78
Flexible modulation of network connectivity related to cognition in Alzheimer's disease. Neuroimage (2014) 0.78
Human models as tools in the development of psychotropic drugs. Dialogues Clin Neurosci (2002) 0.78
Dose effects of triazolam on brain activity during episodic memory encoding: a PET study. Psychopharmacology (Berl) (2006) 0.77
What makes deeply encoded items memorable? Insights into the levels of processing framework from neuroimaging and neuromodulation. Front Psychiatry (2014) 0.76
Elevated stress is associated with prefrontal cortex dysfunction during a verbal memory task in women with HIV. J Neurovirol (2016) 0.76
Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment during Episodic Memory Encoding. Front Psychiatry (2013) 0.76
Quantification of anticholinergic and sedative drug load with the Drug Burden Index: a review of outcomes and methodological quality of studies. Eur J Clin Pharmacol (2016) 0.75
Random-effects models for longitudinal data. Biometrics (1982) 54.17
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr (1994) 15.38
Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev (1992) 14.45
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol (2000) 6.40
The global record of memory in hippocampal neuronal activity. Nature (1999) 4.31
Medial temporal lobe activations in fMRI and PET studies of episodic encoding and retrieval. Hippocampus (1999) 3.00
Estimation and detection of event-related fMRI signals with temporally correlated noise: a statistically efficient and unbiased approach. Hum Brain Mapp (2000) 2.67
Cholinergic enhancement and increased selectivity of perceptual processing during working memory. Science (2000) 2.28
Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease. Arch Neurol (1993) 2.17
Encoding novel face-name associations: a functional MRI study. Hum Brain Mapp (2001) 2.13
Human hippocampus establishes associations in memory. Hippocampus (1997) 2.03
Variability in fMRI: an examination of intersession differences. Neuroimage (2000) 2.01
Encoding and retrieval of episodic memories: role of cholinergic and GABAergic modulation in the hippocampus. Hippocampus (1996) 1.68
The neurophysiology of memory. Ann N Y Acad Sci (2000) 1.61
FMRI of visual encoding: reproducibility of activation. Hum Brain Mapp (2000) 1.46
A double FDG/PET study of the effects of scopolamine in older adults. Neuropsychopharmacology (1994) 1.44
Studies on human memory: the interactions of diazepam, scopolamine, and physostigmine. Psychopharmacology (Berl) (1977) 1.35
Effects of diazepam and scopolamine on storage, retrieval and organizational processes in memory. Psychopharmacologia (1975) 1.19
Critical role of the parahippocampal region for paired-associate learning in rats. Behav Neurosci (1993) 1.17
Effects of scopolamine on delayed-matching-to-sample and paired associates tests of visual memory and learning in human subjects: comparison with diazepam and implications for dementia. Psychopharmacology (Berl) (1997) 1.10
Spatial location memory in amnesia: binding item and location information under incidental and intentional encoding conditions. Memory (1996) 1.00
Pharmacological modulation of behavioral and neuronal correlates of repetition priming. J Neurosci (2001) 0.99
Differentiating the effects of centrally acting drugs on arousal and memory: an event-related potential study of scopolamine, lorazepam and diphenhydramine. Psychopharmacology (Berl) (1998) 0.95
The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task. Exp Brain Res (1995) 0.92
Implicit memory in amnesic patients: when is auditory priming spared? J Int Neuropsychol Soc (1995) 0.87
An investigation of the effects of benzodiazepine receptor ligands and of scopolamine on conceptual priming. Psychopharmacology (Berl) (1998) 0.87
Lorazepam but not diazepam impairs identification of pictures on the basis of specific contour fragments. Psychopharmacology (Berl) (1998) 0.85
Measuring reproducibility of regional brain metabolic responses to lorazepam using statistical parametric maps. J Nucl Med (1999) 0.84
Regional brain activity during shape recognition impaired by a scopolamine challenge to encoding. Eur J Neurosci (1999) 0.83
Positron-emission tomography imaging of long-term shape recognition challenges. Proc Natl Acad Sci U S A (1997) 0.80
Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron (2002) 33.99
Automatically parcellating the human cerebral cortex. Cereb Cortex (2004) 18.32
The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging (2008) 14.68
Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data. Neuroimage (2005) 8.50
Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer. Neuroimage (2006) 7.14
A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement (2008) 6.39
The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex (2008) 5.36
Within-subject template estimation for unbiased longitudinal image analysis. Neuroimage (2012) 5.11
Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature. Neuroimage (2010) 4.55
Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging (2004) 4.38
Dorsal anterior cingulate cortex: a role in reward-based decision making. Proc Natl Acad Sci U S A (2001) 4.20
Highly accurate inverse consistent registration: a robust approach. Neuroimage (2010) 3.98
Distinct genetic influences on cortical surface area and cortical thickness. Cereb Cortex (2009) 3.90
Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol (2009) 3.82
Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants. Neuroimage (2009) 3.74
The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation (2008) 3.30
Acupuncture de qi, from qualitative history to quantitative measurement. J Altern Complement Med (2007) 3.27
Delusions and hallucinations are associated with worse outcome in Alzheimer disease. Arch Neurol (2005) 3.10
Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Arch Neurol (2007) 2.77
Focal thinning of the cerebral cortex in multiple sclerosis. Brain (2003) 2.74
PROMO: Real-time prospective motion correction in MRI using image-based tracking. Magn Reson Med (2010) 2.70
Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation. Neuroimage (2003) 2.55
Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention. Proc Natl Acad Sci U S A (2005) 2.51
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci (2008) 2.36
Decreased interhemispheric functional connectivity in autism. Cereb Cortex (2010) 2.33
Enabling collaborative research using the Biomedical Informatics Research Network (BIRN). J Am Med Inform Assoc (2011) 2.24
Diabetes in midlife and cognitive change over 20 years: a cohort study. Ann Intern Med (2014) 2.20
Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry (2005) 2.18
Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia (2006) 2.17
Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J Nucl Med (2010) 2.15
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
Structural magnetic resonance imaging in established and prodromal Alzheimer disease: a review. Alzheimer Dis Assoc Disord (2003) 2.12
Deep Brain Stimulation in Gilles de la Tourette Syndrome: What Does the Future Hold? A Cohort of 48 Patients. Neurosurgery (2016) 2.07
Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imaging. Neuroimage (2009) 2.01
Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study. Arch Neurol (2008) 1.92
Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II. Neurology (2012) 1.91
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol (2006) 1.84
Increased consumption of fruit and vegetables for the primary prevention of cardiovascular diseases. Cochrane Database Syst Rev (2013) 1.82
Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc Natl Acad Sci U S A (2011) 1.76
Diffusion tensor imaging in autism spectrum disorder: a review. Autism Res (2012) 1.75
Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders. Proc Natl Acad Sci U S A (2011) 1.73
Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun (2004) 1.72
Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism. Neuroimage (2010) 1.69
Time sequence diffeomorphic metric mapping and parallel transport track time-dependent shape changes. Neuroimage (2008) 1.69
A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect. J Neurosci (2008) 1.68
Functional connectivity magnetic resonance imaging classification of autism. Brain (2011) 1.65
Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease. Anal Biochem (2009) 1.64
IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol (2004) 1.64
Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task. Arch Gen Psychiatry (2008) 1.59
Changing cardiac arrest and hospital mortality rates through a medical emergency team takes time and constant review. Crit Care Med (2010) 1.58
Age-associated reductions in cerebral blood flow are independent from regional atrophy. Neuroimage (2010) 1.55
Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet (2004) 1.45
Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia. Neuroimage (2008) 1.43
Developmental study of the hippocampal formation in rhesus monkeys (Macaca mulatta): I. Early ablations spare discrimination learning but not recognition memory. Behav Neurosci (2005) 1.43
Can a handwashing intervention make a difference? Results from a randomized controlled trial in Jerusalem preschools. Prev Med (2005) 1.40
Disruptive behavior as a predictor in Alzheimer disease. Arch Neurol (2007) 1.39
Tuning in to the voices: a multisite FMRI study of auditory hallucinations. Schizophr Bull (2008) 1.38
Seizures in Alzheimer disease: who, when, and how common? Arch Neurol (2009) 1.34
Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging. Appl Opt (2003) 1.32
An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment. Neuroimage (2009) 1.32
Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia. Arch Gen Psychiatry (2010) 1.27
Distinct patterns of neural modulation during the processing of conceptual and syntactic anomalies. J Cogn Neurosci (2003) 1.27
Occludin is required for cytokine-induced regulation of tight junction barriers. J Cell Sci (2010) 1.26
Functional neuroanatomical investigation of vision-related acupuncture point specificity--a multisession fMRI study. Hum Brain Mapp (2009) 1.23
Prospective motion correction for single-voxel 1H MR spectroscopy. Magn Reson Med (2010) 1.22
Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry (2004) 1.22
Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss. Alzheimers Dement (2010) 1.20
Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort. Arch Neurol (2012) 1.20
Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PLoS One (2008) 1.20
The progression of cognition, psychiatric symptoms, and functional abilities in dementia with Lewy bodies and Alzheimer disease. Arch Neurol (2006) 1.20
Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods (2008) 1.19
The effects of patient function and dependence on costs of care in Alzheimer's disease. J Am Geriatr Soc (2008) 1.19
Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC neurocognitive study. Am J Epidemiol (2014) 1.18
Hearing loss and dementia - who is listening? Aging Ment Health (2014) 1.17
Clinical characteristics and longitudinal changes of informal cost of Alzheimer's disease in the community. J Am Geriatr Soc (2006) 1.16
Depressive symptoms in Alzheimer's disease: natural course and temporal relation to function and cognitive status. J Am Geriatr Soc (2005) 1.15
Longitudinal assessment of patient dependence in Alzheimer disease. Arch Neurol (2002) 1.14
CSF biomarker changes precede symptom onset of mild cognitive impairment. Neurology (2013) 1.13
Evaluating imaging biomarkers for neurodegeneration in pre-symptomatic Huntington's disease using machine learning techniques. Neuroimage (2010) 1.12
Monitoring quality in Israeli primary care: The primary care physicians' perspective. Isr J Health Policy Res (2012) 1.12
Psychopathological features in Alzheimer's disease: course and relationship with cognitive status. J Am Geriatr Soc (2003) 1.12
Functional connectivity of the frontoparietal network predicts cognitive modulation of pain. Pain (2012) 1.12
PRKCA: a positional candidate gene for body mass index and asthma. Am J Hum Genet (2009) 1.11
Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease. Alzheimers Dement (2012) 1.11
The fornix sign: a potential sign for Alzheimer's disease based on diffusion tensor imaging. J Neuroimaging (2011) 1.10
Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype. Curr Alzheimer Res (2014) 1.07
Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer's disease. Front Neurol (2011) 1.06
The rate of cognitive decline and risk of reaching clinical milestones in Alzheimer disease. Arch Neurol (2003) 1.06
White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging. Stroke (2006) 1.05
Patient dependence and longitudinal changes in costs of care in Alzheimer's disease. Dement Geriatr Cogn Disord (2008) 1.05
Multisite functional connectivity MRI classification of autism: ABIDE results. Front Hum Neurosci (2013) 1.04